Nature Reviews Nephrology最新文献

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The global landscape of kidney registries: immense challenges and unique opportunities 肾脏登记处的全球格局:巨大的挑战和独特的机遇
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-04-02 DOI: 10.1038/s41581-024-00833-1
Christopher H. Grant, Fergus J. Caskey, M. Razeen Davids, Manisha Sahay, Aminu K. Bello, Dorothea Nitsch, Samira Bell
{"title":"The global landscape of kidney registries: immense challenges and unique opportunities","authors":"Christopher H. Grant, Fergus J. Caskey, M. Razeen Davids, Manisha Sahay, Aminu K. Bello, Dorothea Nitsch, Samira Bell","doi":"10.1038/s41581-024-00833-1","DOIUrl":"10.1038/s41581-024-00833-1","url":null,"abstract":"Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustainable and effective programs for kidney disease prevention and care. Key barriers to implementation of registries at a global scale include funding and data quality. These issues warrant the attention of the global nephrology community.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 6","pages":"349-350"},"PeriodicalIF":41.5,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in kidney metabolism and DKD 肾脏代谢和 DKD 的性别差异。
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-28 DOI: 10.1038/s41581-024-00832-2
Ellen F. Carney
{"title":"Sex differences in kidney metabolism and DKD","authors":"Ellen F. Carney","doi":"10.1038/s41581-024-00832-2","DOIUrl":"10.1038/s41581-024-00832-2","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"271-271"},"PeriodicalIF":41.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal haematopoiesis and AKI 克隆性造血与 AKI。
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-26 DOI: 10.1038/s41581-024-00831-3
Susan J. Allison
{"title":"Clonal haematopoiesis and AKI","authors":"Susan J. Allison","doi":"10.1038/s41581-024-00831-3","DOIUrl":"10.1038/s41581-024-00831-3","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"271-271"},"PeriodicalIF":41.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Switching off SOX9 for epithelial recovery after AKI 关闭 SOX9,促进 AKI 后上皮细胞的恢复。
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-26 DOI: 10.1038/s41581-024-00830-4
Monica Wang
{"title":"Switching off SOX9 for epithelial recovery after AKI","authors":"Monica Wang","doi":"10.1038/s41581-024-00830-4","DOIUrl":"10.1038/s41581-024-00830-4","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"271-271"},"PeriodicalIF":41.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug stewardship in chronic kidney disease to achieve effective and safe medication use 慢性肾脏病药物管理,实现有效安全用药。
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-15 DOI: 10.1038/s41581-024-00823-3
Rasheeda K. Hall, Rümeyza Kazancıoğlu, Teerawat Thanachayanont, Germaine Wong, Dharshana Sabanayagam, Marisa Battistella, Sofia B. Ahmed, Lesley A. Inker, Erin F. Barreto, Edouard L. Fu, Catherine M. Clase, Juan J. Carrero
{"title":"Drug stewardship in chronic kidney disease to achieve effective and safe medication use","authors":"Rasheeda K. Hall, Rümeyza Kazancıoğlu, Teerawat Thanachayanont, Germaine Wong, Dharshana Sabanayagam, Marisa Battistella, Sofia B. Ahmed, Lesley A. Inker, Erin F. Barreto, Edouard L. Fu, Catherine M. Clase, Juan J. Carrero","doi":"10.1038/s41581-024-00823-3","DOIUrl":"10.1038/s41581-024-00823-3","url":null,"abstract":"People living with chronic kidney disease (CKD) often experience multimorbidity and require polypharmacy. Kidney dysfunction can also alter the pharmacokinetics and pharmacodynamics of medications, which can modify their risks and benefits; the extent of these changes is not well understood for all situations or medications. The principle of drug stewardship is aimed at maximizing medication safety and effectiveness in a population of patients through a variety of processes including medication reconciliation, medication selection, dose adjustment, monitoring for effectiveness and safety, and discontinuation (deprescribing) when no longer necessary. This Review is aimed at serving as a resource for achieving optimal drug stewardship for patients with CKD. We describe special considerations for medication use during pregnancy and lactation, during acute illness and in patients with cancer, as well as guidance for the responsible use of over-the-counter drugs, herbal remedies, supplements and sick-day rules. We also highlight inequities in medication access worldwide and suggest policies to improve access to quality and essential medications for all persons with CKD. Further strategies to promote drug stewardship include patient education and engagement, the use of digital health tools, shared decision-making and collaboration within interdisciplinary teams. Throughout, we position the person with CKD at the centre of all drug stewardship efforts. Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can be susceptible to the adverse effects of medications. This Review discusses the principles of drug stewardship — that is, the effective, safe and sustainable use of medications — for people with chronic kidney disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 6","pages":"386-401"},"PeriodicalIF":41.5,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group 结节性硬化综合征肾脏受累的临床实践建议:ERKNet 常染色体显性结构性肾脏疾病工作组和 ERA 基因与肾脏工作组的共识声明
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-05 DOI: 10.1038/s41581-024-00818-0
Djalila Mekahli, Roman-Ulrich Müller, Matko Marlais, Tanja Wlodkowski, Stefanie Haeberle, Marta López de Argumedo, Carsten Bergmann, Luc Breysem, Carla Fladrowski, Elizabeth P. Henske, Peter Janssens, François Jouret, John Christopher Kingswood, Jean-Baptiste Lattouf, Marc Lilien, Geert Maleux, Micaela Rozenberg, Stefan Siemer, Olivier Devuyst, Franz Schaefer, David J. Kwiatkowski, Olivier Rouvière, John Bissler
{"title":"Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group","authors":"Djalila Mekahli, Roman-Ulrich Müller, Matko Marlais, Tanja Wlodkowski, Stefanie Haeberle, Marta López de Argumedo, Carsten Bergmann, Luc Breysem, Carla Fladrowski, Elizabeth P. Henske, Peter Janssens, François Jouret, John Christopher Kingswood, Jean-Baptiste Lattouf, Marc Lilien, Geert Maleux, Micaela Rozenberg, Stefan Siemer, Olivier Devuyst, Franz Schaefer, David J. Kwiatkowski, Olivier Rouvière, John Bissler","doi":"10.1038/s41581-024-00818-0","DOIUrl":"10.1038/s41581-024-00818-0","url":null,"abstract":"Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the presence of proliferative lesions throughout the body. Management of TSC is challenging because patients have a multifaceted systemic illness with prominent neurological and developmental impact as well as potentially severe kidney, heart and lung phenotypes; however, every organ system can be involved. Adequate care for patients with TSC requires a coordinated effort involving a multidisciplinary team of clinicians and support staff. This clinical practice recommendation was developed by nephrologists, urologists, paediatric radiologists, interventional radiologists, geneticists, pathologists, and patient and family group representatives, with a focus on TSC-associated kidney manifestations. Careful monitoring of kidney function and assessment of kidney structural lesions by imaging enable early interventions that can preserve kidney function through targeted approaches. Here, we summarize the current evidence and present recommendations for the multidisciplinary management of kidney involvement in TSC. Care for patients with tuberous sclerosis complex (TSC) should be coordinated by a multidisciplinary team. This Consensus Statement, which involved input from nephrologists, urologists, geneticists, radiologists, interventional radiologists and pathologists as well as patient representatives, provides an overview of TSC-associated kidney manifestations and outlines current recommendations for the management of kidney involvement in TSC.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 6","pages":"402-420"},"PeriodicalIF":41.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41581-024-00818-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140032194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of biophysics and mechanobiology in podocyte physiology 生物物理学和机械生物学在荚膜细胞生理学中的作用。
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-05 DOI: 10.1038/s41581-024-00815-3
Jonathan Haydak, Evren U. Azeloglu
{"title":"Role of biophysics and mechanobiology in podocyte physiology","authors":"Jonathan Haydak, Evren U. Azeloglu","doi":"10.1038/s41581-024-00815-3","DOIUrl":"10.1038/s41581-024-00815-3","url":null,"abstract":"Podocytes form the backbone of the glomerular filtration barrier and are exposed to various mechanical forces throughout the lifetime of an individual. The highly dynamic biomechanical environment of the glomerular capillaries greatly influences the cell biology of podocytes and their pathophysiology. Throughout the past two decades, a holistic picture of podocyte cell biology has emerged, highlighting mechanobiological signalling pathways, cytoskeletal dynamics and cellular adhesion as key determinants of biomechanical resilience in podocytes. This biomechanical resilience is essential for the physiological function of podocytes, including the formation and maintenance of the glomerular filtration barrier. Podocytes integrate diverse biomechanical stimuli from their environment and adapt their biophysical properties accordingly. However, perturbations in biomechanical cues or the underlying podocyte mechanobiology can lead to glomerular dysfunction with severe clinical consequences, including proteinuria and glomerulosclerosis. As our mechanistic understanding of podocyte mechanobiology and its role in the pathogenesis of glomerular disease increases, new targets for podocyte-specific therapeutics will emerge. Treating glomerular diseases by targeting podocyte mechanobiology might improve therapeutic precision and efficacy, with potential to reduce the burden of chronic kidney disease on individuals and health-care systems alike. In this Review, the authors examine the biophysical and biomechanical properties that influence podocyte physiology as they integrate and adapt to stimuli from their dynamic environment within the glomerular capillaries. The authors also discuss how dysregulation and loss of biomechanical resilience in podocytes can contribute to kidney disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 6","pages":"371-385"},"PeriodicalIF":41.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovating dialysis through computational modelling of hollow-fibre haemodialysers 通过中空纤维血液透析器的计算建模创新透析技术
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-03-04 DOI: 10.1038/s41581-024-00826-0
Ruhit Sinha, Michael V. Rocco, Pirouz Daeihagh, Anne E. Staples
{"title":"Innovating dialysis through computational modelling of hollow-fibre haemodialysers","authors":"Ruhit Sinha, Michael V. Rocco, Pirouz Daeihagh, Anne E. Staples","doi":"10.1038/s41581-024-00826-0","DOIUrl":"10.1038/s41581-024-00826-0","url":null,"abstract":"Haemodialyser technology has not advanced much in decades, despite its unresolved shortcomings. Sophisticated new computational tools such as high-fidelity surrogate in silico dialyser models could reduce the time and expense of exploring alternative designs, dialysis dose and operating conditions compared with the current gold standard in vitro studies.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"269-270"},"PeriodicalIF":41.5,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140026482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The renal glucagon receptor is essential to kidney metabolic and homeostatic functions 肾胰高血糖素受体对肾脏代谢和平衡功能至关重要
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-02-29 DOI: 10.1038/s41581-024-00825-1
Ellen F. Carney
{"title":"The renal glucagon receptor is essential to kidney metabolic and homeostatic functions","authors":"Ellen F. Carney","doi":"10.1038/s41581-024-00825-1","DOIUrl":"10.1038/s41581-024-00825-1","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 4","pages":"203-203"},"PeriodicalIF":41.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139994061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells 消除致病性自身抗体分泌细胞的 CAAR NK 细胞方法
IF 41.5 1区 医学
Nature Reviews Nephrology Pub Date : 2024-02-28 DOI: 10.1038/s41581-024-00824-2
Ellen F. Carney
{"title":"A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells","authors":"Ellen F. Carney","doi":"10.1038/s41581-024-00824-2","DOIUrl":"10.1038/s41581-024-00824-2","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 4","pages":"203-203"},"PeriodicalIF":41.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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