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Nature Reviews Nephrology最新文献

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A focus on kidney ageing 关注肾脏老化
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-20 DOI: 10.1038/s41581-024-00879-1
{"title":"A focus on kidney ageing","authors":"","doi":"10.1038/s41581-024-00879-1","DOIUrl":"10.1038/s41581-024-00879-1","url":null,"abstract":"Population ageing will exacerbate the burden of ageing-related diseases, including chronic kidney disease. Mitigating the effects of this burden will require coordinated, multinational efforts.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41581-024-00879-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in uromodulin biology and potential clinical applications 尿调节蛋白生物学研究进展及潜在临床应用
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-19 DOI: 10.1038/s41581-024-00881-7
Azuma Nanamatsu, Larissa de Araújo, Kaice A. LaFavers, Tarek M. El-Achkar
{"title":"Advances in uromodulin biology and potential clinical applications","authors":"Azuma Nanamatsu, Larissa de Araújo, Kaice A. LaFavers, Tarek M. El-Achkar","doi":"10.1038/s41581-024-00881-7","DOIUrl":"https://doi.org/10.1038/s41581-024-00881-7","url":null,"abstract":"<p>Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein secreted bidirectionally into urine and into the circulation, and it is the most abundant protein in normal urine. Although the discovery of uromodulin predates modern medicine, its significance in health and disease has been rather enigmatic. Research studies have gradually revealed that uromodulin exists in multiple forms and has important roles in urinary and systemic homeostasis. Most uromodulin in urine is polymerized into highly organized filaments, whereas non-polymeric uromodulin is detected both in urine and in the circulation, and can have distinct roles. The interactions of uromodulin with the immune system, which were initially reported to be a key role of this protein, are now better understood. Moreover, the discovery that uromodulin is associated with a spectrum of kidney diseases, including acute kidney injury, chronic kidney disease and autosomal-dominant tubulointerstitial kidney disease, has further accelerated investigations into the role of this protein. These discoveries have prompted new questions and ushered in a new era in uromodulin research. Here, we delineate the latest discoveries in uromodulin biology and its emerging roles in modulating kidney and systemic diseases, and consider future directions, including its potential clinical applications.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":41.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the quality of pharmacoepidemiological studies using the target trial emulation framework. 利用目标试验模拟框架提高药物流行病学研究的质量。
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-13 DOI: 10.1038/s41581-024-00884-4
Emilie Lambourg
{"title":"Improving the quality of pharmacoepidemiological studies using the target trial emulation framework.","authors":"Emilie Lambourg","doi":"10.1038/s41581-024-00884-4","DOIUrl":"https://doi.org/10.1038/s41581-024-00884-4","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From improbable to possible: pregnancy with advanced chronic kidney disease 从不可能到可能：晚期慢性肾病患者怀孕
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-07 DOI: 10.1038/s41581-024-00882-6
Alejandra Orozco-Guillén
{"title":"From improbable to possible: pregnancy with advanced chronic kidney disease","authors":"Alejandra Orozco-Guillén","doi":"10.1038/s41581-024-00882-6","DOIUrl":"https://doi.org/10.1038/s41581-024-00882-6","url":null,"abstract":"<p>Reproductive health is an acknowledged right, yet women with chronic kidney disease (CKD) not only face reduced fertility but also higher risks of adverse pregnancy outcomes for mother and baby. These risks are higher in underserved populations, but they can be minimized through empowerment, education and adequate health-care support.</p><p>In Mexico, nearly 37% of the population lives in poverty, with ~8% living in extreme poverty, and this social context affects access to health care. Consequently, after a first encounter at birth, often the second time a woman sees a doctor is when she gets pregnant. Kidney disease is therefore often undiagnosed and might only be detected during pregnancy. Poverty, low availability and limited quality of medical services, lack of family planning programmes, and a high frequency of adolescent pregnancy translate into high morbidity and mortality in high-risk pregnancies.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":41.5,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocytes and innate immune cells in acute kidney injury and repair 急性肾损伤和修复中的淋巴细胞和先天性免疫细胞
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-02 DOI: 10.1038/s41581-024-00875-5
Kyungho Lee, Hye Ryoun Jang, Hamid Rabb
{"title":"Lymphocytes and innate immune cells in acute kidney injury and repair","authors":"Kyungho Lee, Hye Ryoun Jang, Hamid Rabb","doi":"10.1038/s41581-024-00875-5","DOIUrl":"https://doi.org/10.1038/s41581-024-00875-5","url":null,"abstract":"<p>Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which no specific treatments exist. Complex intrarenal inflammatory processes driven by lymphocytes and innate immune cells have key roles in the development and progression of AKI. Many studies have focused on prevention of early injury in AKI. However, most patients with AKI present after injury is already established. Increasing research is therefore focusing on mechanisms of renal repair following AKI and prevention of progression from AKI to chronic kidney disease. CD4<sup>+</sup> and CD8<sup>+</sup> T cells, B cells and neutrophils are probably involved in the development and progression of AKI, whereas regulatory T cells, double-negative T cells and type 2 innate lymphoid cells have protective roles. Several immune cells, such as macrophages and natural killer T cells, can have both deleterious and protective effects, depending on their subtype and/or the stage of AKI. The immune system not only participates in injury and repair processes during AKI but also has a role in mediating AKI-induced distant organ dysfunction. Targeted manipulation of immune cells is a promising therapeutic strategy to improve AKI outcomes.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":41.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making advance care planning easier for adults with kidney disease and their clinicians 让成人肾病患者及其临床医生更轻松地制定预先护理计划。
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-08-01 DOI: 10.1038/s41581-024-00871-9
Ryan D. McMahan, Rebecca L. Sudore
{"title":"Making advance care planning easier for adults with kidney disease and their clinicians","authors":"Ryan D. McMahan,&nbsp;Rebecca L. Sudore","doi":"10.1038/s41581-024-00871-9","DOIUrl":"10.1038/s41581-024-00871-9","url":null,"abstract":"Advance care planning (ACP) has evolved from a narrow focus on end-of-life preference, such as resuscitation, to a continuum of care planning across the life course. Older adults with kidney disease have high morbidity and mortality, and easy-to-use tools can make ACP easier for patients and clinicians.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug repurposing for glomerular diseases: an underutilized resource 肾小球疾病的药物再利用：未充分利用的资源
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-07-31 DOI: 10.1038/s41581-024-00864-8
Monica Suet Ying Ng, Gursimran Kaur, Ross S. Francis, Carmel M. Hawley, David W. Johnson
{"title":"Drug repurposing for glomerular diseases: an underutilized resource","authors":"Monica Suet Ying Ng, Gursimran Kaur, Ross S. Francis, Carmel M. Hawley, David W. Johnson","doi":"10.1038/s41581-024-00864-8","DOIUrl":"https://doi.org/10.1038/s41581-024-00864-8","url":null,"abstract":"<p>Drug repurposing in glomerular disease can deliver opportunities for steroid-free regimens, enable personalized multi-target options for resistant or relapsing disease and enhance treatment options for understudied populations (for example, children) and in resource-limited settings. Identification of drug-repurposing candidates can be data driven, which utilizes existing data on disease pathobiology, drug features and clinical outcomes, or experimental, which involves high-throughput drug screens. Information from databases of approved drugs, clinical trials and PubMed registries suggests that at least 96 drugs on the market cover 49 targets with immunosuppressive potential that could be candidates for drug repurposing in glomerular disease. Furthermore, evidence to support drug repurposing is available for 191 immune drug target–glomerular disease pairs. Non-immunological drug repurposing includes strategies to reduce haemodynamic overload, podocyte injury and kidney fibrosis. Recommended strategies to expand drug-repurposing capacity in glomerular disease include enriching drug databases with glomeruli-specific information, enhancing the accessibility of primary clinical trial data, biomarker discovery to improve participant selection into clinical trials and improve surrogate outcomes and initiatives to reduce patent, regulatory and organizational hurdles.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":41.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-nephrin autoantibodies: a paradigm shift in podocytopathies 抗胰岛素自身抗体：荚膜细胞病的范式转变。
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-07-30 DOI: 10.1038/s41581-024-00873-7
Zhao Cui, Ming-hui Zhao
{"title":"Anti-nephrin autoantibodies: a paradigm shift in podocytopathies","authors":"Zhao Cui,&nbsp;Ming-hui Zhao","doi":"10.1038/s41581-024-00873-7","DOIUrl":"10.1038/s41581-024-00873-7","url":null,"abstract":"A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental glomerulosclerosis. This insight not only provides a non-invasive diagnostic alternative to kidney biopsies, but also suggests potential for novel targeted therapies.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tertiary lymphoid organs contribute to kidney allograft rejection 三级淋巴器官导致肾脏异体移植排斥反应
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-07-29 DOI: 10.1038/s41581-024-00880-8
Ellen F. Carney
{"title":"Tertiary lymphoid organs contribute to kidney allograft rejection","authors":"Ellen F. Carney","doi":"10.1038/s41581-024-00880-8","DOIUrl":"10.1038/s41581-024-00880-8","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The GLP-1 receptor agonist revolution comes to nephrology 肾脏病学迎来 GLP-1 受体激动剂革命
IF 28.6 1区 医学
Nature Reviews Nephrology Pub Date : 2024-07-29 DOI: 10.1038/s41581-024-00876-4
Merlin C. Thomas, Mark E. Cooper
{"title":"The GLP-1 receptor agonist revolution comes to nephrology","authors":"Merlin C. Thomas,&nbsp;Mark E. Cooper","doi":"10.1038/s41581-024-00876-4","DOIUrl":"10.1038/s41581-024-00876-4","url":null,"abstract":"Glucagon-like peptide 1 receptor agonists improve glucose control, promote weight loss and reduce the risk of major cardiovascular events in people with type 2 diabetes mellitus. The FLOW study now provides unequivocal evidence of kidney protective effects with semaglutide in adults with type 2 diabetes mellitus and chronic kidney disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":null,"pages":null},"PeriodicalIF":28.6,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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