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Polarized endoplasmic reticulum–plasma membrane contacts in cell migration 细胞迁移中的极化内质网-质膜接触。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-07-01 DOI: 10.1038/s41580-024-00759-3
Lisa Heinke
{"title":"Polarized endoplasmic reticulum–plasma membrane contacts in cell migration","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00759-3","DOIUrl":"10.1038/s41580-024-00759-3","url":null,"abstract":"In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and plasma membrane in migrating cells, whereby higher density of contacts in the back of the cells prevents the formation of additional migration fronts.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Mechanisms controlling cellular and systemic iron homeostasis 作者更正：控制细胞和全身铁平衡的机制。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00760-w
Bruno Galy, Marcus Conrad, Martina Muckenthaler
{"title":"Author Correction: Mechanisms controlling cellular and systemic iron homeostasis","authors":"Bruno Galy, Marcus Conrad, Martina Muckenthaler","doi":"10.1038/s41580-024-00760-w","DOIUrl":"10.1038/s41580-024-00760-w","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00760-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the deep learning power of foundation models in single-cell omics 在单细胞全息研究中利用基础模型的深度学习能力。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00756-6
Qin Ma, Yi Jiang, Hao Cheng, Dong Xu
{"title":"Harnessing the deep learning power of foundation models in single-cell omics","authors":"Qin Ma, Yi Jiang, Hao Cheng, Dong Xu","doi":"10.1038/s41580-024-00756-6","DOIUrl":"10.1038/s41580-024-00756-6","url":null,"abstract":"Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practices in applying foundation models to interrogate data and improve downstream tasks in single-cell omics. This Comment discusses the progress, limitations and best practices in applying foundation models to single-cell omics data.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of RNA structures and their roles in RNA functions 识别 RNA 结构及其在 RNA 功能中的作用
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00748-6
Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan
{"title":"Identification of RNA structures and their roles in RNA functions","authors":"Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan","doi":"10.1038/s41580-024-00748-6","DOIUrl":"https://doi.org/10.1038/s41580-024-00748-6","url":null,"abstract":"<p>The development of high-throughput RNA structure profiling methods in the past decade has greatly facilitated our ability to map and characterize different aspects of RNA structures transcriptome-wide in cell populations, single cells and single molecules. The resulting high-resolution data have provided insights into the static and dynamic nature of RNA structures, revealing their complexity as they perform their respective functions in the cell. In this Review, we discuss recent technical advances in the determination of RNA structures, and the roles of RNA structures in RNA biogenesis and functions, including in transcription, processing, translation, degradation, localization and RNA structure-dependent condensates. We also discuss the current understanding of how RNA structures could guide drug design for treating genetic diseases and battling pathogenic viruses, and highlight existing challenges and future directions in RNA structure research.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of cellular and systemic sphingolipid homeostasis 调节细胞和全身的鞘脂平衡
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-18 DOI: 10.1038/s41580-024-00742-y
Andrew Kuo, Timothy Hla
{"title":"Regulation of cellular and systemic sphingolipid homeostasis","authors":"Andrew Kuo, Timothy Hla","doi":"10.1038/s41580-024-00742-y","DOIUrl":"https://doi.org/10.1038/s41580-024-00742-y","url":null,"abstract":"<p>One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules mediate many essential functions in embryonic development and normal physiology. In addition, sphingolipid metabolism and signalling pathways are dysregulated in a wide range of pathologies, and therapeutic agents that target sphingolipids are now used to treat several human diseases. However, our understanding of sphingolipid regulation at cellular and organismal levels and their functions in developmental, physiological and pathological settings is rudimentary. In this Review, we discuss recent advances in sphingolipid pathways in different organelles, how secreted sphingolipid mediators modulate physiology and disease, progress in sphingolipid-targeted therapeutic and diagnostic research, and the trans-cellular sphingolipid metabolic networks between microbiota and mammals. Advances in sphingolipid biology have led to a deeper understanding of mammalian physiology and may lead to progress in the management of many diseases.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembly and fission of tubular carriers mediating protein sorting in endosomes 内体中介导蛋白质分拣的管状载体的组装和裂变
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-17 DOI: 10.1038/s41580-024-00746-8
Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer
{"title":"Assembly and fission of tubular carriers mediating protein sorting in endosomes","authors":"Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer","doi":"10.1038/s41580-024-00746-8","DOIUrl":"https://doi.org/10.1038/s41580-024-00746-8","url":null,"abstract":"<p>Endosomes are central protein-sorting stations at the crossroads of numerous membrane trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and cellular signalling and are involved in the pathogenesis of numerous diseases. Endosome-associated protein assemblies or coats collect transmembrane cargo proteins and concentrate them into retrieval domains. These domains can extend into tubular carriers, which then pinch off from the endosomal membrane and deliver the cargoes to appropriate subcellular compartments. Here we discuss novel insights into the structure of a number of tubular membrane coats that mediate the recruitment of cargoes into these carriers, focusing on sorting nexin-based coats such as Retromer, Commander and ESCPE-1. We summarize current and emerging views of how selective tubular endosomal carriers form and detach from endosomes by fission, highlighting structural aspects, conceptual challenges and open questions.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":112.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Fundamentals of redox regulation in biology 作者更正：生物学中的氧化还原调节基础。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-17 DOI: 10.1038/s41580-024-00754-8
Helmut Sies, Ryan J. Mailloux, Ursula Jakob
{"title":"Author Correction: Fundamentals of redox regulation in biology","authors":"Helmut Sies,&nbsp;Ryan J. Mailloux,&nbsp;Ursula Jakob","doi":"10.1038/s41580-024-00754-8","DOIUrl":"10.1038/s41580-024-00754-8","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00754-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A histone code controls positional identity in limb regeneration 组蛋白密码控制肢体再生中的位置特性
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-10 DOI: 10.1038/s41580-024-00751-x
Lisa Heinke
{"title":"A histone code controls positional identity in limb regeneration","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00751-x","DOIUrl":"10.1038/s41580-024-00751-x","url":null,"abstract":"Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP 磷酸肌醇 PI5P 可抑制 Hippo 通路效应因子 YAP
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-10 DOI: 10.1038/s41580-024-00750-y
Kim Baumann
{"title":"The phosphoinositide PI5P inhibits the Hippo pathway effector YAP","authors":"Kim Baumann","doi":"10.1038/s41580-024-00750-y","DOIUrl":"10.1038/s41580-024-00750-y","url":null,"abstract":"This study uncovered a link between PI5P, PI5P4Ks and the Hippo pathway, whereby PI5P reinforces the inhibition of YAP, the effector of the Hippo pathway.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring subcellular protein localization at scale in live cells 在活细胞中大规模监测亚细胞蛋白质定位
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-10 DOI: 10.1038/s41580-024-00749-5
Jiří Reiniš, Andreas Reicher
{"title":"Monitoring subcellular protein localization at scale in live cells","authors":"Jiří Reiniš,&nbsp;Andreas Reicher","doi":"10.1038/s41580-024-00749-5","DOIUrl":"10.1038/s41580-024-00749-5","url":null,"abstract":"In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protein-tagging strategy that allows live-cell monitoring of multiple proteins.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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