Nanomedicine : nanotechnology, biology, and medicine最新文献

{"title":"Dual PLGA nanoparticles co-encapsulating P5091 and Resveratrol synergistically target the USP7–MDM2–P53 axis for glioma therapy","authors":"Sunny Kumar,&nbsp;Mrinal K. Ghosh","doi":"10.1016/j.nano.2026.102990","DOIUrl":"10.1016/j.nano.2026.102990","url":null,"abstract":"<div><div>Glioma, a Grade-IV brain tumor, often exhibits functional suppression of P53 signaling due to aberrant stabilization of MDM2 by the deubiquitinase USP7, presenting a therapeutically exploitable vulnerability that remains under-utilised because of poor drug bioavailability and limited blood–brain barrier penetration. Here, we developed a rationally designed PLGA-based dual-loaded nanoformulation co-encapsulating USP7 inhibitor P5091 and P53-modulating polyphenol Resveratrol, to significantly attenuate the USP7–MDM2–P53 axis. Guided by synergy analysis, nanoparticles were formulated at an optimized molar ratio enabling controlled and sustained drug release with favourable physicochemical stability. Dual nanoencapsulation significantly enhanced synergistic cytotoxicity in glioma cells and 3D spheroids by inducing apoptosis through significant P53 restoration. Dual co-encapsulation improves pharmacokinetics and suppresses tumor growth with improved survival in orthotopic glioma model without any obvious vital organs histological damage. These findings highlight a mechanism-guided nanotherapeutic strategy for glioma treatment.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102990"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative polymer-based modalities for diabetic foot ulcers: From material design to clinical translation","authors":"Ankur Das,&nbsp;Madhulika Pradhan,&nbsp;Ajazuddin,&nbsp;Sanjay Kumar Gupta,&nbsp;Kushagra Nagori,&nbsp;Parag Jain,&nbsp;Mukesh Sharma,&nbsp;Krishna Yadav","doi":"10.1016/j.nano.2026.102988","DOIUrl":"10.1016/j.nano.2026.102988","url":null,"abstract":"<div><div>Diabetic foot ulcers (DFUs) cause one amputation every 20 s globally, driven by ischemia, dysregulated growth factors, recalcitrant biofilms, and oxidative stress that render conventional therapies ineffective. This review examines smart polymer dressings that actively sense pathological cues and respond with spatiotemporal precision. Natural polymers (chitosan, collagen, hyaluronic acid) provide biochemical signals for cell recruitment and angiogenesis, while synthetic polymers (Polylactic glycolic acid, Polycaprolactone, Polyethylene glycol) enable controlled degradation and drug release. Hybrid systems include glucose-responsive hydrogels, VEGF-loaded nanofibers for hypoxic zones, and microneedles that disrupt biofilms while delivering antimicrobials. In preclinical testing, these advanced dressings possess the capacity to achieve total wound closure in diabetic animal models. However, clinical translation is hindered by GMP manufacturing challenges, regulatory complexity, and cost barriers. This review analyses the state-of-the-art polymer design and engineering transforming passive dressings into active therapeutics and identifies critical gaps between laboratory breakthroughs and clinical implementation.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102988"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving landscape of osteoarthritis management: From conventional pharmacotherapy to gene therapy, stem cell therapy and nanotechnology-based therapeutics","authors":"Umme Jiba,&nbsp;Mohammad Arif Khan,&nbsp;Mohd Shahrukh,&nbsp;Mohammad Adil,&nbsp;Nazeer Hasan,&nbsp;Farhan Jalees Ahmad,&nbsp;Saima Amin","doi":"10.1016/j.nano.2026.102984","DOIUrl":"10.1016/j.nano.2026.102984","url":null,"abstract":"<div><div>Osteoarthritis (OA) is a primary contributor to long-term disability globally due to persistent cartilage degradation and joint inflammation. Global experts have focused their efforts on symptom management rather than addressing the underlying problem. The article elucidates the intricate pathophysiology of OA, demonstrating the progression of disease comprehension from mere mechanical injury to its contemporary recognition as an inflammatory condition. The article explores existing non-pharmacological and pharmacological treatment alternatives, emphasizing emerging medical solutions, including a shift from conventional therapeutics to nanotechnology, gene therapy, and stem cell therapy. Nanocarriers serve as an efficient mechanism that facilitates the delivery of pharmaceutical drugs and herbal drugs to their targeted site while safeguarding them from destruction. Various gene therapy strategies are currently being developed for therapeutic administration. The review anticipates that future OA therapies will develop into regenerative medical approaches including ancient herbal practices with modern nanotechnology and biotechnology advancements.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102984"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing imidazole capped laminin inspired peptide hydrogels in the presence of biologically relevant metal salts to fabricate advanced biofunctional scaffold for controlling cellular behaviour","authors":"Rakesh Kumar,&nbsp;Pooja Sharma,&nbsp;Sweta Mohanty,&nbsp;Sangita Roy","doi":"10.1016/j.nano.2026.102978","DOIUrl":"10.1016/j.nano.2026.102978","url":null,"abstract":"<div><div>Self-assembling peptides inspired from extracellular matrix (ECM) proteins provide a versatile platform for tissue engineering due to their biocompatible and biodegradable nature. Short oligopeptides can self-assemble into supramolecular hydrogels with nanofibrillar architecture supporting cellular adhesion and proliferation. Herein, we design a novel laminin-inspired peptide, Imidazole-Phe-Ser-Ile-Lys-Val-Ala-Val (Imi-FSIKVAV), which demonstrates the ability to self-assemble into nanofibers at physiological pH, aiming to improve hydrophilicity and biocompatibility. The incorporation of imidazole, a common motif in biomolecules like histidine, introduces binding sites for metal ion coordination. Our findings indicate that the addition of biologically relevant metal ions such as Ca²⁺ or Mg²⁺ significantly improves the self-assembling propensity, resulting in the formation of dense nanostructured hydrogel. These metal-ion coordinated hydrogels exhibit superior mechanical properties and support the cellular adhesion and proliferation of neuroblastoma cells. By leveraging the unique interactions between peptides and metal ions, we can create advanced materials that can not only mimic the structural characteristics of the natural ECM but can also promote cellular functions necessary for tissue repair and regeneration. Our research highlights the potential of metal-ion-mediated peptide self-assembly as a strategy for designing innovative biomaterials suitable for diverse biomedical applications, paving the way for future advancements in tissue engineering and regenerative therapies.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102978"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluvastatin-loaded chitosan-coated transfersomes for tumor-targeted nanotheranostics: Optimization, in-vitro cytotoxicity, and in-vivo radiokinetic evaluation","authors":"Khaled M. Attallah,&nbsp;Marwa Eid Sayyed,&nbsp;Shymaa Hatem","doi":"10.1016/j.nano.2026.102989","DOIUrl":"10.1016/j.nano.2026.102989","url":null,"abstract":"<div><div>This study focused on developing chitosan-coated fluvastatin (FLU)-loaded transfersomes (TFs) as a nanovesicular system for tumor targeting and <em>in-vivo</em> tracking using technetium-99 m. The vesicles were prepared, characterized, and tested for cytotoxicity on breast cancer cell lines. TFs showed nanoscale size (256.70–646.70 nm), high entrapment efficiency (39.80–72.45%), and good stability. Chitosan coating imparted a positive surface charge, enhancing efficacy, while sustained drug release over 24 h and high deformability were observed. Radiolabeling efficiency reached 96.5 ± 1% with favorable stability. <em>In-vivo</em> biodistribution studies revealed a 4.6-fold increase in tumor uptake compared to FLU solution, and pharmacokinetic analysis demonstrated higher C_max and AUC values, indicating improved systemic exposure. Enhanced cytotoxicity was confirmed in both tested breast cancer cell lines. These findings suggest that chitosan-coated FLU-TFs represent a promising platform for targeted drug delivery and radiokinetic imaging in solid tumors, though further validation in breast cancer-specific <em>in-vivo</em> models is required.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102989"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano formulated daidzein and genistein as a multi-targeted therapeutic strategy for letrozole-induced PCOS in rats","authors":"Neelam L. Dashputre,&nbsp;Umesh D. Laddha,&nbsp;Nayana K. Patil,&nbsp;Vishal D. Dhopare","doi":"10.1016/j.nano.2026.102975","DOIUrl":"10.1016/j.nano.2026.102975","url":null,"abstract":"<div><h3>Background</h3><div>The common endocrine disorder characterised by metabolic abnormalities, hyperandrogenism, and ovulatory dysfunction is polycystic ovary syndrome (PCOS). Natural phytoestrogens like Daidzein and Genistein show promise in modulating PCOS-related pathologies, but their clinical utility is limited by poor bioavailability.</div></div><div><h3>Objectives</h3><div>This study aimed to develop and evaluate nanoparticle (NP)-based formulations of Daidzein and Genistein to improve their therapeutic efficacy in a letrozole-induced PCOS rat model.</div></div><div><h3>Methods</h3><div>Daidzein and Genistein nanoparticles (NPs) were prepared using a single-emulsion solvent evaporation technique and optimised through a 3² full factorial design. Physicochemical characterisation included FTIR, DSC, XRD, particle size, zeta potential, and FE-SEM analyses. PCOS was induced in female Wistar rats using letrozole, followed by oral administration of combined Daidzein-Genistein nanoformulations at low (25 mg/kg) and high (50 mg/kg) doses for 35 days. Animals were divided into naïve control, PCOS control, standard treatment (Clomiphene citrate), and treatment groups. Therapeutic efficacy was evaluated by assessing oestrous cyclicity, body and ovarian weight, hormonal and lipid profiles, oral glucose tolerance, oxidative stress markers, pro-inflammatory cytokines, and ovarian histopathology.</div></div><div><h3>Results</h3><div>Optimised NPs demonstrated particle sizes of 198–450 nm and &gt;90% entrapment efficiency. NP-treated groups showed significant restoration of oestrous cycles, reduced body and ovarian weight, and normalised hormone levels (LH, FSH, E2, TTST). There were notable improvements in insulin sensitivity, glucose tolerance, and lipid profiles. Markers of oxidative stress and inflammation, such as GSH, SOD, CAT, MDA, IL-6, and TNF-α, were modulated, while antioxidant enzymes and key regulators (SIRT1, PGC-1α) were upregulated. Histopathology confirmed improved follicular architecture.</div></div><div><h3>Conclusion</h3><div>Daidzein and Genistein NPs offer a potent, multi-targeted therapy for PCOS, outperforming plain drug formulations and demonstrating efficacy comparable to standard treatment. Nanotechnology-based delivery significantly enhances the bioefficacy of natural isoflavones, supporting their potential in PCOS management.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102975"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHP/MMP2 dual-targeting soft mesoporous organosilica nanoparticles loaded with losartan for modulating cardiac fibrosis","authors":"Qing Yang,&nbsp;Shilin Zhang,&nbsp;Meng Dang,&nbsp;Cynthia Taub,&nbsp;Christopher Lee,&nbsp;Fen Chen,&nbsp;Zhaogang Teng,&nbsp;Jing Yao","doi":"10.1016/j.nano.2026.102974","DOIUrl":"10.1016/j.nano.2026.102974","url":null,"abstract":"<div><div>Myocardial fibrosis (MF) drives heart failure and arrhythmias, yet drug delivery to injured myocardium is hindered by the dynamic cardiac microenvironment and lack of lesion-specific targeting. Here, we developed a dual-targeted, soft mesoporous organosilica nanoparticles (SMONs) system, which were co-functionalized with a cardiac homing peptide (CHP) and an anti-matrix metalloproteinase 2 antibody (Ab-MMP 2) for the delivery of losartan (LOS). LOS@SMONs-CHP/MMP2 exhibited excellent deformability and outstanding cellular uptake capability. In a murine model of isoproterenol (ISO)-induced myocardial fibrosis, LOS@SMONs-CHP/MMP2 exhibited significantly increased accumulation of fibrosis. <em>In vitro</em> treatment with these nanoparticles potently suppressed cardiac fibroblast activation, proliferation and migration, and markedly reduced collagen deposition and expression of fibrotic markers <em>in vivo</em>. Consequently, cardiac systolic function was substantially improved, outperforming free losartan. Comprehensive biosafety evaluations confirmed minimal cytotoxicity and no acute organ toxicity. This study offering a promising and translatable nano platform for the treatment of cardiac fibrosis.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102974"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers","authors":"Marie BOLON,&nbsp;Audrey BARBEREAU,&nbsp;Mélanie AIMARD,&nbsp;Claire MONGE,&nbsp;Pauline BOUVET,&nbsp;Claire MEISSIREL,&nbsp;Sophie RICHARD","doi":"10.1016/j.nano.2026.102987","DOIUrl":"10.1016/j.nano.2026.102987","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease, characterized by a progressive cognitive decline, represents a major global health challenge. A novel blocking peptide (seq: KRKKSRYKSWSVYVG) which binds with high affinity for toxic amyloid beta oligomers implicated in the early stages of the disease pathogenesis, has shown promising therapeutic potential. To overcome the challenges of brain drug delivery, nanoparticles combined with a nose-to-brain delivery approach were used to enhance brain biodistribution and drug delivery efficiency. In this study, we evaluated the feasibility of using these nanoparticles to deliver the blocking peptide to the brain.</div></div><div><h3>Results</h3><div>Nanoparticles composed of polylactic acid and poloxamer P188 were synthesized and successfully functionalised with surface-adsorbed blocking peptide, exhibiting physicochemical characteristics suitable for nose-to-brain delivery. The nanoparticles preserved the blocking peptide therapeutic activity against amyloid beta aggregation and, in addition, protected it from enzymatic degradation. Functional cellular evaluation showed biocompatibility of the nanoparticle-blocking peptide compound and potential internalization by neuronal cells. Importantly, <em>in vivo</em> experiments demonstrated the successful delivery of the nanoparticles from the nasal cavity to the brain, representing a significant step forward in targeted brain delivery.</div></div><div><h3>Conclusion</h3><div>Nanoparticles functionalised with an anti-amyloid beta aggregation peptide successfully reached the brain following intranasal administration, suggesting their potential as a therapeutic strategy against the Alzheimer's disease.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102987"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanin chelating zinc ions for NIR-I photoacoustic imaging-guided photothermal-pyroptosis therapy of breast cancer","authors":"Wenwen Cai,&nbsp;Chenyao Song,&nbsp;Jie Dong,&nbsp;Xinyu Guo,&nbsp;Peng Yang,&nbsp;Xuhui Zhao,&nbsp;Ruiping Zhang","doi":"10.1016/j.nano.2026.102973","DOIUrl":"10.1016/j.nano.2026.102973","url":null,"abstract":"<div><div>Melanin nanoparticles (MNPs), as an endogenous pigment, boasts excellent biocompatibility, multifunctional properties including photothermal conversion and radical scavenging, which exhibit broad potential for transformative biomedical applications. MNPs modified with polyethylene glycol-amine (PEG-NH₂) exhibit superior near-infrared (NIR) absorption and stable photothermal performance. In this study, we designed and fabricated a melanin‑zinc ion chelation nanoplatform (MNP-Zn NPs). MNP-Zn NPs possessed ultrasmall size, PAI but also demonstrated high photothermal conversion efficiency under near infrared irradiation. Mechanistically, the system activated the Caspase 1/gasdermin D (GSDMD) pathway to trigger pyroptosis. This platform achieves highly efficient anti-tumor effects through the synergistic action of the photothermal effect of melanin and zinc ion-mediated pyroptosis. <em>In vivo</em> animal experiments demonstrated that MNP-Zn NPs possess excellent biocompatibility and can effectively induce tumor cell death under NIR excitation.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102973"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dihydroartemisinin-stachyose conjugate (sDHA) improves the oral bioavailability of dihydroartemisinin and antiemphalitic malaria effects","authors":"Wen Zhao,&nbsp;Jun Wang,&nbsp;Xiao-yue Du,&nbsp;Meng-ke Xie,&nbsp;Xiu-hua Zhao","doi":"10.1016/j.nano.2026.102982","DOIUrl":"10.1016/j.nano.2026.102982","url":null,"abstract":"<div><div>A dihydroartemisinin (DHA)–stachyose conjugate (sDHA) was synthesized via succinate ester linkage to enhance solubility and anti-cerebral malaria efficacy. Structural characterization (FT-IR, ¹H NMR) confirmed a 1:1 M ratio. sDHA exhibited 55, 86, and 66 fold higher saturated solubility in water, simulated gastric fluid, and intestinal fluid (4.68 ± 0.36, 13.74 ± 1.07, and 10.62 ± 0.78 mg/mL) than free DHA, with a critical micelle concentration of 1.91 ± 0.32 mg/mL. In rats, oral sDHA achieved a 3.71-fold higher <em>AUC</em>_{<em>0-12h</em>}(14.56 ± 1.23 vs. 3.93 ± 0.41 μg·h/mL) and 2.75-fold longer absorption half-life (<em>t</em>_{<em>1/2α</em>}: 3.37 ± 0.28 vs. 1.22 ± 0.15 h) versus DHA. In Plasmodium-infected mice, high-dose sDHA reduced parasitemia by 60% versus controls, lowered mortality by 33%–40%, extended survival by 26%–50%, and alleviated neurobehavioral deficits. This excipient-free oligosaccharide conjugate offers a translatable strategy for improving BCS IV antimalarial drugs.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"75 ","pages":"Article 102982"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}