Molecular machineries and pathways of mitochondrial protein transport

IF 81.3 1区 生物学 Q1 CELL BIOLOGY
Toshiya Endo, Nils Wiedemann
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引用次数: 0

Abstract

Mitochondria contain about 1,000–1,500 different proteins, most of which are encoded by the nuclear genome and synthesized in the cytosol, although a handful are specified by the mitochondrial DNA and translated within mitochondria. The coordinated transport of nucleus-encoded proteins into mitochondria, followed by their proper folding, assembly and/or integration into mitochondrial membranes, is central to mitochondrial biogenesis. In this Review, we describe the pathways and machineries for protein transport across and insertion into the inner and outer mitochondrial membranes, as well as the targeting and sorting signals, and energy requirements for these processes. These machineries include the TOM and SAM complexes in the outer membrane and the TIM complexes in the inner membrane, and some components in the intermembrane space. We emphasize recent developments in our understanding of the protein structures of the transport machineries and discuss mechanisms for the shift of protein localization and correction of mislocalization.

Abstract Image

线粒体蛋白转运的分子机制和途径
线粒体含有大约1000 - 1500种不同的蛋白质,其中大部分由核基因组编码并在细胞质中合成,尽管少数由线粒体DNA指定并在线粒体内翻译。核编码蛋白的协调运输进入线粒体,随后它们的适当折叠,组装和/或整合到线粒体膜,是线粒体生物发生的核心。在这篇综述中,我们描述了蛋白质转运和插入线粒体内外膜的途径和机制,以及这些过程的靶向和分选信号,以及能量需求。这些机制包括外膜上的TOM和SAM复合物和内膜上的TIM复合物,以及膜间空间的一些组分。我们强调了我们对转运机制的蛋白质结构的理解的最新进展,并讨论了蛋白质定位的转移和错误定位的纠正机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology 生物-细胞生物学
CiteScore
173.60
自引率
0.50%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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