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Nature Reviews Nephrology最新文献

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Advances and challenges in kidney fibrosis therapeutics
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2025-02-11 DOI: 10.1038/s41581-025-00934-5
Lilia Abbad, Emmanuel Esteve, Christos Chatziantoniou
{"title":"Advances and challenges in kidney fibrosis therapeutics","authors":"Lilia Abbad, Emmanuel Esteve, Christos Chatziantoniou","doi":"10.1038/s41581-025-00934-5","DOIUrl":"https://doi.org/10.1038/s41581-025-00934-5","url":null,"abstract":"<p>Chronic kidney disease (CKD) is a major global health burden that affects more than 10% of the adult population. Current treatments, including dialysis and transplantation, are costly and not curative. Kidney fibrosis, defined as an abnormal accumulation of extracellular matrix in the kidney parenchyma, is a common outcome in CKD, regardless of disease aetiology, and is a major cause of loss of kidney function and kidney failure. For this reason, research efforts have focused on identifying mediators of kidney fibrosis to inform the development of effective anti-fibrotic treatments. Given the prominent role of the transforming growth factor-β (TGFβ) family in fibrosis, efforts have focused on inhibiting TGFβ signalling. Despite hopes raised by the efficacy of this approach in preclinical models, translation into clinical practice has not met expectations. Antihypertensive and antidiabetic drugs slow the decline in kidney function and could slow fibrosis but, owing to the lack of technologies for in vivo renal imaging, their anti-fibrotic effect cannot be truly assessed at present. The emergence of new drugs targeting pro-fibrotic signalling, or enabling cell repair and cell metabolic reprogramming, combined with better stratification of people with CKD and the arrival of nanotechnologies for kidney-specific drug delivery, open up new perspectives for the treatment of this major public health challenge.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"50 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2025-02-04 DOI: 10.1038/s41581-025-00939-0
Dieter Haffner, Francesco Emma, Lothar Seefried, Wolfgang Högler, Kassim M. Javaid, Detlef Bockenhauer, Justine Bacchetta, Deborah Eastwood, Martin Biosse Duplan, Dirk Schnabel, Philippe Wicart, Gema Ariceta, Elena Levtchenko, Pol Harvengt, Martha Kirchhoff, Oliver Gardiner, Federico Di Rocco, Catherine Chaussain, Maria Luisa Brandi, Lars Savendahl, Karine Briot, Peter Kamenický, Lars Rejnmark, Agnès Linglart
{"title":"Publisher Correction: Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia","authors":"Dieter Haffner, Francesco Emma, Lothar Seefried, Wolfgang Högler, Kassim M. Javaid, Detlef Bockenhauer, Justine Bacchetta, Deborah Eastwood, Martin Biosse Duplan, Dirk Schnabel, Philippe Wicart, Gema Ariceta, Elena Levtchenko, Pol Harvengt, Martha Kirchhoff, Oliver Gardiner, Federico Di Rocco, Catherine Chaussain, Maria Luisa Brandi, Lars Savendahl, Karine Briot, Peter Kamenický, Lars Rejnmark, Agnès Linglart","doi":"10.1038/s41581-025-00939-0","DOIUrl":"https://doi.org/10.1038/s41581-025-00939-0","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Nephrology</i> https://doi.org/10.1038/s41581-024-00926-x, published online 15 January 2025.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"76 2 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence approaches to enable early detection of CKD
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-02-03 DOI: 10.1038/s41581-025-00933-6
Navdeep Tangri, Charumathi Sabanayagam
{"title":"Artificial intelligence approaches to enable early detection of CKD","authors":"Navdeep Tangri,&nbsp;Charumathi Sabanayagam","doi":"10.1038/s41581-025-00933-6","DOIUrl":"10.1038/s41581-025-00933-6","url":null,"abstract":"The late diagnosis of chronic kidney disease (CKD) is a global problem that limits the opportunity to initiate disease-modifying therapies. Artificial intelligence approaches using imaging or laboratory-based models can facilitate the early detection and risk stratification of CKD and thereby enable optimal treatment to reduce the burden of the disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"153-154"},"PeriodicalIF":28.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The kidney harbours a microbiota that may influence lithogenesis
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-30 DOI: 10.1038/s41581-025-00937-2
Ellen F. Carney
{"title":"The kidney harbours a microbiota that may influence lithogenesis","authors":"Ellen F. Carney","doi":"10.1038/s41581-025-00937-2","DOIUrl":"10.1038/s41581-025-00937-2","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"155-155"},"PeriodicalIF":28.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk-directed management of chronic kidney disease
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-30 DOI: 10.1038/s41581-025-00931-8
Matthew F. Blum, Brendon L. Neuen, Morgan E. Grams
{"title":"Risk-directed management of chronic kidney disease","authors":"Matthew F. Blum, Brendon L. Neuen, Morgan E. Grams","doi":"10.1038/s41581-025-00931-8","DOIUrl":"https://doi.org/10.1038/s41581-025-00931-8","url":null,"abstract":"<p>The timely and rational institution of therapy is a key step towards reducing the global burden of chronic kidney disease (CKD). CKD is a heterogeneous entity with varied aetiologies and diverse trajectories, which include risk of kidney failure but also cardiovascular events and death. Developments in the past decade include substantial progress in CKD risk prediction, driven in part by the accumulation of electronic health records data. In addition, large randomized clinical trials have demonstrated the effectiveness of sodium–glucose co-transporter 2 inhibitors, glucagon-like peptide 1 receptor agonists and mineralocorticoid receptor antagonists in reducing adverse events in CKD, greatly expanding the options for effective therapy. Alongside angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, these classes of medication have been proposed to be the four pillars of CKD pharmacotherapy. However, all of these drug classes are underutilized, even in individuals at high risk. Leveraging prognostic estimates to guide therapy could help clinicians to prescribe CKD-related therapies to those who are most likely to benefit from their use. Risk-based CKD management thus aligns patient risk and care, allowing the prioritization of absolute benefit in determining therapeutic selection and timing. Here, we discuss CKD prognosis tools, evidence-based management and prognosis-guided therapies.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"53 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of B cell protection in uraemic kidney disease
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-29 DOI: 10.1038/s41581-025-00936-3
Monica Wang
{"title":"Loss of B cell protection in uraemic kidney disease","authors":"Monica Wang","doi":"10.1038/s41581-025-00936-3","DOIUrl":"10.1038/s41581-025-00936-3","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"155-155"},"PeriodicalIF":28.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the burden of CKDu
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-28 DOI: 10.1038/s41581-025-00935-4
Susan J. Allison
{"title":"Insights into the burden of CKDu","authors":"Susan J. Allison","doi":"10.1038/s41581-025-00935-4","DOIUrl":"10.1038/s41581-025-00935-4","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"155-155"},"PeriodicalIF":28.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Born too soon: lifelong kidney risks and the importance of early intervention 过早出生：终生肾脏风险和早期干预的重要性
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-22 DOI: 10.1038/s41581-025-00932-7
Enrico Vidal, Daniele Trevisanuto
{"title":"Born too soon: lifelong kidney risks and the importance of early intervention","authors":"Enrico Vidal,&nbsp;Daniele Trevisanuto","doi":"10.1038/s41581-025-00932-7","DOIUrl":"10.1038/s41581-025-00932-7","url":null,"abstract":"Premature birth and low birth weight disrupt kidney development substantially, which leads to an increased risk of acute kidney injury, chronic kidney disease and hypertension. Broader awareness of these risks, implementation of preventive strategies and optimization of neonatal care are key to safeguarding kidney health and ensuring better long-term outcomes.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"151-152"},"PeriodicalIF":28.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches to raise awareness of CKD among patients and the general population 提高患者和公众对慢性肾脏病认识的方法
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-20 DOI: 10.1038/s41581-025-00928-3
Delphine S. Tuot, Laura Plantinga
{"title":"Approaches to raise awareness of CKD among patients and the general population","authors":"Delphine S. Tuot,&nbsp;Laura Plantinga","doi":"10.1038/s41581-025-00928-3","DOIUrl":"10.1038/s41581-025-00928-3","url":null,"abstract":"Improved awareness of chronic kidney disease (CKD) is vital to enable at-risk individuals to benefit from new therapies. Investment in primary care, improved recognition of CKD by primary care providers and public health approaches to increase CKD awareness are required to enhance CKD care delivery and improve kidney and cardiovascular outcomes.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"147-148"},"PeriodicalIF":28.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing risk factors and early intervention for chronic kidney disease 慢性肾脏疾病的危险因素管理和早期干预
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2025-01-15 DOI: 10.1038/s41581-025-00930-9
Robert Kalyesubula, Valerie Ann Luyckx
{"title":"Managing risk factors and early intervention for chronic kidney disease","authors":"Robert Kalyesubula,&nbsp;Valerie Ann Luyckx","doi":"10.1038/s41581-025-00930-9","DOIUrl":"10.1038/s41581-025-00930-9","url":null,"abstract":"The high global burden of kidney disease highlights an urgent need for early diagnosis and the implementation of interventions to prevent disease progression. Such an approach requires the identification and management of risk factors and equitable access to quality care.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 3","pages":"149-150"},"PeriodicalIF":28.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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