Nature Reviews Molecular Cell Biology最新文献_第3页

Uncovering the complexity of RNA–protein interactions 揭示rna -蛋白质相互作用的复杂性

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-12 DOI: 10.1038/s41580-025-00859-8

Maïwen Caudron-Herger

引用次数: 0

The diffraction limit of light taken by storm 光的衍射极限。

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-06 DOI: 10.1038/s41580-025-00856-x

Maria Pia Cosma

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An evolving landscape of PRC2–RNA interactions in chromatin regulation 染色质调控中PRC2-RNA相互作用的演变图景

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-30 DOI: 10.1038/s41580-025-00850-3

Rodrigo Aguilar, Michael Rosenberg, Vered Levy, Jeannie T. Lee

{"title":"An evolving landscape of PRC2–RNA interactions in chromatin regulation","authors":"Rodrigo Aguilar, Michael Rosenberg, Vered Levy, Jeannie T. Lee","doi":"10.1038/s41580-025-00850-3","DOIUrl":"https://doi.org/10.1038/s41580-025-00850-3","url":null,"abstract":"A major unsolved problem in epigenetics is how RNA regulates Polycomb repressive complex 2 (PRC2), a complex that trimethylates histone H3 Lys27 (H3K27me3) to form repressive chromatin. Key questions include how PRC2 binds RNA in vivo and what the functional consequences of binding are. In this Perspective, we expound on the viewpoint that RNA is integral to the stepwise regulation of PRC2 activity. Using the long non-coding RNA XIST and X chromosome inactivation as a model, we discuss evidence indicating that RNA is involved in PRC2 recruitment onto chromatin, in induction of its catalytic activity and in its eviction from chromatin. Studies have also implicated RNA in controlling promoter-proximal pausing of RNA polymerase II. The cumulative data argue that the functional consequences of PRC2–RNA interactions crucially depend on RNA conformation. We recognize that alternative hypotheses exist and therefore we attempt to integrate contrary data. Thus, although an RNA-rich landscape is emerging for Polycomb complexes, additional work is required to resolve a broad range of data interpretations.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"46 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurons whisper, tissues respond: neurons as orchestrators of stress responses 神经元窃窃私语，组织作出反应：神经元作为应激反应的协调者

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-24 DOI: 10.1038/s41580-025-00853-0

Evandro A. De-Souza

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Rapid evolution to preserve a conserved function 快速进化以保持不变的功能

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-11 DOI: 10.1038/s41580-025-00848-x

Mia T. Levine

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p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases p53调控的非凋亡细胞死亡途径及其在癌症和其他疾病中的相关性

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-09 DOI: 10.1038/s41580-025-00842-3

Yanqing Liu, Brent R. Stockwell, Xuejun Jiang, Wei Gu

{"title":"p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases","authors":"Yanqing Liu, Brent R. Stockwell, Xuejun Jiang, Wei Gu","doi":"10.1038/s41580-025-00842-3","DOIUrl":"https://doi.org/10.1038/s41580-025-00842-3","url":null,"abstract":"Programmed cell death is a mechanism that is crucial for numerous physiological and pathological processes. Whereas p53-mediated apoptosis is a major cell death pathway in cancer, accumulating evidence indicates that p53 also has crucial roles in controlling different non-apoptotic cell death (NACD) pathways, including ferroptosis, necroptosis, pyroptosis, autophagy-dependent cell death, entotic cell death, parthanatos and paraptosis, and may regulate PANoptosis, cuproptosis and disulfidptosis. Notably, the function of p53 in these NACDs substantially contributes to its biological effects, particularly in cancer development and other pathological processes. In this Review, we discuss recent advances in understanding the roles and underlying mechanisms of p53-mediated NACDs, focusing on ferroptosis, necroptosis and pyroptosis. We discuss the complex and distinct physiological settings in which NACDs are regulated by p53, and potential targeting of p53-regulated NACDs for the treatment of cancer and other human diseases. Finally, we highlight several important questions concerning p53-regulated NACDs that warrant further investigation.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"39 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recommendations for robust and reproducible research on ferroptosis 建议对铁下垂进行可靠和可重复的研究

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-09 DOI: 10.1038/s41580-025-00843-2

Eikan Mishima, Toshitaka Nakamura, Sebastian Doll, Bettina Proneth, Maria Fedorova, Derek A. Pratt, José Pedro Friedmann Angeli, Scott J. Dixon, Adam Wahida, Marcus Conrad

{"title":"Recommendations for robust and reproducible research on ferroptosis","authors":"Eikan Mishima, Toshitaka Nakamura, Sebastian Doll, Bettina Proneth, Maria Fedorova, Derek A. Pratt, José Pedro Friedmann Angeli, Scott J. Dixon, Adam Wahida, Marcus Conrad","doi":"10.1038/s41580-025-00843-2","DOIUrl":"https://doi.org/10.1038/s41580-025-00843-2","url":null,"abstract":"Ferroptosis is a necrotic, non-apoptotic cell death modality triggered by unrestrained iron-dependent lipid peroxidation. By unveiling the regulatory mechanisms of ferroptosis and its relevance to various diseases, research over the past decade has positioned ferroptosis as a promising therapeutic target. The rapid growth of this research field presents challenges, associated with potentially inadequate experimental approaches that may lead to misinterpretations in the assessment of ferroptosis. Typical examples include assessing whether an observed phenotype is indeed linked to ferroptosis, and selecting appropriate animal models and small-molecule modulators of ferroptotic cell death. This Expert Recommendation outlines state-of-the-art methods and tools to reliably study ferroptosis and increase the reproducibility and robustness of experimental results. We present highly validated compounds and animal models, and discuss their advantages and limitations. Furthermore, we provide an overview of the regulatory mechanisms and the best-studied players in ferroptosis regulation, such as GPX4, FSP1, SLC7A11 and ACSL4, discussing frequent pitfalls in experimental design and relevant guidance. These recommendations are intended for researchers at all levels, including those entering the expanding and exciting field of ferroptosis research.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"33 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blebbisomes are one bleb away from a functional cell 气泡体离功能细胞只有一个气泡之遥

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-09 DOI: 10.1038/s41580-025-00849-w

Lisa Heinke

引用次数: 0

Anticancer effects of zotatifin are mediated by RNA structure remodelling 佐他替芬的抗癌作用是通过RNA结构重塑介导的

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-07 DOI: 10.1038/s41580-025-00846-z

Caroline Barranco

引用次数: 0

Understanding the machinery that reads the genome 了解解读基因组的机制