全氟辛酸影响雄激素代谢

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-12-06 DOI:10.1038/s41585-024-00985-6

Louise Lloyd

引用次数: 0

摘要

全氟烷基物质全氟辛酸（PFOA）影响雄激素代谢的一种新的内分泌干扰特性已经被发现。这一发现对我们理解PFOA对雄激素作用的影响具有启示意义。在荧光光谱抑制剂筛选和抑制研究中，PFOA被鉴定为有效的、竞争性的和特异性的抑制醛酮还原酶1C2 (AKR1C2)，该酶催化5α-二氢睾酮（5α-DHT）在纳摩尔范围内还原为无活性的类固醇3α-雄甾二醇。这种特性被发现是缬氨酸存在于装订袋中的结果。因此，PFOA抑制了5α-DHT的还原，导致其积累。pfoa通过抑制AKR1C2而阻断5α-DHT代谢，增加雄激素受体的转激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PFOA affects androgen metabolism

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.