{"title":"人类和非人类灵长类动物衰老的生物标志物","authors":"Zeming Wu, Jing Qu, Weiqi Zhang, Guang-Hui Liu","doi":"10.1038/s41580-025-00883-8","DOIUrl":null,"url":null,"abstract":"<p>Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"29 1","pages":""},"PeriodicalIF":90.2000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biomarkers of ageing of humans and non-human primates\",\"authors\":\"Zeming Wu, Jing Qu, Weiqi Zhang, Guang-Hui Liu\",\"doi\":\"10.1038/s41580-025-00883-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.</p>\",\"PeriodicalId\":19051,\"journal\":{\"name\":\"Nature Reviews Molecular Cell Biology\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":90.2000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Molecular Cell Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41580-025-00883-8\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Molecular Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41580-025-00883-8","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Biomarkers of ageing of humans and non-human primates
Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.
期刊介绍：
Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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