Nature Reviews Urology最新文献_第2页

Better PrEParation for HIV prevention in minority groups

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00981-w

Louise Lloyd

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Robot-assisted radical prostatectomy haemostasis techniques and outcomes

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-12-05 DOI: 10.1038/s41585-024-00978-5

Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu

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Advancing the state of the art in congenital obstructive uropathy

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00976-7

Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell

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Time is on our side — rethinking the concept of time to treatment for prostate cancer

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00977-6

Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington

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Opening up about cancer and mental health 畅谈癌症和心理健康

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-27 DOI: 10.1038/s41585-024-00975-8

Anna Schueth

{"title":"Opening up about cancer and mental health","authors":"Anna Schueth","doi":"10.1038/s41585-024-00975-8","DOIUrl":"https://doi.org/10.1038/s41585-024-00975-8","url":null,"abstract":"Everyone understands the tragedy of cancer; however, the severity of its effects are only known to those who have first-hand experience. Thus, not everyone understands how it feels to receive a diagnosis yourself or to support a loved one, or how colleagues and peers react at work and school. It begs the question: why are people who are dealing with a cancer diagnosis often still keeping it a secret?I have spoken with many patients who were diagnosed with cancer during their childhood or as a teenager or young adult; in this scenario, the parents are responsible for bringing their children to a check-up in the hospital or their health practitioner, which also comes with a heavy emotional burden. A patient who recently finished her chemotherapy told me that she did not want to talk with high school friends about her diagnosis and that she would select carefully when and to whom she would open up about her cancer. People would react differently, ranging from overly friendly to avoiding the topic at all, meaning that it quickly became clear who her true friends were and who she could trust. Now that she has finished treatment, she still does not necessarily bring up the topic with new friends on her college campus. However, speaking with someone who is aware of how difficult life can be after cancer can enable her to understand her circumstances and support her during her studies, as college life can be hard on anyone, even those in perfect health.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"257 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis development in non-muscle-invasive bladder cancer 非肌层浸润性膀胱癌的转移发展

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-20 DOI: 10.1038/s41585-024-00963-y

Michael Leyderman, Thenappan Chandrasekar, Petros Grivas, Roger Li, Seetharam Bhat, Alina Basnet, Oleg Shapiro, Joseph Jacob, Michael A. Daneshvar, Eyal Kord, Gennady Bratslavsky, Hanan Goldberg

引用次数: 0

Tomorrow’s patient management: LLMs empowered by external tools 未来的病人管理：借助外部工具增强法学硕士的能力

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-20 DOI: 10.1038/s41585-024-00965-w

Kelvin Szolnoky, Tobias Nordström, Martin Eklund

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Disruption of circadian rhythm as a potential pathogenesis of nocturia. 昼夜节律紊乱是夜尿症的潜在发病机制。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-14 DOI: 10.1038/s41585-024-00961-0

Qi-Xiang Song, Sylvia O Suadicani, Hiromitsu Negoro, Hai-Hong Jiang, Rita Jabr, Christopher Fry, Wei Xue, Margot S Damaser

{"title":"Disruption of circadian rhythm as a potential pathogenesis of nocturia.","authors":"Qi-Xiang Song, Sylvia O Suadicani, Hiromitsu Negoro, Hai-Hong Jiang, Rita Jabr, Christopher Fry, Wei Xue, Margot S Damaser","doi":"10.1038/s41585-024-00961-0","DOIUrl":"10.1038/s41585-024-00961-0","url":null,"abstract":"Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still remains to be elucidated. Contemporary clinical medications are mostly symptom based, aimed at either reducing nocturnal urine volume or targeting autonomic receptors within the bladder to facilitate urine storage. The day-night switch of the micturition pattern is controlled by circadian clocks located both in the central nervous system and in the peripheral organs. Arousal threshold and secretion of melatonin and vasopressin increase at night-time to achieve high-quality sleep and minimize nocturnal urine production. In response to the increased vasopressin, the kidney reduces the glomerular filtration rate and facilitates the reabsorption of water. Synchronously, in the bladder, circadian oscillation of crucial molecules occurs to reduce afferent sensory input and maintain sufficient bladder capacity during the night sleep period. Thus, nocturia might occur as a result of desynchronization in one or more of these circadian regulatory mechanisms. Disrupted rhythmicity of the central nervous system, kidney and bladder (known as the brain-kidney-bladder circadian axis) contributes to the pathogenesis of nocturia. Novel insights into the chronobiological nature of nocturia will be crucial to promote a revolutionary shift towards effective therapeutics targeting the realignment of the circadian rhythm.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSD3B1, prostate cancer mortality and modifiable outcomes HSD3B1、前列腺癌死亡率和可改变的结果

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-14 DOI: 10.1038/s41585-024-00953-0

Pedro F. S. Freitas, Alireza Abdshah, Rana R. McKay, Nima Sharifi

{"title":"HSD3B1, prostate cancer mortality and modifiable outcomes","authors":"Pedro F. S. Freitas, Alireza Abdshah, Rana R. McKay, Nima Sharifi","doi":"10.1038/s41585-024-00953-0","DOIUrl":"https://doi.org/10.1038/s41585-024-00953-0","url":null,"abstract":"Androgen receptor stimulation by testosterone and dihydrotestosterone is crucial for prostate cancer progression. Despite the initial effectiveness of androgen deprivation therapy (ADT), castration-resistant prostate cancer eventually develops in most men. A common germline missense-encoding polymorphism in HSD3B1 increases extra-gonadal androgen biosynthesis from adrenal precursors owing to increased availability of the encoded enzyme 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) — hence, it is called the adrenal-permissive enzyme. This mechanism explains the more rapid progression to castration-resistant prostate cancer in men who inherit this allele than in men without it via sustained androgen receptor activation despite ADT. Multiple clinical studies, including data derived from prospective phase III studies, have linked adrenal-permissive allele inheritance to inferior clinical responses to ADT and increased mortality, but reversal is possible with upfront adrenal androgen blockade. The adrenal-permissive allele exhibits divergent frequencies across various groups worldwide, which could contribute to differences in clinical outcomes among these populations. Large-scale data from the Million Veteran Program have shown homozygous HSD3B1 adrenal-permissive allele inheritance to be an independent biomarker of prostate cancer-specific mortality. Together, these observations support the integration of HSD3B1 into germline testing and clinical trials as it might help to identify groups at increased likelihood of benefiting from early, intensified, AR-targeting interventions. Lastly, 3βHSD1 is a promising target for pharmacological inhibition, which enables new strategies for systemic prostate cancer therapy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"72 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular imaging of renal cell carcinomas: ready for prime time. 肾细胞癌的分子成像：准备就绪。

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-14 DOI: 10.1038/s41585-024-00962-z

Qianyun Wu, Hongda Shao, Wei Zhai, Gang Huang, Jianjun Liu, Jeremie Calais, Weijun Wei

引用次数: 0