Nature Reviews Nephrology最新文献_第6页

Natural killer cell-mediated innate microvascular rejection 自然杀伤细胞介导的先天性微血管排斥反应

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-19 DOI: 10.1038/s41581-024-00862-w

Olivier Thaunat

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Unlocking the benefits of transplantation with kidneys from older donors 利用老年捐献者的肾脏释放移植的益处。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-18 DOI: 10.1038/s41581-024-00851-z

Vidya A. Fleetwood, Krista L. Lentine

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Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes 肺动脉高压和慢性肾脏病：发病率、病理生理学和结果。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-18 DOI: 10.1038/s41581-024-00857-7

Katarina Zeder, Edward D. Siew, Gabor Kovacs, Evan L. Brittain, Bradley A. Maron

{"title":"Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes","authors":"Katarina Zeder, Edward D. Siew, Gabor Kovacs, Evan L. Brittain, Bradley A. Maron","doi":"10.1038/s41581-024-00857-7","DOIUrl":"10.1038/s41581-024-00857-7","url":null,"abstract":"Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) or kidney failure, with an estimated prevalence of up to 78% in those referred for right-heart catheterization. PH is independently associated with adverse outcomes in CKD, raising the possibility that early detection and appropriate management of PH might improve outcomes in at-risk patients. Among patients with PH, the prevalence of CKD stages 3 and 4 is estimated to be as high as 36%, and CKD is also independently associated with adverse outcomes. However, the complex, heterogenous pathophysiology and clinical profile of CKD–PH requires further characterization. CKD is often associated with elevated left ventricular filling pressure and volume overload, which presumably leads to pulmonary vascular stiffening and post-capillary PH. By contrast, a distinct subgroup of patients at high risk is characterized by elevated pulmonary vascular resistance and right ventricular dysfunction in the absence of pulmonary venous hypertension, which may represent a right-sided cardiorenal syndrome defined in principle by hypervolaemia, salt avidity, low cardiac output and normal left ventricular function. Current understanding of CKD–PH is limited, despite its potentially important ramifications for clinical decision making. In particular, whether PH should be considered when determining the suitability and timing of kidney replacement therapy or kidney transplantation is unclear. More research is urgently needed to address these knowledge gaps and improve the outcomes of patients with or at risk of CKD–PH. In this Review, the authors discuss potential pathophenotypes of coexisting chronic kidney disease and pulmonary hypertension, discuss the principles of clinical management of patients with chronic kidney disease or kidney failure and pulmonary hypertension, and outline key areas for further research.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 11","pages":"742-754"},"PeriodicalIF":28.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy ageing and the kidney — lessons from centenarians 健康老龄化与肾脏--百岁老人的启示

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-17 DOI: 10.1038/s41581-024-00860-y

Yasumichi Arai, Motoko Yanagita

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Gene regulatory networks in disease and ageing 疾病和老化中的基因调控网络

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-12 DOI: 10.1038/s41581-024-00849-7

Paula Unger Avila, Tsimafei Padvitski, Ana Carolina Leote, He Chen, Julio Saez-Rodriguez, Martin Kann, Andreas Beyer

{"title":"Gene regulatory networks in disease and ageing","authors":"Paula Unger Avila, Tsimafei Padvitski, Ana Carolina Leote, He Chen, Julio Saez-Rodriguez, Martin Kann, Andreas Beyer","doi":"10.1038/s41581-024-00849-7","DOIUrl":"10.1038/s41581-024-00849-7","url":null,"abstract":"The precise control of gene expression is required for the maintenance of cellular homeostasis and proper cellular function, and the declining control of gene expression with age is considered a major contributor to age-associated changes in cellular physiology and disease. The coordination of gene expression can be represented through models of the molecular interactions that govern gene expression levels, so-called gene regulatory networks. Gene regulatory networks can represent interactions that occur through signal transduction, those that involve regulatory transcription factors, or statistical models of gene–gene relationships based on the premise that certain sets of genes tend to be coexpressed across a range of conditions and cell types. Advances in experimental and computational technologies have enabled the inference of these networks on an unprecedented scale and at unprecedented precision. Here, we delineate different types of gene regulatory networks and their cell-biological interpretation. We describe methods for inferring such networks from large-scale, multi-omics datasets and present applications that have aided our understanding of cellular ageing and disease mechanisms. Perturbations in the regulation of gene expression can contribute to disease- and ageing-associated changes in cell physiology. This review describes how the coordination of gene expression within and between cells can be represented through models of the molecular interactions that govern gene expression levels, and how such models can be used to understand age-associated changes in cell physiology.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 9","pages":"616-633"},"PeriodicalIF":28.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic kidney disease in American Indians and Alaska Natives 美国印第安人和阿拉斯加原住民的慢性肾病

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-07 DOI: 10.1038/s41581-024-00859-5

Vallabh O. Shah, Tassy Parker, Giselle Rodriguez de Sosa, Mark L. Unruh

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Home monitoring of patients with chronic kidney disease 对慢性肾病患者进行家庭监测。

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-04 DOI: 10.1038/s41581-024-00858-6

Sabine H. Josemans, Lucas Lindeboom, Karin G. F. Gerritsen, Fokko P. Wieringa, Jeroen P. Kooman, Joris I. Rotmans

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Cystatin C and the misdiagnosis of CKD in older adults 胱抑素 C 与老年人慢性肾功能衰竭的误诊

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-06-03 DOI: 10.1038/s41581-024-00852-y

Andrew D. Rule, Richard J. Glassock

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VHL loss attracts immune cells to tumours VHL缺失会将免疫细胞吸引到肿瘤上

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-05-31 DOI: 10.1038/s41581-024-00856-8

Monica Wang

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Mutational signatures of ccRCC vary between geographical regions 不同地理区域ccRCC的基因突变特征各不相同

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2024-05-31 DOI: 10.1038/s41581-024-00855-9

Ellen F. Carney

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