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AI-driven detection and analysis of label-free protein aggregates 人工智能驱动的无标记蛋白质聚集体检测与分析。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-08 DOI: 10.1038/s41580-024-00708-0
Khalid A. Ibrahim
{"title":"AI-driven detection and analysis of label-free protein aggregates","authors":"Khalid A. Ibrahim","doi":"10.1038/s41580-024-00708-0","DOIUrl":"10.1038/s41580-024-00708-0","url":null,"abstract":"In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: White adipocyte dysfunction and obesity-associated pathologies in humans 出版商更正：人类白色脂肪细胞功能障碍与肥胖相关病症。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-08 DOI: 10.1038/s41580-024-00712-4
Carolina E. Hagberg, Kirsty L. Spalding
{"title":"Publisher Correction: White adipocyte dysfunction and obesity-associated pathologies in humans","authors":"Carolina E. Hagberg, Kirsty L. Spalding","doi":"10.1038/s41580-024-00712-4","DOIUrl":"10.1038/s41580-024-00712-4","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00712-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condensates burst the bridge for transcription 凝结物为转录架起桥梁
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-08 DOI: 10.1038/s41580-024-00711-5
Eytan Zlotorynski
{"title":"Condensates burst the bridge for transcription","authors":"Eytan Zlotorynski","doi":"10.1038/s41580-024-00711-5","DOIUrl":"10.1038/s41580-024-00711-5","url":null,"abstract":"A recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139705001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dynamic culture system that models the intricacy of the mammary gland 动态培养系统可模拟复杂的乳腺。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-05 DOI: 10.1038/s41580-024-00704-4
Lei Yuan
{"title":"A dynamic culture system that models the intricacy of the mammary gland","authors":"Lei Yuan","doi":"10.1038/s41580-024-00704-4","DOIUrl":"10.1038/s41580-024-00704-4","url":null,"abstract":"In this Tools of the Trade article, Lei Yuan (from the Cai lab) highlights a new culture system that allows in vitro reconstitution of a dynamic miniature mammary gland.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bookmarking pluripotency genes 多能基因书签
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-02 DOI: 10.1038/s41580-024-00707-1
Lisa Heinke
{"title":"Bookmarking pluripotency genes","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00707-1","DOIUrl":"10.1038/s41580-024-00707-1","url":null,"abstract":"Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR technologies for genome, epigenome and transcriptome editing 用于基因组、表观基因组和转录组编辑的 CRISPR 技术
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-02-02 DOI: 10.1038/s41580-023-00697-6
Lukas Villiger, Julia Joung, Luke Koblan, Jonathan Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg
{"title":"CRISPR technologies for genome, epigenome and transcriptome editing","authors":"Lukas Villiger, Julia Joung, Luke Koblan, Jonathan Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg","doi":"10.1038/s41580-023-00697-6","DOIUrl":"10.1038/s41580-023-00697-6","url":null,"abstract":"Our ability to edit genomes lags behind our capacity to sequence them, but the growing understanding of CRISPR biology and its application to genome, epigenome and transcriptome engineering is narrowing this gap. In this Review, we discuss recent developments of various CRISPR-based systems that can transiently or permanently modify the genome and the transcriptome. The discovery of further CRISPR enzymes and systems through functional metagenomics has meaningfully broadened the applicability of CRISPR-based editing. Engineered Cas variants offer diverse capabilities such as base editing, prime editing, gene insertion and gene regulation, thereby providing a panoply of tools for the scientific community. We highlight the strengths and weaknesses of current CRISPR tools, considering their efficiency, precision, specificity, reliance on cellular DNA repair mechanisms and their applications in both fundamental biology and therapeutics. Finally, we discuss ongoing clinical trials that illustrate the potential impact of CRISPR systems on human health. L. Villiger, J. Joung et al. review CRISPR applications for programmable editing of the genome, epigenome and transcriptome. They discuss how CRISPR–Cas systems can be optimized to further improve editing specificity and efficiency and highlight a multitude of applications in basic biological research and for changing clinical practice.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Translating the midbody for cytokinesis 出版商更正：为细胞分裂翻译中体。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-01-26 DOI: 10.1038/s41580-024-00705-3
Lisa Heinke
{"title":"Publisher Correction: Translating the midbody for cytokinesis","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00705-3","DOIUrl":"10.1038/s41580-024-00705-3","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00705-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance 长非编码 RNA 的转录调控：机制与疾病相关性
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-01-19 DOI: 10.1038/s41580-023-00694-9
Jorge Ferrer, Nadya Dimitrova
{"title":"Transcription regulation by long non-coding RNAs: mechanisms and disease relevance","authors":"Jorge Ferrer, Nadya Dimitrova","doi":"10.1038/s41580-023-00694-9","DOIUrl":"10.1038/s41580-023-00694-9","url":null,"abstract":"Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the control of gene transcription. Some of the best characterized lncRNAs have essential transcription cis-regulatory functions that cannot be easily accomplished by DNA-interacting transcription factors, such as XIST, which controls X-chromosome inactivation, or imprinted lncRNAs that direct allele-specific repression. A growing number of lncRNA transcription units, including CHASERR, PVT1 and HASTER (also known as HNF1A-AS1) act as transcription-stabilizing elements that fine-tune the activity of dosage-sensitive genes that encode transcription factors. Genetic experiments have shown that defects in such transcription stabilizers often cause severe phenotypes. Other lncRNAs, such as lincRNA-p21 (also known as Trp53cor1) and Maenli (Gm29348) contribute to local activation of gene transcription, whereas distinct lncRNAs influence gene transcription in trans. We discuss findings of lncRNAs that elicit a function through either activation of their transcription, transcript elongation and processing or the lncRNA molecule itself. We also discuss emerging evidence of lncRNA involvement in human diseases, and their potential as therapeutic targets. This Review discusses the emerging roles of long non-coding RNAs (lncRNAs) in the regulation of transcription, for example by controlling the expression of transcription factors. Some lncRNA loci function in trans, but most function in cis, through their own transcription or through the lncRNA transcripts themselves.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Patterning of the cell cortex by Rho GTPases 出版商更正：通过 Rho GTPases 对细胞皮层进行图案化。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-01-15 DOI: 10.1038/s41580-024-00701-7
William M. Bement, Andrew B. Goryachev, Ann L. Miller, George von Dassow
{"title":"Publisher Correction: Patterning of the cell cortex by Rho GTPases","authors":"William M. Bement, Andrew B. Goryachev, Ann L. Miller, George von Dassow","doi":"10.1038/s41580-024-00701-7","DOIUrl":"10.1038/s41580-024-00701-7","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00701-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating the midbody for cytokinesis 为细胞分裂翻译中体
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-01-09 DOI: 10.1038/s41580-024-00699-y
Lisa Heinke
{"title":"Translating the midbody for cytokinesis","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00699-y","DOIUrl":"10.1038/s41580-024-00699-y","url":null,"abstract":"Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139400422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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