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Nature Reviews Molecular Cell Biology最新文献

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Revealing the invisible transcriptome. 揭示不可见的转录组。
IF 118 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-14 DOI: 10.1038/s41580-026-01040-5
Rosemary Kiernan
{"title":"Revealing the invisible transcriptome.","authors":"Rosemary Kiernan","doi":"10.1038/s41580-026-01040-5","DOIUrl":"https://doi.org/10.1038/s41580-026-01040-5","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ubiquitin phosphorylation opens a hatch to a code still largely undeciphered. 泛素磷酸化打开了一个很大程度上仍未破译的密码的大门。
IF 118 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-13 DOI: 10.1038/s41580-026-01043-2
Lorenza Penengo
{"title":"Ubiquitin phosphorylation opens a hatch to a code still largely undeciphered.","authors":"Lorenza Penengo","doi":"10.1038/s41580-026-01043-2","DOIUrl":"https://doi.org/10.1038/s41580-026-01043-2","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaling up measurements of the interactions that build condensates. 扩大对形成凝聚物的相互作用的测量。
IF 118 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-13 DOI: 10.1038/s41580-026-01044-1
Rasmus K Norrild
{"title":"Scaling up measurements of the interactions that build condensates.","authors":"Rasmus K Norrild","doi":"10.1038/s41580-026-01044-1","DOIUrl":"https://doi.org/10.1038/s41580-026-01044-1","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic, structural and molecular insights into GPCR ligand binding and signalling. GPCR配体结合和信号传导的原子、结构和分子见解。
IF 118 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-13 DOI: 10.1038/s41580-026-01030-7
Katarina Nemec, Bálint Mészáros, Georgios Skiniotis, Scott C Blanchard, M Madan Babu
{"title":"Atomic, structural and molecular insights into GPCR ligand binding and signalling.","authors":"Katarina Nemec, Bálint Mészáros, Georgios Skiniotis, Scott C Blanchard, M Madan Babu","doi":"10.1038/s41580-026-01030-7","DOIUrl":"https://doi.org/10.1038/s41580-026-01030-7","url":null,"abstract":"<p><p>G-protein-coupled receptors (GPCRs) are the largest group of human membrane proteins, comprising over 800 members, and represent the most common target of therapeutics. GPCRs orchestrate context-dependent functions and have diverse physiological roles. Recent advances have enabled the exploration of GPCR structure, function and regulation, leading to a deeper understanding of their signalling complexity. In this Review, we synthesize these advances at different scales of increasing complexity and discuss atomic-level, structural-level and molecular-level insights into GPCR signalling. Specifically, we highlight the context-dependent mechanisms by which GPCRs translate extracellular cues into intracellular signals through ligand recognition, ligand-induced conformational changes, engagement with different adaptors and interactions with various molecular pathways, as well as how these processes are modulated during disease, and the new therapeutic opportunities they present. Through inter-disciplinary efforts aimed at elucidating GPCR multiscale signalling, we are approaching a holistic understanding that will inform the rational development of specific, effective and safer medicines.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering synthetic proteins to toggle function in response to kinase signals 工程合成蛋白在响应激酶信号时切换功能
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-05 DOI: 10.1038/s41580-026-01036-1
Qinhao Cao
{"title":"Engineering synthetic proteins to toggle function in response to kinase signals","authors":"Qinhao Cao","doi":"10.1038/s41580-026-01036-1","DOIUrl":"https://doi.org/10.1038/s41580-026-01036-1","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"17 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a systematic understanding of the diverse subtypes, biogenesis and functions of large extracellular vesicles 对大细胞外囊泡的不同亚型、生物发生和功能有系统的了解
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-05 DOI: 10.1038/s41580-026-01021-8
Yuwei Huang,Renxiang Xie,Junjie Ma,Li Yu
{"title":"Towards a systematic understanding of the diverse subtypes, biogenesis and functions of large extracellular vesicles","authors":"Yuwei Huang,Renxiang Xie,Junjie Ma,Li Yu","doi":"10.1038/s41580-026-01021-8","DOIUrl":"https://doi.org/10.1038/s41580-026-01021-8","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"9 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chaperone-mediated autophagy in physiological homeostasis, disease and ageing 伴侣介导的自噬在生理稳态、疾病和衰老中的作用
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-05 DOI: 10.1038/s41580-026-01023-6
Susmita Kaushik,Ana Maria Cuervo
{"title":"Chaperone-mediated autophagy in physiological homeostasis, disease and ageing","authors":"Susmita Kaushik,Ana Maria Cuervo","doi":"10.1038/s41580-026-01023-6","DOIUrl":"https://doi.org/10.1038/s41580-026-01023-6","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"11 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrality as the null hypothesis of biological evolution 中性是生物进化的零假设
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-02 DOI: 10.1038/s41580-026-01032-5
Eugene V. Koonin
{"title":"Neutrality as the null hypothesis of biological evolution","authors":"Eugene V. Koonin","doi":"10.1038/s41580-026-01032-5","DOIUrl":"https://doi.org/10.1038/s41580-026-01032-5","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"9 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HoT self-blinking probes for chromatin imaging HoT自闪烁探针用于染色质成像
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-10-01 DOI: 10.1038/s41580-026-01033-4
Aiping Wang,Jie Zhang
{"title":"HoT self-blinking probes for chromatin imaging","authors":"Aiping Wang,Jie Zhang","doi":"10.1038/s41580-026-01033-4","DOIUrl":"https://doi.org/10.1038/s41580-026-01033-4","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"8 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technological prominence alone does not justify leadership in SynCell governance 技术上的突出并不能证明SynCell管理的领导地位
IF 118 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-09-30 DOI: 10.1038/s41580-026-01034-3
Milena-Jael Silva-Morales
{"title":"Technological prominence alone does not justify leadership in SynCell governance","authors":"Milena-Jael Silva-Morales","doi":"10.1038/s41580-026-01034-3","DOIUrl":"10.1038/s41580-026-01034-3","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 11","pages":"874-874"},"PeriodicalIF":118.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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