Cardiovascular mortality increases with stage of cardiovascular–kidney–metabolic syndrome

Abstract

Cardiovascular–kidney–metabolic (CKM) syndrome is categorized into 5 stages that range from stage 0 (no risk factors) to stage 4 (clinical cardiovascular disease in CKM syndrome). A new study by Sophie Claudel, Ashish Verma and coauthors validates this staging system by demonstrating that the risk of cardiovascular and all-cause mortality increases with CKM syndrome stage.

“CKM syndrome stages 1 to 4 are associated with a graded increase in risk of cardiovascular mortality,” comments Verma. “Given the lack of a strong association of CKM syndrome stage with either non-cardiovascular or cancer mortality, we found that the prognostic significance of these stages is specific to cardiovascular mortality. These findings validate the pathophysiologic basis that was used to develop the CKM syndrome staging system.”