Bringing bi-paternal offspring a step closer

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2025-02-17 DOI:10.1038/s41585-025-01012-y

Louise Lloyd

引用次数: 0

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让双父系后代更近一步

根据发表在《细胞干细胞》杂志上的一项新研究，成功培育出了存活到成年的双父系小鼠。这一进展对生殖和再生医学具有重要意义。以前，基因组印迹的不稳定性限制了胚胎干细胞产生可存活后代的潜力。在这项研究中，作者使用移码突变、基因缺失和调控区编辑来引入20个基因修饰，这些修饰影响了数百个印迹基因，以解决在双父系胚胎中观察到的最严重的发育缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.