尿和血浆代谢水平的遗传决定因素

IF 28.6 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Nephrology Pub Date : 2025-03-26 DOI:10.1038/s41581-025-00953-2

Seth L. Alper, David J. Friedman

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引用次数: 0

摘要

先进的仪器和快速的计算正在产生更多关于人类遗传学、表观遗传学、转录组学、蛋白质组学和代谢组学的数据，这对整合和解释提出了挑战。新的研究对肾脏疾病患者的遗传变异进行了严格的统计分析，以发现尿液和血浆代谢组（病理）生理差异的驱动因素。

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Genetic determinants of urine and plasma metabolite levels

Advanced instrumentation and rapid computation are generating ever more data on human genetics, epigenetics, transcriptomics, proteomics and metabolomics, posing challenges of integration and interpretation. New research has applied rigorous statistical analyses to genetic variations identified in patients with kidney disease to find drivers of (patho)physiological differences in urine and plasma metabolomes.

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来源期刊

Nature Reviews Nephrology 医学-泌尿学与肾脏学

CiteScore

39.00

自引率

1.20%

发文量

127

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.