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Nature Reviews Nephrology最新文献

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Multifaceted innovations needed to advance transplant nephrology 推进移植肾病学需要多方面的创新
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-07 DOI: 10.1038/s41581-024-00924-z
Vidya A. Fleetwood, Krista L. Lentine
{"title":"Multifaceted innovations needed to advance transplant nephrology","authors":"Vidya A. Fleetwood, Krista L. Lentine","doi":"10.1038/s41581-024-00924-z","DOIUrl":"10.1038/s41581-024-00924-z","url":null,"abstract":"Over the past year, several new research insights and policy changes have advanced the field of kidney transplantation: kidney xenotransplantation has reached its first human recipients, previously under-used organs are becoming transplantable with new procurement and preservation approaches, and post-transplant care, including prevention of complications, has become safer.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 2","pages":"81-82"},"PeriodicalIF":28.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein handling in kidney tubules 肾小管中的蛋白质处理
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-06 DOI: 10.1038/s41581-024-00914-1
Andrew M. Hall
{"title":"Protein handling in kidney tubules","authors":"Andrew M. Hall","doi":"10.1038/s41581-024-00914-1","DOIUrl":"10.1038/s41581-024-00914-1","url":null,"abstract":"The kidney proximal tubule reabsorbs and degrades filtered plasma proteins to reclaim valuable nutrients and maintain body homeostasis. Defects in this process result in proteinuria, one of the most frequently used biomarkers of kidney disease. Filtered proteins enter proximal tubules via receptor-mediated endocytosis and are processed within a highly developed apical endo-lysosomal system (ELS). Proteinuria is a strong risk factor for chronic kidney disease progression and genetic disorders of the ELS cause hereditary kidney diseases, so deepening understanding of how the proximal tubule handles proteins is crucial for translational nephrology. Moreover, the ELS is both an entry point for nephrotoxins that induce tubular damage and a target for novel therapies to prevent it. Cutting-edge research techniques, such as functional intravital imaging and computational modelling, are shedding light on spatial and integrative aspects of renal tubular protein processing in vivo, how these are altered under pathological conditions and the consequences for other tubular functions. These insights have potentially important implications for understanding the origins of systemic complications arising in proteinuric states, and might lead to the development of new ways of monitoring and treating kidney diseases. The kidney tubules have a crucial role in homeostasis as they modify and regulate the kidney filtrate. This Review examines current data on how filtered proteins are processed along the kidney tubule, including evidence from defects in the endo-lysosomal system, and their therapeutic implications.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"241-252"},"PeriodicalIF":28.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trained immunity: from kidney failure to organ transplantation 训练免疫：从肾衰竭到器官移植
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-06 DOI: 10.1038/s41581-024-00927-w
Jordi Ochando, Alberto Ortiz
{"title":"Trained immunity: from kidney failure to organ transplantation","authors":"Jordi Ochando, Alberto Ortiz","doi":"10.1038/s41581-024-00927-w","DOIUrl":"10.1038/s41581-024-00927-w","url":null,"abstract":"Innate immune memory represents a barrier to successful kidney transplantation. The discovery that uraemic toxins in people with kidney failure induce trained immunity suggests that, as chronic kidney disease progresses, long-lived memory macrophages promote systemic chronic inflammation, which could contribute to organ transplant rejection.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"224-225"},"PeriodicalIF":28.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the mechanisms of fibrosis and progressive kidney injury 纤维化和进行性肾损伤机制的深入研究
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-03 DOI: 10.1038/s41581-024-00922-1
Santiago Lamas, Marta Ruiz-Ortega
{"title":"Insights into the mechanisms of fibrosis and progressive kidney injury","authors":"Santiago Lamas, Marta Ruiz-Ortega","doi":"10.1038/s41581-024-00922-1","DOIUrl":"10.1038/s41581-024-00922-1","url":null,"abstract":"Progression of chronic kidney disease to kidney fibrosis is a key challenge in nephrology. Several contributions from the past year have shed light not only on the general molecular signature of human kidney fibrosis, but also on specific new mechanisms involved in its development.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 2","pages":"79-80"},"PeriodicalIF":28.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of sensory receptors in non-sensory organs: the kidney and beyond 感觉受体在非感觉器官中的作用：肾脏及其他
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-03 DOI: 10.1038/s41581-024-00917-y
Jiaojiao Xu, Blythe D. Shepard, Jennifer L. Pluznick
{"title":"Roles of sensory receptors in non-sensory organs: the kidney and beyond","authors":"Jiaojiao Xu, Blythe D. Shepard, Jennifer L. Pluznick","doi":"10.1038/s41581-024-00917-y","DOIUrl":"10.1038/s41581-024-00917-y","url":null,"abstract":"Olfactory receptors (ORs), taste receptors and opsins are well-known for their pivotal roles in mediating the senses of smell, taste and sight, respectively. However, in the past two decades, research has shown that these sensory receptors also regulate physiological processes in a variety of non-sensory tissues. Although ORs, taste receptors and opsins have all been shown to have physiological roles beyond their traditional locations, most work in the kidney has focused on ORs. To date, renal ORs have been shown to have roles in blood pressure regulation (OLFR78 and OLFR558) and glucose homeostasis (OLFR1393). However, sensory receptors remain drastically understudied outside of traditional sensory systems, in part because of inherent challenges in studying these receptors. Increased knowledge of the physiological and pathophysiological roles of sensory receptors has the potential to substantially improve understanding of the function of numerous organs and systems, including the kidney. In addition, most sensory receptors are G protein-coupled receptors, which are considered to be the most druggable class of proteins, and thus could potentially be exploited as future therapeutic targets. Sensory receptors in non-sensory organs respond to chemical stimuli, initiate signalling cascades and have important roles in cell biology and physiology. Here, the authors discuss key examples of sensory receptors with physiological roles in the kidney and other tissues.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"253-263"},"PeriodicalIF":28.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A golden year of innovative kidney disease therapeutics 创新肾脏疾病治疗的黄金年
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-03 DOI: 10.1038/s41581-024-00916-z
Monica Suet Ying Ng, Carmel M. Hawley
{"title":"A golden year of innovative kidney disease therapeutics","authors":"Monica Suet Ying Ng, Carmel M. Hawley","doi":"10.1038/s41581-024-00916-z","DOIUrl":"10.1038/s41581-024-00916-z","url":null,"abstract":"In 2024, a plethora of novel therapeutic strategies for kidney disease progressed to clinical trials, including an RNA interference therapeutic, a glucagon-like peptide 1 receptor agonist, a soluble guanylate cyclase activator and an off-the-shelf, virus-specific T cell therapy. These advances herald new hope for people with kidney disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 2","pages":"75-76"},"PeriodicalIF":28.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steps forward in the treatment of IgA nephropathy IgA肾病治疗的新进展
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-12-18 DOI: 10.1038/s41581-024-00925-y
Rosanna Coppo
{"title":"Steps forward in the treatment of IgA nephropathy","authors":"Rosanna Coppo","doi":"10.1038/s41581-024-00925-y","DOIUrl":"10.1038/s41581-024-00925-y","url":null,"abstract":"A turning point in the treatment of IgA nephropathy has been marked by several new publications that describe promising outcomes associated with the targeting of key pathogenic disease processes, including the production of galactose-deficient IgA1 and IgA-containing immune complexes, complement and endothelin system activation.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"218-219"},"PeriodicalIF":28.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dare to HOPE: a step closer to HIV+-to-HIV+ kidney transplantation as standard of care 敢于希望：向将艾滋病毒携带者对艾滋病毒携带者的肾移植作为标准护理方法迈进了一步
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-12-18 DOI: 10.1038/s41581-024-00920-3
Deirdre Sawinski, Marshall J. Glesby
{"title":"Dare to HOPE: a step closer to HIV+-to-HIV+ kidney transplantation as standard of care","authors":"Deirdre Sawinski, Marshall J. Glesby","doi":"10.1038/s41581-024-00920-3","DOIUrl":"10.1038/s41581-024-00920-3","url":null,"abstract":"New data demonstrate that in people with HIV infection, transplantation outcomes with HIV-positive donor kidneys are not inferior to those with HIV-negative donor kidneys and donor-derived HIV strains do not persist in the recipients. This approach should be standard of care for kidney transplantation in people living with HIV.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"220-221"},"PeriodicalIF":28.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term lessons from EMPA-KIDNEY EMPA-KIDNEY的长期教训
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-12-18 DOI: 10.1038/s41581-024-00921-2
Lauren Heath, Carol Pollock
{"title":"Long-term lessons from EMPA-KIDNEY","authors":"Lauren Heath, Carol Pollock","doi":"10.1038/s41581-024-00921-2","DOIUrl":"10.1038/s41581-024-00921-2","url":null,"abstract":"Sodium–glucose co-transporter 2 inhibitors have revolutionized the management of chronic kidney disease. However, long-term data regarding their use are lacking. The post-trial follow-up study to EMPA-KIDNEY provides several insights into how the effects of these powerful medications might be optimized, but several key questions remain unanswered.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 4","pages":"222-223"},"PeriodicalIF":28.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial dysfunction has a central role in diabetic kidney disease 线粒体功能障碍在糖尿病肾病中起核心作用
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-12-16 DOI: 10.1038/s41581-024-00919-w
Shen Li, Katalin Susztak
{"title":"Mitochondrial dysfunction has a central role in diabetic kidney disease","authors":"Shen Li, Katalin Susztak","doi":"10.1038/s41581-024-00919-w","DOIUrl":"10.1038/s41581-024-00919-w","url":null,"abstract":"Diabetic kidney disease (DKD), the most common cause of chronic kidney disease, is primarily caused by metabolic dysfunction, likely due to mitochondrial abnormalities. In 2024, several studies made important strides towards defining the molecular mechanisms that underlie the development of DKD.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 2","pages":"77-78"},"PeriodicalIF":28.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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