Nature Reviews Molecular Cell Biology最新文献_第8页

Modes of Notch signalling in development and disease Notch信号在发育和疾病中的模式

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-03-10 DOI: 10.1038/s41580-025-00835-2

Sarah J. Bray, Anna Bigas

{"title":"Modes of Notch signalling in development and disease","authors":"Sarah J. Bray, Anna Bigas","doi":"10.1038/s41580-025-00835-2","DOIUrl":"10.1038/s41580-025-00835-2","url":null,"abstract":"Many different animal developmental and homeostatic processes rely on signalling via the highly conserved Notch pathway. Often Notch signalling has iterative roles during cell specification and differentiation, controlling not only the state of progenitor cells but also the fate and function of their progeny. Its roles continue throughout the lifespan of the organism, regulating normal tissue maintenance, as well as operating in response to damage. Consistent with such fundamental roles, the pathway has been associated with numerous diseases, including cancers. Understanding how Notch signalling is orchestrated to bring about different outcomes is challenging, given that it has many diverse functions. Classic models proposed that stochastic differences in cell states were important to polarise signalling during cell fate decisions. Subsequently, the importance of oscillatory Notch signalling was uncovered, and it became clear that it operates in different modalities depending on the regulatory inputs. With the advent of ever-more-sensitive live-imaging and quantitative approaches, it is becoming evident that differences in the dynamics, levels and architectures of Notch signalling are critical in shaping and maintaining tissues. This Review focuses on the cellular and molecular mechanisms involved in conferring different modalities on Notch pathway operations and how these enable different types of functional outcomes from pathway activation. We also discuss their dysregulation in cancer. The Notch pathway regulates many developmental and homeostatic processes in animals. This Review discusses how different modes of Notch signalling can have different functional outcomes, and how their dysregulation is associated with cancer states.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 7","pages":"522-537"},"PeriodicalIF":81.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR–Cas applications in agriculture and plant research CRISPR-Cas在农业和植物研究中的应用

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-03-07 DOI: 10.1038/s41580-025-00834-3

Aytug Tuncel, Changtian Pan, Joshua S. Clem, Degao Liu, Yiping Qi

{"title":"CRISPR–Cas applications in agriculture and plant research","authors":"Aytug Tuncel, Changtian Pan, Joshua S. Clem, Degao Liu, Yiping Qi","doi":"10.1038/s41580-025-00834-3","DOIUrl":"10.1038/s41580-025-00834-3","url":null,"abstract":"Growing world population and deteriorating climate conditions necessitate the development of new crops with high yields and resilience. CRISPR–Cas-mediated genome engineering presents unparalleled opportunities to engineer crop varieties cheaper, easier and faster than ever. In this Review, we discuss how the CRISPR–Cas toolbox has rapidly expanded from Cas9 and Cas12 to include different Cas orthologues and engineered variants. We present various CRISPR–Cas-based methods, including base editing and prime editing, which are used for precise genome, epigenome and transcriptome engineering, and methods used to deliver the genome editors into plants, such as bacterial-mediated and viral-mediated transformation. We then discuss how promoter editing and chromosome engineering are used in crop breeding for trait engineering and fixation, and important applications of CRISPR–Cas in crop improvement, such as de novo domestication and enhancing tolerance to abiotic stresses. We conclude with discussing future prospects of plant genome engineering. CRISPR–Cas-mediated genome, epigenome and transcriptome engineering in crops is crucial as the human population grows and climate deteriorates. This Review discusses new CRISPR–Cas tools for precise engineering, and their uses in improving crop traits such as yield and tolerance to climate stresses.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 6","pages":"419-441"},"PeriodicalIF":81.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dodging mitochondrial mislocalization 避免线粒体错位

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-03-06 DOI: 10.1038/s41580-025-00840-5

Lisa Heinke

引用次数: 0

In tumour suppressors, synonymous is not always silent 在肿瘤抑制因子中，同义词并不总是沉默的

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-03-03 DOI: 10.1038/s41580-025-00838-z

Michael Attwaters

引用次数: 0

Improving chemical reprogramming strategies 改进化学重编程策略

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-02-17 DOI: 10.1038/s41580-025-00836-1

Yanglu Wang, Lin Cheng

引用次数: 0

Profiling the disordered proteome in cells using a chemical tag 利用化学标签分析细胞中紊乱的蛋白质组。

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-02-13 DOI: 10.1038/s41580-025-00833-4

Tze Cin Owyong, Shouxiang Zhang

引用次数: 0

Regulation and function of insulin and insulin-like growth factor receptor signalling 胰岛素和胰岛素样生长因子受体信号的调控和功能

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-02-10 DOI: 10.1038/s41580-025-00826-3

Eunhee Choi, Cunming Duan, Xiao-chen Bai

{"title":"Regulation and function of insulin and insulin-like growth factor receptor signalling","authors":"Eunhee Choi, Cunming Duan, Xiao-chen Bai","doi":"10.1038/s41580-025-00826-3","DOIUrl":"10.1038/s41580-025-00826-3","url":null,"abstract":"Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multiple aspects of animal physiology throughout life. In addition to regulating metabolism and growth, insulin–IGF receptor signalling has recently been linked to a variety of new, cell type-specific functions. In the last century, key questions have focused on how structural differences of insulin and IGFs affect receptor activation, and how insulin–IGF receptor signalling translates into pleiotropic biological functions. Technological advances such as cryo-electron microscopy have provided a detailed understanding of how native and engineered ligands activate insulin–IGF receptors. In this Review, we highlight recent structural and functional insights into the activation of insulin–IGF receptors, and summarize new agonists and antagonists developed for intervening in the activation of insulin–IGF receptor signalling. Furthermore, we discuss recently identified regulatory mechanisms beyond ligand–receptor interactions and functions of insulin–IGF receptor signalling in diseases. Insulin and insulin-like growth factor (IGF) signalling regulates metabolism, cell growth and proliferation and diverse cell-specific processes. This Review discusses recent structural insights into insulin–receptor and IGF–receptor binding and activation, regulation of insulin and IGF signalling and new agonists with therapeutic potential.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 7","pages":"558-580"},"PeriodicalIF":81.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The bystander effect of pyroptosis 焦亡的旁观者效应

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-02-04 DOI: 10.1038/s41580-025-00831-6

Lisa Heinke

引用次数: 0

Expanding the genetic code for site-specific lysine lactylation 扩展位点特异性赖氨酸乳酸化的遗传密码

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-02-04 DOI: 10.1038/s41580-025-00832-5

Zhi Zong

引用次数: 0

Unravelling the complexity of gene regulation through multiplexed protein mapping 通过多重蛋白定位揭示基因调控的复杂性