{"title":"Testosterone affects the vaginal microbiome in transgender men","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01052-4","DOIUrl":null,"url":null,"abstract":"<p>Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencing sexual health outcomes, specifically the occurrence of bacterial vaginosis.</p><p>In this prospective longitudinal study, participants who were assigned female sex at birth with natal genitalia and reporting transgender male or nonbinary identity, aged ≥18 years and interested in initiating injectable testosterone were screened. If participants had Amsel criteria and Nugent scoring evaluations consistent with optimal vaginal microbiota, they were enrolled. After enrolment, vaginal samples were tested for <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae</i> and <i>Trichomonas vaginalis</i> and HIV test results obtained. Overall, nine participants were included in the study, of whom eight identified as transgender men and one as nonbinary.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"30 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-01052-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Gender-affirming hormone therapy for transgender men can affect their vaginal microbiome, potentially adversely influencing sexual health outcomes, specifically the occurrence of bacterial vaginosis.
In this prospective longitudinal study, participants who were assigned female sex at birth with natal genitalia and reporting transgender male or nonbinary identity, aged ≥18 years and interested in initiating injectable testosterone were screened. If participants had Amsel criteria and Nugent scoring evaluations consistent with optimal vaginal microbiota, they were enrolled. After enrolment, vaginal samples were tested for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis and HIV test results obtained. Overall, nine participants were included in the study, of whom eight identified as transgender men and one as nonbinary.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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