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Telomere function and regulation from mouse models to human ageing and disease 从小鼠模型到人类衰老和疾病的端粒功能和调控
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-29 DOI: 10.1038/s41580-024-00800-5
Corey Jones-Weinert, Laura Mainz, Jan Karlseder
{"title":"Telomere function and regulation from mouse models to human ageing and disease","authors":"Corey Jones-Weinert, Laura Mainz, Jan Karlseder","doi":"10.1038/s41580-024-00800-5","DOIUrl":"10.1038/s41580-024-00800-5","url":null,"abstract":"Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When telomeres become critically short or damaged, a DNA damage response is activated. Telomeres then become dysfunctional and trigger cellular senescence or death. Telomere shortening occurs with ageing and may contribute to associated maladies such as infertility, neurodegeneration, cancer, lung dysfunction and haematopoiesis disorders. Telomere dysfunction (sometimes without shortening) is associated with various diseases, known as telomere biology disorders (also known as telomeropathies). Telomere biology disorders include dyskeratosis congenita, Høyeraal–Hreidarsson syndrome, Coats plus syndrome and Revesz syndrome. Although mouse models have been invaluable in advancing telomere research, full recapitulation of human telomere-related diseases in mice has been challenging, owing to key differences between the species. In this Review, we discuss telomere protection, maintenance and damage. We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human diseases and mouse models. Finally, we discuss recent efforts to generate new ‘humanized’ mouse models to better model human telomere biology. A better understanding of the limitations of mouse telomere models will pave the road for more human-like models and further our understanding of telomere biology disorders, which will contribute towards the development of new therapies. Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and mouse telomeres have key differences. This Review discusses telomere maintenance and damage, and recent efforts to generate ‘humanized’-telomere mouse models.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 4","pages":"297-313"},"PeriodicalIF":81.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three decades of protein-fragment complementation 蛋白质片段互补三十年
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-28 DOI: 10.1038/s41580-024-00813-0
Stephen W. Michnick
{"title":"Three decades of protein-fragment complementation","authors":"Stephen W. Michnick","doi":"10.1038/s41580-024-00813-0","DOIUrl":"10.1038/s41580-024-00813-0","url":null,"abstract":"This year marks the 30th anniversary of the publication of a novel approach to measuring protein–protein interactions (PPIs) in living cells, called the ubiquitin-based split-protein sensor (USPS), the inspiration for the protein-fragment complementation assays (PCAs) that followed. Here I provide a brief history of PCAs and discuss advances in their applications and possible future developments. Stephen Michnick provides a brief history of protein-fragment complementation — an approach to studying protein–protein interactions in living cells — and discusses advances in its applications and possible future developments.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"3-4"},"PeriodicalIF":81.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How proteins sense their cellular environment 蛋白质如何感知细胞环境
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-28 DOI: 10.1038/s41580-024-00812-1
Monika Fuxreiter
{"title":"How proteins sense their cellular environment","authors":"Monika Fuxreiter","doi":"10.1038/s41580-024-00812-1","DOIUrl":"10.1038/s41580-024-00812-1","url":null,"abstract":"The cellular environment is critical to protein function. How is information from many cellular components decoded in order to fine-tune biological activity? New models of biomolecular recognition raise the possibility that proteins engage in specific, yet fuzzy, interactions with their functional partners, which can provide a readout mechanism of the cellular context. Manipulating the cellular context to control protein function offers new therapeutic opportunities. In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing cellular environments.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 3","pages":"169-170"},"PeriodicalIF":81.3,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment 利用细胞周期依赖性去磷酸化实现有丝分裂特异性蛋白质招募
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-20 DOI: 10.1038/s41580-024-00808-x
Xiaofu Cao
{"title":"Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment","authors":"Xiaofu Cao","doi":"10.1038/s41580-024-00808-x","DOIUrl":"10.1038/s41580-024-00808-x","url":null,"abstract":"In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma membrane, exploiting the cell cycle’s natural regulation of PLEKHA5 phosphorylation.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"5-5"},"PeriodicalIF":81.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paleoproteomics sheds light on million-year-old fossils 古蛋白质组学揭示百万年前化石的奥秘
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-19 DOI: 10.1038/s41580-024-00803-2
Ryan Sinclair Paterson, Palesa Petunia Madupe, Enrico Cappellini
{"title":"Paleoproteomics sheds light on million-year-old fossils","authors":"Ryan Sinclair Paterson, Palesa Petunia Madupe, Enrico Cappellini","doi":"10.1038/s41580-024-00803-2","DOIUrl":"10.1038/s41580-024-00803-2","url":null,"abstract":"It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequencing of ancient proteins is currently the only viable methodology for retrieving the genetic data required to resolve evolutionary relations between vertebrate species that disappeared millions of years ago. Ancient proteins can provide phylogenetic information at a timescale that supersedes ancient DNA. Paleoproteomics could thus provide invaluable evolutionary insights, including into human evolution.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"1-2"},"PeriodicalIF":81.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting cells through TNT 通过 TNT 连接细胞
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-18 DOI: 10.1038/s41580-024-00811-2
Lisa Heinke
{"title":"Connecting cells through TNT","authors":"Lisa Heinke","doi":"10.1038/s41580-024-00811-2","DOIUrl":"10.1038/s41580-024-00811-2","url":null,"abstract":"Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in the zebrafish embryo, enabling the transport of proteins and organelles.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 1","pages":"6-6"},"PeriodicalIF":81.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA communication between organisms inspires innovative eco-friendly strategies for disease control 生物体之间的 RNA 通信激发了创新的生态友好型疾病控制策略
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-15 DOI: 10.1038/s41580-024-00807-y
Rachael Hamby, Qiang Cai, Hailing Jin
{"title":"RNA communication between organisms inspires innovative eco-friendly strategies for disease control","authors":"Rachael Hamby, Qiang Cai, Hailing Jin","doi":"10.1038/s41580-024-00807-y","DOIUrl":"10.1038/s41580-024-00807-y","url":null,"abstract":"Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secreted and trafficked and how they function within the recipient organisms remain unclear. Here, we discuss how understanding inter-organismal RNA communication can assist in disease management in both agriculture and medicine. Cross-species host–pathogen or mutualistic RNA communication, especially through extracellular vesicles, can have important applications, including gene silencing in agriculture and RNA-based therapeutics.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 2","pages":"81-82"},"PeriodicalIF":81.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grand roles for microproteins 微蛋白的巨大作用
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-14 DOI: 10.1038/s41580-024-00806-z
Valerie A. Tornini
{"title":"Grand roles for microproteins","authors":"Valerie A. Tornini","doi":"10.1038/s41580-024-00806-z","DOIUrl":"10.1038/s41580-024-00806-z","url":null,"abstract":"Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading frames, and highlights the potential for this research field in fundamental and clinical research.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 2","pages":"84-84"},"PeriodicalIF":81.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intraflagellar transport cycle 叶栅内运输循环
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-13 DOI: 10.1038/s41580-024-00797-x
Samuel E. Lacey, Gaia Pigino
{"title":"The intraflagellar transport cycle","authors":"Samuel E. Lacey, Gaia Pigino","doi":"10.1038/s41580-024-00797-x","DOIUrl":"10.1038/s41580-024-00797-x","url":null,"abstract":"Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intraflagellar transport (IFT) contributes to the formation of the highly specialized ciliary proteome by active and selective transport of soluble and membrane proteins into and out of cilia. IFT is performed by the IFT-A and IFT-B protein complexes, which together link cargoes to the microtubule motors kinesin and dynein. In this Review, we discuss recent structural and mechanistic insights on how the IFT complexes are first recruited to the base of the cilium, how they polymerize into an anterograde IFT train, and how this complex imports cargoes from the cytoplasm. We will describe insights into how kinesin-driven anterograde trains are carried to the ciliary tip, where they are remodelled into dynein-driven retrograde trains for cargo export. We will also present how the interplay between IFT-A and IFT-B complexes, motor proteins and cargo adaptors is regulated for bidirectional ciliary transport. Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facilitates cargo import, whereas remodelling into a retrograde train at the ciliary tip enables cargo export.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 3","pages":"175-192"},"PeriodicalIF":81.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies 作者更正：所有我们看不见的地方RNA 修饰研究中假阴性的来源与缓解
IF 81.3 1区 生物学
Nature Reviews Molecular Cell Biology Pub Date : 2024-11-12 DOI: 10.1038/s41580-024-00810-3
Shalini Oberdoerffer, Wendy V. Gilbert
{"title":"Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies","authors":"Shalini Oberdoerffer, Wendy V. Gilbert","doi":"10.1038/s41580-024-00810-3","DOIUrl":"10.1038/s41580-024-00810-3","url":null,"abstract":"","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 3","pages":"249-249"},"PeriodicalIF":81.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41580-024-00810-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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