Nature Reviews Nephrology最新文献_第7页

Lymphocytes and innate immune cells in acute kidney injury and repair 急性肾损伤和修复中的淋巴细胞和先天性免疫细胞

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-08-02 DOI: 10.1038/s41581-024-00875-5

Kyungho Lee, Hye Ryoun Jang, Hamid Rabb

{"title":"Lymphocytes and innate immune cells in acute kidney injury and repair","authors":"Kyungho Lee, Hye Ryoun Jang, Hamid Rabb","doi":"10.1038/s41581-024-00875-5","DOIUrl":"10.1038/s41581-024-00875-5","url":null,"abstract":"Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which no specific treatments exist. Complex intrarenal inflammatory processes driven by lymphocytes and innate immune cells have key roles in the development and progression of AKI. Many studies have focused on prevention of early injury in AKI. However, most patients with AKI present after injury is already established. Increasing research is therefore focusing on mechanisms of renal repair following AKI and prevention of progression from AKI to chronic kidney disease. CD4+ and CD8+ T cells, B cells and neutrophils are probably involved in the development and progression of AKI, whereas regulatory T cells, double-negative T cells and type 2 innate lymphoid cells have protective roles. Several immune cells, such as macrophages and natural killer T cells, can have both deleterious and protective effects, depending on their subtype and/or the stage of AKI. The immune system not only participates in injury and repair processes during AKI but also has a role in mediating AKI-induced distant organ dysfunction. Targeted manipulation of immune cells is a promising therapeutic strategy to improve AKI outcomes. Here, the authors describe the roles of lymphocytes and innate immune cells in inflammatory responses and repair processes during acute kidney injury (AKI). They also discuss the roles of immune cells in crosstalk pathways that result in AKI-induced distant organ dysfunction.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 12","pages":"789-805"},"PeriodicalIF":28.6,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Making advance care planning easier for adults with kidney disease and their clinicians 让成人肾病患者及其临床医生更轻松地制定预先护理计划。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-08-01 DOI: 10.1038/s41581-024-00871-9

Ryan D. McMahan, Rebecca L. Sudore

引用次数: 0

Drug repurposing for glomerular diseases: an underutilized resource 肾小球疾病的药物再利用：未充分利用的资源

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-31 DOI: 10.1038/s41581-024-00864-8

Monica Suet Ying Ng, Gursimran Kaur, Ross S. Francis, Carmel M. Hawley, David W. Johnson

{"title":"Drug repurposing for glomerular diseases: an underutilized resource","authors":"Monica Suet Ying Ng, Gursimran Kaur, Ross S. Francis, Carmel M. Hawley, David W. Johnson","doi":"10.1038/s41581-024-00864-8","DOIUrl":"10.1038/s41581-024-00864-8","url":null,"abstract":"Drug repurposing in glomerular disease can deliver opportunities for steroid-free regimens, enable personalized multi-target options for resistant or relapsing disease and enhance treatment options for understudied populations (for example, children) and in resource-limited settings. Identification of drug-repurposing candidates can be data driven, which utilizes existing data on disease pathobiology, drug features and clinical outcomes, or experimental, which involves high-throughput drug screens. Information from databases of approved drugs, clinical trials and PubMed registries suggests that at least 96 drugs on the market cover 49 targets with immunosuppressive potential that could be candidates for drug repurposing in glomerular disease. Furthermore, evidence to support drug repurposing is available for 191 immune drug target–glomerular disease pairs. Non-immunological drug repurposing includes strategies to reduce haemodynamic overload, podocyte injury and kidney fibrosis. Recommended strategies to expand drug-repurposing capacity in glomerular disease include enriching drug databases with glomeruli-specific information, enhancing the accessibility of primary clinical trial data, biomarker discovery to improve participant selection into clinical trials and improve surrogate outcomes and initiatives to reduce patent, regulatory and organizational hurdles. Drug repurposing could expand the therapeutic options available to patients with glomerular disease. Here, the authors examine different approaches to the identification of drug candidates, consider current immunosuppressive and non-immunological options and discuss strategies to maximize drug repurposing in glomerular disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 11","pages":"707-721"},"PeriodicalIF":28.6,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-nephrin autoantibodies: a paradigm shift in podocytopathies 抗胰岛素自身抗体：荚膜细胞病的范式转变。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-30 DOI: 10.1038/s41581-024-00873-7

Zhao Cui, Ming-hui Zhao

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Tertiary lymphoid organs contribute to kidney allograft rejection 三级淋巴器官导致肾脏异体移植排斥反应

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-29 DOI: 10.1038/s41581-024-00880-8

Ellen F. Carney

引用次数: 0

The GLP-1 receptor agonist revolution comes to nephrology 肾脏病学迎来 GLP-1 受体激动剂革命

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-29 DOI: 10.1038/s41581-024-00876-4

Merlin C. Thomas, Mark E. Cooper

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Obesity promotes tumour growth by boosting PD1 levels on macrophages 肥胖会提高巨噬细胞上的 PD1 水平，从而促进肿瘤生长。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-26 DOI: 10.1038/s41581-024-00878-2

Monica Wang

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Ketogenic diet benefits in critically ill patients with sepsis 生酮饮食对败血症重症患者的益处。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-24 DOI: 10.1038/s41581-024-00877-3

Monica Wang

引用次数: 0

CD38 — a new target in renal immune disease CD38--肾脏免疫疾病的新靶点。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-23 DOI: 10.1038/s41581-024-00874-6

Ton J. Rabelink, Aiko P. J. de Vries

引用次数: 0

Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors G 蛋白偶联受体的空间、时间和配体偏倚的功能性后果

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-07-22 DOI: 10.1038/s41581-024-00869-3

András D. Tóth, Gábor Turu, László Hunyady

{"title":"Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors","authors":"András D. Tóth, Gábor Turu, László Hunyady","doi":"10.1038/s41581-024-00869-3","DOIUrl":"10.1038/s41581-024-00869-3","url":null,"abstract":"G protein-coupled receptors (GPCRs) regulate every aspect of kidney function by mediating the effects of various endogenous and exogenous substances. A key concept in GPCR function is biased signalling, whereby certain ligands may selectively activate specific pathways within the receptor’s signalling repertoire. For example, different agonists may induce biased signalling by stabilizing distinct active receptor conformations — a concept that is supported by advances in structural biology. However, the processes underlying functional selectivity in receptor signalling are extremely complex, involving differences in subcellular compartmentalization and signalling dynamics. Importantly, the molecular mechanisms of spatiotemporal bias, particularly its connection to ligand binding kinetics, have been detailed for GPCRs critical to kidney function, such as the AT1 angiotensin receptor (AT1R), V2 vasopressin receptor (V2R) and the parathyroid hormone 1 receptor (PTH1R). This expanding insight into the multifaceted nature of biased signalling paves the way for innovative strategies for targeting GPCR functions; the development of novel biased agonists may represent advanced pharmacotherapeutic approaches to the treatment of kidney diseases and related systemic conditions, such as hypertension, diabetes and heart failure. G protein-coupled receptors (GPCRs) elicit cellular responses to an array of stimuli to regulate the function of virtually all organs. The diverse functions of GPCRs are determined by their expression profiles and their ability to adopt different active and inactive conformations, resulting in functional selectivity or biased signalling. This Review describes the mechanisms and consequences of biased GPCR signalling with a focus on GPCRs of relevance to the kidney.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 11","pages":"722-741"},"PeriodicalIF":28.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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