{"title":"JAK–STAT signalling and prostate basal cell fate","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00983-8","DOIUrl":null,"url":null,"abstract":"<p>A rare intermediate population of basal cells expressing luminal markers has been identified. Markers of this cell population include <i>Nkx3.1</i>, <i>Pbsn</i>, <i>C1rb</i>, <i>Fgl1</i> and <i>Mmp7</i>. In these cells, termed Basal-B cells, activated JAK–STAT signalling was identified and its inhibition reduced expression of the markers characterizing these cells. Inflammation increased Basal-B cell-to-luminal cell transdifferentiation and JAK–STAT inhibition decreased this process. Deletion of PTEN increased the numbers of NKX3.1-expressing Basal-B-like cells. Thus, Basal-B cells have been identified as a crucial intermediate population within the prostate basal cell population. Moreover, JAK–STAT signalling was identified as a potential target for patients with prostate inflammation.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"20 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-024-00983-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A rare intermediate population of basal cells expressing luminal markers has been identified. Markers of this cell population include Nkx3.1, Pbsn, C1rb, Fgl1 and Mmp7. In these cells, termed Basal-B cells, activated JAK–STAT signalling was identified and its inhibition reduced expression of the markers characterizing these cells. Inflammation increased Basal-B cell-to-luminal cell transdifferentiation and JAK–STAT inhibition decreased this process. Deletion of PTEN increased the numbers of NKX3.1-expressing Basal-B-like cells. Thus, Basal-B cells have been identified as a crucial intermediate population within the prostate basal cell population. Moreover, JAK–STAT signalling was identified as a potential target for patients with prostate inflammation.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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