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Nature Reviews Urology最新文献

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Bladder instillations of gentamicin to treat refractory recurrent urinary tract infection
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-20 DOI: 10.1038/s41585-025-01010-0
Sachin Malde
{"title":"Bladder instillations of gentamicin to treat refractory recurrent urinary tract infection","authors":"Sachin Malde","doi":"10.1038/s41585-025-01010-0","DOIUrl":"https://doi.org/10.1038/s41585-025-01010-0","url":null,"abstract":"Bladder instillation of gentamicin is safe and effective in treating recurrent urinary tract infection that has failed to resolve with current guideline-based treatments. It also reduces the rate of antimicrobial resistance.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"14 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-01008-8
Peter Lang, Matt Vassar
{"title":"Addressing diversity barriers in prostate cancer clinical trials for equitable healthcare outcomes","authors":"Peter Lang, Matt Vassar","doi":"10.1038/s41585-025-01008-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01008-8","url":null,"abstract":"Prostate cancer is the most common cancer in men, yet disparities persist in screening, diagnosis and treatment among populations with low socioeconomic status. Minority groups face barriers to clinical trial inclusion including limited awareness and financial challenges. Promoting diversity in clinical trials is crucial for inclusivity, improving treatment efficacy and achieving equitable health outcomes in prostate cancer care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"16 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment strategies in human papillomavirus-related advanced penile cancer
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-18 DOI: 10.1038/s41585-025-00994-z
Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini
{"title":"Treatment strategies in human papillomavirus-related advanced penile cancer","authors":"Mattia Longoni, Christian D. Fankhauser, Fausto Negri, Andrea Salonia, Giuseppe Basile, Peter A. S. Johnstone, Marco Bandini","doi":"10.1038/s41585-025-00994-z","DOIUrl":"https://doi.org/10.1038/s41585-025-00994-z","url":null,"abstract":"<p>Penile cancer is a rare neoplasm with heterogeneous prevalence influenced by risk factors such as smoking, poor hygiene and human papillomavirus (HPV) infection. Southern Africa, South America and Southeast Asia have the highest incidence of this disease. Penile squamous cell carcinomas (PSCCs) account for the majority of instances of penile cancer, with HPV-related carcinogenesis implicated in up to half of them. Increases in PSCC incidence in industrialized nations parallel the rising high-risk HPV infection rates, particularly HPV-16. Early-stage, localized PSCC is often manageable, but treatment options in advanced disease remain limited, with poor survival outcomes. Emerging evidence suggests that HPV-positive PSCC might exhibit unique therapeutic responses, including increased sensitivity to radiotherapy and chemotherapy, as has been observed in HPV-driven head and neck squamous cell carcinoma. Results of studies in HPV-positive PSCC demonstrate improved responses to chemoradiotherapy and immunotherapy, underscoring the potential for tailored treatments and de-escalation. Additionally, incorporating immunotherapy with radiotherapy in HPV-driven PSCC might provide greater oncological benefits than standard chemotherapy. These observations suggest that treatment strategies for HPV-positive PSCC might benefit from de-escalated chemoradiotherapy regimens or immunotherapy incorporation, potentially optimizing efficacy while minimizing toxic effects. Furthermore, biomarkers such as tumour mutational burden, programmed cell death ligand 1 expression, and genetic alterations could be crucial for predicting treatment response. Comprehensive biomarker assessment and accurate HPV status determination are essential for developing patient-tailored therapeutic strategies. These data provide evidence of the potential benefits of individualized approaches based on tumour biology and biomarker profiles.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"129 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing bi-paternal offspring a step closer
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-02-17 DOI: 10.1038/s41585-025-01012-y
Louise Lloyd
{"title":"Bringing bi-paternal offspring a step closer","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01012-y","DOIUrl":"10.1038/s41585-025-01012-y","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 3","pages":"127-127"},"PeriodicalIF":12.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An exploratory study of new predictive biomarkers of castration resistance
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-02-12 DOI: 10.1038/s41585-025-01007-9
Annette Fenner
{"title":"An exploratory study of new predictive biomarkers of castration resistance","authors":"Annette Fenner","doi":"10.1038/s41585-025-01007-9","DOIUrl":"10.1038/s41585-025-01007-9","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 3","pages":"128-128"},"PeriodicalIF":12.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GDF15 blockade can reduce immunotherapy resistance in urothelial cancer
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-02-11 DOI: 10.1038/s41585-025-01005-x
Maria Chiara Masone
{"title":"GDF15 blockade can reduce immunotherapy resistance in urothelial cancer","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01005-x","DOIUrl":"10.1038/s41585-025-01005-x","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 3","pages":"129-129"},"PeriodicalIF":12.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The key to humanitarian urology: do not import the surgeon, create trained local surgical teams
IF 12.1 1区 医学
Nature Reviews Urology Pub Date : 2025-02-10 DOI: 10.1038/s41585-025-01003-z
J. Rubio-Briones, A. Gallioli
{"title":"The key to humanitarian urology: do not import the surgeon, create trained local surgical teams","authors":"J. Rubio-Briones,&nbsp;A. Gallioli","doi":"10.1038/s41585-025-01003-z","DOIUrl":"10.1038/s41585-025-01003-z","url":null,"abstract":"Humanitarian surgical missions provide substantial benefits to the involved surgeon and to the recipient communities. These missions should be planned and executed with the final aim to train local teams to implement innovative or standard surgical techniques.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 4","pages":"188-189"},"PeriodicalIF":12.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking barriers in urology — surgical accessibility for urologists with paraplegia
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-02-10 DOI: 10.1038/s41585-025-01004-y
Juan Carlos Castaño Botero
{"title":"Breaking barriers in urology — surgical accessibility for urologists with paraplegia","authors":"Juan Carlos Castaño Botero","doi":"10.1038/s41585-025-01004-y","DOIUrl":"https://doi.org/10.1038/s41585-025-01004-y","url":null,"abstract":"The path to become a urological surgeon is full of obstacles. Historically, individuals with a physical disability have faced substantial barriers in their training and practice. However, the development of the right environment can ensure that these challenges do not hinder the progress of surgeons.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"41 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact and importance of a new men’s health strategy in England
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-31 DOI: 10.1038/s41585-025-01001-1
John Chisholm
{"title":"Impact and importance of a new men’s health strategy in England","authors":"John Chisholm","doi":"10.1038/s41585-025-01001-1","DOIUrl":"https://doi.org/10.1038/s41585-025-01001-1","url":null,"abstract":"The Government’s commitment to a Men’s Health Strategy in England, announced by Wes Streeting, the Secretary of State for Health and Social Care, on 28 November 2024, is a welcome development. The implementation of a strategy will hopefully lead to improved access to services and health outcomes for men and boys.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"24 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers
IF 15.3 1区 医学
Nature Reviews Urology Pub Date : 2025-01-29 DOI: 10.1038/s41585-024-00993-6
Daniela Perotti, Maureen J. O’Sullivan, Amy L. Walz, Jonathan Davick, Reem Al-Saadi, Daniel J. Benedetti, Jack Brzezinski, Sara Ciceri, Nicholas G. Cost, Jeffrey S. Dome, Jarno Drost, Nicholas Evageliou, Rhoikos Furtwängler, Norbert Graf, Mariana Maschietto, Elizabeth A. Mullen, Andrew J. Murphy, Michael V. Ortiz, Justine N. van der Beek, Arnauld Verschuur, Jenny Wegert, Richard Williams, Filippo Spreafico, James I. Geller, Marry M. van den Heuvel-Eibrink, Andrew L. Hong
{"title":"Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers","authors":"Daniela Perotti, Maureen J. O’Sullivan, Amy L. Walz, Jonathan Davick, Reem Al-Saadi, Daniel J. Benedetti, Jack Brzezinski, Sara Ciceri, Nicholas G. Cost, Jeffrey S. Dome, Jarno Drost, Nicholas Evageliou, Rhoikos Furtwängler, Norbert Graf, Mariana Maschietto, Elizabeth A. Mullen, Andrew J. Murphy, Michael V. Ortiz, Justine N. van der Beek, Arnauld Verschuur, Jenny Wegert, Richard Williams, Filippo Spreafico, James I. Geller, Marry M. van den Heuvel-Eibrink, Andrew L. Hong","doi":"10.1038/s41585-024-00993-6","DOIUrl":"https://doi.org/10.1038/s41585-024-00993-6","url":null,"abstract":"<p>Approximately 20% of paediatric and adolescent/young adult patients with renal tumours are diagnosed with non-Wilms tumour, a broad heterogeneous group of tumours that includes clear-cell sarcoma of the kidney, congenital mesoblastic nephroma, malignant rhabdoid tumour of the kidney, renal-cell carcinoma, renal medullary carcinoma and other rare histologies. The differential diagnosis of these tumours dates back many decades, when these pathologies were identified initially through clinicopathological observation of entities with outcomes that diverged from Wilms tumour, corroborated with immunohistochemistry and molecular cytogenetics and, subsequently, through next-generation sequencing. These advances enabled near-definitive recognition of different tumours and risk stratification of patients. In parallel, the generation of new renal-tumour models of some of these pathologies including cell lines, organoids, xenografts and genetically engineered mouse models improved our understanding of the development of these tumours and have facilitated the identification of new therapeutic targets. Despite these many achievements, paediatric and adolescent/young adult patients continue to die from such rare cancers at higher rates than patients with Wilms tumour. Thus, international coordinated efforts are needed to answer unresolved questions and improve outcomes.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"40 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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