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The discovery of oncogene-induced senescence 发现癌基因诱导的衰老
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-09 DOI: 10.1038/s41580-024-00791-3
Akiko Takahashi
{"title":"The discovery of oncogene-induced senescence","authors":"Akiko Takahashi","doi":"10.1038/s41580-024-00791-3","DOIUrl":"10.1038/s41580-024-00791-3","url":null,"abstract":"Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar phenotype to replicative senescence, establishing the connection between senescence and cancer.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"951-951"},"PeriodicalIF":81.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Following the electric current 跟随电流
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-04 DOI: 10.1038/s41580-024-00781-5
Elias H. Barriga
{"title":"Following the electric current","authors":"Elias H. Barriga","doi":"10.1038/s41580-024-00781-5","DOIUrl":"10.1038/s41580-024-00781-5","url":null,"abstract":"Elias Barriga discusses a seminal 2006 paper from Zhao et al., which was the first study to integrate electrotaxis signals into the established molecular framework enabling directed cell migration.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 11","pages":"844-844"},"PeriodicalIF":81.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sorting membrane proteins by size in the Golgi 在高尔基体中按大小对膜蛋白进行分类
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-04 DOI: 10.1038/s41580-024-00783-3
Pauline Kasper, Lisa Heinke
{"title":"Sorting membrane proteins by size in the Golgi","authors":"Pauline Kasper, Lisa Heinke","doi":"10.1038/s41580-024-00783-3","DOIUrl":"10.1038/s41580-024-00783-3","url":null,"abstract":"De Caestecker and Macara find that the sorting of membrane proteins in the Golgi relies on a size filter that enables correct localization of proteins with a short cytosolic domain to the apical membrane.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 11","pages":"842-842"},"PeriodicalIF":81.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and regulation of substrate degradation by the 26S proteasome 26S 蛋白酶体降解底物的机制和调控
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-03 DOI: 10.1038/s41580-024-00778-0
Connor Arkinson, Ken C. Dong, Christine L. Gee, Andreas Martin
{"title":"Mechanisms and regulation of substrate degradation by the 26S proteasome","authors":"Connor Arkinson, Ken C. Dong, Christine L. Gee, Andreas Martin","doi":"10.1038/s41580-024-00778-0","DOIUrl":"https://doi.org/10.1038/s41580-024-00778-0","url":null,"abstract":"<p>The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this Review, we discuss the principles that underly substrate recognition and ATP-dependent degradation by the proteasome. We focus on recent insights into the mechanisms of conventional ubiquitin-dependent and ubiquitin-independent protein turnover, and discuss the plethora of modulators for proteasome function, including substrate-delivering cofactors, ubiquitin ligases and deubiquitinases that enable the targeting of a highly diverse substrate pool. Furthermore, we summarize recent progress in our understanding of substrate processing upstream of the 26S proteasome by the p97 protein unfoldase. The advances in our knowledge of proteasome structure, function and regulation also inform new strategies for specific inhibition or harnessing the degradation capabilities of the proteasome for the treatment of human diseases, for instance, by using proteolysis targeting chimera molecules or molecular glues.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"24 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases 染色质和基因组不稳定性在细胞衰老中的作用及其与衰老和相关疾病的关系
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-03 DOI: 10.1038/s41580-024-00775-3
Zeming Wu, Jing Qu, Guang-Hui Liu
{"title":"Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases","authors":"Zeming Wu,&nbsp;Jing Qu,&nbsp;Guang-Hui Liu","doi":"10.1038/s41580-024-00775-3","DOIUrl":"10.1038/s41580-024-00775-3","url":null,"abstract":"Ageing is a complex biological process in which a gradual decline in physiological fitness increases susceptibility to diseases such as neurodegenerative disorders and cancer. Cellular senescence, a state of irreversible cell-growth arrest accompanied by functional deterioration, has emerged as a pivotal driver of ageing. In this Review, we discuss how heterochromatin loss, telomere attrition and DNA damage contribute to cellular senescence, ageing and age-related diseases by eliciting genome instability, innate immunity and inflammation. We also discuss how emerging therapeutic strategies could restore heterochromatin stability, maintain telomere integrity and boost the DNA repair capacity, and thus counteract cellular senescence and ageing-associated pathologies. Finally, we outline current research challenges and future directions aimed at better comprehending and delaying ageing. Heterochromatin loss, telomere attrition and DNA damage induce cellular senescence by eliciting genome instability and innate immunity responses, thereby promoting ageing and age-related diseases. This Review discusses the underlying mechanisms of these processes and emerging cell-senescence therapeutics that target them.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 12","pages":"979-1000"},"PeriodicalIF":81.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation 崛起与SINE：转录因子和逆转录转座子在子代基因组激活中的作用
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-02 DOI: 10.1038/s41580-024-00772-6
Pavel Kravchenko, Kikuë Tachibana
{"title":"Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation","authors":"Pavel Kravchenko,&nbsp;Kikuë Tachibana","doi":"10.1038/s41580-024-00772-6","DOIUrl":"10.1038/s41580-024-00772-6","url":null,"abstract":"In sexually reproducing organisms, life begins with the fusion of transcriptionally silent gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as zygotic genome activation (ZGA), is universally required for development, the transcription factors regulating this process are poorly conserved. In this Perspective, we discuss recent insights into the mechanisms of ZGA in totipotent mammalian embryos, namely ZGA regulation by several transcription factors, including by orphan nuclear receptors (OrphNRs) such as the pioneer transcription factor NR5A2, and by factors of the DUX, TPRX and OBOX families. We performed a meta-analysis and compiled a list of pan-ZGA genes, and found that most of these genes are indeed targets of the above transcription factors. Remarkably, more than a third of these ZGA genes appear to be regulated both by OrphNRs such as NR5A2 and by OBOX proteins, whose motifs co-occur in SINE B1 retrotransposable elements, which are enriched near ZGA genes. We propose that ZGA in mice is activated by recruitment of multiple transcription factors to SINE B1 elements that function as enhancers, and discuss a potential relevance of this mechanism to Alu retrotransposable elements in human ZGA. Although zygotic genome activation (ZGA) is universally required for development, the responsible transcription factors are poorly conserved. In mammalian totipotent embryos, (pioneer) transcription factors of two families co-regulate many ZGA genes by binding to nearby SINE retrotransposons, which thus function as their enhancers.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"68-79"},"PeriodicalIF":81.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteoforms: a tale of two (initiation) sites 蛋白质形式：两个（启动）位点的故事
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-10-01 DOI: 10.1038/s41580-024-00788-y
Eytan Zlotorynski
{"title":"Proteoforms: a tale of two (initiation) sites","authors":"Eytan Zlotorynski","doi":"10.1038/s41580-024-00788-y","DOIUrl":"10.1038/s41580-024-00788-y","url":null,"abstract":"mRNAs with alternative in-frame translation initiation sites can yield proteoforms with distinct localization and functions.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 11","pages":"843-843"},"PeriodicalIF":81.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role and regulation of integrins in cell migration and invasion 整合素在细胞迁移和侵袭中的作用与调控
IF 112.7 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-09-30 DOI: 10.1038/s41580-024-00777-1
Megan R. Chastney, Jasmin Kaivola, Veli-Matti Leppänen, Johanna Ivaska
{"title":"The role and regulation of integrins in cell migration and invasion","authors":"Megan R. Chastney, Jasmin Kaivola, Veli-Matti Leppänen, Johanna Ivaska","doi":"10.1038/s41580-024-00777-1","DOIUrl":"https://doi.org/10.1038/s41580-024-00777-1","url":null,"abstract":"<p>Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the formation of heterogeneous multi-protein assemblies termed integrin adhesion complexes (IACs) that enable integrins to transform extracellular cues into intracellular signals that affect many cellular processes, especially cell motility. Cell migration is essential for diverse physiological and pathological processes and is dysregulated in cancer to favour cell invasion and metastasis. Here, we discuss recent findings on the role of integrins in cell migration with a focus on cancer cell dissemination. We review how integrins regulate the spatial distribution and dynamics of different IACs, covering classical focal adhesions, emerging adhesion types and adhesion regulation. We discuss the diverse roles integrins have during cancer progression from cell migration across varied ECM landscapes to breaching barriers such as the basement membrane, and eventual colonization of distant organs.</p>","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"37 1","pages":""},"PeriodicalIF":112.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: The role of the haematopoietic stem cell niche in development and ageing 作者更正：造血干细胞龛在发育和衰老中的作用
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-09-26 DOI: 10.1038/s41580-024-00787-z
Terri L. Cain, Marta Derecka, Shannon McKinney-Freeman
{"title":"Author Correction: The role of the haematopoietic stem cell niche in development and ageing","authors":"Terri L. Cain,&nbsp;Marta Derecka,&nbsp;Shannon McKinney-Freeman","doi":"10.1038/s41580-024-00787-z","DOIUrl":"10.1038/s41580-024-00787-z","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"80-80"},"PeriodicalIF":81.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00787-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels 作者更正：电压门控离子通道的结构生物学和分子药理学
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-09-24 DOI: 10.1038/s41580-024-00786-0
Jian Huang, Xiaojing Pan, Nieng Yan
{"title":"Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels","authors":"Jian Huang,&nbsp;Xiaojing Pan,&nbsp;Nieng Yan","doi":"10.1038/s41580-024-00786-0","DOIUrl":"10.1038/s41580-024-00786-0","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 11","pages":"947-947"},"PeriodicalIF":81.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00786-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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