Nature Reviews Urology最新文献_第4页

Untangling the anterolateral periprostatic neurovasculature and its implications for nerve-sparing radical prostatectomy. 解开前列腺前外侧周围神经血管及其对保留神经的根治性前列腺切除术的意义。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2026-07-01 DOI: 10.1038/s41585-026-01169-0

Behnam Nabavizadeh,Conner R Hill,Jim C Hu

引用次数: 0

The role of CFTR in spermatogenesis and sperm quality. CFTR在精子发生和精子质量中的作用。

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2026-06-26 DOI: 10.1038/s41585-026-01173-4

Sara C Pereira,Mariana P Monteiro,Raquel L Bernardino,Mário Sousa

{"title":"The role of CFTR in spermatogenesis and sperm quality.","authors":"Sara C Pereira,Mariana P Monteiro,Raquel L Bernardino,Mário Sousa","doi":"10.1038/s41585-026-01173-4","DOIUrl":"https://doi.org/10.1038/s41585-026-01173-4","url":null,"abstract":"Cystic fibrosis (CF) is primarily recognized for its severe systemic effects, especially in the lungs, pancreas and digestive tract. Thus, the effect of CF transmembrane conductance regulator (CFTR) dysfunction on male fertility has been relatively overlooked despite its important roles in spermatogenesis orchestration and spermatozoa function. CFTR has physiological functions as a chloride and bicarbonate channel and a role in regulating water movement. CFTR participates in spermatogenesis, and evidence suggests its involvement in seminiferous intratubular fluid control, maintenance of the blood-testis barrier, and improvement in follicle-stimulating hormone signalling, among other functions. Emerging evidence also suggests that CFTR variant carriers, typically considered to be healthy, have reduced sperm quality. Diminished CFTR expression has been observed in spermatozoa from men with various sperm quality abnormalities (teratozoospermia, asthenozoospermia and oligozoospermia), and correlates positively with sperm motility and morphology. CFTR is thought to be involved in sperm capacitation and osmoregulation via interactions with ion and water channels. Advances in CF therapy, such as CFTR modulators, gene therapy and liposome-mediated CFTR delivery, might affect CFTR's role in sperm function and could potentially be applied to improve the fertility of individuals with CFTR dysfunction.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"6 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148336115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urolithiasis in patients with cancer. 癌症患者的尿石症。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-22 DOI: 10.1038/s41585-026-01168-1

Priya Dave, Amy Yau, A Ari Hakimi, Mantu Gupta, William Atallah, Alexander C Small, Kavita Gupta, Douglas S Scherr, David S Goldfarb, Aisha Shaikh

{"title":"Urolithiasis in patients with cancer.","authors":"Priya Dave, Amy Yau, A Ari Hakimi, Mantu Gupta, William Atallah, Alexander C Small, Kavita Gupta, Douglas S Scherr, David S Goldfarb, Aisha Shaikh","doi":"10.1038/s41585-026-01168-1","DOIUrl":"https://doi.org/10.1038/s41585-026-01168-1","url":null,"abstract":"Urolithiasis is increasingly common, with rising rates driven by obesity, diabetes and metabolic syndrome. Patients with cancer have additional, unique risks of stone formation owing to effects on fluid and electrolyte balance, systemic cancer therapies, tumour lysis syndrome and anatomical alterations after urinary diversion or nephrectomy. Moreover, urolithiasis itself has been linked to increased rates of renal cell carcinoma, urothelial carcinoma and bladder cancer, potentially mediated by chronic inflammation, recurrent infections and shared metabolic or environmental factors. Management in this setting is complex and must be individualized. Percutaneous nephrolithotomy achieves the highest stone-free rates in patients with altered urinary tract anatomy, whereas retrograde intrarenal surgery and shock wave lithotripsy have more selective roles. Preventive strategies focus on thorough metabolic evaluation, hydration optimization and addressing cancer-specific risk factors such as hypercalcaemia, acidosis and chronic urinary stasis. Despite these insights, data on the epidemiology, mechanistic underpinnings and optimal management of urolithiasis in patients with cancer remain limited. Prospective studies are needed to clarify causal relationships, refine preventive strategies and develop evidence-based treatment algorithms for this growing and complex population.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in the updated National Institute for Health and Care Excellence (NICE) fertility problems guideline 2026? 更新后的国家健康与护理卓越研究所（NICE）生育问题指南2026中有什么新内容？

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-19 DOI: 10.1038/s41585-026-01167-2

Anthony Emmanuel, Evangelos Psallidas, Majed Shabbir

引用次数: 0

Animal models of spinal cord injury in neuro-urological research. 神经-泌尿学研究中脊髓损伤的动物模型。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-19 DOI: 10.1038/s41585-026-01163-6

Alice Giannotti, Daniel Medina Aguinaga, Ana Ferreira, Charles H Hubscher, Célia Duarte Cruz

{"title":"Animal models of spinal cord injury in neuro-urological research.","authors":"Alice Giannotti, Daniel Medina Aguinaga, Ana Ferreira, Charles H Hubscher, Célia Duarte Cruz","doi":"10.1038/s41585-026-01163-6","DOIUrl":"https://doi.org/10.1038/s41585-026-01163-6","url":null,"abstract":"Spinal cord injury (SCI) is a life-changing and costly condition. SCI causes major disturbances in sensory, motor and autonomic function, resulting in permanent loss of function and strongly affecting the physical, psychological and social well-being of patients and caregivers. A particularly debilitating consequence of SCI is loss of voluntary control over bladder function, which substantially affects patients' dignity, health and quality of life. Current understanding of the complex pathophysiological mechanisms of SCI and associated comorbidities has heavily relied on the use of animal models, which have also been crucial in devising new therapeutic approaches and fine-tuning existent ones. However, a debate about the persistent challenges in translating preclinical data into treatment is ongoing. Technological advances are generating innovative modelling approaches with the support of regulatory bodies, aiming to reduce or eventually substitute animal use. In this Review, we address the current use of animal SCI models in neuro-urological research and debate whether we will still be using these models by 2035.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy for acute Peyronie' s disease: a success story of translation from bench to bedside. 急性佩罗尼病的联合治疗：从实验到临床的成功案例。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-17 DOI: 10.1038/s41585-026-01171-6

David J Ralph, Selim Cellek

引用次数: 0

Why counting women is not enough: from inclusion to equity in oncology trials. 为什么只考虑女性是不够的：从肿瘤试验的包容性到公平性。

IF 13.6 1区医学

Nature Reviews Urology Pub Date : 2026-06-16 DOI: 10.1038/s41585-026-01170-7

David J Benjamin, Sophie Zaaijer, Shera Feinstein, Arash Rezazadeh Kalebasty

引用次数: 0

Patient advocacy matters. 病人权益很重要。