Brittney L. Gorman, Catelynn C. Shafer, Nagarjunachary Ragi, Kumar Sharma, Elizabeth K. Neumann, Christopher R. Anderton
{"title":"Imaging and spatially resolved mass spectrometry applications in nephrology","authors":"Brittney L. Gorman, Catelynn C. Shafer, Nagarjunachary Ragi, Kumar Sharma, Elizabeth K. Neumann, Christopher R. Anderton","doi":"10.1038/s41581-025-00946-1","DOIUrl":"https://doi.org/10.1038/s41581-025-00946-1","url":null,"abstract":"<p>The application of spatially resolved mass spectrometry (MS) and MS imaging approaches for studying biomolecular processes in the kidney is rapidly growing. These powerful methods, which enable label-free and multiplexed detection of many molecular classes across omics domains (including metabolites, drugs, proteins and protein post-translational modifications), are beginning to reveal new molecular insights related to kidney health and disease. The complexity of the kidney often necessitates multiple scales of analysis for interrogating biofluids, whole organs, functional tissue units, single cells and subcellular compartments. Various MS methods can generate omics data across these spatial domains and facilitate both basic science and pathological assessment of the kidney. Optimal processes related to sample preparation and handling for different MS applications are rapidly evolving. Emerging technology and methods, improvement of spatial resolution, broader molecular characterization, multimodal and multiomics approaches and the use of machine learning and artificial intelligence approaches promise to make these applications even more valuable in the field of nephology. Overall, spatially resolved MS and MS imaging methods have the potential to fill much of the omics gap in systems biology analysis of the kidney and provide functional outputs that cannot be obtained using genomics and transcriptomic methods.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"99 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic determinants of urine and plasma metabolite levels","authors":"Seth L. Alper, David J. Friedman","doi":"10.1038/s41581-025-00953-2","DOIUrl":"https://doi.org/10.1038/s41581-025-00953-2","url":null,"abstract":"Advanced instrumentation and rapid computation are generating ever more data on human genetics, epigenetics, transcriptomics, proteomics and metabolomics, posing challenges of integration and interpretation. New research has applied rigorous statistical analyses to genetic variations identified in patients with kidney disease to find drivers of (patho)physiological differences in urine and plasma metabolomes.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"23 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GWAS scorecard prioritizes kidney genes using coding and regulatory variants","authors":"Matthias Wuttke, Cristian Pattaro","doi":"10.1038/s41581-025-00952-3","DOIUrl":"https://doi.org/10.1038/s41581-025-00952-3","url":null,"abstract":"Based on genome-wide association study data from 2.2 million individuals, a functional prioritization scorecard integrates classical omics with allele-specific gene expression, chromatin accessibility and gene regulatory circuits in kidney tissues and specific cell types. This approach prioritized 601 kidney function-related genes, including genes associated with nephropathy in mice and humans.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"366 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neutrophils and NETs in kidney disease","authors":"Daigo Nakazawa, Sakiko Masuda, Yuka Nishibata, Kanako Watanabe-Kusunoki, Utano Tomaru, Akihiro Ishizu","doi":"10.1038/s41581-025-00944-3","DOIUrl":"https://doi.org/10.1038/s41581-025-00944-3","url":null,"abstract":"<p>Neutrophils, conventionally regarded as a homogeneous immune cell population, have emerged as a heterogeneous group of cells with distinct gene profiles and immune properties. Activated neutrophils release a spectrum of bioactive substances, including cytokines, chemokines, proteolytic enzymes, reactive oxygen species and neutrophil extracellular traps (NETs), which are composed of decondensed DNA and antimicrobial proteins. NETs have a pivotal role in innate immunity, including in preventing the ascent of uropathogenic bacteria into the kidneys, as they efficiently trap pathogenic microorganisms. However, although indispensable for defence against pathogens, NETs also pose risks of self-damage owing to their cytotoxicity, thrombogenicity and autoantigenicity. Accordingly, neutrophils and NETs have been implicated in the pathogenesis of various disorders that affect the kidneys, including acute kidney injury, vasculitis, systemic lupus erythematosus, thrombotic microangiopathy and in various aetiologies of chronic kidney disease. Pathological alterations in the glomerular vascular wall can promote the infiltration of neutrophils, which can cause tissue damage and inflammation through their interactions with kidney-resident cells, including mesangial cells and podocytes, leading to local cell death. Targeting neutrophil activation and NET formation might therefore represent a new therapeutic strategy for these conditions.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"43 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unequal access: the prohibitive costs of new drugs in low- and middle-income countries","authors":"John M. Pettifor, Haroon Saloojee","doi":"10.1038/s41581-025-00948-z","DOIUrl":"https://doi.org/10.1038/s41581-025-00948-z","url":null,"abstract":"The prohibitive costs of new pharmacological agents, particularly biologicals, have largely limited their use to high-income countries, resulting in widening of health disparities. Urgent action from the pharmaceutical industry, governments and healthcare organizations is needed to improve access to treatment and address these inequities.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"42 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Haydak, Jacob Wright, Paula L. Croxson, Ilse S. Daehn
{"title":"Lived experience is essential for innovation in biomedical research","authors":"Jonathan Haydak, Jacob Wright, Paula L. Croxson, Ilse S. Daehn","doi":"10.1038/s41581-025-00940-7","DOIUrl":"https://doi.org/10.1038/s41581-025-00940-7","url":null,"abstract":"The inclusion of individuals with disabilities and patients as partners in biomedical research is critical for driving innovation. Equally important are patient–researchers, who are instrumental in identifying key research problems and driving research towards areas of direct benefit. We call for institutions to actively work towards accommodating patient–researchers.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"54 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A difficult path to point-of-care measurement of glomerular filtration rate","authors":"Pierre Delanaye, Richard J. Glassock","doi":"10.1038/s41581-025-00947-0","DOIUrl":"https://doi.org/10.1038/s41581-025-00947-0","url":null,"abstract":"Transdermal detection of fluorescent markers has potential to provide point-of-care measurement of glomerular filtration rate. However, validation of proposed approaches and confirmation of their clinical utility should be required ahead of their adoption in the clinic.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"54 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lilia Cervantes, Sri Lekha Tummalapalli, Delphine Tuot, Russell E. Glasgow
{"title":"The role of implementation science in advancing equity in kidney health","authors":"Lilia Cervantes, Sri Lekha Tummalapalli, Delphine Tuot, Russell E. Glasgow","doi":"10.1038/s41581-025-00949-y","DOIUrl":"https://doi.org/10.1038/s41581-025-00949-y","url":null,"abstract":"Awareness of chronic kidney disease (CKD) and uptake of evidence-based interventions (EBIs) that increase awareness and/or slow progression to kidney failure remain alarmingly low. The global rise in immigration might exacerbate CKD prevalence among minoritized groups, which underscores the need for the nephrology community to acknowledge the diverse contexts that influence EBI implementation and to integrate health equity approaches.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"39 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reya H. Mokiao, Jason F. Deen, Amanda M. Fretts, Bessie A. Young
{"title":"Systemic interventions towards kidney health equity in American Indian and Alaska Native communities","authors":"Reya H. Mokiao, Jason F. Deen, Amanda M. Fretts, Bessie A. Young","doi":"10.1038/s41581-025-00943-4","DOIUrl":"https://doi.org/10.1038/s41581-025-00943-4","url":null,"abstract":"Kidney disease disproportionately affects American Indian and Alaska Native (AI/AN) communities, largely owing to adverse social drivers of health that stem from systemic issues including colonization, structural racism and historical trauma. Kidney health equity for AI/AN communities requires systemic and multilevel interventions across the CKD spectrum and life course.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"13 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fiji’s rising tide: the growing burden of diabetic kidney disease on emerging nephrology services","authors":"Anis Ta’eed, Abhitesh Raj, Yogeshni Chandra, Shilpanjali Jesudason, Angus Ritchie","doi":"10.1038/s41581-025-00942-5","DOIUrl":"https://doi.org/10.1038/s41581-025-00942-5","url":null,"abstract":"A growing burden of diabetic kidney disease in Fiji threatens to overwhelm newly established nephrology services. Greater attention to early detection and intervention, incorporation of kidney health into national strategic plans, and international support to prioritize chronic kidney disease as a global priority is imperative.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"28 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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