{"title":"与 GalNAc-T14 相关的 IgA 肾病 B 细胞归巢缺陷","authors":"Susan J. Allison","doi":"10.1038/s41581-025-00964-z","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 6","pages":"365-365"},"PeriodicalIF":39.8000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"GalNAc-T14-associated defects in B cell homing in IgA nephropathy\",\"authors\":\"Susan J. Allison\",\"doi\":\"10.1038/s41581-025-00964-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":19059,\"journal\":{\"name\":\"Nature Reviews Nephrology\",\"volume\":\"21 6\",\"pages\":\"365-365\"},\"PeriodicalIF\":39.8000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Nephrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41581-025-00964-z\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Nephrology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41581-025-00964-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
IgA肾病(IgAN)是肾小球肾炎的常见形式。其发病机制与IgA1铰链区域的异常o糖基化有关,这被认为是肾小球中含有IgA1的免疫复合物形成的基础。新的见解表明,IgA o糖基化也可能影响其他过程,包括粘膜免疫和B细胞归巢到粘膜和非粘膜淋巴组织。Sindhuri Prakash和他的同事们通过在一个IgAN分离家族(两名活检证实的IgAN患者,一名IgA血管炎患者和其他血尿患者)和一名散发性IgAN患者中鉴定n -乙酰半乳糖氨基转移酶14 (GALNT14)编码基因GALNT14的独立功能丧失变体,开始了他们的研究。乙酰半乳糖氨基转移酶是启动IgAN o -糖基化的第一步的酶,这表明已鉴定的变异具有致病作用。
期刊介绍:
Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves.
It strives to publish authoritative, accessible articles.
Articles are enhanced with clearly understandable figures, tables, and other display items.
Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements.
The content is relevant to nephrologists and basic science researchers.
The broad scope of the journal ensures that the work reaches the widest possible audience.