JAK-STAT信号与前列腺基底细胞的命运

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Louise Lloyd
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引用次数: 0

摘要

一个罕见的中间群体的基底细胞表达腔标记已被确定。该细胞群的标记物包括Nkx3.1、Pbsn、cl1rb、Fgl1和Mmp7。在这些被称为基底- b细胞的细胞中,JAK-STAT信号被激活,其抑制作用降低了这些细胞特征标记物的表达。炎症增加了基底- b细胞向腔细胞的转分化,而JAK-STAT抑制了这一过程。PTEN的缺失增加了表达nkx3.1的basal - b样细胞的数量。因此,基底- b细胞已被确定为前列腺基底细胞群中至关重要的中间群体。此外,JAK-STAT信号被确定为前列腺炎症患者的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
JAK–STAT signalling and prostate basal cell fate
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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