Nanomedicine : nanotechnology, biology, and medicine最新文献

{"title":"Corrigendum to “Functional engineered mesenchymal stem cells with fibronectin‑gold composite coated catheters for vascular tissue regeneration” [Nanomed: Nanotechnol Biol Med 14 (2018) 699–711]","authors":"Yun-Wen Chen , Shu-Chen Hsieh , Yi-Chin Yang , Shan-hui Hsu , Mei-Lang Kung , Pei-Ying Lin , Hsien-Hsu Hsieh , Ching-Hao Lin , Cheng-Ming Tang , Huey-Shan Hung","doi":"10.1016/j.nano.2026.102960","DOIUrl":"10.1016/j.nano.2026.102960","url":null,"abstract":"","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"74 ","pages":"Article 102960"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “the effects of TPGS-modified liposomal ginger extract in the treatment of acetic acid-induced ulcerative colitis in rats” [Nanomedicine: Nanotechnology, biology and medicine, volume 72, March 2026, 102903]","authors":"Zakieh Keshavarzi , Sonia Fathi-karkan , Ali Siahposht- Khachaki , Reza Kheirandish , Mohammad Hadi Nematollahi , Mohammad Amin Rajizadeh","doi":"10.1016/j.nano.2026.102911","DOIUrl":"10.1016/j.nano.2026.102911","url":null,"abstract":"","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"74 ","pages":"Article 102911"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A novel bidirectional perfusion-like administered system for NIR-II fluorescence imaging precision diagnosis of bladder cancer” [Nanomed Nanotechnol Biol Med 49 (April 2023) 102661]","authors":"Shilei Ren PhD , Rong Dai PhD , Ziliang Zheng PhD , Qin Liu PhD , Xiaochun Zheng MSc , Juan Li MSc , Shutong Wu MSc , Ruiping Zhang PhD , Zhiguo Gui PhD","doi":"10.1016/j.nano.2026.102916","DOIUrl":"10.1016/j.nano.2026.102916","url":null,"abstract":"","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"74 ","pages":"Article 102916"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles” [Nanomed Nanotechnol Biol Med 10.1016/j.nano.2016.11.019 [pubmed: 27979747 issn: 1549-9634]]","authors":"A.A. Ali , C.M. McCrudden , J. McCaffrey , J.W. McBride , G. Cole , N.J. Dunne , T. Robson , A. Kissenpfennig , R.F. Donnelly , H.O. McCarthy","doi":"10.1016/j.nano.2026.102932","DOIUrl":"10.1016/j.nano.2026.102932","url":null,"abstract":"","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"74 ","pages":"Article 102932"},"PeriodicalIF":4.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the anticancer potential of Amphiroa anceps: Folic acid-based liposomal nanocarriers for cancer cell killing in vitro","authors":"Gopalarethinam Janani ,&nbsp;Agnishwar Girigoswami ,&nbsp;Balasubramanian Deepika ,&nbsp;Saranya Udayakumar ,&nbsp;Devadass Jessy Mercy ,&nbsp;Koyeli Girigoswami","doi":"10.1016/j.nano.2026.102901","DOIUrl":"10.1016/j.nano.2026.102901","url":null,"abstract":"<div><div>Cancer continues to pose a significant global health issue, highlighting the demand for novel and targeted treatment options. This research explores the anticancer capabilities of folic acid conjugated liposomal nanoformulation of <em>Amphiroa ancep</em>s, a marine red alga to improve tumour specificity. <em>In vitro</em> tests revealed that the incorporation of folic acid substantially enhanced the effectiveness of tumour targeting, while biocompatibility assessments confirmed greater specificity for cancer cells compared to the extract without conjugation. <em>In vivo</em> studies showed that the formulation was safe at doses under 100 μg/mL. Furthermore, the chorioallantoic membrane (CAM) assay indicated the presence of anti-angiogenic properties, which were further amplified through folic acid conjugation, implying a potential role in obstructing the development of tumour vasculature. These results underscore the promise of <em>A. anceps</em> as a natural anticancer agent and highlight the benefits of folic acid-based targeting in enhancing therapeutic effectiveness.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102901"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoacoustic imaging and biodistribution analysis of trimethyl chitosan-stabilized ZnO nanoparticles embedded in nanofiber scaffolds for diabetic wound healing","authors":"Ankit Kumar Malik ,&nbsp;Pooja Goswami ,&nbsp;Vaishali ,&nbsp;Rajesh Saini ,&nbsp;Datta Maroti Pawde ,&nbsp;Aseem Setia ,&nbsp;Biplob Koch ,&nbsp;Madaswamy S. Muthu","doi":"10.1016/j.nano.2026.102908","DOIUrl":"10.1016/j.nano.2026.102908","url":null,"abstract":"<div><div>Chronic wounds associated with diabetes represent a persistent clinical challenge, primarily due to their delayed healing dynamics and heightened vulnerability to microbial invasion, which can precipitate serious adverse outcomes. In response to these issues, we have developed a nanofiber scaffold loaded with trimethyl chitosan-derived ZnO nanoparticles (ZnO-TMC-NPs-NFs) to enhance diabetic wound-healing therapy. The developed nanoparticle (ZnO-TMC-NPs) has a size of 16.1 ± 3.7 nm and a zeta potential of +26.3 ± 1.7 mV. Integration of ZnO-TMC-NPs into chitosan poly(vinyl-alcohol) nanofiber scaffolds was performed to develop nanoformulation ranging between 120 and 240 nm. Moreover, the robustness of this research is enhanced by <em>in vitro</em> cell line evaluations using L929 mouse fibroblast and A549 lung cancer cell lines, and by integrating <em>in vivo</em> optical modalities with advanced ultrasound/photoacoustic (PA) imaging. Collectively, the results underscore the therapeutic promise of this nanofibrous scaffold, particularly when functionalized with TMC-ZnO, as a viable intervention for diabetic wound management.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102908"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-enhanced approaches to stroke: Overcoming challenges in diagnosis and treatment","authors":"Yalda Yazdani ,&nbsp;Vahid Alivirdiloo ,&nbsp;Mobasher Hajiabbasi ,&nbsp;Mahya Mohammadi ,&nbsp;Somayye Hosseini ,&nbsp;Sogand Omidi Gargari ,&nbsp;Reza Kheradmand ,&nbsp;Faezeh Hatefnia ,&nbsp;Ahmad Mobed","doi":"10.1016/j.nano.2026.102909","DOIUrl":"10.1016/j.nano.2026.102909","url":null,"abstract":"<div><div>Nanoparticle-based drug delivery and molecular imaging methods offer promising advancements in the diagnosis and treatment of stroke, addressing key challenges such as the blood-brain barrier (BBB) and limited imaging resolution. Nanocarriers like PEGylated liposomes, exosomes, and polymeric nanoparticles have shown improved drug targeting, enhanced therapeutic efficacy, and reduced side effects in stroke treatment. In molecular imaging, nanoparticle-enhanced techniques, including PET, MRI, and CT, enable more precise detection of ischemic areas and thrombus formation, though limitations such as low signal sensitivity and poor tissue penetration persist. While these approaches demonstrate significant potential, challenges remain, including nanoparticle toxicity, imaging insensitivity, and the need for combination imaging methods. Looking ahead, future research should focus on overcoming these barriers through the development of multifunctional nanoparticles for theranostics, which combine drug delivery with real-time imaging. Further advancements in molecular imaging and personalized nanomedicine could enhance diagnostic accuracy and treatment personalization. With continued innovation, nanoparticle-based strategies could revolutionize stroke management, improving both therapeutic outcomes and diagnostic precision in clinical settings.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102909"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing curcumin bioavailability using bifunctional periodic mesoporous organosilica for pH-responsive anticancer drug delivery","authors":"Sedigheh Abedanzadeh ,&nbsp;Babak Karimi ,&nbsp;Omid Pourshiani ,&nbsp;Samira Sadat Abolmaali ,&nbsp;Jun Hong ,&nbsp;Ali A. Moosavi-Movahedi","doi":"10.1016/j.nano.2025.102898","DOIUrl":"10.1016/j.nano.2025.102898","url":null,"abstract":"<div><div>This research aimed to improve the bioavailability and anticancer efficacy of curcumin by leveraging the unique properties of bifunctional periodic mesoporous organosilica (BFPMO). The imidazolium and benzene organic moieties embedded in the pore walls of BFPMO, play dual supporting and stabilizing functions for curcumin without causing pore blockage, thereby facilitating high drug loading content (60 %) and excellent encapsulation efficiency (88 %). Comprehensive structural analyses (N₂ adsorption–desorption, FT-IR, TGA, HRTEM, FESEM, EDAX) confirmed successful curcumin immobilization. BFPMO demonstrated good hemocompatibility, and DPPH assays showed improved curcumin stability after encapsulation. <em>In vitro</em> release studies revealed a strong pH-responsive profile. CUR@BFPMO significantly reduced the viability of HEPG2 and A2780 cancer cells while exhibiting lower toxicity toward NIH-3T3 normal cells. Flow cytometry and fluorescence imaging indicated time-dependent apoptosis induction. These findings highlight the potential of BFPMO as a smart, biocompatible nanocarrier for curcumin delivery, offering improved bioavailability, pH-responsive release, and enhanced anticancer efficacy.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102898"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of TPGS-modified liposomal ginger extract in the treatment of acetic acid-induced ulcerative colitis in rats","authors":"Zakieh Keshavarzi ,&nbsp;Sonia Fathi-karkan ,&nbsp;Ali Siahposht- Khachaki ,&nbsp;Reza Kheirandish ,&nbsp;Mohammad Hadi Nematollahi ,&nbsp;Mohammad Amin Rajizadeh","doi":"10.1016/j.nano.2026.102903","DOIUrl":"10.1016/j.nano.2026.102903","url":null,"abstract":"<div><h3>Background</h3><div>Ulcerative colitis (UC) is a long-term inflammatory bowel disease that causes damage to the mucosa and oxidative stress. Natural substances, such as ginger extract, are known to have anti-inflammatory and antioxidant effects. However, the clinical effectiveness of active ingredients like ginger extract is limited by their low bioavailability. Liposomal drug delivery systems, especially those modified with D-α-tocopheryl polyethylene glycol succinate (TPGS), may enhance the stability and absorption of ginger, making it more effective as a medicinal agent. Since regular ginger extract doesn't work very well as a treatment, it's essential to develop and test new drug delivery systems, such as TPGS-modified liposomes, to enhance the outcomes of UC treatment.</div></div><div><h3>Methods</h3><div>A total of 54 male rats were utilized, randomly allocated into nine groups (number in each group = 6). Colitis was induced in rats through enemas containing a 4% solution of acetic acid. Four days post-induction of colitis, rats were administered simple, liposomal, and TPGS-modified liposomal forms of 100 and 300 mg/kg of alcoholic ginger extract intraperitoneally for five days.</div></div><div><h3>Results</h3><div>The results of this study showed that administration of liposomal forms of ginger extract reduced TNFα (<em>P</em> &lt; 0.001) and IL6 (<em>P</em> &lt; 0.001) levels in the colon tissue of rats. These compounds also increased SOD and catalase activity in the colon tissue and reduced NO levels. At the histological level, liposomal forms of ginger were also able to reduce tissue inflammation. Also, our results showed that the encapsulation efficiency of ginger extract was 73 ± 0.38%.</div></div><div><h3>Conclusion</h3><div>Overall, this research showed that following UC, the colon inflammation and oxidative stress were higher than the healthy animals. Also, the results of this study showed that administration of the liposomal and TPGS-modified liposome was able to exert strong anti-inflammatory and antioxidant effects compared to simple forms.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102903"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimizing systemic toxicity of doxorubicin via targeted delivery of hypoxia-sensitive polymersomes","authors":"Joanna Ciepła ,&nbsp;Katarzyna Jelonek ,&nbsp;Monika Musiał-Kulik ,&nbsp;Joanna Jaworska ,&nbsp;Justyna Czapla ,&nbsp;Alina Drzyzga ,&nbsp;Tomasz Cichoń ,&nbsp;Sybilla Matuszczak ,&nbsp;Ewelina Pilny ,&nbsp;Magdalena Jarosz-Biej ,&nbsp;Ryszard Smolarczyk","doi":"10.1016/j.nano.2026.102902","DOIUrl":"10.1016/j.nano.2026.102902","url":null,"abstract":"<div><div>Hypoxia is a hallmark of solid tumors that reduces chemotherapy efficacy and enhances systemic toxicity. This study evaluated hypoxia-sensitive polymersomes as a delivery system for doxorubicin (DOX) to improve antitumor efficacy and reduce side effects. Methods: Polymersomes were synthesized, loaded with DOX, and tested on cancer and healthy cells under normoxic and hypoxic conditions. Cytotoxicity, cellular uptake, apoptosis induction, and potential mechanism of degradation were assessed. <em>In vivo</em> efficacy was investigated in 4T1 tumor-bearing mice treated intravenously with free DOX or DOX-loaded hypoxia-sensitive polymersomes (three times 5 mg/kg). Tumor volume, body weight, histology, and immunochemistry were analyzed. <em>In vitro</em>, both free DOX and DOX-loaded polymersomes induced significant cytotoxicity and apoptosis. The effect was enhanced under hypoxia, consistent with elevated NQO1 expression. <em>In vivo</em>, both formulations suppressed tumor growth to a comparable degree; however, polymersome-treated mice exhibited markedly reduced weight loss, indicating lowered systemic toxicity. Histological examination showed extensive necrosis and architectural disruption in tumors from both treatment groups. Hypoxia-sensitive polymersomes effectively deliver doxorubicin to hypoxic regions, achieving tumor growth inhibition comparable to that of the free drug while reducing treatment-associated toxicity. These findings support encapsulated DOX as a promising strategy for safer chemotherapy in hypoxic cancers.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102902"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}