Nature Reviews Molecular Cell Biology最新文献_第5页

The prompt to discover senolytics 发现老年痴呆症的提示

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-23 DOI: 10.1038/s41580-024-00795-z

James L. Kirkland

引用次数: 0

All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies 我们看不到的所有位点RNA 修饰研究中假阴性的来源与缓解

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-21 DOI: 10.1038/s41580-024-00784-2

Shalini Oberdoeffer, Wendy V. Gilbert

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引用次数: 0

Molecular mechanisms of mitochondrial dynamics 线粒体动力学的分子机制

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-17 DOI: 10.1038/s41580-024-00785-1

Luis-Carlos Tábara, Mayuko Segawa, Julien Prudent

{"title":"Molecular mechanisms of mitochondrial dynamics","authors":"Luis-Carlos Tábara, Mayuko Segawa, Julien Prudent","doi":"10.1038/s41580-024-00785-1","DOIUrl":"10.1038/s41580-024-00785-1","url":null,"abstract":"Mitochondria not only synthesize energy required for cellular functions but are also involved in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation and immunity. Mitochondria are dynamic organelles that undergo cycles of fission and fusion, and these transitions between fragmented and hyperfused networks ensure mitochondrial function, enabling adaptations to metabolic changes or cellular stress. Defects in mitochondrial morphology have been associated with numerous diseases, highlighting the importance of elucidating the molecular mechanisms regulating mitochondrial morphology. Here, we discuss recent structural insights into the assembly and mechanism of action of the core mitochondrial dynamics proteins, such as the dynamin-related protein 1 (DRP1) that controls division, and the mitofusins (MFN1 and MFN2) and optic atrophy 1 (OPA1) driving membrane fusion. Furthermore, we provide an updated view of the complex interplay between different proteins, lipids and organelles during the processes of mitochondrial membrane fusion and fission. Overall, we aim to present a valuable framework reflecting current perspectives on how mitochondrial membrane remodelling is regulated. Mitochondrial fusion and fission events are tightly regulated by core mitochondrial dynamics proteins. Recent structural and functional findings have characterized how these proteins interact with each other, with the mitochondrial membrane and with other organelles to guide membrane remodelling.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 2","pages":"123-146"},"PeriodicalIF":81.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Goodbye, senescent cells: CAR-T cells unleashed to fight ageing 再见了，衰老的细胞释放 CAR-T 细胞，对抗衰老

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-16 DOI: 10.1038/s41580-024-00792-2

Raffaella Di Micco

引用次数: 0

IL-11 as a master regulator of ageing IL-11 是衰老的主调节因子

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-16 DOI: 10.1038/s41580-024-00793-1

Ana O’Loghlen

引用次数: 0

Molecular tools for analysing in vivo senescence 分析体内衰老的分子工具

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-14 DOI: 10.1038/s41580-024-00790-4

Allison B. Herman, Myriam Gorospe

引用次数: 0

Mechanism and regulation of kinesin motors 驱动蛋白马达的机制与调控

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-11 DOI: 10.1038/s41580-024-00780-6

Ahmet Yildiz

{"title":"Mechanism and regulation of kinesin motors","authors":"Ahmet Yildiz","doi":"10.1038/s41580-024-00780-6","DOIUrl":"10.1038/s41580-024-00780-6","url":null,"abstract":"Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a characteristic motor domain that powers unidirectional motility and force generation along microtubules, and they possess unique tail domains that recruit accessory proteins and facilitate oligomerization, regulation and cargo recognition. The location, direction and timing of kinesin-driven processes are tightly regulated by various cofactors, adaptors, microtubule tracks and microtubule-associated proteins. This Review focuses on recent structural and functional studies that reveal how members of the kinesin superfamily use the energy of ATP hydrolysis to transport cargoes, depolymerize microtubules and regulate microtubule dynamics. I also survey how accessory proteins and post-translational modifications regulate the autoinhibition, cargo binding and motility of some of the best-studied kinesins. Despite much progress, the mechanism and regulation of kinesins are still emerging, and unresolved questions can now be tackled using newly developed approaches in biophysics and structural biology. Kinesin-mediated transport of intracellular cargo depends on finely tuned interactions between kinesin motor domains, microtubules and cofactors. Recent structural and functional insights are uncovering the mechanochemical cycle that drives kinesin motility, as well as the regulatory processes that modulate kinesin activity.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 2","pages":"86-103"},"PeriodicalIF":81.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The discovery of oncogene-induced senescence 发现癌基因诱导的衰老

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-09 DOI: 10.1038/s41580-024-00791-3

Akiko Takahashi

引用次数: 0

Following the electric current 跟随电流

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-10-04 DOI: 10.1038/s41580-024-00781-5

Elias H. Barriga

引用次数: 0

Sorting membrane proteins by size in the Golgi 在高尔基体中按大小对膜蛋白进行分类