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The mechanism of action of neuromodulation in the treatment of overactive bladder 神经调节治疗膀胱过动症的作用机制
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00967-8
Jan Krhut, Hanne Kobberø, Reine Kanaan, Mikkel Fode, Mads Poulsen, Peter Zvara
{"title":"The mechanism of action of neuromodulation in the treatment of overactive bladder","authors":"Jan Krhut, Hanne Kobberø, Reine Kanaan, Mikkel Fode, Mads Poulsen, Peter Zvara","doi":"10.1038/s41585-024-00967-8","DOIUrl":"https://doi.org/10.1038/s41585-024-00967-8","url":null,"abstract":"<p>Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"28 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serial ctDNA to understand PARPi resistance 序列ctDNA了解PARPi抗性
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00984-7
Annette Fenner
{"title":"Serial ctDNA to understand PARPi resistance","authors":"Annette Fenner","doi":"10.1038/s41585-024-00984-7","DOIUrl":"10.1038/s41585-024-00984-7","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"3-3"},"PeriodicalIF":12.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PFOA affects androgen metabolism 全氟辛酸影响雄激素代谢
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00985-6
Louise Lloyd
{"title":"PFOA affects androgen metabolism","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00985-6","DOIUrl":"10.1038/s41585-024-00985-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PEACEing together prostate cancer therapy 和平共处前列腺癌治疗
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00982-9
Louise Lloyd
{"title":"PEACEing together prostate cancer therapy","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00982-9","DOIUrl":"10.1038/s41585-024-00982-9","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK–STAT signalling and prostate basal cell fate JAK-STAT信号与前列腺基底细胞的命运
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00983-8
Louise Lloyd
{"title":"JAK–STAT signalling and prostate basal cell fate","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00983-8","DOIUrl":"10.1038/s41585-024-00983-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Better PrEParation for HIV prevention in minority groups 加强对少数群体艾滋病毒预防的准备
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00981-w
Louise Lloyd
{"title":"Better PrEParation for HIV prevention in minority groups","authors":"Louise Lloyd","doi":"10.1038/s41585-024-00981-w","DOIUrl":"10.1038/s41585-024-00981-w","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 1","pages":"4-4"},"PeriodicalIF":12.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robot-assisted radical prostatectomy haemostasis techniques and outcomes 机器人辅助根治性前列腺切除术止血技术及结果
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-12-05 DOI: 10.1038/s41585-024-00978-5
Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu
{"title":"Robot-assisted radical prostatectomy haemostasis techniques and outcomes","authors":"Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu","doi":"10.1038/s41585-024-00978-5","DOIUrl":"https://doi.org/10.1038/s41585-024-00978-5","url":null,"abstract":"The robot-assisted approach to radical prostatectomy has enabled same-day discharge. A substantial concern associated with this practice could be haemorrhage, but sound and thorough robot-assisted radical prostatectomy haemostasis surgical techniques that were introduced to prevent bleeding mitigate this phenomenon.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing the state of the art in congenital obstructive uropathy 推进先天性梗阻性尿路病变的最新进展
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00976-7
Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell
{"title":"Advancing the state of the art in congenital obstructive uropathy","authors":"Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell","doi":"10.1038/s41585-024-00976-7","DOIUrl":"https://doi.org/10.1038/s41585-024-00976-7","url":null,"abstract":"In March 2024, we convened a symposium to consider the state of the art regarding the mechanisms and management of congenital obstructive uropathy caused by bladder outlet obstruction, at which overarching themes emerged and opportunities for research were discussed to fill key knowledge gaps in achieving the best future for children with congenital obstructive uropathy.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"27 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time is on our side — rethinking the concept of time to treatment for prostate cancer 时间站在我们这一边——重新思考前列腺癌治疗的时间概念
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00977-6
Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington
{"title":"Time is on our side — rethinking the concept of time to treatment for prostate cancer","authors":"Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington","doi":"10.1038/s41585-024-00977-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00977-6","url":null,"abstract":"Prostate cancer is often an indolent disease, and delays in treatment up to 6 months do not seem to affect cancer-free survival. Inadequate pre-treatment assessment and uninformed shared decision-making can lead to decision regret and disparities in receipt of treatments. Time is on our side to allocate sufficient time and resources to consider the most appropriate and individualized treatment decision in prostate cancer care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"26 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opening up about cancer and mental health 畅谈癌症和心理健康
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2024-11-27 DOI: 10.1038/s41585-024-00975-8
Anna Schueth
{"title":"Opening up about cancer and mental health","authors":"Anna Schueth","doi":"10.1038/s41585-024-00975-8","DOIUrl":"https://doi.org/10.1038/s41585-024-00975-8","url":null,"abstract":"<p>Everyone understands the tragedy of cancer; however, the severity of its effects are only known to those who have first-hand experience. Thus, not everyone understands how it feels to receive a diagnosis yourself or to support a loved one, or how colleagues and peers react at work and school. It begs the question: why are people who are dealing with a cancer diagnosis often still keeping it a secret?</p><p>I have spoken with many patients who were diagnosed with cancer during their childhood or as a teenager or young adult; in this scenario, the parents are responsible for bringing their children to a check-up in the hospital or their health practitioner, which also comes with a heavy emotional burden. A patient who recently finished her chemotherapy told me that she did not want to talk with high school friends about her diagnosis and that she would select carefully when and to whom she would open up about her cancer. People would react differently, ranging from overly friendly to avoiding the topic at all, meaning that it quickly became clear who her true friends were and who she could trust. Now that she has finished treatment, she still does not necessarily bring up the topic with new friends on her college campus. However, speaking with someone who is aware of how difficult life can be after cancer can enable her to understand her circumstances and support her during her studies, as college life can be hard on anyone, even those in perfect health.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"257 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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