Nature Reviews Nephrology最新文献_第8页

Neutrophils and NETs in kidney disease 肾脏疾病中的中性粒细胞和NETs

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-18 DOI: 10.1038/s41581-025-00944-3

Daigo Nakazawa, Sakiko Masuda, Yuka Nishibata, Kanako Watanabe-Kusunoki, Utano Tomaru, Akihiro Ishizu

{"title":"Neutrophils and NETs in kidney disease","authors":"Daigo Nakazawa, Sakiko Masuda, Yuka Nishibata, Kanako Watanabe-Kusunoki, Utano Tomaru, Akihiro Ishizu","doi":"10.1038/s41581-025-00944-3","DOIUrl":"10.1038/s41581-025-00944-3","url":null,"abstract":"Neutrophils, conventionally regarded as a homogeneous immune cell population, have emerged as a heterogeneous group of cells with distinct gene profiles and immune properties. Activated neutrophils release a spectrum of bioactive substances, including cytokines, chemokines, proteolytic enzymes, reactive oxygen species and neutrophil extracellular traps (NETs), which are composed of decondensed DNA and antimicrobial proteins. NETs have a pivotal role in innate immunity, including in preventing the ascent of uropathogenic bacteria into the kidneys, as they efficiently trap pathogenic microorganisms. However, although indispensable for defence against pathogens, NETs also pose risks of self-damage owing to their cytotoxicity, thrombogenicity and autoantigenicity. Accordingly, neutrophils and NETs have been implicated in the pathogenesis of various disorders that affect the kidneys, including acute kidney injury, vasculitis, systemic lupus erythematosus, thrombotic microangiopathy and in various aetiologies of chronic kidney disease. Pathological alterations in the glomerular vascular wall can promote the infiltration of neutrophils, which can cause tissue damage and inflammation through their interactions with kidney-resident cells, including mesangial cells and podocytes, leading to local cell death. Targeting neutrophil activation and NET formation might therefore represent a new therapeutic strategy for these conditions. Neutrophils and neutrophil extracellular traps are known for their key role in pathogen clearance. Here, the authors explore the dual role of neutrophils and neutrophil extracellular traps, as they can also have a pathogenic role in many kidney diseases through pro-inflammatory and pro-thrombotic effects, and by promoting autoimmunity.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 6","pages":"383-398"},"PeriodicalIF":39.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unequal access: the prohibitive costs of new drugs in low- and middle-income countries 获取不平等：中低收入国家新药的高昂费用

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-14 DOI: 10.1038/s41581-025-00948-z

John M. Pettifor, Haroon Saloojee

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Lived experience is essential for innovation in biomedical research 生活经验对生物医学研究的创新至关重要

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-13 DOI: 10.1038/s41581-025-00940-7

Jonathan Haydak, Jacob Wright, Paula L. Croxson, Ilse S. Daehn

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A difficult path to point-of-care measurement of glomerular filtration rate 对肾小球滤过率进行即时测量的困难途径

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-12 DOI: 10.1038/s41581-025-00947-0

Pierre Delanaye, Richard J. Glassock

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The role of implementation science in advancing equity in kidney health 实施科学在促进肾脏健康公平中的作用

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-11 DOI: 10.1038/s41581-025-00949-y

Lilia Cervantes, Sri Lekha Tummalapalli, Delphine Tuot, Russell E. Glasgow

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Systemic interventions towards kidney health equity in American Indian and Alaska Native communities 对美国印第安人和阿拉斯加土著社区肾脏健康公平的系统干预

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-03-06 DOI: 10.1038/s41581-025-00943-4

Reya H. Mokiao, Jason F. Deen, Amanda M. Fretts, Bessie A. Young

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Fiji’s rising tide: the growing burden of diabetic kidney disease on emerging nephrology services 斐济的上升趋势：糖尿病肾病对新兴肾脏病服务日益加重的负担

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-02-28 DOI: 10.1038/s41581-025-00942-5

Anis Ta’eed, Abhitesh Raj, Yogeshni Chandra, Shilpanjali Jesudason, Angus Ritchie

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Cross-species evolution of capsid libraries for gene delivery to the kidneys 基因传递到肾脏的衣壳文库的跨物种进化

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2025-02-26 DOI: 10.1038/s41581-025-00945-2

Monica Wang

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A personalized vaccine for kidney cancer 一种针对肾癌的个性化疫苗

IF 28.6 1区医学

Nature Reviews Nephrology Pub Date : 2025-02-25 DOI: 10.1038/s41581-025-00941-6

Susan J. Allison

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Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease 内质网应激是肾脏疾病的驱动因素和治疗靶点

IF 39.8 1区医学

Nature Reviews Nephrology Pub Date : 2025-02-24 DOI: 10.1038/s41581-025-00938-1

Jae Hyun Byun, Paul F. Lebeau, Jackie Trink, Nikhil Uppal, Matthew B. Lanktree, Joan C. Krepinsky, Richard C. Austin

{"title":"Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease","authors":"Jae Hyun Byun, Paul F. Lebeau, Jackie Trink, Nikhil Uppal, Matthew B. Lanktree, Joan C. Krepinsky, Richard C. Austin","doi":"10.1038/s41581-025-00938-1","DOIUrl":"10.1038/s41581-025-00938-1","url":null,"abstract":"The endoplasmic reticulum (ER) has crucial roles in metabolically active cells, including protein translation, protein folding and quality control, lipid biosynthesis, and calcium homeostasis. Adverse metabolic conditions or pathogenic genetic variants that cause misfolding and accumulation of proteins within the ER of kidney cells initiate an injurious process known as ER stress that contributes to kidney disease and its cardiovascular complications. Initiation of ER stress activates the unfolded protein response (UPR), a cellular defence mechanism that functions to restore ER homeostasis. However, severe or chronic ER stress rewires the UPR to activate deleterious pathways that exacerbate inflammation, apoptosis and fibrosis, resulting in kidney injury. This insidious crosstalk between ER stress, UPR activation, oxidative stress and inflammation forms a vicious cycle that drives kidney disease and vascular damage. Furthermore, genetic variants that disrupt protein-folding mechanisms trigger ER stress, as evidenced in autosomal-dominant tubulointerstitial kidney disease and Fabry disease. Emerging therapeutic strategies that enhance protein-folding capacity and reduce the burden of ER stress have shown promising results in kidney diseases. Thus, integrating knowledge of how genetic variants cause protein misfolding and ER stress into clinical practice will enhance treatment strategies and potentially improve outcomes for various kidney diseases and their vascular complications. Endoplasmic reticulum (ER) stress is known to exacerbate chronic kidney disease and cardiovascular disease. Here, the authors discuss the role of ER stress in kidney disease and the link between ER stress, chronic kidney disease and cardiovascular disease.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 5","pages":"299-313"},"PeriodicalIF":39.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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