Nature Reviews Urology最新文献_第3页

Metabolism, mitochondria and metastasis in kidney cancer 肾癌的代谢、线粒体和转移

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-13 DOI: 10.1038/s41585-024-00968-7

Louise Lloyd

引用次数: 0

The urge to advance: ICS 2024 drives innovation in continence care 前进的动力：ICS 2024 推动尿失禁护理创新

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-11 DOI: 10.1038/s41585-024-00972-x

Maria Chiara Masone

引用次数: 0

Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects 探索脂质应激对精子细胞骨架的影响：启示与展望

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-11 DOI: 10.1038/s41585-024-00952-1

Tania E. Saez Lancellotti, María V. Avena, Abi K. Funes, María-Rosa Bernal-López, Ricardo Gómez-Huelgas, Miguel W. Fornes

{"title":"Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects","authors":"Tania E. Saez Lancellotti, María V. Avena, Abi K. Funes, María-Rosa Bernal-López, Ricardo Gómez-Huelgas, Miguel W. Fornes","doi":"10.1038/s41585-024-00952-1","DOIUrl":"https://doi.org/10.1038/s41585-024-00952-1","url":null,"abstract":"The decline in male fertility correlates with the global rise in obesity and dyslipidaemia, representing significant public health challenges. High-fat diets induce metabolic alterations, including hypercholesterolaemia, hepatic steatosis and atherosclerosis, with detrimental effects on testicular function. Testicular tissue, critically dependent on lipids for steroidogenesis, is particularly vulnerable to these metabolic disruptions. Excessive lipid accumulation within the testes, including cholesterol, triglycerides and specific fatty acids, disrupts essential sperm production processes such as membrane formation, maturation, energy metabolism and cell signalling. This leads to apoptosis, impaired spermatogenesis, and abnormal sperm morphology and function, ultimately compromising male fertility. During spermiogenesis, round spermatids undergo extensive reorganization, including the formation of the acrosome, manchette and specialized filamentous structures, which are essential for defining the final sperm cell shape. In this Perspective, we examine the impact of high-fat diets on the cytoskeleton of spermatogenic cells and its consequences to identify the mechanisms underlying male infertility associated with dyslipidaemia. Understanding these processes may facilitate the development of therapeutic strategies, such as dietary interventions or natural product supplementation, that aim to address infertility in men with obesity and hypercholesterolaemia. The investigation of cytoskeleton response to lipid stress extends beyond male reproduction, offering insights with broader implications.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"11 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tivozanib monotherapy outperforms combination therapy in post-ICI RCC Tivozanib单药治疗ICI后RCC的疗效优于联合疗法

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-11 DOI: 10.1038/s41585-024-00971-y

Maria Chiara Masone

引用次数: 0

177Lu-PSMA-617 extends progression-free survival in taxane-naive mCRPC 177Lu-PSMA-617可延长抗类固醇药物无效mCRPC患者的无进展生存期

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-11-11 DOI: 10.1038/s41585-024-00970-z

Maria Chiara Masone

引用次数: 0

Prostate cancer in transgender women — challenges in research and clinical care 变性妇女的前列腺癌--研究和临床护理方面的挑战

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-11-04 DOI: 10.1038/s41585-024-00966-9

Farnoosh Nik-Ahd, Jennifer T. Anger, Matthew R. Cooperberg, Stephen J. Freedland

引用次数: 0

Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer 治疗前转移活检：迈向尿路癌精准肿瘤学的一步

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-29 DOI: 10.1038/s41585-024-00951-2

Niklas Klümper, Alexander Cox, Gottfrid Sjödahl, Florian Roghmann, Christian Bolenz, Arndt Hartmann, Viktor Grünwald, Bishoy M. Faltas, Michael Hölzel, Markus Eckstein

{"title":"Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer","authors":"Niklas Klümper, Alexander Cox, Gottfrid Sjödahl, Florian Roghmann, Christian Bolenz, Arndt Hartmann, Viktor Grünwald, Bishoy M. Faltas, Michael Hölzel, Markus Eckstein","doi":"10.1038/s41585-024-00951-2","DOIUrl":"https://doi.org/10.1038/s41585-024-00951-2","url":null,"abstract":"Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours. However, translational and clinical studies frequently do not account for such heterogeneity and often investigate primary tumour samples that might not be representative in patients with mUC. We propose this as a potential factor for why many biomarkers for mUC have failed to be integrated into clinical practice. Fresh pre-treatment metastatic biopsies enable the capturing of prevailing tumour biology in real time. The characterization of metastatic tumour samples can improve response prediction to immunotherapy, the anti-NECTIN4 antibody–drug conjugate enfortumab vedotin and the FGFR inhibitor erdafitinib. Routine metastatic biopsy can thus improve the precision of identifying driver druggable alterations, thus improving treatment selection for patients with mUC.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"15 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

20 years of ‘spilling the tea’ in urology 泌尿外科 20 年的 "茶香四溢

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-25 DOI: 10.1038/s41585-024-00955-y

引用次数: 0

Author Correction: Metaverse in surgery - origins and future potential. 作者更正：外科手术中的 Metaverse - 起源与未来潜力。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-23 DOI: 10.1038/s41585-024-00964-x

Enrico Checcucci,Alessandro Veccia,Stefano Puliatti,Pieter De Backer,Pietro Piazza,Karl-Friedrich Kowalewski,Severin Rodler,Mark Taratkin,Ines Rivero Belenchon,Loic Baekelandt,Sabrina De Cillis,Alberto Piana,Ahmed Eissa,Juan Gomez Rivas,Giovanni Cacciamani,Francesco Porpiglia

引用次数: 0

Racial disparities in prostate cancer in the UK and the USA: similarities, differences and steps forwards 英国和美国在前列腺癌方面的种族差异：相似之处、差异和前进步骤

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-18 DOI: 10.1038/s41585-024-00948-x

Edward Christopher Dee, Rebecca Todd, Kenrick Ng, Gloryanne Aidoo-Micah, Troy B. Amen, Zoe Moon, Randy Vince, Vinayak Muralidhar, Katherine Mutsvangwa, Garth Funston, Luke T. A. Mounce, Elias Pintus, Kosj Yamoah, Daniel E. Spratt, Brandon A. Mahal, Jonathan Shamash, Robert Horne, Paul L. Nguyen

{"title":"Racial disparities in prostate cancer in the UK and the USA: similarities, differences and steps forwards","authors":"Edward Christopher Dee, Rebecca Todd, Kenrick Ng, Gloryanne Aidoo-Micah, Troy B. Amen, Zoe Moon, Randy Vince, Vinayak Muralidhar, Katherine Mutsvangwa, Garth Funston, Luke T. A. Mounce, Elias Pintus, Kosj Yamoah, Daniel E. Spratt, Brandon A. Mahal, Jonathan Shamash, Robert Horne, Paul L. Nguyen","doi":"10.1038/s41585-024-00948-x","DOIUrl":"https://doi.org/10.1038/s41585-024-00948-x","url":null,"abstract":"In the USA, Black men are approximately twice as likely to be diagnosed with and to die of prostate cancer than white men. In the UK, despite Black men having vastly different ancestral contexts and health-care systems from Black men in the USA, the lifetime risk of being diagnosed with prostate cancer is two-to-three times higher among Black British men than among white British men and Black British men are twice as likely to die of prostate cancer as white British men. Examination of racial disparities in prostate cancer in the USA and UK highlights systemic, socio-economic and sociocultural factors that might contribute to these differences. Variation by ancestry could affect incidence and tumour genomics. Disparities in incidence might also be affected by screening guidelines and access to and uptake of screening. Disparities in treatment access, continuity of care and outcomes could contribute to survival differences. In both localized and metastatic settings, equal access could diminish the observed disparities in both the USA and the UK. An understanding of behavioural medicine, especially an appreciation of cultural beliefs about illness and treatment, could inform and improve the ways in which health systems can engage with and deliver care to patients in minoritized groups affected by prostate cancer. Methods of promoting equity include targeting systemic barriers including systemic racism, proportional recruitment of patients into clinical trials, diversifying the health-care workforce and facilitating care informed by cultural humility. Actively engaging patients and communities in research and intervention might enable the translation of research into increasingly equitable care for patients with prostate cancer in the UK, the USA and globally.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"33 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0