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The double-edged sword of eliminating senescent cells 消除衰老细胞的双刃剑
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-24 DOI: 10.1038/s41580-024-00798-w
Eric Gilson
{"title":"The double-edged sword of eliminating senescent cells","authors":"Eric Gilson","doi":"10.1038/s41580-024-00798-w","DOIUrl":"10.1038/s41580-024-00798-w","url":null,"abstract":"Removal of different types of senescent cells can be either beneficial or detrimental to health, with potential consequences to senotherapies.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"957-957"},"PeriodicalIF":81.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When senescence generates pluripotent stem cells 当衰老产生多能干细胞时
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-24 DOI: 10.1038/s41580-024-00799-9
Miria Ricchetti
{"title":"When senescence generates pluripotent stem cells","authors":"Miria Ricchetti","doi":"10.1038/s41580-024-00799-9","DOIUrl":"10.1038/s41580-024-00799-9","url":null,"abstract":"Senescent cells in the amputated head of the cnidarian Hydractinia symbiolongicarpus drive the reprogramming of somatic cells into pluripotent stem cells, which are required for full body regeneration.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"952-952"},"PeriodicalIF":81.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nuclear morphology-based machine learning algorithm for senescence detection 基于核形态学的衰老检测机器学习算法
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-23 DOI: 10.1038/s41580-024-00796-y
Imanol Duran
{"title":"A nuclear morphology-based machine learning algorithm for senescence detection","authors":"Imanol Duran","doi":"10.1038/s41580-024-00796-y","DOIUrl":"10.1038/s41580-024-00796-y","url":null,"abstract":"In this Tools of the Trade article, Duran (Gil lab) describes the development of novel machine learning algorithms that enable the detection of senescent cells in vitro and in diverse tissues based solely on nuclear morphologeny analysis.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"949-949"},"PeriodicalIF":81.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prompt to discover senolytics 发现老年痴呆症的提示
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-23 DOI: 10.1038/s41580-024-00795-z
James L. Kirkland
{"title":"The prompt to discover senolytics","authors":"James L. Kirkland","doi":"10.1038/s41580-024-00795-z","DOIUrl":"10.1038/s41580-024-00795-z","url":null,"abstract":"James Kirkland discusses how work by Norman Sharpless and colleagues, published in 2004, paved the way for the development of senolytics, which are now in early phase clinical trials for the treatment of multiple disorders.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"953-953"},"PeriodicalIF":81.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies 我们看不到的所有位点RNA 修饰研究中假阴性的来源与缓解
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-21 DOI: 10.1038/s41580-024-00784-2
Shalini Oberdoeffer, Wendy V. Gilbert
{"title":"All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies","authors":"Shalini Oberdoeffer, Wendy V. Gilbert","doi":"10.1038/s41580-024-00784-2","DOIUrl":"https://doi.org/10.1038/s41580-024-00784-2","url":null,"abstract":"<p>RNA modifications are essential for human health — too much or too little of them leads to serious illnesses ranging from neurodevelopmental disorders to cancer. Technical advances in RNA modification sequencing are beginning to uncover the RNA targets of diverse RNA-modifying enzymes that are dysregulated in disease. However, the emerging transcriptome-wide maps of modified nucleosides installed by these enzymes should be considered as first drafts. In particular, a range of technical artefacts lead to false negatives — modified sites that are overlooked owing to technique-dependent, and often sequence-context-specific, ‘blind spots’. In this Review, we discuss potential sources of false negatives in sequencing-based RNA modification maps, propose mitigation strategies and suggest guidelines for transparent reporting of sensitivity to detect modified sites in profiling studies. Important considerations for recognition and avoidance of false negatives include assessment and reporting of position-specific sequencing depth, identification of protocol-dependent RNA capture biases and applying controls for false negatives as well as for false positives. Despite their limitations, emerging maps of RNA modifications reveal exciting and largely uncharted potential for post-transcriptional control of all aspects of RNA function.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"23 4S 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of mitochondrial dynamics 线粒体动力学的分子机制
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-17 DOI: 10.1038/s41580-024-00785-1
Luis-Carlos Tábara, Mayuko Segawa, Julien Prudent
{"title":"Molecular mechanisms of mitochondrial dynamics","authors":"Luis-Carlos Tábara, Mayuko Segawa, Julien Prudent","doi":"10.1038/s41580-024-00785-1","DOIUrl":"https://doi.org/10.1038/s41580-024-00785-1","url":null,"abstract":"<p>Mitochondria not only synthesize energy required for cellular functions but are also involved in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation and immunity. Mitochondria are dynamic organelles that undergo cycles of fission and fusion, and these transitions between fragmented and hyperfused networks ensure mitochondrial function, enabling adaptations to metabolic changes or cellular stress. Defects in mitochondrial morphology have been associated with numerous diseases, highlighting the importance of elucidating the molecular mechanisms regulating mitochondrial morphology. Here, we discuss recent structural insights into the assembly and mechanism of action of the core mitochondrial dynamics proteins, such as the dynamin-related protein 1 (DRP1) that controls division, and the mitofusins (MFN1 and MFN2) and optic atrophy 1 (OPA1) driving membrane fusion. Furthermore, we provide an updated view of the complex interplay between different proteins, lipids and organelles during the processes of mitochondrial membrane fusion and fission. Overall, we aim to present a valuable framework reflecting current perspectives on how mitochondrial membrane remodelling is regulated.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"29 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing 再见了，衰老的细胞释放 CAR-T 细胞，对抗衰老
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-16 DOI: 10.1038/s41580-024-00792-2
Raffaella Di Micco
{"title":"Goodbye, senescent cells: CAR-T cells unleashed to fight ageing","authors":"Raffaella Di Micco","doi":"10.1038/s41580-024-00792-2","DOIUrl":"10.1038/s41580-024-00792-2","url":null,"abstract":"Raffaella Di Micco discusses the importance of a 2020 study in which CAR-T cells were engineered to eliminate senescent cells.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"955-955"},"PeriodicalIF":81.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-11 as a master regulator of ageing IL-11 是衰老的主调节因子
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-16 DOI: 10.1038/s41580-024-00793-1
Ana O’Loghlen
{"title":"IL-11 as a master regulator of ageing","authors":"Ana O’Loghlen","doi":"10.1038/s41580-024-00793-1","DOIUrl":"10.1038/s41580-024-00793-1","url":null,"abstract":"Ana O’Loghlen highlights a recent study that indicates that inhibiting the pro-inflammatory cytokine IL-11 has anti-ageing effects, and how such findings could have implications for the treatment of ageing-associated diseases.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"956-956"},"PeriodicalIF":81.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular tools for analysing in vivo senescence 分析体内衰老的分子工具
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-14 DOI: 10.1038/s41580-024-00790-4
Allison B. Herman, Myriam Gorospe
{"title":"Molecular tools for analysing in vivo senescence","authors":"Allison B. Herman,&nbsp;Myriam Gorospe","doi":"10.1038/s41580-024-00790-4","DOIUrl":"10.1038/s41580-024-00790-4","url":null,"abstract":"Enrichment of senescent cells from organs holds great promise for studying cell senescence and ageing, and for identifying therapeutic vulnerabilities.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"954-954"},"PeriodicalIF":81.3,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism and regulation of kinesin motors 驱动蛋白马达的机制与调控
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-11 DOI: 10.1038/s41580-024-00780-6
Ahmet Yildiz
{"title":"Mechanism and regulation of kinesin motors","authors":"Ahmet Yildiz","doi":"10.1038/s41580-024-00780-6","DOIUrl":"https://doi.org/10.1038/s41580-024-00780-6","url":null,"abstract":"<p>Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a characteristic motor domain that powers unidirectional motility and force generation along microtubules, and they possess unique tail domains that recruit accessory proteins and facilitate oligomerization, regulation and cargo recognition. The location, direction and timing of kinesin-driven processes are tightly regulated by various cofactors, adaptors, microtubule tracks and microtubule-associated proteins. This Review focuses on recent structural and functional studies that reveal how members of the kinesin superfamily use the energy of ATP hydrolysis to transport cargoes, depolymerize microtubules and regulate microtubule dynamics. I also survey how accessory proteins and post-translational modifications regulate the autoinhibition, cargo binding and motility of some of the best-studied kinesins. Despite much progress, the mechanism and regulation of kinesins are still emerging, and unresolved questions can now be tackled using newly developed approaches in biophysics and structural biology.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"43 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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