Nature Reviews Nephrology最新文献_第2页

From fat to filter: the effect of adipose tissue-derived signals on kidney function 从脂肪到过滤器：脂肪组织来源的信号对肾功能的影响

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-04-02 DOI: 10.1038/s41581-025-00950-5

Nermin Ahmed, Carolina Dalmasso, Meghan B. Turner, Gertrude Arthur, Cole Cincinelli, Analia S. Loria

{"title":"From fat to filter: the effect of adipose tissue-derived signals on kidney function","authors":"Nermin Ahmed, Carolina Dalmasso, Meghan B. Turner, Gertrude Arthur, Cole Cincinelli, Analia S. Loria","doi":"10.1038/s41581-025-00950-5","DOIUrl":"https://doi.org/10.1038/s41581-025-00950-5","url":null,"abstract":"Obesity is associated with severe consequences for the renal system, including chronic kidney disease, kidney failure and increased mortality. Obesity has both direct and indirect effects on kidney health through several mechanisms, including activation of the renin–angiotensin system, mechanical compression, inflammation, fibrosis, increased filtration barrier permeability and renal nerve activity. The expansion of adipose tissue through hypertrophy and hyperplasia can induce haemodynamic changes that promote glomerular hyperfiltration to compensate for the greater metabolic demands of the increased body weight. Adipose expansion is also associated with the release of adipokines and pro-inflammatory cytokines, hyperinsulinaemia and insulin resistance, which exert direct and indirect effects on kidney function via various mechanisms. Increased uptake of fatty acids by the kidney leads to alterations in lipid metabolism and lipotoxicity, also contributing to the pro-inflammatory and pro-fibrotic environment. The role of the adipose tissue–brain–kidney axis in the obesity-associated decline in renal function is sustained by studies showing that stimulation of adipose tissue sensory neurons by locally released factors increases renal sympathetic nerve activity. Conversely, pre-existent kidney disease can contribute to adipose dysfunction through the accumulation of uraemic toxins and hormonal changes. These findings highlight the importance of crosstalk between adipose tissue and the kidneys and provide insights into the mechanisms underlying the associations between obesity and kidney disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"89 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of LILRB3 variants with kidney transplant failure in African Americans LILRB3变异与非裔美国人肾移植失败的关系

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-04-01 DOI: 10.1038/s41581-025-00959-w

Susan J. Allison

{"title":"Association of LILRB3 variants with kidney transplant failure in African Americans","authors":"Susan J. Allison","doi":"10.1038/s41581-025-00959-w","DOIUrl":"https://doi.org/10.1038/s41581-025-00959-w","url":null,"abstract":"African American kidney transplant recipients exhibit a higher risk of graft failure than other racial and ethnic groups even after accounting for HLA mismatches and socioeconomic status, which suggests a role for other risk factors. Now, researchers have identified a cluster of four consecutive missense single-nucleotide polymorphisms (SNPs) within leukocyte immunoglobulin-like receptor B3 (LILRB3) that is enriched among African American individuals and represents a risk factor for death-censored graft loss and immune-related diseases.Using this approach, the researchers uncovered a cluster of four linked missense SNPs in LILRB3 (termed LILRB3-4SNPs) that was predominantly detected in African American individuals and associated with poor graft outcomes. Further evaluation in other transplantation cohorts and biobank data revealed that LILRB3-4SNPs correlates with a heightened risk of graft loss and progression to kidney failure. These analyses also identified an association between LILRB3-4SNPs and immune-related pathologies, in line with the known role of LILRB3 as a negative regulator of immune responses. Multiomics analyses also demonstrated that transplant recipients with LILRB3-4SNPs demonstrate increased inflammation characterized by persistent activation of T cell and B cell signalling pathways, and monocyte ferroptosis, whereas functional studies in a macrophage cell line demonstrated that the pathogenic effects of LILRB3-4SNPs expression could be reversed by a ferroptosis inhibitor. “This work bridges genetic discovery with translational medicine, offering a pathway to address disparities in transplantation outcomes through precision therapies,” says Zhang. The researchers are now planning further studies to establish the LILRB3-4SNPs cluster as a genetic biomarker for the stratification of graft failure risk in African American transplant recipients and evaluate the efficacy of ferroptosis inhibitors in preclinical models.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"33 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular mortality increases with stage of cardiovascular–kidney–metabolic syndrome 心血管死亡率随心血管-肾-代谢综合征的分期而增加

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-31 DOI: 10.1038/s41581-025-00957-y

Ellen F. Carney

引用次数: 0

Ureter development and associated congenital anomalies 输尿管发育及相关先天性异常

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-31 DOI: 10.1038/s41581-025-00951-4

Andreas Kispert

{"title":"Ureter development and associated congenital anomalies","authors":"Andreas Kispert","doi":"10.1038/s41581-025-00951-4","DOIUrl":"https://doi.org/10.1038/s41581-025-00951-4","url":null,"abstract":"Malformations of the ureter are among the most common birth defects in humans. Although some of these anomalies are asymptomatic, others are clinically relevant, causing perinatal lethality or progressing to kidney failure in childhood. The genetic causes and developmental aetiology of ureteral anomalies are difficult to study in humans; however, embryological and genetic analyses in the mouse have provided insights into the complex developmental programmes that govern ureter formation from simple tissue primordia, and the pathological consequences that result from disruption of these programmes. Abnormalities in the formation of the nephric duct and ureteric bud lead to changes in the number of ureters (and kidneys), whereas the formation of ectopic ureteric buds, failure of the nephric duct to target the cloaca or failure of the distal ureter to mature underlie vesicoureteral reflux, ureter ectopia, ureterocoele and subsequent hydroureter. Alterations in ureter specification, early growth or cyto-differentiation programmes have now also been associated with various forms of perinatal hydroureter and hydronephrosis as a consequence of functional obstruction. The characterization of cellular processes and molecular drivers of ureterogenesis in the mouse may not only aid understanding of the aetiology of human ureteral anomalies, improve prognostication and benefit the development of therapeutic strategies, but may also prove important for efforts to generate a bioartificial organ.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"102 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging and spatially resolved mass spectrometry applications in nephrology 成像和空间分辨质谱在肾脏病学中的应用

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-27 DOI: 10.1038/s41581-025-00946-1

Brittney L. Gorman, Catelynn C. Shafer, Nagarjunachary Ragi, Kumar Sharma, Elizabeth K. Neumann, Christopher R. Anderton

{"title":"Imaging and spatially resolved mass spectrometry applications in nephrology","authors":"Brittney L. Gorman, Catelynn C. Shafer, Nagarjunachary Ragi, Kumar Sharma, Elizabeth K. Neumann, Christopher R. Anderton","doi":"10.1038/s41581-025-00946-1","DOIUrl":"https://doi.org/10.1038/s41581-025-00946-1","url":null,"abstract":"The application of spatially resolved mass spectrometry (MS) and MS imaging approaches for studying biomolecular processes in the kidney is rapidly growing. These powerful methods, which enable label-free and multiplexed detection of many molecular classes across omics domains (including metabolites, drugs, proteins and protein post-translational modifications), are beginning to reveal new molecular insights related to kidney health and disease. The complexity of the kidney often necessitates multiple scales of analysis for interrogating biofluids, whole organs, functional tissue units, single cells and subcellular compartments. Various MS methods can generate omics data across these spatial domains and facilitate both basic science and pathological assessment of the kidney. Optimal processes related to sample preparation and handling for different MS applications are rapidly evolving. Emerging technology and methods, improvement of spatial resolution, broader molecular characterization, multimodal and multiomics approaches and the use of machine learning and artificial intelligence approaches promise to make these applications even more valuable in the field of nephology. Overall, spatially resolved MS and MS imaging methods have the potential to fill much of the omics gap in systems biology analysis of the kidney and provide functional outputs that cannot be obtained using genomics and transcriptomic methods.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"99 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding access to dialysis coverage in Mexico 在墨西哥扩大透析覆盖面

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-27 DOI: 10.1038/s41581-025-00954-1

Magdalena Madero

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Genetic determinants of urine and plasma metabolite levels 尿和血浆代谢水平的遗传决定因素

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-26 DOI: 10.1038/s41581-025-00953-2

Seth L. Alper, David J. Friedman

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GWAS scorecard prioritizes kidney genes using coding and regulatory variants GWAS记分卡使用编码和调节变异体对肾脏基因进行优先排序

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-20 DOI: 10.1038/s41581-025-00952-3

Matthias Wuttke, Cristian Pattaro

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Neutrophils and NETs in kidney disease 肾脏疾病中的中性粒细胞和NETs

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-18 DOI: 10.1038/s41581-025-00944-3

Daigo Nakazawa, Sakiko Masuda, Yuka Nishibata, Kanako Watanabe-Kusunoki, Utano Tomaru, Akihiro Ishizu

{"title":"Neutrophils and NETs in kidney disease","authors":"Daigo Nakazawa, Sakiko Masuda, Yuka Nishibata, Kanako Watanabe-Kusunoki, Utano Tomaru, Akihiro Ishizu","doi":"10.1038/s41581-025-00944-3","DOIUrl":"https://doi.org/10.1038/s41581-025-00944-3","url":null,"abstract":"Neutrophils, conventionally regarded as a homogeneous immune cell population, have emerged as a heterogeneous group of cells with distinct gene profiles and immune properties. Activated neutrophils release a spectrum of bioactive substances, including cytokines, chemokines, proteolytic enzymes, reactive oxygen species and neutrophil extracellular traps (NETs), which are composed of decondensed DNA and antimicrobial proteins. NETs have a pivotal role in innate immunity, including in preventing the ascent of uropathogenic bacteria into the kidneys, as they efficiently trap pathogenic microorganisms. However, although indispensable for defence against pathogens, NETs also pose risks of self-damage owing to their cytotoxicity, thrombogenicity and autoantigenicity. Accordingly, neutrophils and NETs have been implicated in the pathogenesis of various disorders that affect the kidneys, including acute kidney injury, vasculitis, systemic lupus erythematosus, thrombotic microangiopathy and in various aetiologies of chronic kidney disease. Pathological alterations in the glomerular vascular wall can promote the infiltration of neutrophils, which can cause tissue damage and inflammation through their interactions with kidney-resident cells, including mesangial cells and podocytes, leading to local cell death. Targeting neutrophil activation and NET formation might therefore represent a new therapeutic strategy for these conditions.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"43 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unequal access: the prohibitive costs of new drugs in low- and middle-income countries 获取不平等：中低收入国家新药的高昂费用

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-14 DOI: 10.1038/s41581-025-00948-z

John M. Pettifor, Haroon Saloojee

引用次数: 0