Nature Reviews Molecular Cell Biology最新文献_第2页

HoT self-blinking probes for chromatin imaging HoT自闪烁探针用于染色质成像

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-10-01 DOI: 10.1038/s41580-026-01033-4

Aiping Wang,Jie Zhang

引用次数: 0

Technological prominence alone does not justify leadership in SynCell governance 技术上的突出并不能证明SynCell管理的领导地位

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-30 DOI: 10.1038/s41580-026-01034-3

Milena-Jael Silva-Morales

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p53 keeps a transcription–replication balance that prevents chromothripsis P53保持转录-复制平衡，防止染色体断裂。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-28 DOI: 10.1038/s41580-026-01031-6

Diana S. M. Ottoz

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Mechanisms and disease relevance of DNA break repair pathway choice. DNA断裂修复途径选择的机制和疾病相关性。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-18 DOI: 10.1038/s41580-026-01026-3

Michelle L Swift, Cody M Rogers, Hardeep Kaur, Dipanjan Chowdhury, Patrick Sung

{"title":"Mechanisms and disease relevance of DNA break repair pathway choice.","authors":"Michelle L Swift, Cody M Rogers, Hardeep Kaur, Dipanjan Chowdhury, Patrick Sung","doi":"10.1038/s41580-026-01026-3","DOIUrl":"10.1038/s41580-026-01026-3","url":null,"abstract":"Understanding what drives the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) as the DNA double-strand break (DSB) repair pathway can help to elucidate mechanisms of genome repair and acquired drug resistance in cancer cells. This choice is intimately linked with a highly regulated process of DNA end resection, mediated by several nuclease entities. Concerted efforts by many laboratories have identified several factors involved in DNA end resection, but we are only beginning to appreciate the mechanisms that underpin DSB repair pathway choice. In this Review, we highlight how DSB repair factors, DSB repair regulators and chromatin modifications determine whether HR or NHEJ is engaged as the repair pathway, with a focus on the antagonistic roles of the tumour suppressor complex BRCA1-BARD1 and the 53BP1 axis in repair pathway choice. How RNA-DNA hybrids affect HR execution and how they are processed by helicases and HR factors is also discussed. Moreover, we describe how dysfunction in repair pathway choice affects tumorigenesis and drives chemotherapeutic resistance.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A practical guide to studying genome function using single-molecule genomics 使用单分子基因组学研究基因组功能的实用指南。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-14 DOI: 10.1038/s41580-026-01017-4

Arnaud R. Krebs, Nicolas Altemose, L. Stirling Churchman, William J. Greenleaf, Vijay Ramani, Michael B. Stadler, Andrew B. Stergachis

{"title":"A practical guide to studying genome function using single-molecule genomics","authors":"Arnaud R. Krebs, Nicolas Altemose, L. Stirling Churchman, William J. Greenleaf, Vijay Ramani, Michael B. Stadler, Andrew B. Stergachis","doi":"10.1038/s41580-026-01017-4","DOIUrl":"10.1038/s41580-026-01017-4","url":null,"abstract":"Single-molecule genomics (SMG) has transformed our ability to study the mechanisms that regulate the genome by enabling profiling of the activity of regulatory factors on individual DNA molecules genome-wide. SMG is able to quantify molecular heterogeneity and the co-occurrence of regulatory events, including epigenetic modifications, transcription factor binding and chromatin organization on single DNA molecules. SMG reveals dynamics of chromatin interactions that cannot be measured by conventional genomics assays. Therefore, SMG offers a unique platform to study how regulatory events combine to control genome activity. In this Expert Recommendation article, we provide a practical guide for adopting SMG and outline best practices. Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling quantification of molecular heterogeneity and co-occurrence of regulatory events. This Expert Recommendation article provides a practical guide for adopting single-molecule genomics and outlines best practices.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"27 11","pages":"839-854"},"PeriodicalIF":118.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRC2–RNA interactions through the lens of bioinformatics pipeline choices 通过生物信息学管道选择的镜头PRC2-RNA相互作用

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-11 DOI: 10.1038/s41580-026-01028-1

Chen Davidovich

引用次数: 0

Author Correction: Mechanisms and regulation of the Hsp70 chaperone network 作者更正：Hsp70伴侣网络的机制和调控。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-09 DOI: 10.1038/s41580-026-01029-0

Anne Wentink, Rina Rosenzweig, Harm Kampinga, Bernd Bukau

引用次数: 0

Towards 3D-oid models that integrate molecular, morphological and spatial cellular features. 向着整合分子、形态和空间细胞特征的3D-oid模型发展。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-04 DOI: 10.1038/s41580-026-01025-4

Akos Diosdi, Fabian J Theis, Peter Horvath

引用次数: 0

The molecular basis of transcription initiation by RNA polymerase II. RNA聚合酶启动转录的分子基础。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-04 DOI: 10.1038/s41580-026-01019-2

Xizi Chen, Yanhui Xu

{"title":"The molecular basis of transcription initiation by RNA polymerase II.","authors":"Xizi Chen, Yanhui Xu","doi":"10.1038/s41580-026-01019-2","DOIUrl":"https://doi.org/10.1038/s41580-026-01019-2","url":null,"abstract":"Transcription initiation in eukaryotes is a major regulatory checkpoint for ensuring that genes are precisely activated. Although the basic components of the transcription machinery were identified decades ago, recent breakthroughs in high-resolution cryo-electron microscopy have transformed our understanding of how these massive complexes function as dynamic assemblies rather than as static entities. In this Review, we focus on transcription by RNA polymerase II (Pol II) and discuss the integrated roles of the universal promoter scaffold factor TFIID, the transcription co-activator Mediator and the epigenetic status of the +1 nucleosome. We first discuss the structural basis of TFIID-mediated recognition of the core promoter and the modular assembly of the pre-initiation complex and pre-initiation complex-Mediator, which involves phosphorylation of the Pol II C-terminal domain. We then discuss how the chromatin environment regulates selection of the transcription start site and transcription directionality, before turning to the progression from transcription initiation to elongation, including promoter opening and promoter escape. Finally, we discuss transcription initiation as a programmed process, in which inhibitory factors are released and regulatory factors are progressively exchanged through competition for binding surfaces.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":118.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CDK1 links RNA methylation to mitosis progression CDK1将RNA甲基化与有丝分裂进程联系起来。

IF 118 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2026-09-03 DOI: 10.1038/s41580-026-01027-2

Lisa Heinke

引用次数: 0