Nanomedicine : nanotechnology, biology, and medicine最新文献_第10页

Incorporation of glycyrrhizic acid and polyene phosphatidylcholine in lipid nanoparticles ameliorates acute liver injury via delivering p65 siRNA. 在脂质纳米颗粒中掺入甘草酸和多烯磷脂酰胆碱可通过传递p65 siRNA改善急性肝损伤。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-12-01 DOI: 10.2139/ssrn.4096906

Qiming Yin, Xiangling Song, Peng-fei Yang, Wen Yang, Xinyu Li, Xuejun Wang, Shengnan Wang

引用次数: 3

Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens. 具有支链脂肪烃成孔剂的多孔层状微球的研制。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-12-01 DOI: 10.2139/ssrn.4189034

Farah Shahjin, Milankumar Patel, Mahmudul Hasan, Jacob D. Cohen, Farhana Islam, Md Ashaduzzaman, Mohammad Ullah Nayan, Mahadevan Subramaniam, You Zhou, Irene Andreu, H. Gendelman, B. Kevadiya

引用次数: 0

Cell membrane-camouflaged liposomes and neopeptide-loaded liposomes with TLR agonist R848 provides a prime and boost strategy for efficient personalized cancer vaccine therapy. TLR激动剂R848的细胞膜伪装脂质体和新肽负载脂质体为有效的个性化癌症疫苗治疗提供了一种主要和促进策略。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-12-01 DOI: 10.2139/ssrn.4251197

Lu Shi, H. Gu

{"title":"Cell membrane-camouflaged liposomes and neopeptide-loaded liposomes with TLR agonist R848 provides a prime and boost strategy for efficient personalized cancer vaccine therapy.","authors":"Lu Shi, H. Gu","doi":"10.2139/ssrn.4251197","DOIUrl":"https://doi.org/10.2139/ssrn.4251197","url":null,"abstract":"Recent advances in bioinformatics and nanotechnology offer great opportunities for personalized cancer vaccine development. However, the timely identification of neoantigens and unsatisfactory efficacy of therapeutic cancer vaccines remain two obstacles for clinical transformation. We propose a \"prime and boost\" strategy to facilitate neoantigen-based immunotherapy. To prime the immune system, we first constructed personalized liposomes with cancer cell membranes and adjuvant R848 to provide immunostimulatory efficacy and time for identifying tumor antigens. Liposomes loaded with personalized neopeptides and adjuvants were used to boost the immune response. In vitro experiments verified potent immune responses, including macrophage polarization, dendritic cell maturation, and T lymphocyte activation. In vivo B16F10 and TC-1 cancer model were used to investigate efficient tumor growth suppression. Liposomal vaccines with neopeptides could stimulate human dendritic cells and T lymphocytes in vitro. These results demonstrate that the \"prime and boost\" strategy provides simple, quick, and efficient personalized vaccines for cancer therapy.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88067350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets. 使用装载智能甲氨蝶呤的全氟己烷纳米液滴的超声引导乳腺癌放化疗。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-12-01 DOI: 10.2139/ssrn.4210211

R. K. Samani, Fatemeh Maghsoudinia, Fatemeh Mehradnia, S. Hejazi, M. Saeb, Tayebe Sobhani, Zohreh Farahbakhsh, M. Mehrgardi, M. Tavakoli

{"title":"Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets.","authors":"R. K. Samani, Fatemeh Maghsoudinia, Fatemeh Mehradnia, S. Hejazi, M. Saeb, Tayebe Sobhani, Zohreh Farahbakhsh, M. Mehrgardi, M. Tavakoli","doi":"10.2139/ssrn.4210211","DOIUrl":"https://doi.org/10.2139/ssrn.4210211","url":null,"abstract":"Chemoradiotherapy with controlled-release nanocarriers such as sono-sensitive nanodroplets (NDs) can enhance the anticancer activity of chemotherapy medicines and reduces normal tissue side effects. In this study, folic acid-functionalized methotrexate-loaded perfluorohexane NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated in vitro and in vivo. The cancer cell (4T1) viabilities and surviving fractions after NDs and ultrasound treatments were significantly decreased. However, this reduction was much more significant for ultrasound in combination with X-ray irradiation. The in vitro and in vivo results confirmed that MTX-loaded NDs are highly biocompatible and they have no significant hemolytic activity and organ toxicity. Furthermore, the in vivo results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. In conclusion, FA-functionalized MTX/PFH@alginate NDs have a great theranostic performance for ultrasound-controlled drug delivery in combination with radiotherapy of breast cancer.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76743569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Isolation-free measurement of single urinary extracellular vesicles by imaging flow cytometry. 成像流式细胞术对单个尿细胞外囊泡的无隔离测定。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-12-01 DOI: 10.2139/ssrn.4240649

Liang Wu, W. Woud, C. Baan, D. Hesselink, E. van der Pol, G. Jenster, K. Boer

引用次数: 3

Muscle cytotoxicity and immuno-reactivity analysis of the porous carbon nanospheres fabricated by high temperature calcination. 高温煅烧制备多孔碳纳米球的肌肉细胞毒性和免疫反应性分析。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-11-01 DOI: 10.2139/ssrn.4182790

Jingwen Huang, Xiaoting Jian, Mengmeng Xu, Han Wang, Zhaohong Liao, Hai-ying Lan, Linge Wang, Jijie Hu, Qianqian Yu, Hua Liao

{"title":"Muscle cytotoxicity and immuno-reactivity analysis of the porous carbon nanospheres fabricated by high temperature calcination.","authors":"Jingwen Huang, Xiaoting Jian, Mengmeng Xu, Han Wang, Zhaohong Liao, Hai-ying Lan, Linge Wang, Jijie Hu, Qianqian Yu, Hua Liao","doi":"10.2139/ssrn.4182790","DOIUrl":"https://doi.org/10.2139/ssrn.4182790","url":null,"abstract":"Carbon-based nanomaterials have a high specific surface area, biocompatibility, and controlled mesopore structures. These characteristics make carbon nanospheres excellent carriers for drugs, biological dyes, photosensitizers, etc. Nevertheless, little is known about the impact of topological features on the surface of carbon nanomaterials on their in vivo immunoreactivity. In this study, we fabricated mesoporous carbon nanoparticles (MCNs) and solvent-processable carbon vesicles (CVs) by high-temperature calcination. The hematoxylin and eosin (H&E) staining suggested CVs' relatively poor dispersion capacity compared to MCNs and carbon precursors (CPs), leading to more severe muscle inflammation and necrosis. Immunostaining and Fluorescence Activated Cell Sorter (FACS) analysis further showed that both MCNs and CVs triggered a transient immune response in transplanted muscle and muscle-draining lymph nodes, but did not alter muscle resistance to exogenous viruses. In conclusion, this study provides insights into how carbon nanoparticles modulate the activation of immune responses in vivo.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80305020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combinational chemo-immune therapy using outer membrane vesicles for enhanced cancer therapy by RGD targeting. 利用外膜囊泡的组合化疗免疫疗法，通过 RGD 靶向增强癌症治疗。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-10-15 DOI: 10.1016/j.nano.2022.102610

Shuping Li, Xiaodong Gao

引用次数: 0

A combinational chemo-immune therapy using outer membrane vesicles for enhanced cancer therapy by RGD targeting. 一种利用外膜囊泡增强肿瘤RGD靶向治疗的化学免疫联合疗法。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-10-01 DOI: 10.2139/ssrn.4156334

Shuping Li, Xiaodong Gao

引用次数: 1

Multifunctional nanoprobe for real-time in vivo monitoring of T cell activation. 实时监测T细胞活化的多功能纳米探针。

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-08-01 DOI: 10.2139/ssrn.4094098

O. Betzer, Yue Gao, Astar Shamul, M. Motiei, T. Sadan, R. Yehuda, Ayelet Atkins, C. Cohen, Mingwu Shen, Xiangyang Shi, R. Popovtzer

{"title":"Multifunctional nanoprobe for real-time in vivo monitoring of T cell activation.","authors":"O. Betzer, Yue Gao, Astar Shamul, M. Motiei, T. Sadan, R. Yehuda, Ayelet Atkins, C. Cohen, Mingwu Shen, Xiangyang Shi, R. Popovtzer","doi":"10.2139/ssrn.4094098","DOIUrl":"https://doi.org/10.2139/ssrn.4094098","url":null,"abstract":"Genetically engineered T cells are a powerful new modality for cancer immunotherapy. However, their clinical application for solid tumors is challenging, and crucial knowledge on cell functionality in vivo is lacking. Here, we fabricated a nanoprobe composed of dendrimers incorporating a calcium sensor and gold nanoparticles, for dual-modal monitoring of engineered T cells within a solid tumor. T cells engineered to express a melanoma-specific T-cell receptor and loaded with the nanoprobe were longitudinally monitored within melanoma xenografts in mice. Fluorescent imaging of the nanoprobe's calcium sensor revealed increased intra-tumoral activation of the T cells over time, up to 24 h. Computed tomography imaging of the nanoprobe's gold nanoparticles revealed the cells' intra-tumoral distribution pattern. Quantitative analysis revealed the intra-tumoral T cell quantities. Thus, this nanoprobe reveals intra-tumoral persistence, penetration and functional status of genetically engineered T cells, which can advance T cell-based immunotherapy and promote next-generation live cell imaging.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76725367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerium dioxide, a Jekyll and Hyde nanomaterial, can increase basal and decrease elevated inflammation and oxidative stress 二氧化铈是一种具有双重人格的纳米材料，可以增加和减少炎症和氧化应激

IF 5.4 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2022-07-01 DOI: 10.1016/j.nano.2022.102565

Robert A. Yokel PhD , Marsha L. Ensor MSc , Hemendra J. Vekaria PhD , Patrick G. Sullivan PhD , David J. Feola PharmD, PhD , Arnold Stromberg PhD , Michael T. Tseng PhD , Douglas A. Harrison PhD

{"title":"Cerium dioxide, a Jekyll and Hyde nanomaterial, can increase basal and decrease elevated inflammation and oxidative stress","authors":"Robert A. Yokel PhD , Marsha L. Ensor MSc , Hemendra J. Vekaria PhD , Patrick G. Sullivan PhD , David J. Feola PharmD, PhD , Arnold Stromberg PhD , Michael T. Tseng PhD , Douglas A. Harrison PhD","doi":"10.1016/j.nano.2022.102565","DOIUrl":"10.1016/j.nano.2022.102565","url":null,"abstract":"<div>It was hypothesized that the catalyst nanoceria can increase inflammation/oxidative stress from the basal and reduce it from the elevated state. Macrophages clear nanoceria. To test the hypothesis, M0 (non-polarized), M1- (classically activated, pro-inflammatory), and M2-like (alternatively activated, regulatory phenotype) RAW 264.7 macrophages were nanoceria exposed. Inflammatory responses were quantified by IL-1β level, arginase activity, and RT-qPCR and metabolic changes and oxidative stress by the mito and glycolysis stress tests (MST and GST). Morphology was determined by light microscopy, macrophage phenotype marker expression, and a novel three-dimensional immunohistochemical method. Nanoceria blocked IL-1β and arginase effects, increased M0 cell OCR and GST toward the M2 phenotype and altered multiple M1- and M2-like cell endpoints toward the M0 level. M1-like cells had greater volume and less circularity/roundness. M2-like cells had greater volume than M0 macrophages. The results are overall consistent with the hypothesis.</div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89820938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3