Nature Reviews Urology最新文献_第4页

Source renewal is essential for mouse TIME models 源头更新对小鼠 TIME 模型至关重要

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-14 DOI: 10.1038/s41585-024-00960-1

Annette Fenner

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Disulfidptosis-related genes could target personalized therapy and aid prognostics 与二硫化硫相关的基因可作为个性化治疗的目标并有助于预后分析

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-14 DOI: 10.1038/s41585-024-00959-8

Annette Fenner

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Looking backwards and looking forwards: the view from the middle 回顾过去，展望未来：从中间看问题

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-11 DOI: 10.1038/s41585-024-00956-x

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Nature Reviews Urology: evolving with the field for 20 years 自然-泌尿学评论》：20 年来与该领域共同发展

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-11 DOI: 10.1038/s41585-024-00957-w

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Immunoliposome targeting IL-30 靶向 IL-30 的免疫脂质体

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-10 DOI: 10.1038/s41585-024-00958-9

Louise Lloyd

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Cell death score predicts prostate cancer metastasis and immunotherapy response 细胞死亡评分可预测前列腺癌转移和免疫疗法反应

IF 12.1 1区医学

Nature Reviews Urology Pub Date : 2024-10-10 DOI: 10.1038/s41585-024-00954-z

Maria Chiara Masone

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Interactions between androgen and IGF1 axes in prostate tumorigenesis 雄激素和 IGF1 轴在前列腺肿瘤发生中的相互作用

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-07 DOI: 10.1038/s41585-024-00942-3

Yao Mawulikplimi Adzavon, Zoran Culig, Zijie Sun

{"title":"Interactions between androgen and IGF1 axes in prostate tumorigenesis","authors":"Yao Mawulikplimi Adzavon, Zoran Culig, Zijie Sun","doi":"10.1038/s41585-024-00942-3","DOIUrl":"https://doi.org/10.1038/s41585-024-00942-3","url":null,"abstract":"Androgen signalling through the androgen receptor (AR) is essential for prostate tumorigenesis. However, androgen signalling pathways also interact with other growth factor-mediated signalling pathways to regulate the prostatic cell cycle, differentiation, apoptosis and proliferation in the initiation and progression of prostate cancer. Insulin-like growth factor 1 (IGF1) is one of the most prominent growth factors in prostate tumorigenesis. Clinical and experimental evidence has demonstrated that IGF1 signalling supports both androgen-dependent and androgen-independent prostate tumorigenesis, suggesting that improved understanding of the interactions between the IGF1 and androgen axes might aid the development of new therapeutic strategies. Available data have shown a dynamic role of androgen–AR signalling in the activation of IGF1-signalling pathways by augmenting transcription of the IGF1 receptor in prostatic basal epithelial cells and by increasing IGF1 secretion through the suppression of IGF-binding protein 3 expression in prostatic stromal cells. In turn, IGF1 stimulates Wnt–β-catenin signalling in prostatic basal progenitors to promote prostatic oncogenic transformation and prostate cancer development. These findings highlight the cooperative, autocrine and paracrine interactions that underlie the oncogenic effects of androgens and IGF1 and open up new opportunities for therapeutic targeting.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"224 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Plant-based diets and urological health 植物性饮食与泌尿系统健康

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-07 DOI: 10.1038/s41585-024-00939-y

Stacy Loeb, James F. Borin, Greeshma Venigalla, Manish Narasimman, Natasha Gupta, Alexander P. Cole, Katherine Amin

{"title":"Plant-based diets and urological health","authors":"Stacy Loeb, James F. Borin, Greeshma Venigalla, Manish Narasimman, Natasha Gupta, Alexander P. Cole, Katherine Amin","doi":"10.1038/s41585-024-00939-y","DOIUrl":"https://doi.org/10.1038/s41585-024-00939-y","url":null,"abstract":"Plant-based diets have grown in popularity owing to multiple health and environmental benefits. Some evidence suggests that plant-based diets are associated with benefits for urological health. In genitourinary oncology, most research has focused on prostate cancer. Clinical trial results suggest a favourable influence of healthy lifestyle modifications including plant-based diets before and after prostate cancer treatment. Epidemiological evidence shows that a diet higher in plant-based and lower in animal-based food is associated with a lower risk of aggressive prostate cancer and better quality-of-life scores than a diet with less plant-based and more animal-based food. Studies on bladder and kidney cancer are scarce, but limited data suggest that vegetarian or plant-forward dietary patterns (increased consumption of fruits and vegetables and minimizing meat) are associated with a lower risk of development of these cancers than dietary patterns with fewer fruits and vegetables and more meat. With respect to benign urological conditions, epidemiological studies suggest that plant-based dietary patterns are associated with a lower risk of benign prostatic hyperplasia and urinary tract infections than non-plant-based dietary patterns. Compared with diets high in animal-based foods and low in plant-based foods, a substantial body of epidemiological evidence also suggests that increased consumption of healthy plant-based food is associated with a lower risk of erectile dysfunction. Plant-based dietary patterns that are high in fruits and vegetables with normal calcium intake, while limiting animal protein and salt, are associated with a lower risk of kidney stone development than dietary patterns that do not follow these parameters. Overall, increasing consumption of plant-based foods and reducing intake of animal-based foods has favourable associations with multiple urological conditions.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"6 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pimping in the clinical learning environment: representation of women in surgery 临床学习环境中的 "拉皮条"：女性在外科手术中的代表性

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-10-01 DOI: 10.1038/s41585-024-00950-3

Efe Chantal Ghanney Simons, John J. Guardiola, Indira Bhavsar-Burke

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Metaverse in surgery — origins and future potential 外科中的元宇宙--起源与未来潜力

IF 15.3 1区医学

Nature Reviews Urology Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00941-4

Enrico Checcucci, Alessandro Veccia, Stefano Puliatti, Pieter De Backer, Pietro Piazza, Karl-Friedrich Kowalewski, Severin Rodler, Mark Taratkin, Ines Rivero Belenchon, Loic Baekelandt, Sabrina De Cillis, Alberto Piana, Ahmed Eissa, Juan Gomez Rivas, Giovanni Cacciamani, Francesco Porpiglia

{"title":"Metaverse in surgery — origins and future potential","authors":"Enrico Checcucci, Alessandro Veccia, Stefano Puliatti, Pieter De Backer, Pietro Piazza, Karl-Friedrich Kowalewski, Severin Rodler, Mark Taratkin, Ines Rivero Belenchon, Loic Baekelandt, Sabrina De Cillis, Alberto Piana, Ahmed Eissa, Juan Gomez Rivas, Giovanni Cacciamani, Francesco Porpiglia","doi":"10.1038/s41585-024-00941-4","DOIUrl":"https://doi.org/10.1038/s41585-024-00941-4","url":null,"abstract":"The metaverse refers to a collective virtual space that combines physical and digital realities to create immersive, interactive environments. This space is powered by technologies such as augmented reality (AR), virtual reality (VR), artificial intelligence (AI) and blockchain. In healthcare, the metaverse can offer many applications. Specifically in surgery, potential uses of the metaverse include the possibility of conducting immersive surgical training in a VR or AR setting, and enhancing surgical planning through the adoption of three-dimensional virtual models and simulated procedures. At the intraoperative level, AR-guided surgery can assist the surgeon in real time to increase surgical precision in tumour identification and selective management of vessels. In post-operative care, potential uses of the metaverse include recovery monitoring and patient education. In urology, AR and VR have been widely explored in the past decade, mainly for surgical navigation in prostate and kidney cancer surgery, whereas only anecdotal metaverse experiences have been reported to date, specifically in partial nephrectomy. In the future, further integration of AI will improve the metaverse experience, potentially increasing the possibility of carrying out surgical navigation, data collection and virtual trials within the metaverse. However, challenges concerning data security and regulatory compliance must be addressed before the metaverse can be used to improve patient care.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"26 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0