Nature Reviews Nephrology最新文献_第3页

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2025-09-04 DOI: 10.1038/s41581-025-00997-4

Vanja Ivković, Urmila Anandh, Samira Bell, Andreas Kronbichler, Maria Jose Soler, Annette Bruchfeld

{"title":"Long COVID and the kidney","authors":"Vanja Ivković, Urmila Anandh, Samira Bell, Andreas Kronbichler, Maria Jose Soler, Annette Bruchfeld","doi":"10.1038/s41581-025-00997-4","DOIUrl":"https://doi.org/10.1038/s41581-025-00997-4","url":null,"abstract":"<p>Long coronavirus disease (COVID) — commonly defined as symptoms and/or long-term effects that persist for at least 3 months after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cannot be explained by an alternative diagnosis — is a complex, multifaceted and heterogeneous disease that affects many organ systems, including the kidney. COVID-19 can cause acute kidney injury, and several studies have reported an increased risk of chronic kidney disease (CKD) following COVID-19, suggesting that CKD can be a manifestation of long COVID. Furthermore, patients with CKD are at an increased risk of severe COVID-19 and of long COVID. COVID-19 has also been associated with the development of COVID-19-associated nephropathy, which is a collapsing form of focal segmental glomerulosclerosis, and an increased incidence of new-onset vasculitis. Some early reports described associations of COVID-19 and/or SARS-CoV-2 vaccines with relapse or new-onset of other glomerular diseases, but this link was not confirmed in large population-based studies. SARS-CoV-2 vaccination reduces the risk of COVID-19 and long COVID and is particularly important for protecting vulnerable populations such as patients with CKD. Structured long-term follow-up of patients with COVID-19 and post-infectious sequelae is needed to provide further insight into the trajectory of long COVID and enable identification of those at risk of CKD.</p>","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"48 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accumulation of pathogenic mitochondrial DNA mutations in the kidney 肾脏中致病性线粒体DNA突变的积累

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-29 DOI: 10.1038/s41581-025-01002-8

Ellen F. Carney

引用次数: 0

Regulation of autophagy by a tRNA-derived fragment trna衍生片段对自噬的调控

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-26 DOI: 10.1038/s41581-025-01001-9

Susan J. Allison

引用次数: 0

A strength-based community: transforming renal care through connection and meaning 以力量为基础的社区：通过联系和意义改变肾脏护理。

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-19 DOI: 10.1038/s41581-025-00998-3

Paula A. Marioli

引用次数: 0

Kidney stone disease: risk factors, pathophysiology and management 肾结石疾病：危险因素、病理生理和管理

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-11 DOI: 10.1038/s41581-025-00990-x

Matteo Bargagli, Martin Scoglio, Sarah A. Howles, Daniel G. Fuster

{"title":"Kidney stone disease: risk factors, pathophysiology and management","authors":"Matteo Bargagli, Martin Scoglio, Sarah A. Howles, Daniel G. Fuster","doi":"10.1038/s41581-025-00990-x","DOIUrl":"10.1038/s41581-025-00990-x","url":null,"abstract":"Nephrolithiasis is the most common health condition affecting the kidney and urinary tract and constitutes a major global health-care problem. The prevalence of nephrolithiasis has increased substantially over the past five decades, irrespective of age, sex or ethnicity. Kidney stones cause substantial morbidity, reduced quality of life and enormous health-care expenditure, largely due to their frequent recurrence. Furthermore, nephrolithiasis is now recognized as a systemic condition associated with increased risks of chronic kidney disease, cardiovascular disease, metabolic syndrome and low bone mass. Nephrolithiasis exhibits marked pathophysiological heterogeneity. Dietary and environmental exposures interact with genetic predisposition to shape individual disease risk. Calcium oxalate stones are most prevalent, commonly driven by hypercalciuria, hyperoxaluria, hypocitraturia and low urine volume, whereas the formation of uric acid and calcium phosphate stones is commonly linked to urinary pH. A comprehensive clinical evaluation can uncover underlying metabolic abnormalities, distinguish idiopathic, secondary and Mendelian forms of nephrolithiasis, identify systemic disease associations and guide therapy. Recurrence prevention requires individualized strategies that combine dietary and pharmacological interventions. For established stones, surgical management is effective, with ureteroscopy and percutaneous nephrolithotomy achieving high stone-free rates. Despite its considerable clinical and societal burden, nephrolithiasis remains under-recognized, underserved and under-researched. Greater awareness and investments in research, innovation and education are urgently needed. This Review discusses the pathophysiology of kidney stone formation and examines the contribution of urinary risk factors and genetic variants. The authors also consider current approaches to the management of nephrolithiasis, including the role of metabolic evaluation and interventions for prevention of kidney stone recurrence.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 11","pages":"794-808"},"PeriodicalIF":39.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call for funds and training for kidney genomics programmes 呼吁为肾脏基因组学项目提供资金和培训

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-08 DOI: 10.1038/s41581-025-00995-6

Kar Hui Ng

引用次数: 0

The increasing burden of mild and moderate anaemia in CKD 慢性肾病患者轻中度贫血负担的增加

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-08-05 DOI: 10.1038/s41581-025-00994-7

Hiroshi Nishi, Masaomi Nangaku

引用次数: 0

Endoplasmic reticulum-mediated organelle crosstalk in kidney disease 肾脏疾病内质网介导的细胞器串扰。

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-07-31 DOI: 10.1038/s41581-025-00989-4

Yu Ah Hong (, ), Reiko Inagi (, )

{"title":"Endoplasmic reticulum-mediated organelle crosstalk in kidney disease","authors":"Yu Ah Hong \u0000 (, ), Reiko Inagi \u0000 (, )","doi":"10.1038/s41581-025-00989-4","DOIUrl":"10.1038/s41581-025-00989-4","url":null,"abstract":"The endoplasmic reticulum (ER) is a key organelle involved in a wide range of intracellular biological processes, including Ca2+ homeostasis; lipid metabolism; proteostasis through protein synthesis, folding and processing of secretory and transmembrane proteins; and signal transduction. The ER forms extensive physical interactions with various intracellular organelles through the membrane contact sites, enabling direct exchange of ions and lipids without vesicular transport. At mitochondria-associated membranes, ER–mitochondria communication governs calcium transfer, lipid synthesis, mitochondrial dynamics, the unfolded protein response and inflammation, all of which are essential for maintaining cellular homeostasis. The ER also interacts with the Golgi apparatus, endosomes and plasma membrane to facilitate transfer of calcium and lipids. Disruption of ER–organelle communication contributes to the development and progression of various kidney diseases, including diabetic kidney disease, acute kidney injury and polycystic kidney disease. Accordingly, ER–organelle communication has emerged as a promising therapeutic target. Pharmacological agents such as SGLT2 inhibitors, AMPK activators, mTOR inhibitors and RAAS blockers have been shown to restore ER–mitochondria communication and alleviate kidney injury in experimental models. Advancing our understanding of ER–organelle crosstalk may offer new mechanistic insights and contribute to the optimization of current treatment strategies for kidney disease. Here, the authors discuss communication between the ER and other intracellular organelles under physiological and pathological conditions. They highlight the potential role of this crosstalk in the pathogenesis of kidney diseases and discuss potential therapeutic strategies aimed at modulating this crosstalk.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 11","pages":"736-755"},"PeriodicalIF":39.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen IV in Gould syndrome and Alport syndrome 胶原IV在Gould综合征和Alport综合征

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-07-31 DOI: 10.1038/s41581-025-00982-x

Dawiyat Massoudi, Jeffrey H. Miner, Douglas B. Gould

{"title":"Collagen IV in Gould syndrome and Alport syndrome","authors":"Dawiyat Massoudi, Jeffrey H. Miner, Douglas B. Gould","doi":"10.1038/s41581-025-00982-x","DOIUrl":"10.1038/s41581-025-00982-x","url":null,"abstract":"Collagen IV is a basement membrane component that is encoded by six genes in mammals (COL4Α1–COL4A6). The α-chains encoded by these genes assemble into three known heterotrimers — collagen α1α1α2(IV), α3α4α5(IV) and α5α5α6(IV) — that provide structure and act as multifunctional signalling platforms. The ancestral collagen superfamily members collagen alpha-1(IV) chain (COL4Α1) and collagen alpha-2(IV) chain (COL4Α2) are present throughout the animal kingdom and in all developing and most mature mammalian tissues. Consistent with this broad distribution, variants in COL4A1 and COL4A2 cause a congenital multisystem disorder called Gould syndrome (GS), which is characterized by cerebral, ocular, muscular and kidney defects. The main clinical consequences involve the cerebral vasculature (porencephaly, small-vessel disease, leukoencephalopathy and intracerebral haemorrhage). However, the full clinical spectrum, including the organs affected and acquired phenotypes such as vascular dementia, is still being defined. By contrast, variants in COL4A3, COL4A4 or COL4A5 cause Alport syndrome (AS), a disorder of variable severity that affects the kidney, ear and eye. AS nephropathies often progress from haematuria to proteinuria, renal impairment and kidney failure. The auditory features include sensorineural hearing loss, whereas the ocular features comprise corneal dystrophy, lenticonus, dot-and-fleck retinopathy and maculopathy. Although GS and AS have little clinical resemblance, the high conservation of the genes and proteins suggests common elements of underlying pathophysiology. Conventional therapies that modify haemodynamics have lengthened the time to kidney failure for patients living with AS. However, no curative or mechanism-based interventions exist for GS. Gene-editing approaches hold promise for both disorders. In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and differences between these syndromes, as well as potential targeted therapeutic strategies.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 11","pages":"778-793"},"PeriodicalIF":39.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The kidney stroma in development and disease 发育和疾病中的肾间质

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-07-29 DOI: 10.1038/s41581-025-00985-8

Alexandria N. Fusco, Leif Oxburgh, Thomas J. Carroll

{"title":"The kidney stroma in development and disease","authors":"Alexandria N. Fusco, Leif Oxburgh, Thomas J. Carroll","doi":"10.1038/s41581-025-00985-8","DOIUrl":"10.1038/s41581-025-00985-8","url":null,"abstract":"The kidney is one of the most complex organs in the body. It is made up of thousands of patterned epithelial and endothelial tubules that work together to maintain body chemistry. Precise spatial integration of these different cell types is essential for the organ to function optimally. A complex and heterogeneous network of cells collectively referred to as ‘stroma’ lies between the epithelial and endothelial tubules. A growing body of evidence suggests that the stroma mediates communication between the epithelia and endothelia, and functions to support a variety of processes during kidney development and in the adult kidney, with implications for disease. However, stromal cells remain far less well defined than the epithelia and endothelia, and we understand only a fraction of their functions, leading some to refer to the stroma as the ‘dark matter’ of the kidney. In this Review, we discuss the developmental origins of the stroma and describe current understanding of its roles in the growth and patterning of the renal epithelia and endothelia, and in the maintenance and repair of the adult organ. Finally, we highlight critical questions that remain unanswered and the resources that will be required to answer them so that we can fully understand the function of these enigmatic cells. Available evidence suggests that the kidney stroma mediates cell communication and supports a variety of processes during kidney development and in the adult kidney. This Review describes the developmental origins of the stroma and current understanding of its roles in the growth and patterning of renal epithelia and endothelia, and in the maintenance and repair of the adult organ.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 11","pages":"756-777"},"PeriodicalIF":39.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0