Nature Reviews Urology最新文献_第7页

Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes 解决前列腺癌临床试验中的多样性障碍，促进公平的医疗保健结果

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-01008-8

Peter Lang, Matt Vassar

引用次数: 0

Treatment strategies in human papillomavirus-related advanced penile cancer 人乳头瘤病毒相关晚期阴茎癌的治疗策略

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-00994-z

Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini

{"title":"Treatment strategies in human papillomavirus-related advanced penile cancer","authors":"Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini","doi":"10.1038/s41585-025-00994-z","DOIUrl":"https://doi.org/10.1038/s41585-025-00994-z","url":null,"abstract":"Penile cancer is a rare neoplasm with heterogeneous prevalence influenced by risk factors such as smoking, poor hygiene and human papillomavirus (HPV) infection. Southern Africa, South America and Southeast Asia have the highest incidence of this disease. Penile squamous cell carcinomas (PSCCs) account for the majority of instances of penile cancer, with HPV-related carcinogenesis implicated in up to half of them. Increases in PSCC incidence in industrialized nations parallel the rising high-risk HPV infection rates, particularly HPV-16. Early-stage, localized PSCC is often manageable, but treatment options in advanced disease remain limited, with poor survival outcomes. Emerging evidence suggests that HPV-positive PSCC might exhibit unique therapeutic responses, including increased sensitivity to radiotherapy and chemotherapy, as has been observed in HPV-driven head and neck squamous cell carcinoma. Results of studies in HPV-positive PSCC demonstrate improved responses to chemoradiotherapy and immunotherapy, underscoring the potential for tailored treatments and de-escalation. Additionally, incorporating immunotherapy with radiotherapy in HPV-driven PSCC might provide greater oncological benefits than standard chemotherapy. These observations suggest that treatment strategies for HPV-positive PSCC might benefit from de-escalated chemoradiotherapy regimens or immunotherapy incorporation, potentially optimizing efficacy while minimizing toxic effects. Furthermore, biomarkers such as tumour mutational burden, programmed cell death ligand 1 expression, and genetic alterations could be crucial for predicting treatment response. Comprehensive biomarker assessment and accurate HPV status determination are essential for developing patient-tailored therapeutic strategies. These data provide evidence of the potential benefits of individualized approaches based on tumour biology and biomarker profiles.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"129 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bringing bi-paternal offspring a step closer 让双父系后代更近一步

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-02-17 DOI: 10.1038/s41585-025-01012-y

Louise Lloyd

引用次数: 0

An exploratory study of new predictive biomarkers of castration resistance 去势抗性新的预测性生物标志物的探索性研究

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-02-12 DOI: 10.1038/s41585-025-01007-9

Annette Fenner

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GDF15 blockade can reduce immunotherapy resistance in urothelial cancer 阻断GDF15可降低尿路上皮癌的免疫治疗耐药

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-02-11 DOI: 10.1038/s41585-025-01005-x

Maria Chiara Masone

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The key to humanitarian urology: do not import the surgeon, create trained local surgical teams 人道主义泌尿外科的关键是：不要引进外科医生，建立训练有素的当地外科团队

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2025-02-10 DOI: 10.1038/s41585-025-01003-z

J. Rubio-Briones, A. Gallioli

引用次数: 0

Breaking barriers in urology — surgical accessibility for urologists with paraplegia 突破泌尿外科障碍——截瘫泌尿科医生的手术可及性

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-02-10 DOI: 10.1038/s41585-025-01004-y

Juan Carlos Castaño Botero

引用次数: 0

Impact and importance of a new men’s health strategy in England 英格兰新男性健康战略的影响和重要性

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-31 DOI: 10.1038/s41585-025-01001-1

John Chisholm

引用次数: 0

Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers 非威尔姆肿瘤儿童肾癌生物学的标志性发现

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-29 DOI: 10.1038/s41585-024-00993-6

Daniela Perotti, Maureen J. O’Sullivan, Amy L. Walz, Jonathan Davick, Reem Al-Saadi, Daniel J. Benedetti, Jack Brzezinski, Sara Ciceri, Nicholas G. Cost, Jeffrey S. Dome, Jarno Drost, Nicholas Evageliou, Rhoikos Furtwängler, Norbert Graf, Mariana Maschietto, Elizabeth A. Mullen, Andrew J. Murphy, Michael V. Ortiz, Justine N. van der Beek, Arnauld Verschuur, Jenny Wegert, Richard Williams, Filippo Spreafico, James I. Geller, Marry M. van den Heuvel-Eibrink, Andrew L. Hong

{"title":"Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers","authors":"Daniela Perotti, Maureen J. O’Sullivan, Amy L. Walz, Jonathan Davick, Reem Al-Saadi, Daniel J. Benedetti, Jack Brzezinski, Sara Ciceri, Nicholas G. Cost, Jeffrey S. Dome, Jarno Drost, Nicholas Evageliou, Rhoikos Furtwängler, Norbert Graf, Mariana Maschietto, Elizabeth A. Mullen, Andrew J. Murphy, Michael V. Ortiz, Justine N. van der Beek, Arnauld Verschuur, Jenny Wegert, Richard Williams, Filippo Spreafico, James I. Geller, Marry M. van den Heuvel-Eibrink, Andrew L. Hong","doi":"10.1038/s41585-024-00993-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00993-6","url":null,"abstract":"Approximately 20% of paediatric and adolescent/young adult patients with renal tumours are diagnosed with non-Wilms tumour, a broad heterogeneous group of tumours that includes clear-cell sarcoma of the kidney, congenital mesoblastic nephroma, malignant rhabdoid tumour of the kidney, renal-cell carcinoma, renal medullary carcinoma and other rare histologies. The differential diagnosis of these tumours dates back many decades, when these pathologies were identified initially through clinicopathological observation of entities with outcomes that diverged from Wilms tumour, corroborated with immunohistochemistry and molecular cytogenetics and, subsequently, through next-generation sequencing. These advances enabled near-definitive recognition of different tumours and risk stratification of patients. In parallel, the generation of new renal-tumour models of some of these pathologies including cell lines, organoids, xenografts and genetically engineered mouse models improved our understanding of the development of these tumours and have facilitated the identification of new therapeutic targets. Despite these many achievements, paediatric and adolescent/young adult patients continue to die from such rare cancers at higher rates than patients with Wilms tumour. Thus, international coordinated efforts are needed to answer unresolved questions and improve outcomes.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"40 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, diagnosis and treatment of anterior prostate cancer 前前列腺癌的流行病学、诊断和治疗

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2025-01-28 DOI: 10.1038/s41585-024-00992-7

Sammy Gharbieh, Joshua Mullin, Ata Jaffer, Daniel Chia, Ben Challacombe

{"title":"Epidemiology, diagnosis and treatment of anterior prostate cancer","authors":"Sammy Gharbieh, Joshua Mullin, Ata Jaffer, Daniel Chia, Ben Challacombe","doi":"10.1038/s41585-024-00992-7","DOIUrl":"https://doi.org/10.1038/s41585-024-00992-7","url":null,"abstract":"Anterior prostate cancers (APCs) are a group of impalpable neoplasms located in regions anterior to the urethra, which comprise the transition zone, apical peripheral zone and anterior fibromuscular stroma. These regions are typically undersampled using conventional biopsy schemes, leading to a low detection rate for APC and a high rate of false negatives. Radical prostatectomy series suggest prevalence rates of at least 10–30%, but transperineal systematic biopsy is ideal for diagnosis, particularly where multiparametric MRI is unavailable. Combined MRI-targeted and systematic biopsies demonstrate high concordance with final histopathology and lead to the fewest incidences of upgrading and upstaging at radical prostatectomy. Thus, the use of combined biopsy techniques has important implications for preoperative work-up and surgical planning, as APCs are associated with larger cancer volumes and a higher rate of positive surgical margins than posterior prostate cancer. Nevertheless, anterior tumour location might confer a relative resistance to stage progression, as APCs exhibit lower rates of extraprostatic extension, seminal vesical invasion and lymph node metastases than the more commonly seen posterior neoplasms. Few studies have examined the long-term outcomes of partial gland approaches to APCs, but MRI-targeted techniques have the potential to provide real-time intraoperative guidance and maximize the oncological safety of anterior focal treatment options in patients with APC.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0