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Distal enhancers loop to proximal enhancers, not to promoters 远端增强子循环到近端增强子，而不是启动子
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-26 DOI: 10.1038/s41580-025-00889-2
Kevin Struhl
{"title":"Distal enhancers loop to proximal enhancers, not to promoters","authors":"Kevin Struhl","doi":"10.1038/s41580-025-00889-2","DOIUrl":"10.1038/s41580-025-00889-2","url":null,"abstract":"Although enhancers activate transcription from long distances, they stimulate transcription only through short-range interactions with the RNA polymerase II machinery. I posit that action at a distance is mediated by loops between distal and proximal enhancers that thereby bring proteins associated with distal enhancers near promoters. This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops between distal and proximal enhancers, not between enhancers and promoters.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 10","pages":"730-731"},"PeriodicalIF":90.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redox-driven cell death by disulfidptosis and its therapeutic potential 氧化还原酶驱动的双眼皮细胞死亡及其治疗潜力
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-22 DOI: 10.1038/s41580-025-00888-3
Boyi Gan
{"title":"Redox-driven cell death by disulfidptosis and its therapeutic potential","authors":"Boyi Gan","doi":"10.1038/s41580-025-00888-3","DOIUrl":"10.1038/s41580-025-00888-3","url":null,"abstract":"Disulfidptosis is an emerging form of redox-driven cell death with implications in cancer and immunity. This Comment explores gaps in our mechanistic understanding, unanswered questions, and the therapeutic potential of targeting disulfidptosis, highlighting key challenges and future directions in decoding this unique cell death pathway. In this Comment, Boyi Gan discusses disulfidptosis, a newly identified, redox-driven cell death pathway triggered by disulfide stress, and highlights its therapeutic potential while underscoring gaps in mechanistic understanding and key challenges for future research.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 10","pages":"727-729"},"PeriodicalIF":90.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Snoozing APC/C for a sweet cell cycle entry 打盹的APC/C进入甜蜜的细胞周期
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-21 DOI: 10.1038/s41580-025-00891-8
Lisa Heinke
{"title":"Snoozing APC/C for a sweet cell cycle entry","authors":"Lisa Heinke","doi":"10.1038/s41580-025-00891-8","DOIUrl":"10.1038/s41580-025-00891-8","url":null,"abstract":"Paul et al. demonstrate that entry into the cell cycle from quiescence involves a transient, partial inactivation of the APC/C ubiquitin ligase, which halts the degradation of glycolysis enzymes and ensures sufficient ATP production for cell division.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 10","pages":"733-733"},"PeriodicalIF":90.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemistry and regulation of histone lysine L-lactylation. 组蛋白赖氨酸l -乳酸化的生物化学及调控。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-19 DOI: 10.1038/s41580-025-00876-7
Xinlei Sheng, Hening Lin, Philip A Cole, Yingming Zhao
{"title":"Biochemistry and regulation of histone lysine L-lactylation.","authors":"Xinlei Sheng, Hening Lin, Philip A Cole, Yingming Zhao","doi":"10.1038/s41580-025-00876-7","DOIUrl":"10.1038/s41580-025-00876-7","url":null,"abstract":"<p><p>Histone L-lactylation is a newly identified, metabolism-linked short-chain Lys acylation. Mounting evidence indicates that Lys L-lactylation has key roles in transcription regulation and many other cellular processes and is associated with diverse pathophysiological changes. In this Review, we discuss the unique features of histone L-lactylation, emphasizing the differences between L-lactylation and its isomers, such as D-lactylation. We discuss the regulation of L-lactylation by writers and erasers, its readers and its cofactor L-lactyl-CoA. We highlight the dynamic regulation of nuclear L-lactyl-CoA and L-lactyl-CoA synthetases, which are crucial determinants of the specificity of histone Lys L-lactylation. We also discuss an emerging L-lactyl-CoA-independent L-lactylation pathway. By integrating these findings, we aim to deepen our understanding of the biochemistry and regulation of histone L-lactylation and its broad biological significance.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":" ","pages":""},"PeriodicalIF":90.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical reprogramming of human blood cells 人类血细胞的化学重编程
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-07 DOI: 10.1038/s41580-025-00887-4
Kim Baumann
{"title":"Chemical reprogramming of human blood cells","authors":"Kim Baumann","doi":"10.1038/s41580-025-00887-4","DOIUrl":"10.1038/s41580-025-00887-4","url":null,"abstract":"This study reports the successful reprogramming of human blood cells to pluripotent stem cells using small molecules.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"647-647"},"PeriodicalIF":90.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A histone variant that manages abiotic stress in plants 一种在植物中控制非生物胁迫的组蛋白变体
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-06 DOI: 10.1038/s41580-025-00884-7
Eytan Zlotorynski
{"title":"A histone variant that manages abiotic stress in plants","authors":"Eytan Zlotorynski","doi":"10.1038/s41580-025-00884-7","DOIUrl":"10.1038/s41580-025-00884-7","url":null,"abstract":"H3.14, a histone variant of unknown role, has a dual transcriptional function in the abiotic stress response in plants: activation of stress response genes and inhibition of growth genes.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"646-646"},"PeriodicalIF":90.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomal membrane homeostasis and its importance in physiology and disease. 溶酶体膜稳态及其在生理和疾病中的重要性。
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-04 DOI: 10.1038/s41580-025-00873-w
Maja Radulovic,Chonglin Yang,Harald Stenmark
{"title":"Lysosomal membrane homeostasis and its importance in physiology and disease.","authors":"Maja Radulovic,Chonglin Yang,Harald Stenmark","doi":"10.1038/s41580-025-00873-w","DOIUrl":"https://doi.org/10.1038/s41580-025-00873-w","url":null,"abstract":"Lysosomes are membranous organelles that are crucial for cell function and organ physiology. Serving as the terminal stations of the endocytic pathway, lysosomes have fundamental roles in the degradation of endogenous and exogenous macromolecules and particles as well as damaged or superfluous organelles. Moreover, the lysosomal membrane is a docking and activation platform for several signalling components, including mTOR complex 1 (mTORC1), which orchestrates metabolic signalling in the cell. The integrity of their membrane is crucial for lysosomes to function as hubs for the regulation of cell metabolism. Various agents, including pathogens, nanoparticles and drugs, can compromise lysosomal membrane integrity. Membrane permeabilization causes leakage of proteases and cations into the cytosol, which can induce cell death pathways and innate immunity signalling. Multiple pathways repair damaged lysosomes, and severely damaged lysosomes are degraded by an autophagic process, lysophagy. Moreover, lysosome damage activates transcriptional programmes that orchestrate lysosome biogenesis to replenish the cellular lysosome pool. In this Review, we discuss recent insights into the mechanisms that ensure the maintenance of lysosomal membrane homeostasis, including novel mechanisms of lysosomal membrane repair and the interplay between lysosome damage, repair, lysophagy and lysosome biogenesis. We highlight the importance of lysosomal membrane homeostasis in cell function, physiology, disease and ageing, and discuss the potential for therapeutic exploitation of lysosomal membrane permeabilization.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"15 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Modelling human brain development and disease with organoids 作者更正：用类器官模拟人脑发育和疾病。
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-04 DOI: 10.1038/s41580-025-00886-5
Marcella Birtele, Madeline Lancaster, Giorgia Quadrato
{"title":"Author Correction: Modelling human brain development and disease with organoids","authors":"Marcella Birtele,&nbsp;Madeline Lancaster,&nbsp;Giorgia Quadrato","doi":"10.1038/s41580-025-00886-5","DOIUrl":"10.1038/s41580-025-00886-5","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"725-725"},"PeriodicalIF":90.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41580-025-00886-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-repair-driven cell death compels us to rethink cancer therapies dna修复驱动的细胞死亡迫使我们重新思考癌症治疗方法
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-08-01 DOI: 10.1038/s41580-025-00879-4
Radoslaw Szmyd, Harriet E. Gee, Anthony J. Cesare
{"title":"DNA-repair-driven cell death compels us to rethink cancer therapies","authors":"Radoslaw Szmyd,&nbsp;Harriet E. Gee,&nbsp;Anthony J. Cesare","doi":"10.1038/s41580-025-00879-4","DOIUrl":"10.1038/s41580-025-00879-4","url":null,"abstract":"Cancer cell death following genotoxic therapy is often attributed to excessive or unrepaired genome damage. However, emerging evidence suggests that the repair of DNA double-strand breaks, rather than the damage itself, frequently drives lethality. The repair pathway that is engaged shapes not only cell fate, but also its immunological consequences. Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"643-644"},"PeriodicalIF":90.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condensate-mediated intracellular organelle sequestration 凝聚物介导的胞内细胞器隔离
IF 90.2 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2025-07-31 DOI: 10.1038/s41580-025-00880-x
Emma Pasquier, Chems Amari
{"title":"Condensate-mediated intracellular organelle sequestration","authors":"Emma Pasquier,&nbsp;Chems Amari","doi":"10.1038/s41580-025-00880-x","DOIUrl":"10.1038/s41580-025-00880-x","url":null,"abstract":"In this Tools of the Trade article, Pasquier and Amari (Gueroui lab) describe the development of ControLD, which allows the intracellular sequestration of organelles through condensate formation, enabling the control of inter-organelle communication.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 10","pages":"734-734"},"PeriodicalIF":90.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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