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Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment 利用细胞周期依赖性去磷酸化实现有丝分裂特异性蛋白质招募
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-20 DOI: 10.1038/s41580-024-00808-x
Xiaofu Cao
{"title":"Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment","authors":"Xiaofu Cao","doi":"10.1038/s41580-024-00808-x","DOIUrl":"https://doi.org/10.1038/s41580-024-00808-x","url":null,"abstract":"In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma membrane, exploiting the cell cycle’s natural regulation of PLEKHA5 phosphorylation.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"18 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paleoproteomics sheds light on million-year-old fossils 古蛋白质组学揭示百万年前化石的奥秘
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-19 DOI: 10.1038/s41580-024-00803-2
Ryan Sinclair Paterson, Palesa Petunia Madupe, Enrico Cappellini
{"title":"Paleoproteomics sheds light on million-year-old fossils","authors":"Ryan Sinclair Paterson, Palesa Petunia Madupe, Enrico Cappellini","doi":"10.1038/s41580-024-00803-2","DOIUrl":"https://doi.org/10.1038/s41580-024-00803-2","url":null,"abstract":"It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequencing of ancient proteins is currently the only viable methodology for retrieving the genetic data required to resolve evolutionary relations between vertebrate species that disappeared millions of years ago. Ancient proteins can provide phylogenetic information at a timescale that supersedes ancient DNA. Paleoproteomics could thus provide invaluable evolutionary insights, including into human evolution.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"46 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting cells through TNT 通过 TNT 连接细胞
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-18 DOI: 10.1038/s41580-024-00811-2
Lisa Heinke
{"title":"Connecting cells through TNT","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00811-2","DOIUrl":"https://doi.org/10.1038/s41580-024-00811-2","url":null,"abstract":"Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in the zebrafish embryo, enabling the transport of proteins and organelles.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"21 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA communication between organisms inspires innovative eco-friendly strategies for disease control 生物体之间的 RNA 通信激发了创新的生态友好型疾病控制策略
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-15 DOI: 10.1038/s41580-024-00807-y
Rachael Hamby, Qiang Cai, Hailing Jin
{"title":"RNA communication between organisms inspires innovative eco-friendly strategies for disease control","authors":"Rachael Hamby, Qiang Cai, Hailing Jin","doi":"10.1038/s41580-024-00807-y","DOIUrl":"https://doi.org/10.1038/s41580-024-00807-y","url":null,"abstract":"Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secreted and trafficked and how they function within the recipient organisms remain unclear. Here, we discuss how understanding inter-organismal RNA communication can assist in disease management in both agriculture and medicine. Cross-species host–pathogen or mutualistic RNA communication, especially through extracellular vesicles, can have important applications, including gene silencing in agriculture and RNA-based therapeutics.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"7 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grand roles for microproteins 微蛋白的巨大作用
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-14 DOI: 10.1038/s41580-024-00806-z
Valerie A. Tornini
{"title":"Grand roles for microproteins","authors":"Valerie A. Tornini","doi":"10.1038/s41580-024-00806-z","DOIUrl":"https://doi.org/10.1038/s41580-024-00806-z","url":null,"abstract":"Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading frames, and highlights the potential for this research field in fundamental and clinical research.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"44 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intraflagellar transport cycle 叶栅内运输循环
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-13 DOI: 10.1038/s41580-024-00797-x
Samuel E. Lacey, Gaia Pigino
{"title":"The intraflagellar transport cycle","authors":"Samuel E. Lacey, Gaia Pigino","doi":"10.1038/s41580-024-00797-x","DOIUrl":"https://doi.org/10.1038/s41580-024-00797-x","url":null,"abstract":"<p>Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intraflagellar transport (IFT) contributes to the formation of the highly specialized ciliary proteome by active and selective transport of soluble and membrane proteins into and out of cilia. IFT is performed by the IFT-A and IFT-B protein complexes, which together link cargoes to the microtubule motors kinesin and dynein. In this Review, we discuss recent structural and mechanistic insights on how the IFT complexes are first recruited to the base of the cilium, how they polymerize into an anterograde IFT train, and how this complex imports cargoes from the cytoplasm. We will describe insights into how kinesin-driven anterograde trains are carried to the ciliary tip, where they are remodelled into dynein-driven retrograde trains for cargo export. We will also present how the interplay between IFT-A and IFT-B complexes, motor proteins and cargo adaptors is regulated for bidirectional ciliary transport.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"161 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies 作者更正：所有我们看不见的地方RNA 修饰研究中假阴性的来源与缓解
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-12 DOI: 10.1038/s41580-024-00810-3
Shalini Oberdoerffer, Wendy V. Gilbert
{"title":"Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies","authors":"Shalini Oberdoerffer, Wendy V. Gilbert","doi":"10.1038/s41580-024-00810-3","DOIUrl":"https://doi.org/10.1038/s41580-024-00810-3","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Molecular Cell Biology</i> https://doi.org/10.1038/s41580-024-00784-2, published online 21 October 2024.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"55 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription regulation by biomolecular condensates 生物分子凝聚体的转录调控
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-08 DOI: 10.1038/s41580-024-00789-x
Gaofeng Pei, Heankel Lyons, Pilong Li, Benjamin R. Sabari
{"title":"Transcription regulation by biomolecular condensates","authors":"Gaofeng Pei, Heankel Lyons, Pilong Li, Benjamin R. Sabari","doi":"10.1038/s41580-024-00789-x","DOIUrl":"https://doi.org/10.1038/s41580-024-00789-x","url":null,"abstract":"<p>Biomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic models of transcription regulation focus on the recruitment and regulation of RNA polymerase II by the formation of complexes at the 1–10 nm length scale, which are driven by structured and stoichiometric interactions. These complexes are further organized into condensates at the 100–1,000 nm length scale, which are driven by dynamic multivalent interactions often involving domain–ligand pairs or intrinsically disordered regions. Regulation through condensate-mediated organization does not supersede the processes occurring at the 1–10 nm scale, but it provides regulatory mechanisms for promoting or preventing these processes in the crowded nuclear environment. Regulation of transcription by transcriptional condensates is involved in cell state transitions during animal and plant development, cell signalling and cellular responses to the environment. These condensate-mediated processes are dysregulated in developmental disorders, cancer and neurodegeneration. In this Review, we discuss the principles underlying the regulation of transcriptional condensates, their roles in physiology and their dysregulation in human diseases.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"94 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Homeostasis control in health and disease by the unfolded protein response 未折叠蛋白反应对健康和疾病的平衡控制
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-05 DOI: 10.1038/s41580-024-00794-0
Diego Acosta-Alvear, Jonathan M. Harnoss, Peter Walter, Avi Ashkenazi
{"title":"Homeostasis control in health and disease by the unfolded protein response","authors":"Diego Acosta-Alvear, Jonathan M. Harnoss, Peter Walter, Avi Ashkenazi","doi":"10.1038/s41580-024-00794-0","DOIUrl":"https://doi.org/10.1038/s41580-024-00794-0","url":null,"abstract":"<p>Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized transmembrane and secretory proteins — essential for cellular structure–function and for both intracellular and intercellular communication. To ensure the operative fidelity of the ER, eukaryotic cells leverage the unfolded protein response (UPR) — a stress-sensing and signalling network that maintains homeostasis by rebalancing the biosynthetic capacity of the ER according to need. The metazoan UPR can also redirect signalling from cytoprotective adaptation to programmed cell death if homeostasis restoration fails. As such, the UPR benefits multicellular organisms by preserving optimally functioning cells while removing damaged ones. Nevertheless, dysregulation of the UPR can be harmful. In this Review, we discuss the UPR and its regulatory processes as a paradigm in health and disease. We highlight important recent advances in molecular and mechanistic understanding of the UPR that enable greater precision in designing and developing innovative strategies to harness its potential for therapeutic gain. We underscore the rheostatic character of the UPR, its contextual nature and critical open questions for its further elucidation.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"8 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic discovery by enzyme activity profiling 通过酶活性分析发现表观遗传学
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-25 DOI: 10.1038/s41580-024-00801-4
Manini S. Penikalapati, Jordan L. Meier
{"title":"Epigenetic discovery by enzyme activity profiling","authors":"Manini S. Penikalapati, Jordan L. Meier","doi":"10.1038/s41580-024-00801-4","DOIUrl":"https://doi.org/10.1038/s41580-024-00801-4","url":null,"abstract":"C. David Allis’s discovery of the first histone acetyltransferase from Tetrahymena&nbsp;exemplifies an approach that continues to evolve and now has a crucial role in drug development.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"74 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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