Regulation of inflammatory processes by caspases

IF 90.2 1区 生物学 Q1 CELL BIOLOGY
Manuel Beltrán-Visiedo, Ruth Soler-Agesta, Kristopher A. Sarosiek, Douglas R. Green, Lorenzo Galluzzi
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Abstract

Historically, mammalian caspases (a group of cysteine proteases) have been catalogued into two main families based on major biological function: inflammatory caspases and apoptotic caspases. Accumulating evidence from preclinical models, however, argues against such a clearcut distinction, for two main reasons. First, at least in mammals, apoptotic caspases are generally dispensable for cells to succumb to apoptotic stimuli but instead regulate the kinetic and microenvironmental manifestations of the cellular demise in the context of a complex interplay with other cell death pathways. Second, most (if not all) mammalian caspases have evolved into positive or negative regulators of inflammatory processes, either directly or via their ability to control apoptotic and non-apoptotic cell death modalities. Here we discuss the molecular mechanisms through which mammalian caspases regulate inflammation, with emphasis on the ability of apoptotic caspases to suppress inflammatory responses in support of preserved organismal homeostasis.

Abstract Image

半胱天冬酶调节炎症过程
历史上,哺乳动物半胱天冬酶(一组半胱氨酸蛋白酶)根据主要的生物学功能被分为两大家族:炎症性半胱天冬酶和凋亡性半胱天冬酶。然而,从临床前模型中积累的证据反对这种明显的区别,主要有两个原因。首先,至少在哺乳动物中,凋亡半胱天酶对于细胞屈服于凋亡刺激通常是必不可少的,而是在与其他细胞死亡途径复杂相互作用的背景下调节细胞死亡的动力学和微环境表现。其次,大多数(如果不是全部的话)哺乳动物半胱天蛋白酶已经进化成炎症过程的积极或消极调节因子,直接或通过它们控制凋亡和非凋亡细胞死亡模式的能力。在这里,我们讨论了哺乳动物半胱天冬酶调节炎症的分子机制,重点讨论了凋亡的半胱天冬酶抑制炎症反应的能力,以支持保存的生物体稳态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology 生物-细胞生物学
CiteScore
173.60
自引率
0.50%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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