Distal enhancers loop to proximal enhancers, not to promoters

IF 90.2 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2025-08-26 DOI:10.1038/s41580-025-00889-2

Kevin Struhl

引用次数: 0

Abstract

Although enhancers activate transcription from long distances, they stimulate transcription only through short-range interactions with the RNA polymerase II machinery. I posit that action at a distance is mediated by loops between distal and proximal enhancers that thereby bring proteins associated with distal enhancers near promoters. This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops between distal and proximal enhancers, not between enhancers and promoters.

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远端增强子循环到近端增强子，而不是启动子

虽然增强子从远距离激活转录，但它们仅通过与RNA聚合酶II机制的短程相互作用来刺激转录。我假设远距离的作用是由远端和近端增强子之间的环介导的，从而将与远端增强子相关的蛋白质带到启动子附近。这篇评论认为，增强子仅通过短程相互作用刺激转录机制，因此，远距离增强子活性是由远端和近端增强子之间的染色质环介导的，而不是在增强子和启动子之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.