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Heterochromatin as a balancing act between transcription and gene silencing 异染色质是转录和基因沉默之间的平衡。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-07-03 DOI: 10.1038/s41580-024-00762-8
Sigurd Braun
{"title":"Heterochromatin as a balancing act between transcription and gene silencing","authors":"Sigurd Braun","doi":"10.1038/s41580-024-00762-8","DOIUrl":"10.1038/s41580-024-00762-8","url":null,"abstract":"An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resolution in super-resolution microscopy — definition, trade-offs and perspectives 超分辨率显微镜的分辨率--定义、权衡与展望。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-07-01 DOI: 10.1038/s41580-024-00755-7
Kirti Prakash, David Baddeley, Christian Eggeling, Reto Fiolka, Rainer Heintzmann, Suliana Manley, Aleksandra Radenovic, Carlas Smith, Hari Shroff, Lothar Schermelleh
{"title":"Resolution in super-resolution microscopy — definition, trade-offs and perspectives","authors":"Kirti Prakash, David Baddeley, Christian Eggeling, Reto Fiolka, Rainer Heintzmann, Suliana Manley, Aleksandra Radenovic, Carlas Smith, Hari Shroff, Lothar Schermelleh","doi":"10.1038/s41580-024-00755-7","DOIUrl":"10.1038/s41580-024-00755-7","url":null,"abstract":"Super-resolution microscopy (SRM) is gaining popularity in biosciences; however, claims about optical resolution are contested and often misleading. In this Viewpoint, experts share their views on resolution and common trade-offs, such as labelling and post-processing, aiming to clarify them for biologists and facilitate deeper understanding and best use of SRM. In this Viewpoint, experts discuss resolution and common trade-offs in super-resolution microscopy, aiming to improve how biologists use the technology.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists 哺乳动物样本脂质质谱分析中的误区--生物学家简明指南。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-07-01 DOI: 10.1038/s41580-024-00758-4
Tore Skotland, Kim Ekroos, Jeffrey McDonald, Robert Ahrends, Gerhard Liebisch, Kirsten Sandvig
{"title":"Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists","authors":"Tore Skotland, Kim Ekroos, Jeffrey McDonald, Robert Ahrends, Gerhard Liebisch, Kirsten Sandvig","doi":"10.1038/s41580-024-00758-4","DOIUrl":"10.1038/s41580-024-00758-4","url":null,"abstract":"This Comment discusses erroneous reporting of mass spectrometry analyses of lipids in mammalian samples, and provides recommendations for how to avoid it. Publications that report mass spectrometry analyses of lipids often include lipid species that probably do not exist in the samples. Here we provide recommendations for scientists on submitting lipid data, and for reviewers, editors and readers on evaluating these data, to reduce the reporting of erroneous lipid species.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration 细胞迁移中的极化内质网-质膜接触。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-07-01 DOI: 10.1038/s41580-024-00759-3
Lisa Heinke
{"title":"Polarized endoplasmic reticulum–plasma membrane contacts in cell migration","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00759-3","DOIUrl":"10.1038/s41580-024-00759-3","url":null,"abstract":"In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and plasma membrane in migrating cells, whereby higher density of contacts in the back of the cells prevents the formation of additional migration fronts.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Mechanisms controlling cellular and systemic iron homeostasis 作者更正：控制细胞和全身铁平衡的机制。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00760-w
Bruno Galy, Marcus Conrad, Martina Muckenthaler
{"title":"Author Correction: Mechanisms controlling cellular and systemic iron homeostasis","authors":"Bruno Galy, Marcus Conrad, Martina Muckenthaler","doi":"10.1038/s41580-024-00760-w","DOIUrl":"10.1038/s41580-024-00760-w","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00760-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the deep learning power of foundation models in single-cell omics 在单细胞全息研究中利用基础模型的深度学习能力。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00756-6
Qin Ma, Yi Jiang, Hao Cheng, Dong Xu
{"title":"Harnessing the deep learning power of foundation models in single-cell omics","authors":"Qin Ma, Yi Jiang, Hao Cheng, Dong Xu","doi":"10.1038/s41580-024-00756-6","DOIUrl":"10.1038/s41580-024-00756-6","url":null,"abstract":"Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practices in applying foundation models to interrogate data and improve downstream tasks in single-cell omics. This Comment discusses the progress, limitations and best practices in applying foundation models to single-cell omics data.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of RNA structures and their roles in RNA functions 识别 RNA 结构及其在 RNA 功能中的作用
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-26 DOI: 10.1038/s41580-024-00748-6
Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan
{"title":"Identification of RNA structures and their roles in RNA functions","authors":"Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan","doi":"10.1038/s41580-024-00748-6","DOIUrl":"10.1038/s41580-024-00748-6","url":null,"abstract":"The development of high-throughput RNA structure profiling methods in the past decade has greatly facilitated our ability to map and characterize different aspects of RNA structures transcriptome-wide in cell populations, single cells and single molecules. The resulting high-resolution data have provided insights into the static and dynamic nature of RNA structures, revealing their complexity as they perform their respective functions in the cell. In this Review, we discuss recent technical advances in the determination of RNA structures, and the roles of RNA structures in RNA biogenesis and functions, including in transcription, processing, translation, degradation, localization and RNA structure-dependent condensates. We also discuss the current understanding of how RNA structures could guide drug design for treating genetic diseases and battling pathogenic viruses, and highlight existing challenges and future directions in RNA structure research. Recently developed RNA structure profiling methods are transforming our understanding of static and dynamic facets of RNA structures at single-cell and single-molecule resolution. These data have revealed new roles for structures in RNA biogenesis and function, and guide drug design against viral RNAs and for treatment of genetic diseases.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of cellular and systemic sphingolipid homeostasis 调节细胞和全身的鞘脂平衡
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-18 DOI: 10.1038/s41580-024-00742-y
Andrew Kuo, Timothy Hla
{"title":"Regulation of cellular and systemic sphingolipid homeostasis","authors":"Andrew Kuo, Timothy Hla","doi":"10.1038/s41580-024-00742-y","DOIUrl":"10.1038/s41580-024-00742-y","url":null,"abstract":"One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules mediate many essential functions in embryonic development and normal physiology. In addition, sphingolipid metabolism and signalling pathways are dysregulated in a wide range of pathologies, and therapeutic agents that target sphingolipids are now used to treat several human diseases. However, our understanding of sphingolipid regulation at cellular and organismal levels and their functions in developmental, physiological and pathological settings is rudimentary. In this Review, we discuss recent advances in sphingolipid pathways in different organelles, how secreted sphingolipid mediators modulate physiology and disease, progress in sphingolipid-targeted therapeutic and diagnostic research, and the trans-cellular sphingolipid metabolic networks between microbiota and mammals. Advances in sphingolipid biology have led to a deeper understanding of mammalian physiology and may lead to progress in the management of many diseases. Sphingolipids are a heterogeneous group of lipids with important roles in membrane form and function, cell signalling, and development. This Review discusses the regulation of sphingolipid metabolism at the subcellular and organismal levels and explores the therapeutic potential of targeting sphingolipids in human diseases.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembly and fission of tubular carriers mediating protein sorting in endosomes 内体中介导蛋白质分拣的管状载体的组装和裂变
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-17 DOI: 10.1038/s41580-024-00746-8
Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer
{"title":"Assembly and fission of tubular carriers mediating protein sorting in endosomes","authors":"Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer","doi":"10.1038/s41580-024-00746-8","DOIUrl":"10.1038/s41580-024-00746-8","url":null,"abstract":"Endosomes are central protein-sorting stations at the crossroads of numerous membrane trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and cellular signalling and are involved in the pathogenesis of numerous diseases. Endosome-associated protein assemblies or coats collect transmembrane cargo proteins and concentrate them into retrieval domains. These domains can extend into tubular carriers, which then pinch off from the endosomal membrane and deliver the cargoes to appropriate subcellular compartments. Here we discuss novel insights into the structure of a number of tubular membrane coats that mediate the recruitment of cargoes into these carriers, focusing on sorting nexin-based coats such as Retromer, Commander and ESCPE-1. We summarize current and emerging views of how selective tubular endosomal carriers form and detach from endosomes by fission, highlighting structural aspects, conceptual challenges and open questions. Endosomes function as sorting stations that segregate cargo proteins into endosomal carriers, enabling their distribution to subcellular target compartments. Increasingly detailed structural insights have revealed how proteins, such as sorting nexins, assemble on endosomal membranes to form a coat that facilitates the formation and detachment of tubular carriers.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Fundamentals of redox regulation in biology 作者更正：生物学中的氧化还原调节基础。
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-06-17 DOI: 10.1038/s41580-024-00754-8
Helmut Sies, Ryan J. Mailloux, Ursula Jakob
{"title":"Author Correction: Fundamentals of redox regulation in biology","authors":"Helmut Sies, Ryan J. Mailloux, Ursula Jakob","doi":"10.1038/s41580-024-00754-8","DOIUrl":"10.1038/s41580-024-00754-8","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":null,"pages":null},"PeriodicalIF":81.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00754-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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