Nature Reviews Nephrology最新文献_第10页

Organ trafficking — a continuing challenge 器官贩运--持续的挑战。

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-02-26 DOI: 10.1038/s41581-024-00821-5

Thomas F. Mueller, Sanjay Nagral

引用次数: 0

Sirtuins in kidney health and disease 肾脏健康和疾病中的 Sirtuins。

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-02-06 DOI: 10.1038/s41581-024-00806-4

Luca Perico, Giuseppe Remuzzi, Ariela Benigni

{"title":"Sirtuins in kidney health and disease","authors":"Luca Perico, Giuseppe Remuzzi, Ariela Benigni","doi":"10.1038/s41581-024-00806-4","DOIUrl":"10.1038/s41581-024-00806-4","url":null,"abstract":"Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation. Furthermore, altered SIRT activity has been implicated in the pathophysiology and progression of acute and chronic kidney diseases, including acute kidney injury, diabetic kidney disease, chronic kidney disease, polycystic kidney disease, autoimmune diseases and renal ageing. The renoprotective roles of SIRTs in these diseases make them attractive therapeutic targets. A number of SIRT-activating compounds have shown beneficial effects in kidney disease models; however, further research is needed to identify novel SIRT-targeting strategies with the potential to treat and/or prevent the progression of kidney diseases and increase the average human healthspan. This Review summarizes the roles of sirtuins in kidney development, physiological processes and the pathogenesis of acute and chronic kidney diseases. The authors also highlight the potential of sirtuins as therapeutic targets to limit human kidney disease and renal ageing.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"313-329"},"PeriodicalIF":41.5,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophages clean out the tubules 巨噬细胞清理肾小管

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-02-01 DOI: 10.1038/s41581-024-00816-2

Monica Wang

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Design of a renal-sparing antifungal 设计一种保护肾脏的抗真菌药物

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-30 DOI: 10.1038/s41581-024-00813-5

Susan J. Allison

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Effects of SGLT2 inhibitors on the metabolic environment and uraemic toxins SGLT2 抑制剂对代谢环境和尿毒症毒素的影响。

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-30 DOI: 10.1038/s41581-024-00814-4

Ellen F. Carney

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A united vision for cardiovascular–kidney–metabolic health 心血管-肾脏-代谢健康的统一愿景

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-29 DOI: 10.1038/s41581-024-00812-6

Susan E. Quaggin, Benjamin Magod

引用次数: 0

The multifaceted links between hearing loss and chronic kidney disease 听力损失与慢性肾病之间的多方面联系

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-29 DOI: 10.1038/s41581-024-00808-2

Dina Greenberg, Norman D. Rosenblum, Marcello Tonelli

{"title":"The multifaceted links between hearing loss and chronic kidney disease","authors":"Dina Greenberg, Norman D. Rosenblum, Marcello Tonelli","doi":"10.1038/s41581-024-00808-2","DOIUrl":"10.1038/s41581-024-00808-2","url":null,"abstract":"Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability worldwide. Chronic kidney disease (CKD) is also a common condition that is associated with adverse clinical outcomes and high health-care costs. From a developmental perspective, the structures responsible for hearing have a common morphogenetic origin with the kidney, and genetic abnormalities that cause familial forms of hearing loss can also lead to kidney disease. On a cellular level, normal kidney and cochlea function both depend on cilial activities at the apical surface, and kidney tubular cells and sensory epithelial cells of the inner ear use similar transport mechanisms to modify luminal fluid. The two organs also share the same collagen IV basement membrane network. Thus, strong developmental and physiological links exist between hearing and kidney function. These theoretical considerations are supported by epidemiological data demonstrating that CKD is associated with a graded and independent excess risk of sensorineural hearing loss. In addition to developmental and physiological links between kidney and cochlear function, hearing loss in patients with CKD may be driven by specific medications or treatments, including haemodialysis. The associations between these two common conditions are not commonly appreciated, yet have important implications for research and clinical practice. Chronic kidney disease is associated with a graded and independent excess risk of sensorineural hearing loss. This Review describes how disruption of shared signalling pathways that are important for the development of both the ear and the kidney and/or the presence of clinical drivers, such as specific medications or treatments, may underlie these associations.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"295-312"},"PeriodicalIF":41.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139573495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The changing landscape of HIV-associated kidney disease 不断变化的艾滋病毒相关肾脏疾病状况

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-25 DOI: 10.1038/s41581-023-00801-1

Nina E. Diana, Saraladevi Naicker

{"title":"The changing landscape of HIV-associated kidney disease","authors":"Nina E. Diana, Saraladevi Naicker","doi":"10.1038/s41581-023-00801-1","DOIUrl":"10.1038/s41581-023-00801-1","url":null,"abstract":"The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a diagnosis of HIV infection no longer automatically confers death. However, morbidity and mortality remain substantial among people living with HIV. HIV can directly infect the kidney to cause HIV-associated nephropathy (HIVAN) — a disease characterized by podocyte and tubular damage and associated with an increased risk of kidney failure. The reports of HIVAN occurring primarily in those of African ancestry led to the discovery of its association with APOL1 risk alleles. The advent of ART has led to a substantial decrease in the prevalence of HIVAN; however, reports have emerged of an increase in the prevalence of other kidney pathology, such as focal segmental glomerulosclerosis and pathological conditions associated with co-morbidities of ageing, such as hypertension and diabetes mellitus. Early initiation of ART also results in a longer cumulative exposure to medications, increasing the likelihood of nephrotoxicity. A substantial body of literature supports the use of kidney transplantation in people living with HIV, demonstrating significant survival benefits compared with that of people undergoing chronic dialysis, and similar long-term allograft and patient survival compared with that of HIV-negative kidney transplant recipients. The availability of antiretroviral therapy has led to a transformation in the spectrum of kidney diseases associated with HIV infection. This Review describes the changing pattern of kidney diseases associated with HIV infection, their risk factors, methods of evaluating kidney function in patients with HIV and current therapeutic approaches.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 5","pages":"330-346"},"PeriodicalIF":41.5,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139550793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic alterations in hereditary and sporadic renal cell carcinoma 遗传性和散发性肾细胞癌的代谢改变

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-22 DOI: 10.1038/s41581-023-00800-2

Nathan J. Coffey, M. Celeste Simon

{"title":"Metabolic alterations in hereditary and sporadic renal cell carcinoma","authors":"Nathan J. Coffey, M. Celeste Simon","doi":"10.1038/s41581-023-00800-2","DOIUrl":"10.1038/s41581-023-00800-2","url":null,"abstract":"Kidney cancer is the seventh leading cause of cancer in the world, and its incidence is on the rise. Renal cell carcinoma (RCC) is the most common form and is a heterogeneous disease comprising three major subtypes that vary in their histology, clinical course and driver mutations. These subtypes include clear cell RCC, papillary RCC and chromophobe RCC. Molecular analyses of hereditary and sporadic forms of RCC have revealed that this complex and deadly disease is characterized by metabolic pathway alterations in cancer cells that lead to deregulated oxygen and nutrient sensing, as well as impaired tricarboxylic acid cycle activity. These metabolic changes facilitate tumour growth and survival. Specifically, studies of the metabolic features of RCC have led to the discovery of oncometabolites — fumarate and succinate — that can promote tumorigenesis, moonlighting functions of enzymes, and substrate auxotrophy owing to the disruption of pathways that enable the production of arginine and cholesterol. These metabolic alterations within RCC can be exploited to identify new therapeutic targets and interventions, in combination with novel approaches that minimize the systemic toxicity of metabolic inhibitors and reduce the risk of drug resistance owing to metabolic plasticity. Renal cell carcinoma is a metabolic disease linked to a variety of alterations in genes that regulate cellular metabolism. Here, the authors examine cell-intrinsic metabolic alterations in hereditary and sporadic renal cell carcinoma, and how they can be exploited to develop novel therapeutic interventions.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"20 4","pages":"233-250"},"PeriodicalIF":41.5,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139510890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplifying the voices of patients with kidney disease 放大肾病患者的声音

IF 41.5 1区医学

Nature Reviews Nephrology Pub Date : 2024-01-22 DOI: 10.1038/s41581-024-00810-8

Miranda Scanlon

引用次数: 0