Nature Reviews Molecular Cell Biology最新文献_第6页

N-glycan-dependent protein maturation and quality control in the ER 内质网中n-聚糖依赖蛋白的成熟和质量控制

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-19 DOI: 10.1038/s41580-025-00855-y

Kevin P. Guay, Wen-Chuan Chou, Nathan P. Canniff, Kylie B. Paul, Daniel N. Hebert

引用次数: 0

Mechanisms of auxin action in plant growth and development 生长素在植物生长发育中的作用机制

IF 90.2 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-19 DOI: 10.1038/s41580-025-00851-2

Steffen Vanneste, Yuanrong Pei, Jiří Friml

{"title":"Mechanisms of auxin action in plant growth and development","authors":"Steffen Vanneste, Yuanrong Pei, Jiří Friml","doi":"10.1038/s41580-025-00851-2","DOIUrl":"10.1038/s41580-025-00851-2","url":null,"abstract":"The phytohormone auxin is a major signal coordinating growth and development in plants. The variety of its effects arises from its ability to form local auxin maxima and gradients within tissues, generated through directional cell-to-cell transport and elaborate metabolic control. These auxin distribution patterns instruct cells in a context-dependent manner to undergo predefined developmental transitions. In this Review, we discuss advances in auxin action at the level of homeostasis and signalling. We highlight key insights into the structural basis of PIN-mediated intercellular auxin transport and explore two novel non-transcriptional auxin signalling mechanisms: one involving intracellular Ca2+ transients and another involving cell-surface auxin perception that mediates global, ultrafast phosphorylation. Furthermore, we examine emerging evidence indicating the involvement of cyclic adenosine monophosphate as a second messenger in the transcriptional auxin response. Together, these recent developments in auxin research have profoundly deepened our understanding of the complex and diverse activities of auxin in plant growth and development. The phytohormone auxin coordinates plant growth by forming local maxima and gradients through cell-to-cell transport and metabolic control. Recent research has identified novel signalling mechanisms involving extracellular auxin perception and auxin-mediated cyclic AMP production.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"648-666"},"PeriodicalIF":90.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular machineries shaping the mitochondrial inner membrane 形成线粒体内膜的分子机制

IF 90.2 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-14 DOI: 10.1038/s41580-025-00854-z

Oliver Daumke, Martin van der Laan

{"title":"Molecular machineries shaping the mitochondrial inner membrane","authors":"Oliver Daumke, Martin van der Laan","doi":"10.1038/s41580-025-00854-z","DOIUrl":"10.1038/s41580-025-00854-z","url":null,"abstract":"Mitochondria display intricately shaped deep invaginations of the mitochondrial inner membrane (MIM) termed cristae. This peculiar membrane architecture is essential for diverse mitochondrial functions, such as oxidative phosphorylation or the biosynthesis of cellular building blocks. Conserved protein nano-machineries such as F1Fo-ATP synthase oligomers and the mitochondrial contact site and cristae organizing system (MICOS) act as adaptable protein–lipid scaffolds controlling MIM biogenesis and its dynamic remodelling. Signal-dependent rearrangements of cristae architecture and MIM fusion events are governed by the dynamin-like GTPase optic atrophy 1 (OPA1). Recent groundbreaking structural insights into these nano-machineries have considerably advanced our understanding of the functional architecture of mitochondria. In this Review, we discuss how the MIM-shaping machineries cooperate to control cristae and crista junction dynamics, including MIM fusion, in response to cellular signalling pathways. We also explore how mutations affecting MIM-shaping machineries compromise mitochondrial functions. The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusion, and discusses recent structural insights that have increased our understanding of mitochondrial architecture.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 9","pages":"706-724"},"PeriodicalIF":90.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone H1 deamidation regulates DNA double-strand break repair 组蛋白H1脱酰胺调节DNA双链断裂修复

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-13 DOI: 10.1038/s41580-025-00860-1

Caroline Barranco

引用次数: 0

Fat accumulation in middle-aged male animals 中年雄性动物的脂肪积累

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-13 DOI: 10.1038/s41580-025-00861-0

Kim Baumann

引用次数: 0

Uncovering the complexity of RNA–protein interactions 揭示rna -蛋白质相互作用的复杂性

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-12 DOI: 10.1038/s41580-025-00859-8

Maïwen Caudron-Herger

引用次数: 0

The diffraction limit of light taken by storm 光的衍射极限。

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-05-06 DOI: 10.1038/s41580-025-00856-x

Maria Pia Cosma

引用次数: 0

An evolving landscape of PRC2–RNA interactions in chromatin regulation 染色质调控中PRC2-RNA相互作用的演变图景

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-30 DOI: 10.1038/s41580-025-00850-3

Rodrigo Aguilar, Michael Rosenberg, Vered Levy, Jeannie T. Lee

{"title":"An evolving landscape of PRC2–RNA interactions in chromatin regulation","authors":"Rodrigo Aguilar, Michael Rosenberg, Vered Levy, Jeannie T. Lee","doi":"10.1038/s41580-025-00850-3","DOIUrl":"10.1038/s41580-025-00850-3","url":null,"abstract":"A major unsolved problem in epigenetics is how RNA regulates Polycomb repressive complex 2 (PRC2), a complex that trimethylates histone H3 Lys27 (H3K27me3) to form repressive chromatin. Key questions include how PRC2 binds RNA in vivo and what the functional consequences of binding are. In this Perspective, we expound on the viewpoint that RNA is integral to the stepwise regulation of PRC2 activity. Using the long non-coding RNA XIST and X chromosome inactivation as a model, we discuss evidence indicating that RNA is involved in PRC2 recruitment onto chromatin, in induction of its catalytic activity and in its eviction from chromatin. Studies have also implicated RNA in controlling promoter-proximal pausing of RNA polymerase II. The cumulative data argue that the functional consequences of PRC2–RNA interactions crucially depend on RNA conformation. We recognize that alternative hypotheses exist and therefore we attempt to integrate contrary data. Thus, although an RNA-rich landscape is emerging for Polycomb complexes, additional work is required to resolve a broad range of data interpretations. This Perspective discusses unresolved questions about how the chromatin modifier Polycomb repressive complex 2 (PRC2) binds RNA in vivo and the functional consequences of binding. The authors posit that RNA conformation is integral to PRC2 control and thus to regulation of chromatin state.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"26 8","pages":"631-642"},"PeriodicalIF":81.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurons whisper, tissues respond: neurons as orchestrators of stress responses 神经元窃窃私语，组织作出反应：神经元作为应激反应的协调者

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-24 DOI: 10.1038/s41580-025-00853-0

Evandro A. De-Souza

引用次数: 0

Rapid evolution to preserve a conserved function 快速进化以保持不变的功能

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2025-04-11 DOI: 10.1038/s41580-025-00848-x

Mia T. Levine

引用次数: 0