Nature Reviews Molecular Cell Biology最新文献_第10页

Relaying gasdermin D to the membrane 将气敏素 D 转运到膜上

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-17 DOI: 10.1038/s41580-024-00737-9

Lisa Heinke

引用次数: 0

Early insights into co-translational assembly of protein complexes 对蛋白质复合物共翻译组装的初步认识

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-12 DOI: 10.1038/s41580-024-00728-w

Ayala Shiber

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In memoriam Judy Campisi: spreading cellular senescence 悼念朱迪-坎皮西：传播细胞衰老

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-12 DOI: 10.1038/s41580-024-00736-w

Fabrizio d’Adda di Fagagna

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Mechanical state transitions in the regulation of tissue form and function 调节组织形态和功能的机械状态转换

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-10 DOI: 10.1038/s41580-024-00719-x

Yanlan Mao, Sara A. Wickström

{"title":"Mechanical state transitions in the regulation of tissue form and function","authors":"Yanlan Mao, Sara A. Wickström","doi":"10.1038/s41580-024-00719-x","DOIUrl":"10.1038/s41580-024-00719-x","url":null,"abstract":"From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in genome activity, cell fate, proliferation, movement, metabolism and growth. Importantly, these biological state transitions are coupled to changes in the mechanical and material properties of cells and tissues, termed mechanical state transitions. These mechanical states share features with physical states of matter, liquids and solids. Tissues can switch between mechanical states by changing behavioural dynamics or connectivity between cells. Conversely, these changes in tissue mechanical properties are known to control cell and tissue function, most importantly the ability of cells to move or tissues to deform. Thus, tissue mechanical state transitions are implicated in transmitting information across biological length and time scales, especially during processes of early development, wound healing and diseases such as cancer. This Review will focus on the biological basis of tissue-scale mechanical state transitions, how they emerge from molecular and cellular interactions, and their roles in organismal development, homeostasis, regeneration and disease. Tissues undergo changes in their mechanical and material properties through alterations in cytoskeleton organization, extracellular matrix adhesion and cell–cell connectivity. These mechanical state transitions orchestrate cell proliferation and movement and tissue growth during development, in adult tissue repair and in disease contexts.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 8","pages":"654-670"},"PeriodicalIF":81.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140545123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling tauopathies 牛磺酸病建模

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-09 DOI: 10.1038/s41580-024-00734-y

Kim Baumann

引用次数: 0

A novel photosystem assembly line worker 新型光系统装配线工人

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-08 DOI: 10.1038/s41580-024-00732-0

Lisa Heinke

引用次数: 0

Fibroblast and myofibroblast activation in normal tissue repair and fibrosis 正常组织修复和纤维化过程中的成纤维细胞和肌成纤维细胞活化

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-08 DOI: 10.1038/s41580-024-00716-0

Fereshteh Sadat Younesi, Andrew E. Miller, Thomas H. Barker, Fabio M. V. Rossi, Boris Hinz

{"title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis","authors":"Fereshteh Sadat Younesi, Andrew E. Miller, Thomas H. Barker, Fabio M. V. Rossi, Boris Hinz","doi":"10.1038/s41580-024-00716-0","DOIUrl":"10.1038/s41580-024-00716-0","url":null,"abstract":"The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although phenotypically similar, these subpopulations are functionally distinct, maintaining tissue integrity and serving as local progenitor reservoirs. In response to tissue injury, these cells undergo a dynamic fibroblast–myofibroblast transition, marked by extracellular matrix secretion and contraction of actomyosin-based stress fibres. Importantly, whereas transient activation into myofibroblasts aids in tissue repair, persistent activation triggers pathological fibrosis. In this Review, we discuss the roles of mechanical cues, such as tissue stiffness and strain, alongside cell signalling pathways and extracellular matrix ligands in modulating myofibroblast activation and survival. We also highlight the role of epigenetic modifications and myofibroblast memory in physiological and pathological processes. Finally, we discuss potential strategies for therapeutically interfering with these factors and the associated signal transduction pathways to improve the outcome of dysregulated healing. Fibroblasts undergo transient activation into myofibroblasts to restore homeostasis to injured tissues. This Review explores the influence of mechanical cues and epigenetic modifications on (myo)fibroblast activation and memory and discusses potential therapeutic prevention of persistent myofibroblast activation in fibrosis.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 8","pages":"617-638"},"PeriodicalIF":81.3,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140538527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing transcription in real time 实时查看转录

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-05 DOI: 10.1038/s41580-024-00731-1

Tineke L. Lenstra

引用次数: 0

Opportunities and challenges in design and optimization of protein function 设计和优化蛋白质功能的机遇与挑战

IF 81.3 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-02 DOI: 10.1038/s41580-024-00718-y

Dina Listov, Casper A. Goverde, Bruno E. Correia, Sarel Jacob Fleishman

{"title":"Opportunities and challenges in design and optimization of protein function","authors":"Dina Listov, Casper A. Goverde, Bruno E. Correia, Sarel Jacob Fleishman","doi":"10.1038/s41580-024-00718-y","DOIUrl":"10.1038/s41580-024-00718-y","url":null,"abstract":"The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calculations, as well as machine learning tools, have dramatically improved protein engineering and design. In this Review, we discuss how these methods have enabled the design of increasingly complex structures and therapeutically relevant activities. Additionally, protein optimization methods have improved the stability and activity of complex eukaryotic proteins. Thanks to their increased reliability, computational design methods have been applied to improve therapeutics and enzymes for green chemistry and have generated vaccine antigens, antivirals and drug-delivery nano-vehicles. Moreover, the high success of design methods reflects an increased understanding of basic rules that govern the relationships among protein sequence, structure and function. However, de novo design is still limited mostly to α-helix bundles, restricting its potential to generate sophisticated enzymes and diverse protein and small-molecule binders. Designing complex protein structures is a challenging but necessary next step if we are to realize our objective of generating new-to-nature activities. Recent combinations of structure-based and sequence-based calculations and machine learning tools have dramatically improved protein engineering and design. Although designing complex protein structures remains challenging, these methods have enabled the design of therapeutically relevant activities, including vaccine antigens, antivirals and drug-delivery nano-vehicles.","PeriodicalId":19051,"journal":{"name":"Nature Reviews Molecular Cell Biology","volume":"25 8","pages":"639-653"},"PeriodicalIF":81.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How ancient RNA survives and what we can learn from it 古老的 RNA 是如何存活下来的，以及我们能从中学到什么。

IF 112.7 1区生物学

Nature Reviews Molecular Cell Biology Pub Date : 2024-03-28 DOI: 10.1038/s41580-024-00726-y

Marc R. Friedländer, M. Thomas P. Gilbert

引用次数: 0