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STING signalling as a mediator between lipid metabolism and innate immunity. STING信号作为脂质代谢和先天免疫之间的中介。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-30 DOI: 10.1038/s41580-026-00967-z
Soumyabrata Guha,Nadine Laguette
{"title":"STING signalling as a mediator between lipid metabolism and innate immunity.","authors":"Soumyabrata Guha,Nadine Laguette","doi":"10.1038/s41580-026-00967-z","DOIUrl":"https://doi.org/10.1038/s41580-026-00967-z","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"111 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target. 系统性表观遗传失调作为衰老的驱动因素和治疗靶点。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-27 DOI: 10.1038/s41580-026-00958-0
A Doğa Yücel,Vadim N Gladyshev
{"title":"Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target.","authors":"A Doğa Yücel,Vadim N Gladyshev","doi":"10.1038/s41580-026-00958-0","DOIUrl":"https://doi.org/10.1038/s41580-026-00958-0","url":null,"abstract":"Although epigenetic changes during ageing are well documented, we lack an integrated framework to systematically explain their mechanistic relationships. In this Review, we present a systems-level framework that demonstrates how epigenetic regulation controls ageing. We discuss four interdependent processes through which epigenetic fidelity - the capacity of chromatin regulatory systems to maintain precise gene expression states - progressively fails: deterioration of nuclear architecture, including breakdown of lamina-associated domains; dysregulation of epigenetic memory through chromatin-modifying complexes such as Polycomb repressive complex 2 (PRC2); nucleosome alterations involving replication-independent accumulation of the histone variant H3.3; and transcription reprogramming driven by transcription factors. These processes interact through cross-regulatory feedback, producing cascading failures in gene expression and cell-state maintenance. This framework reveals why therapeutics targeting epigenetic systems have consistent effects across multiple model systems and ageing phenotypes. The interconnected organization of chromatin regulation mechanisms creates concrete therapeutic targets to restore regulatory coherence. By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing, rather than individual molecular defects.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"4 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147524602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming the challenge of preferred particle orientation in cryo-EM 克服低温电镜中粒子择优取向的挑战。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-26 DOI: 10.1038/s41580-026-00962-4
Yang Yang, Bin Liu
{"title":"Overcoming the challenge of preferred particle orientation in cryo-EM","authors":"Yang Yang, Bin Liu","doi":"10.1038/s41580-026-00962-4","DOIUrl":"10.1038/s41580-026-00962-4","url":null,"abstract":"Preferred particle orientation poses a challenge in single-particle cryogenic electron microscopy (cryo-EM) studies by limiting angular sampling and the quality of 3D reconstruction. Here, we discuss recent strategies that help address orientation bias and offer practical advice to optimize high-resolution structure determination by cryo-EM. Yang and Liu discuss strategies that help address particle orientation bias in cryogenic electron microscopy (cryo-EM), and offer practical advice to tackle it.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 5","pages":"337-339"},"PeriodicalIF":90.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technologies to measure and modulate protein subcellular localization. 测量和调节蛋白质亚细胞定位的技术。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-19 DOI: 10.1038/s41580-026-00957-1
William Leineweber,Reika Tei,Anna Mäkiniemi,Alice Ting,Emma Lundberg
{"title":"Technologies to measure and modulate protein subcellular localization.","authors":"William Leineweber,Reika Tei,Anna Mäkiniemi,Alice Ting,Emma Lundberg","doi":"10.1038/s41580-026-00957-1","DOIUrl":"https://doi.org/10.1038/s41580-026-00957-1","url":null,"abstract":"How proteins localize to specific compartments, function in coordination with other biomolecules and, ultimately, contribute to diverse cellular activities are crucial questions in cell biology. Complicating the answers to these questions are multilocalizing and multifunctional proteins, whose impact on the cell depends on both spatial and temporal contexts. Therefore, contextualizing protein functions based on their subcellular localization is necessary to fully understand cell behaviours. Recent advances in instrumentation and protein labelling techniques are rapidly increasing the availability of tools, technologies and applications that measure and control protein localization and compartment-specific function. In this Review, we first discuss microscopy, mass spectrometry-based correlation profiling and proximity labelling methods that assign localizations to proteins, ranging from cellular compartments to protein-protein interactions. We next examine the available tools for manipulating protein localization and measuring the effects of these manipulations, including localization tags and bifunctional molecules. For each technology, we assess the strengths and weaknesses that ultimately determine their usefulness. We conclude with an outlook on future technological advances in the field of spatial subcellular proteomics and their potential implications for cell biology and clinical applications.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"11 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming cytoskeleton instability in the early embryo 克服早期胚胎细胞骨架的不稳定性。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-06 DOI: 10.1038/s41580-026-00960-6
Lisa Heinke
{"title":"Overcoming cytoskeleton instability in the early embryo","authors":"Lisa Heinke","doi":"10.1038/s41580-026-00960-6","DOIUrl":"10.1038/s41580-026-00960-6","url":null,"abstract":"Cytoplasmic partitioning in early embryos depends on microtubule asters. A study reveals that different species use distinct mechanisms to stabilize these inherently unstable structures and preserve robust cytoplasmic compartments.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 4","pages":"257-257"},"PeriodicalIF":90.2,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural crest gene regulatory networks as drivers of development, diversification and disease. 神经嵴基因调控网络作为发展、多样化和疾病的驱动因素。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-03-04 DOI: 10.1038/s41580-026-00949-1
Jan Stundl,Ayyappa Raja Desingu Rajan,Marianne E Bronner
{"title":"Neural crest gene regulatory networks as drivers of development, diversification and disease.","authors":"Jan Stundl,Ayyappa Raja Desingu Rajan,Marianne E Bronner","doi":"10.1038/s41580-026-00949-1","DOIUrl":"https://doi.org/10.1038/s41580-026-00949-1","url":null,"abstract":"The neural crest is an important stem cell population characterized by its multipotency, migratory behaviour and broad ability to differentiate into numerous derivatives throughout the vertebrate body, as diverse as cell types contributing to the cardiovascular system, craniofacial skeleton, peripheral nervous system and pigmentation of the skin. The developmental trajectory of the neural crest is governed by a complex gene regulatory network (GRN) that mediates induction and specification at the neural plate border, emergence of neural crest cells (NCCs) from the neural tube, their migration through the periphery and cell fate determination en route to different final destinations. In this Review, we discuss the significant progress in investigating the neural crest GRN, which has increased our understanding of how NCCs impact vertebrate development and evolution, their role in adult tissue regeneration and their contribution to diseases derived from abnormalities in NCCs.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"227 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: The hunter becomes the hunted in target-directed microRNA degradation. 作者更正：在靶向microRNA降解中，猎人变成了猎物。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-02-27 DOI: 10.1038/s41580-026-00956-2
Katherine McJunkin
{"title":"Author Correction: The hunter becomes the hunted in target-directed microRNA degradation.","authors":"Katherine McJunkin","doi":"10.1038/s41580-026-00956-2","DOIUrl":"https://doi.org/10.1038/s41580-026-00956-2","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":90.2,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precise protein expression through microRNA-mediated gene dosage compensation 通过microrna介导的基因剂量补偿精确表达蛋白。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-02-27 DOI: 10.1038/s41580-026-00959-z
Rongrong Du
{"title":"Precise protein expression through microRNA-mediated gene dosage compensation","authors":"Rongrong Du","doi":"10.1038/s41580-026-00959-z","DOIUrl":"10.1038/s41580-026-00959-z","url":null,"abstract":"Based on microRNAs, DIMMERs is a modular tool for dampening expression fluctuations of multiple proteins in a cell owing to transgene copy number variations.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 4","pages":"256-256"},"PeriodicalIF":90.2,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging importance of UBA6 in ubiquitylation and proteostasis UBA6在泛素化和蛋白质停滞中的重要性
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-02-20 DOI: 10.1038/s41580-026-00954-4
Gali Prag, Avraham Ashkenazi
{"title":"The emerging importance of UBA6 in ubiquitylation and proteostasis","authors":"Gali Prag, Avraham Ashkenazi","doi":"10.1038/s41580-026-00954-4","DOIUrl":"10.1038/s41580-026-00954-4","url":null,"abstract":"In addition to ubiquitin-like modifier-activating enzyme 1 (UBA1), the related UBA6 defines a second, structurally distinct ubiquitin-activating pathway. UBA6 governs cytoskeletal remodelling, proteostasis and neuronal resilience, revealing non-redundant functions obscured by the traditional one-E1 paradigm. Ubiquitination is traditionally viewed as a one-E1 system based on UBA1, but accumulating evidence positions the related UBA6 as a distinct ubiquitin-initiating pathway that operates through unique E2 and E3 enzymes, with important functions in physiology and disease.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 4","pages":"253-254"},"PeriodicalIF":90.2,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146223275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing the effects of protein glycosylation on transcription with induced-proximity tools 利用诱导接近工具探讨蛋白质糖基化对转录的影响
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2026-02-19 DOI: 10.1038/s41580-026-00955-3
Alison C. Mody
{"title":"Probing the effects of protein glycosylation on transcription with induced-proximity tools","authors":"Alison C. Mody","doi":"10.1038/s41580-026-00955-3","DOIUrl":"10.1038/s41580-026-00955-3","url":null,"abstract":"In this Tools of the Trade article, Alison Mody (Woo lab) discusses a proximity-induced platform for targeted O-GlcNAcylation of proteins of interest, enabling researchers to measure the effect of O-GlcNAcylation on protein function.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 5","pages":"341-341"},"PeriodicalIF":90.2,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146223276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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