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Chlorination by-products in drinking water — association with bladder cancer risk
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-03-13 DOI: 10.1038/s41585-025-01017-7
Maria Chiara Masone
{"title":"Chlorination by-products in drinking water — association with bladder cancer risk","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01017-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01017-7","url":null,"abstract":"<p>Chlorination is a common method for disinfecting drinking water but can produce potentially carcinogenic by-products, such as trihalomethanes (THMs). A new systematic review and meta-analysis was conducted to assess the association between residential THM exposure and cancer risk, and the results were published in <i>Environmental Health Perspectives</i>.</p><p>Overall, 29 studies assessing THM concentrations in relation to cancer in 14 organs were analysed, including 8 on bladder cancer. Among all tumours, only bladder cancer and colorectal cancer were eligible for meta-analyses.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"1 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GSTA2 mitigates DEHP-induced reproductive toxic effects
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-03-12 DOI: 10.1038/s41585-025-01016-8
Maria Chiara Masone
{"title":"GSTA2 mitigates DEHP-induced reproductive toxic effects","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01016-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01016-8","url":null,"abstract":"<p>The environmental pollutant bis(2-ethylhexyl) phthalate (DEHP) induces oxidative stress, leading to impaired sperm parameters and reproductive toxicity.</p><p>In a new study published in <i>Molecular and Cellular Endocrinology</i>, the role of glutathione <i>S</i>-transferase A2 (GSTA2) — a known detoxifying agent against environmental pollutants — was assessed in counteracting DEHP-induced reproductive damage.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"68 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-service training programmes to enhance surgical capacity in a resource-limited setting
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-03-12 DOI: 10.1038/s41585-025-01015-9
Maria Chiara Masone
{"title":"In-service training programmes to enhance surgical capacity in a resource-limited setting","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01015-9","DOIUrl":"https://doi.org/10.1038/s41585-025-01015-9","url":null,"abstract":"<p>Radical cystectomy is a primary treatment for muscle-invasive bladder cancer but can be associated with challenges in resource-limited settings owing to limited access to specialized surgical procedures.</p><p>In a new study published in <i>BMC Urology</i>, Taha and colleagues present a pilot study analysing perioperative complications and mortality associated with radical cystectomy at the Gezira Hospital for Renal Disease and Surgery (GHRDS) in Sudan, reflecting outcomes from an in-country training programme established by the Society of International Urology (SIU).</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"20 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the effects of prostate cancer therapies on cardiovascular health
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-26 DOI: 10.1038/s41585-025-01002-0
Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi
{"title":"Assessing the effects of prostate cancer therapies on cardiovascular health","authors":"Steven Tisseverasinghe, Marwan Tolba, Boris Bahoric, Fred Saad, Tamim Niazi","doi":"10.1038/s41585-025-01002-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01002-0","url":null,"abstract":"<p>Contemporary advances in prostate cancer treatments have markedly improved patient outcomes, yet concerns persist regarding the increased cardiovascular toxicity of prostate cancer treatments, which is multifaceted. Local therapies entail non-negligible cardiovascular risks. The effects of androgen deprivation therapy, which is pivotal in disease management, on cardiovascular health remains contentious, with gonadotropin-releasing hormone agonists and antagonists showing varying cardiovascular outcomes. Despite the ongoing controversy over the cardiovascular risks of gonadotropin-releasing hormone antagonists versus agonists, current evidence does not support favouring one over the other based solely on cardiovascular risk. Combination therapy with androgen receptor pathway inhibitors and androgen deprivation therapy shows additive cardiovascular risks, but robust comparative data are lacking. Chemotherapies such as docetaxel and cabazitaxel, along with emerging targeted therapies and radiopharmaceuticals, are associated with varied cardiovascular risks, necessitating personalized patient assessment. Clinicians should adhere to cardio-oncology guidelines when prescribing therapeutic agents, especially for patients with pre-existing cardiovascular conditions. Optimal monitoring and management strategies are essential to mitigate cardiovascular morbidity and mortality.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"15 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing perioperative care in MIBC: insights from NIAGARA
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-24 DOI: 10.1038/s41585-025-01009-7
Stephan Brönimann, Shahrokh F. Shariat
{"title":"Advancing perioperative care in MIBC: insights from NIAGARA","authors":"Stephan Brönimann, Shahrokh F. Shariat","doi":"10.1038/s41585-025-01009-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01009-7","url":null,"abstract":"The results of the NIAGARA trial have considerably advanced treatment for patients with muscle-invasive bladder cancer, establishing a new therapeutic standard for cisplatin-eligible patients. Future trials will help to answer remaining questions about perioperative treatment optimization.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating burnout in healthcare: the price of care in an uncaring system
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-21 DOI: 10.1038/s41585-025-01006-w
Zainab Noor, Shannon L. Wallace
{"title":"Navigating burnout in healthcare: the price of care in an uncaring system","authors":"Zainab Noor, Shannon L. Wallace","doi":"10.1038/s41585-025-01006-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01006-w","url":null,"abstract":"Burnout in healthcare is not merely a by-product of overwork, but a systemic issue driven by a culture of relentless productivity and insufficient support. Self-care practices such as exercise and mindfulness offer temporary relief, but do little to address the root causes of burnout embedded in the healthcare system. By promoting self-compassion and collaboration over competition, healthcare can move beyond burnout, restoring the ‘human being’ in every ‘human doing’ and creating a sustainable, supportive system for all.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"10 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder instillations of gentamicin to treat refractory recurrent urinary tract infection
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-20 DOI: 10.1038/s41585-025-01010-0
Sachin Malde
{"title":"Bladder instillations of gentamicin to treat refractory recurrent urinary tract infection","authors":"Sachin Malde","doi":"10.1038/s41585-025-01010-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01010-0","url":null,"abstract":"Bladder instillation of gentamicin is safe and effective in treating recurrent urinary tract infection that has failed to resolve with current guideline-based treatments. It also reduces the rate of antimicrobial resistance.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"14 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-01008-8
Peter Lang, Matt Vassar
{"title":"Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes","authors":"Peter Lang, Matt Vassar","doi":"10.1038/s41585-025-01008-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01008-8","url":null,"abstract":"Prostate cancer is the most common cancer in men, yet disparities persist in screening, diagnosis and treatment among populations with low socioeconomic status. Minority groups face barriers to clinical trial inclusion including limited awareness and financial challenges. Promoting diversity in clinical trials is crucial for inclusivity, improving treatment efficacy and achieving equitable health outcomes in prostate cancer care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment strategies in human papillomavirus-related advanced penile cancer
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-00994-z
Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini
{"title":"Treatment strategies in human papillomavirus-related advanced penile cancer","authors":"Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini","doi":"10.1038/s41585-025-00994-z","DOIUrl":"https://doi.org/10.1038/s41585-025-00994-z","url":null,"abstract":"<p>Penile cancer is a rare neoplasm with heterogeneous prevalence influenced by risk factors such as smoking, poor hygiene and human papillomavirus (HPV) infection. Southern Africa, South America and Southeast Asia have the highest incidence of this disease. Penile squamous cell carcinomas (PSCCs) account for the majority of instances of penile cancer, with HPV-related carcinogenesis implicated in up to half of them. Increases in PSCC incidence in industrialized nations parallel the rising high-risk HPV infection rates, particularly HPV-16. Early-stage, localized PSCC is often manageable, but treatment options in advanced disease remain limited, with poor survival outcomes. Emerging evidence suggests that HPV-positive PSCC might exhibit unique therapeutic responses, including increased sensitivity to radiotherapy and chemotherapy, as has been observed in HPV-driven head and neck squamous cell carcinoma. Results of studies in HPV-positive PSCC demonstrate improved responses to chemoradiotherapy and immunotherapy, underscoring the potential for tailored treatments and de-escalation. Additionally, incorporating immunotherapy with radiotherapy in HPV-driven PSCC might provide greater oncological benefits than standard chemotherapy. These observations suggest that treatment strategies for HPV-positive PSCC might benefit from de-escalated chemoradiotherapy regimens or immunotherapy incorporation, potentially optimizing efficacy while minimizing toxic effects. Furthermore, biomarkers such as tumour mutational burden, programmed cell death ligand 1 expression, and genetic alterations could be crucial for predicting treatment response. Comprehensive biomarker assessment and accurate HPV status determination are essential for developing patient-tailored therapeutic strategies. These data provide evidence of the potential benefits of individualized approaches based on tumour biology and biomarker profiles.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"129 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing bi-paternal offspring a step closer
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-02-17 DOI: 10.1038/s41585-025-01012-y
Louise Lloyd
{"title":"Bringing bi-paternal offspring a step closer","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01012-y","DOIUrl":"10.1038/s41585-025-01012-y","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 3","pages":"127-127"},"PeriodicalIF":12.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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