氧化还原酶驱动的双眼皮细胞死亡及其治疗潜力

IF 90.2 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2025-08-22 DOI:10.1038/s41580-025-00888-3

Boyi Gan

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引用次数: 0

摘要

双曲下垂是氧化还原酶驱动的细胞死亡的一种新形式，与癌症和免疫有关。这篇评论探讨了我们在机制理解上的差距，未解决的问题，以及靶向双睑下垂的治疗潜力，强调了解码这一独特细胞死亡途径的关键挑战和未来方向。在这篇评论中，Gan Boyi讨论了二硫中毒，这是一种新发现的由二硫化物应激触发的氧化氧化驱动的细胞死亡途径，并强调了其治疗潜力，同时强调了机制理解的差距和未来研究的关键挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Redox-driven cell death by disulfidptosis and its therapeutic potential

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Redox-driven cell death by disulfidptosis and its therapeutic potential

Disulfidptosis is an emerging form of redox-driven cell death with implications in cancer and immunity. This Comment explores gaps in our mechanistic understanding, unanswered questions, and the therapeutic potential of targeting disulfidptosis, highlighting key challenges and future directions in decoding this unique cell death pathway. In this Comment, Boyi Gan discusses disulfidptosis, a newly identified, redox-driven cell death pathway triggered by disulfide stress, and highlights its therapeutic potential while underscoring gaps in mechanistic understanding and key challenges for future research.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.