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Pride, not prejudice 骄傲，而不是偏见
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-21 DOI: 10.1038/s41585-025-01053-3
{"title":"Pride, not prejudice","authors":"","doi":"10.1038/s41585-025-01053-3","DOIUrl":"https://doi.org/10.1038/s41585-025-01053-3","url":null,"abstract":"In June 2020, at the height of the COVID-19 lockdown, Nature Reviews Urology published its first Pride special issue. At the time, we were the first urology journal and the first Nature Reviews journal to produce special content for Pride. Since then, numerous journals have followed suit and highlighted the importance of inclusion and understanding of underserved populations in medicine.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"8 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pronouns in English: a user's guide. 英语代词：使用指南。
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-20 DOI: 10.1038/s41585-025-01043-5
Rachel Oliver,Stephanie Lynnette,Tristan Brown,Tina Rashid
{"title":"Pronouns in English: a user's guide.","authors":"Rachel Oliver,Stephanie Lynnette,Tristan Brown,Tina Rashid","doi":"10.1038/s41585-025-01043-5","DOIUrl":"https://doi.org/10.1038/s41585-025-01043-5","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"31 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic targeting strategies for prostate cancer. 前列腺癌的协同靶向策略。
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-20 DOI: 10.1038/s41585-025-01042-6
Xuanji Li,Zeyu Han,Jianzhong Ai
{"title":"Synergistic targeting strategies for prostate cancer.","authors":"Xuanji Li,Zeyu Han,Jianzhong Ai","doi":"10.1038/s41585-025-01042-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01042-6","url":null,"abstract":"Prostate cancer is the second most commonly diagnosed cancer and the fifth leading cause of death among men worldwide. Androgen deprivation therapy is a common prostate cancer treatment, but its efficacy is often hindered by the development of resistance, which results in reducing survival benefits. Immunotherapy showed great promise in treating solid tumours; however, clinically significant improvements have not been demonstrated for patients with prostate cancer, highlighting specific drawbacks of this therapeutic modality. Hence, exploring novel strategies to synergistically enhance the efficacy of prostate cancer immunotherapy is imperative. Clinical investigations have focused on the combined use of targeted or gene therapy and immunotherapy for prostate cancer. Notably, tumour-specific antigens and inflammatory mediators are released from tumour cells after targeted or gene therapy, and the recruitment and infiltration of immune cells, including CD8+ T cells and natural killer cells activated by immunotherapy, are further augmented, markedly improving the efficacy and prognosis of prostate cancer. Thus, immunotherapy, targeted therapy and gene therapy could have reciprocal synergistic effects in prostate cancer in combination, resulting in a proposed synergistic model encompassing these three therapeutic modalities, presenting novel potential treatment strategies for prostate cancer.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"88 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testosterone affects the vaginal microbiome in transgender men 睾酮会影响变性男性的阴道微生物群
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-19 DOI: 10.1038/s41585-025-01052-4
Louise Lloyd
{"title":"Testosterone affects the vaginal microbiome in transgender men","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01052-4","DOIUrl":"https://doi.org/10.1038/s41585-025-01052-4","url":null,"abstract":"<p>Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencing sexual health outcomes, specifically the occurrence of bacterial vaginosis.</p><p>In this prospective longitudinal study, participants who were assigned female sex at birth with natal genitalia and reporting transgender male or nonbinary identity, aged ≥18 years and interested in initiating injectable testosterone were screened. If participants had Amsel criteria and Nugent scoring evaluations consistent with optimal vaginal microbiota, they were enrolled. After enrolment, vaginal samples were tested for <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae</i> and <i>Trichomonas vaginalis</i> and HIV test results obtained. Overall, nine participants were included in the study, of whom eight identified as transgender men and one as nonbinary.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"30 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives on chemsex 化学性的观点
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-19 DOI: 10.1038/s41585-025-01051-5
Louise Lloyd
{"title":"Perspectives on chemsex","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01051-5","DOIUrl":"https://doi.org/10.1038/s41585-025-01051-5","url":null,"abstract":"<p>Chemsex is a practice that sits at the intersection of substance use and sexuality, which is predominantly reported by men who have sex with men. Understanding the sociodynamics of chemsex is important for developing public health interventions.</p><p>The ANRS-PaacX study was undertaken to improve understanding of chemsex. In this study, the perspectives of different stakeholders, namely people with chemsex experience, clinicians and community health workers, were gathered and key themes in participants’ discourses on chemsex were identified using lexical analysis. The study had two main objectives: to encapsulate and articulate various perspectives and experiences regarding chemsex to improve understanding of the multifaceted nature of this phenomenon; and to scrutinize disparities and commonalities to identify key elements shaping care practices and health outcomes. A multi-level framework in which four distinct levels of analysis in social psychology (intrapersonal, situational or contextual, positional, and ideological) are outlined was used.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"33 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine-disrupting chemicals as prostate carcinogens 干扰内分泌的化学物质作为前列腺癌物
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-16 DOI: 10.1038/s41585-025-01031-9
Mariana Feijó, Tiago M. A. Carvalho, Lara R. S. Fonseca, Cátia V. Vaz, Bruno J. Pereira, José Eduardo B. Cavaco, Cláudio J. Maia, Ana P. Duarte, Endre Kiss-Toth, Sara Correia, Sílvia Socorro
{"title":"Endocrine-disrupting chemicals as prostate carcinogens","authors":"Mariana Feijó, Tiago M. A. Carvalho, Lara R. S. Fonseca, Cátia V. Vaz, Bruno J. Pereira, José Eduardo B. Cavaco, Cláudio J. Maia, Ana P. Duarte, Endre Kiss-Toth, Sara Correia, Sílvia Socorro","doi":"10.1038/s41585-025-01031-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01031-9","url":null,"abstract":"<p>Endocrine-disrupting chemicals (EDCs) are natural or synthetic compounds that are ubiquitous in the environment and in daily-usage products and interfere with the normal function of the endocrine system leading to adverse health effects in humans. Exposure to these chemicals might elevate the risk of metabolic disorders, developmental and reproductive defects, and endocrine-related cancers. Prostate cancer is the most common hormone-dependent cancer in men, and the fifth leading cause of cancer-related mortality, partly owing to a lack of knowledge about the mechanisms that lead to aggressive castration-resistant forms. In addition to the dependence of early-stage prostate cancer on androgen actions, the prostate is a target of oestrogenic regulation. This hormone dependence, along with the fact that exogenous influences are major risk factors for prostate cancer, make the prostate a likely target of harmful actions from EDCs. Various sources of EDCs and their different modes of action might explain their role in prostate carcinogenesis.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"18 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology and potential multimodal therapeutic strategies for IC/BPS. IC/BPS的病理生理学和潜在的多模式治疗策略。
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-15 DOI: 10.1038/s41585-025-01044-4
Jia-Fong Jhang,Wan-Ru Yu,Yuan-Hong Jiang,Hann-Chorng Kuo
{"title":"Pathophysiology and potential multimodal therapeutic strategies for IC/BPS.","authors":"Jia-Fong Jhang,Wan-Ru Yu,Yuan-Hong Jiang,Hann-Chorng Kuo","doi":"10.1038/s41585-025-01044-4","DOIUrl":"https://doi.org/10.1038/s41585-025-01044-4","url":null,"abstract":"Interstitial cystitis/bladder pain syndrome (IC/BPS) is a bladder disorder with no definite aetiology and currently no effective treatment. Its clinical symptoms vary widely, and the bladder condition and extra-bladder dysfunction also show different clinical presentations. This condition is considered to have multiple factors affecting the bladder and clinical symptoms, including urothelial dysfunction, mast cell activation, autoimmune response, neurogenic inflammation, viral or bacterial infection, autonomic nervous dysfunction and central nervous sensitization. Several non-pharmacological, medical, intravesical and novel bladder therapies have been advocated, but the efficacy and durability of these treatments have not been well elucidated. Multimodal therapy has been suggested based on possible pathological mechanisms; however, the most appropriate therapeutic strategy for this disorder has not been well defined. Thus, a rational algorithm for concomitant multimodal therapy for IC/BPS has been proposed.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"9 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What happens in Vegas … shapes the future of urology 在维加斯发生的一切…塑造了泌尿外科的未来
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-15 DOI: 10.1038/s41585-025-01048-0
Maria Chiara Masone
{"title":"What happens in Vegas … shapes the future of urology","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01048-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01048-0","url":null,"abstract":"<p>The American Urological Association (AUA) meeting has celebrated its 120th edition surrounded by gondolas, canals and warm weather. No, it wasn’t Venice, but The Venetian hotel in fabulous Las Vegas, which hosted top-level scientists, clinicians and healthcare professionals from all urology fields across the world.</p><p>Stones featured prominently in the plenary session on day 2. Suction has been presented as the newest and transformative tool in endourology, with the state of the art on this topic discussed by Ben Chew in his lecture “Aspiration Devices—Should We Be Using Them?” Spoiler: the answer is yes. Further exploring endourology, Seth Bechis presented data supporting stent avoidance in patients undergoing uncomplicated ureteroscopy, and Khurshid Ghani reiterated this concept in his state-of-the-art lecture, in which he provided an update on the ongoing SOUL trial, highlighting a strong patient preference for avoiding stents, and expressed his hope for a future in which routine ureteroscopy does not require a stent anymore.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"8 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
XYGO: proposing a new holistic measure of gender identity and sexual orientation. XYGO：提出一种新的性别认同和性取向的整体衡量标准。
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-13 DOI: 10.1038/s41585-025-01041-7
Alexi Di Cristofaro,Tommaso B Jannini,Elena Colonnello,Erika Limoncin,Daniele Mollaioli,Giacomo Ciocca,Andrea Sansone,Emmanuele A Jannini
{"title":"XYGO: proposing a new holistic measure of gender identity and sexual orientation.","authors":"Alexi Di Cristofaro,Tommaso B Jannini,Elena Colonnello,Erika Limoncin,Daniele Mollaioli,Giacomo Ciocca,Andrea Sansone,Emmanuele A Jannini","doi":"10.1038/s41585-025-01041-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01041-7","url":null,"abstract":"Gender identity (GI) and sexual orientation (SO) are key aspects of an individual's sexual identity, which is a major driver of human sexuality. Although definitions for GI and SO have been long established and represented in clinical and theoretical research, often without acknowledgement of their relationship to one another, the ideal means by which they should be measured is unclear. Various tools for measurement have been proposed, each presenting different methodological approaches along with their respective flaws and issues. By providing a comprehensive overview of the major instruments for measuring GI and SO, the XYGO tool aims to integrate their strengths by developing a new, cohesive and inclusive perspective on sexual identity, taking into consideration both dimensions of this unique characteristic of human sexuality. This holistic perspective integrates these components into a single construct capable of providing a more immediate and tailored interpretation to facilitate everyday clinical practice and potentially improve research in sexual medicine and psychosexology.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"74 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testosterone replacement therapy and spermatogenesis in reproductive age men 睾酮替代疗法与育龄男性精子发生
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-05-09 DOI: 10.1038/s41585-025-01032-8
Bryan D. Naelitz, Leila Momtazi-Mar, Sanjay Vallabhaneni, Rossella Cannarella, Sarah C. Vij, Neel V. Parekh, Raevti Bole, Scott D. Lundy
{"title":"Testosterone replacement therapy and spermatogenesis in reproductive age men","authors":"Bryan D. Naelitz, Leila Momtazi-Mar, Sanjay Vallabhaneni, Rossella Cannarella, Sarah C. Vij, Neel V. Parekh, Raevti Bole, Scott D. Lundy","doi":"10.1038/s41585-025-01032-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01032-8","url":null,"abstract":"<p>Testosterone has a pivotal role in spermatogenesis, erectile function, libido and expression of secondary sexual characteristics. The prevalence of symptomatic, laboratory-proven testosterone deficiency increases with age and is often treated with testosterone replacement therapy (TRT). Treatment with exogenous androgens suppresses gonadotropin levels, inhibits endogenous testosterone production and drastically reduces intratesticular testosterone, consequently impairing spermatogenesis. Sperm production often slowly resumes after TRT cessation. However, the rate of recovery shows highly variable kinetics that might complicate family planning. Medical therapies (including aromatase inhibitors and selective oestrogen receptor antagonists) and exogenous gonadotropins (including human chorionic gonadotropin and follicle-stimulating hormone) may be used to preserve or restore spermatogenesis in select populations receiving TRT. Exogenous testosterone is contraindicated in men trying to conceive, but new short-acting formulations, including oral testosterone undecanoate and nasal testosterone gel, might incompletely suppress the hypothalamic–pituitary–gonadal axis and partially preserve spermatogenesis.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"109 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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