睾酮会影响变性男性的阴道微生物群

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2025-05-19 DOI:10.1038/s41585-025-01052-4

Louise Lloyd

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引用次数: 0

摘要

对变性男性进行性别确认激素治疗可影响其阴道微生物群，可能对性健康结果产生不利影响，特别是细菌性阴道病的发生。在这项前瞻性纵向研究中，筛选了年龄≥18岁且对开始注射睾酮感兴趣的出生时被指定为女性和报告变性男性或非二元性别的参与者。如果参与者的Amsel标准和Nugent评分评估与最佳阴道微生物群一致，他们就被纳入。入组后，对阴道样本进行沙眼衣原体、淋病奈瑟菌和阴道毛滴虫检测，并获得艾滋病毒检测结果。总共有9名参与者参与了这项研究，其中8人被认定为跨性别男性，1人是非二元性别。

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Testosterone affects the vaginal microbiome in transgender men

Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencing sexual health outcomes, specifically the occurrence of bacterial vaginosis.

In this prospective longitudinal study, participants who were assigned female sex at birth with natal genitalia and reporting transgender male or nonbinary identity, aged ≥18 years and interested in initiating injectable testosterone were screened. If participants had Amsel criteria and Nugent scoring evaluations consistent with optimal vaginal microbiota, they were enrolled. After enrolment, vaginal samples were tested for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis and HIV test results obtained. Overall, nine participants were included in the study, of whom eight identified as transgender men and one as nonbinary.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.