Nature Reviews Molecular Cell Biology最新文献

A redox–auxin connection in response to water deficit 水缺乏时氧化还原-生长素的连接

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-07-08 DOI: 10.1038/s41580-025-00875-8

Kim Baumann

引用次数: 0

Molecular machineries and pathways of mitochondrial protein transport 线粒体蛋白转运的分子机制和途径

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-07-03 DOI: 10.1038/s41580-025-00865-w

Toshiya Endo, Nils Wiedemann

引用次数: 0

Regulation of inflammatory processes by caspases 半胱天冬酶调节炎症过程

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-07-02 DOI: 10.1038/s41580-025-00869-6

Manuel Beltrán-Visiedo, Ruth Soler-Agesta, Kristopher A. Sarosiek, Douglas R. Green, Lorenzo Galluzzi

引用次数: 0

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease 转座因子的转录和转录后调控及其在发育和疾病中的作用

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-30 DOI: 10.1038/s41580-025-00867-8

İbrahim Avşar Ilık, Xu Yang, ZZ Zhao Zhang, Tuğçe Aktaş

引用次数: 0

Good neighbours transfer nucleotides 好邻居会转移核苷酸

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-24 DOI: 10.1038/s41580-025-00872-x

Lisa Heinke

引用次数: 0

Key challenges and recommendations for defining organelle membrane contact sites. 定义细胞器膜接触部位的主要挑战和建议。

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-23 DOI: 10.1038/s41580-025-00864-x

Tito Calì,Emmanuelle M Bayer,Emily R Eden,György Hajnóczky,Benoit Kornmann,Laura Lackner,Jen Liou,Karin Reinisch,Hyun-Woo Rhee,Rosario Rizzuto,Luca Scorrano,Marisa Brini

{"title":"Key challenges and recommendations for defining organelle membrane contact sites.","authors":"Tito Calì,Emmanuelle M Bayer,Emily R Eden,György Hajnóczky,Benoit Kornmann,Laura Lackner,Jen Liou,Karin Reinisch,Hyun-Woo Rhee,Rosario Rizzuto,Luca Scorrano,Marisa Brini","doi":"10.1038/s41580-025-00864-x","DOIUrl":"https://doi.org/10.1038/s41580-025-00864-x","url":null,"abstract":"Intracellular membrane contact sites (MCSs) between organelles have crucial roles in cellular signalling and homeostasis. These sites, which are often disrupted in pathological conditions, enable the exchange of ions, lipids and metabolites between membrane-bound compartments, helping cells adapt to varying physiological conditions. Specific tether proteins and complexes stabilize these interactions and mediate responses to different intracellular or extracellular stimuli. The study of MCSs has progressed in recent years, owing to the development of new methods such as genetically encoded reporter constructs, advanced imaging techniques, including super-resolution microscopy and electron tomography, and proteomic approaches based on mass spectrometry. These tools have enabled unprecedented visualization and quantification of organelle interactions, as well as identification of the molecular players involved. This Expert Recommendation aims to define and map the 'organelle contactome', describing key proteins involved in contact site formation and the roles of MCSs in cellular function. We also explore contact site dynamics and detail advantages and disadvantages of the methodologies for studying them. Importantly, we consolidate open questions in contact site research and discuss challenges and limitations of the current experimental approaches.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"23 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the interactions and functions of non-coding RNA with artificial intelligence 用人工智能解码非编码RNA的相互作用和功能

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-19 DOI: 10.1038/s41580-025-00857-w

Vincent Jung, Cédric Vincent-Cuaz, Charlotte Tumescheit, Lisa Fournier, Marousa Darsinou, Zhi Ming Xu, Ali Saadat, Yiran Wang, Petros Tsantoulis, Olivier Michielin, Jacques Fellay, Rickie Patani, Andres Ramos, Pascal Frossard, Janna Hastings, Antonella Riccio, Lonneke van der Plas, Raphaëlle Luisier

{"title":"Decoding the interactions and functions of non-coding RNA with artificial intelligence","authors":"Vincent Jung, Cédric Vincent-Cuaz, Charlotte Tumescheit, Lisa Fournier, Marousa Darsinou, Zhi Ming Xu, Ali Saadat, Yiran Wang, Petros Tsantoulis, Olivier Michielin, Jacques Fellay, Rickie Patani, Andres Ramos, Pascal Frossard, Janna Hastings, Antonella Riccio, Lonneke van der Plas, Raphaëlle Luisier","doi":"10.1038/s41580-025-00857-w","DOIUrl":"https://doi.org/10.1038/s41580-025-00857-w","url":null,"abstract":"<p>In addition to encoding proteins, mRNAs have context-specific regulatory roles that contribute to many cellular processes. However, uncovering new mRNA functions is constrained by limitations of traditional biochemical and computational methods. In this Roadmap, we highlight how artificial intelligence can transform our understanding of RNA biology by fostering collaborations between RNA biologists and computational scientists to drive innovation in this fundamental field of research. We discuss how non-coding regions of the mRNA, including introns and 5′ and 3′ untranslated regions, regulate the metabolism and interactomes of mRNA, and the current challenges in characterizing these regions. We further discuss large language models, which can be used to learn biologically meaningful RNA sequence representations. We also provide a detailed roadmap for integrating large language models with graph neural networks to harness publicly available sequencing and knowledge data. Adopting this roadmap will allow us to predict RNA interactions with diverse molecules and the modelling of context-specific mRNA interactomes.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"97 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How machine learning can help us understand what we have grown in the dish 机器学习如何帮助我们理解我们在培养皿中生长的东西

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-10 DOI: 10.1038/s41580-025-00868-7

Roser Vento-Tormo

引用次数: 0

Collective migration modes in development, tissue repair and cancer 发育、组织修复和癌症中的集体迁移模式

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-05 DOI: 10.1038/s41580-025-00858-9

Kevin J. Cheung, Sally Horne-Badovinac

{"title":"Collective migration modes in development, tissue repair and cancer","authors":"Kevin J. Cheung, Sally Horne-Badovinac","doi":"10.1038/s41580-025-00858-9","DOIUrl":"https://doi.org/10.1038/s41580-025-00858-9","url":null,"abstract":"<p>Migrating cells have key functions in shaping tissues during development, repairing tissues after development and supporting cancer invasion and metastasis. In all these contexts, cells often maintain contact with their neighbours and move as a group, in a process termed collective migration. In this Review, we describe the elegant mechanisms used by collectively migrating cells in vivo to coordinate their movements and obtain directional information. We start by highlighting the diverse physiological roles that migrating collectives have within the body and then focus on dominant paradigms for the organization of migrating collectives including the roles of leader and follower cells, local cell–cell adhesion and signalling, and external guidance cues. By comparing collective migrations occurring during development and cancer, we bring into focus shared principles for collective cell movement and distinct strategies used by cancer cells for their own dispersal. Throughout, we pay particular attention to how migrating collectives display emergent properties not exhibited by individually migrating cells and how these properties provide the robustness needed for efficient cell movement.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"19 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleosomes as blueprints of genome architecture 核小体是基因组结构的蓝图

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-06-04 DOI: 10.1038/s41580-025-00866-9

Eytan Zlotorynski

引用次数: 0