智能足细胞:感知和响应复杂的微环境

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY
John F. Bertram, Luise A. Cullen-McEwen, Vinicius Andrade-Oliveira, Niels Olsen Saraiva Câmara
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引用次数: 0

摘要

足细胞是肾小球滤过屏障的关键组成部分,肾小球滤过屏障是一种特殊的结构,负责肾脏过滤血液。因此,它们存在于一个独特的微环境中,暴露在机械力和无数穿过过滤屏障的分子中。为了生存和茁壮成长,足细胞必须不断感知和响应它们不断变化的微环境。传感是通过与周围细胞外基质和邻近细胞的相互作用,通过多种途径来感知环境因素的变化,如营养水平,包括葡萄糖和脂质,氧水平,pH和压力。反应机制同样涉及一系列过程,包括信号通路和启动和调节适当反应的特定细胞器的作用,包括细胞代谢的改变、免疫调节和足细胞结构和同源功能的改变。这些功能最终影响肾小球和肾脏的健康。这些过程的失衡可导致炎症、足细胞损失和肾小球疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The intelligent podocyte: sensing and responding to a complex microenvironment

The intelligent podocyte: sensing and responding to a complex microenvironment

Podocytes are key components of the glomerular filtration barrier — a specialized structure that is responsible for the filtration of blood by the kidneys. They therefore exist in a unique microenvironment exposed to mechanical force and the myriad molecules that cross the filtration barrier. To survive and thrive, podocytes must continually sense and respond to their ever-changing microenvironment. Sensing is achieved by interactions with the surrounding extracellular matrix and neighbouring cells, through a variety of pathways, to sense changes in environmental factors such as nutrient levels including glucose and lipids, oxygen levels, pH and pressure. The response mechanisms similarly involve a range of processes, including signalling pathways and the actions of specific organelles that initiate and regulate appropriate responses, including alterations in cell metabolism, immune regulation and changes in podocyte structure and cognate functions. These functions ultimately affect glomerular and kidney health. Imbalances in these processes can lead to inflammation, podocyte loss and glomerular disease.

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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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