Nature Reviews Urology最新文献_第8页

Urology on a changing planet: links between climate change and urological disease 变化中的星球上的泌尿科：气候变化与泌尿科疾病之间的联系

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-28 DOI: 10.1038/s41585-024-00979-4

Alexander P. Cole, Zhiyu Qian, Natasha Gupta, Michael Leapman, Hanna Zurl, Quoc-Dien Trinh, Jodi D. Sherman, Stacy Loeb, Hari S. Iyer

{"title":"Urology on a changing planet: links between climate change and urological disease","authors":"Alexander P. Cole, Zhiyu Qian, Natasha Gupta, Michael Leapman, Hanna Zurl, Quoc-Dien Trinh, Jodi D. Sherman, Stacy Loeb, Hari S. Iyer","doi":"10.1038/s41585-024-00979-4","DOIUrl":"10.1038/s41585-024-00979-4","url":null,"abstract":"Urological diseases and their varied forms of management warrant special attention in the setting of climate change. Regarding urological cancers, climate change will probably increase the incidence and severity of cancer diagnoses through exposures to certain environmental risk factors, while simultaneously disrupting cancer care delivery and downstream outcomes. Regarding benign urological diseases, a burgeoning body of work exists on climate-related heat waves, dehydration, urolithiasis, renal injury and infectious and vector-borne diseases. Adding to the potential effect on disease pathogenesis, many patients with urological diseases undergo high-tech, resource-intensive interventions, such as robotic surgery, and entail intensive longitudinal assessments over many years. These features incur a considerable carbon footprint, generate substantial waste, and can introduce vulnerabilities to climate-related weather events. Links exist between planetary health (the health of humans and the natural systems that support our health), climate change and urological disease and urological care providers face many challenges in the era of anthropogenic climate change. The next steps and priorities for research, management, and health care delivery include identification and prioritization of health care delivery strategies to minimize waste and carbon emissions, while supporting climate resilience. Examples include supporting telemedicine, limiting low-value care, and building resilience to minimize impacts of climate-related disasters to prepare for the challenges ahead. Here, the authors describe the links between planetary health, climate change and urological disease, as well as some of the challenges and potential strategies for urological care providers in the era of anthropogenic climate change.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"208-222"},"PeriodicalIF":12.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Understanding the roles of the WFDC cluster in sperm development and function 了解WFDC簇在精子发育和功能中的作用

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-17 DOI: 10.1038/s41585-025-00999-8

Annette Fenner

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Prostate cancer epigenetics — from pathophysiology to clinical application 前列腺癌表观遗传学——从病理生理学到临床应用

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-024-00991-8

Vera Constâncio, João Lobo, José Pedro Sequeira, Rui Henrique, Carmen Jerónimo

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A distinct TAM subset mediates immunotherapy resistance in prostate cancer 一个独特的TAM亚群介导前列腺癌的免疫治疗抵抗

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00996-x

Maria Chiara Masone

引用次数: 0

The burden of kidney transplant evaluation — an older adults’ perspective 肾移植负担评估——老年人视角

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00997-w

Maria Chiara Masone

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Particulate matter leaves a bitter taste in testes 微粒物质在睾丸中留下苦涩的味道

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-01000-2

Louise Lloyd

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Efficacy of the Revi system in treating urgency urinary incontinence Revi系统治疗急迫性尿失禁的疗效观察

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00998-9

Maria Chiara Masone

引用次数: 0

Turning down the heat in NEPC 降低NEPC的热度

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-01-16 DOI: 10.1038/s41585-025-00995-y

Louise Lloyd

引用次数: 0

Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology 经皮肾镜取石术中的疼痛处理——一种基于病理生理学的方法

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-13 DOI: 10.1038/s41585-024-00973-w

Kelli Aibel, Robert Chang, Arinze J. Ochuba, Kevin Koo, Jared S. Winoker

{"title":"Pain management in percutaneous nephrolithotomy — an approach rooted in pathophysiology","authors":"Kelli Aibel, Robert Chang, Arinze J. Ochuba, Kevin Koo, Jared S. Winoker","doi":"10.1038/s41585-024-00973-w","DOIUrl":"https://doi.org/10.1038/s41585-024-00973-w","url":null,"abstract":"<p>Pain related to percutaneous nephrolithotomy (PCNL) is multifactorial and poorly elucidated. However, understanding the pathophysiology of pain can enable a practical approach to pain management, which can be tailored to each patient. A number of potential mechanisms underlie pain perception in PCNL, and these mechanisms can be leveraged at various points on the perioperative care pathway. These interventions provide opportunities for modulation of pain associated with PCNL but must take into account various technical, pharmacological and patient-related considerations. Technical considerations include the influence of percutaneous access, stone removal and drainage techniques. Pharmacological aspects include the use of various analgesics and anaesthesia approaches. Patient factors include consideration of the biopsychosocial model in pain experience to understand each individual’s response to pain. By understanding the contemporary evidence surrounding the physiology of postoperative pain and identifying tangible intervention points, we can seek to mitigate postoperative pain in patients undergoing PCNL.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"87 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma 透明细胞肾细胞癌空间转录组分析的经验教训

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-09 DOI: 10.1038/s41585-024-00980-x

Jesper Jespersen, Cecilie Lindgaard, Laura Iisager, Johanne Ahrenfeldt, Iben Lyskjær

{"title":"Lessons learned from spatial transcriptomic analyses in clear-cell renal cell carcinoma","authors":"Jesper Jespersen, Cecilie Lindgaard, Laura Iisager, Johanne Ahrenfeldt, Iben Lyskjær","doi":"10.1038/s41585-024-00980-x","DOIUrl":"https://doi.org/10.1038/s41585-024-00980-x","url":null,"abstract":"<p>Spatial transcriptomics has emerged as a powerful tool for discerning the heterogeneity of the tumour microenvironment across various cancers, including renal cell carcinoma (RCC). Spatial transcriptomics-based studies conducted in clear-cell RCC (the only RCC subtype studied using this technique to date) have given insights into spatial interactions within this disease. These insights include the role of epithelial-to-mesenchymal transitioning, revealing proximity-dependent interactions between tumour cells, fibroblasts, interleukin-2-expressing macrophages and hyalinized regions. Investigations into metabolic programmes have shown high transcriptional heterogeneity within tumours, with a tendency of increased metabolic activity towards the tumour centre. T cell infiltration has been shown to be independent of neoantigen burden, although T cell activity correlates with both metabolic states and various transcripts expressed by tumour cells, fibroblasts and monocytes. The role of tertiary lymphoid structures in both plasma cell maturation and their infiltration of the tumour has been shown through tracks of fibroblasts. Collectively, these findings indicate the potential of spatial transcriptomics to reveal predictive spatial features, supporting its promise in the development of biomarkers for clear-cell RCC management.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"9 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0