Nanomedicine : nanotechnology, biology, and medicine最新文献

{"title":"Corrigendum to \"DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles\" [Nanomed Nanotechnol Biol Med 10.1016/j.nano.2016.11.019 [pubmed: 27979747 issn: 1549-9634]].","authors":"A A Ali, C M McCrudden, J McCaffrey, J W McBride, G Cole, N J Dunne, T Robson, A Kissenpfennig, R F Donnelly, H O McCarthy","doi":"10.1016/j.nano.2026.102932","DOIUrl":"https://doi.org/10.1016/j.nano.2026.102932","url":null,"abstract":"","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102932"},"PeriodicalIF":4.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the anticancer potential of Amphiroa anceps: Folic acid-based liposomal nanocarriers for cancer cell killing in vitro","authors":"Gopalarethinam Janani ,&nbsp;Agnishwar Girigoswami ,&nbsp;Balasubramanian Deepika ,&nbsp;Saranya Udayakumar ,&nbsp;Devadass Jessy Mercy ,&nbsp;Koyeli Girigoswami","doi":"10.1016/j.nano.2026.102901","DOIUrl":"10.1016/j.nano.2026.102901","url":null,"abstract":"<div><div>Cancer continues to pose a significant global health issue, highlighting the demand for novel and targeted treatment options. This research explores the anticancer capabilities of folic acid conjugated liposomal nanoformulation of <em>Amphiroa ancep</em>s, a marine red alga to improve tumour specificity. <em>In vitro</em> tests revealed that the incorporation of folic acid substantially enhanced the effectiveness of tumour targeting, while biocompatibility assessments confirmed greater specificity for cancer cells compared to the extract without conjugation. <em>In vivo</em> studies showed that the formulation was safe at doses under 100 μg/mL. Furthermore, the chorioallantoic membrane (CAM) assay indicated the presence of anti-angiogenic properties, which were further amplified through folic acid conjugation, implying a potential role in obstructing the development of tumour vasculature. These results underscore the promise of <em>A. anceps</em> as a natural anticancer agent and highlight the benefits of folic acid-based targeting in enhancing therapeutic effectiveness.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102901"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoacoustic imaging and biodistribution analysis of trimethyl chitosan-stabilized ZnO nanoparticles embedded in nanofiber scaffolds for diabetic wound healing","authors":"Ankit Kumar Malik ,&nbsp;Pooja Goswami ,&nbsp;Vaishali ,&nbsp;Rajesh Saini ,&nbsp;Datta Maroti Pawde ,&nbsp;Aseem Setia ,&nbsp;Biplob Koch ,&nbsp;Madaswamy S. Muthu","doi":"10.1016/j.nano.2026.102908","DOIUrl":"10.1016/j.nano.2026.102908","url":null,"abstract":"<div><div>Chronic wounds associated with diabetes represent a persistent clinical challenge, primarily due to their delayed healing dynamics and heightened vulnerability to microbial invasion, which can precipitate serious adverse outcomes. In response to these issues, we have developed a nanofiber scaffold loaded with trimethyl chitosan-derived ZnO nanoparticles (ZnO-TMC-NPs-NFs) to enhance diabetic wound-healing therapy. The developed nanoparticle (ZnO-TMC-NPs) has a size of 16.1 ± 3.7 nm and a zeta potential of +26.3 ± 1.7 mV. Integration of ZnO-TMC-NPs into chitosan poly(vinyl-alcohol) nanofiber scaffolds was performed to develop nanoformulation ranging between 120 and 240 nm. Moreover, the robustness of this research is enhanced by <em>in vitro</em> cell line evaluations using L929 mouse fibroblast and A549 lung cancer cell lines, and by integrating <em>in vivo</em> optical modalities with advanced ultrasound/photoacoustic (PA) imaging. Collectively, the results underscore the therapeutic promise of this nanofibrous scaffold, particularly when functionalized with TMC-ZnO, as a viable intervention for diabetic wound management.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102908"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-enhanced approaches to stroke: Overcoming challenges in diagnosis and treatment","authors":"Yalda Yazdani ,&nbsp;Vahid Alivirdiloo ,&nbsp;Mobasher Hajiabbasi ,&nbsp;Mahya Mohammadi ,&nbsp;Somayye Hosseini ,&nbsp;Sogand Omidi Gargari ,&nbsp;Reza Kheradmand ,&nbsp;Faezeh Hatefnia ,&nbsp;Ahmad Mobed","doi":"10.1016/j.nano.2026.102909","DOIUrl":"10.1016/j.nano.2026.102909","url":null,"abstract":"<div><div>Nanoparticle-based drug delivery and molecular imaging methods offer promising advancements in the diagnosis and treatment of stroke, addressing key challenges such as the blood-brain barrier (BBB) and limited imaging resolution. Nanocarriers like PEGylated liposomes, exosomes, and polymeric nanoparticles have shown improved drug targeting, enhanced therapeutic efficacy, and reduced side effects in stroke treatment. In molecular imaging, nanoparticle-enhanced techniques, including PET, MRI, and CT, enable more precise detection of ischemic areas and thrombus formation, though limitations such as low signal sensitivity and poor tissue penetration persist. While these approaches demonstrate significant potential, challenges remain, including nanoparticle toxicity, imaging insensitivity, and the need for combination imaging methods. Looking ahead, future research should focus on overcoming these barriers through the development of multifunctional nanoparticles for theranostics, which combine drug delivery with real-time imaging. Further advancements in molecular imaging and personalized nanomedicine could enhance diagnostic accuracy and treatment personalization. With continued innovation, nanoparticle-based strategies could revolutionize stroke management, improving both therapeutic outcomes and diagnostic precision in clinical settings.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102909"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing curcumin bioavailability using bifunctional periodic mesoporous organosilica for pH-responsive anticancer drug delivery","authors":"Sedigheh Abedanzadeh ,&nbsp;Babak Karimi ,&nbsp;Omid Pourshiani ,&nbsp;Samira Sadat Abolmaali ,&nbsp;Jun Hong ,&nbsp;Ali A. Moosavi-Movahedi","doi":"10.1016/j.nano.2025.102898","DOIUrl":"10.1016/j.nano.2025.102898","url":null,"abstract":"<div><div>This research aimed to improve the bioavailability and anticancer efficacy of curcumin by leveraging the unique properties of bifunctional periodic mesoporous organosilica (BFPMO). The imidazolium and benzene organic moieties embedded in the pore walls of BFPMO, play dual supporting and stabilizing functions for curcumin without causing pore blockage, thereby facilitating high drug loading content (60 %) and excellent encapsulation efficiency (88 %). Comprehensive structural analyses (N₂ adsorption–desorption, FT-IR, TGA, HRTEM, FESEM, EDAX) confirmed successful curcumin immobilization. BFPMO demonstrated good hemocompatibility, and DPPH assays showed improved curcumin stability after encapsulation. <em>In vitro</em> release studies revealed a strong pH-responsive profile. CUR@BFPMO significantly reduced the viability of HEPG2 and A2780 cancer cells while exhibiting lower toxicity toward NIH-3T3 normal cells. Flow cytometry and fluorescence imaging indicated time-dependent apoptosis induction. These findings highlight the potential of BFPMO as a smart, biocompatible nanocarrier for curcumin delivery, offering improved bioavailability, pH-responsive release, and enhanced anticancer efficacy.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102898"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of TPGS-modified liposomal ginger extract in the treatment of acetic acid-induced ulcerative colitis in rats","authors":"Zakieh Keshavarzi ,&nbsp;Sonia Fathi-karkan ,&nbsp;Ali Siahposht- Khachaki ,&nbsp;Reza Kheirandish ,&nbsp;Mohammad Hadi Nematollahi ,&nbsp;Mohammad Amin Rajizadeh","doi":"10.1016/j.nano.2026.102903","DOIUrl":"10.1016/j.nano.2026.102903","url":null,"abstract":"<div><h3>Background</h3><div>Ulcerative colitis (UC) is a long-term inflammatory bowel disease that causes damage to the mucosa and oxidative stress. Natural substances, such as ginger extract, are known to have anti-inflammatory and antioxidant effects. However, the clinical effectiveness of active ingredients like ginger extract is limited by their low bioavailability. Liposomal drug delivery systems, especially those modified with D-α-tocopheryl polyethylene glycol succinate (TPGS), may enhance the stability and absorption of ginger, making it more effective as a medicinal agent. Since regular ginger extract doesn't work very well as a treatment, it's essential to develop and test new drug delivery systems, such as TPGS-modified liposomes, to enhance the outcomes of UC treatment.</div></div><div><h3>Methods</h3><div>A total of 54 male rats were utilized, randomly allocated into nine groups (number in each group = 6). Colitis was induced in rats through enemas containing a 4% solution of acetic acid. Four days post-induction of colitis, rats were administered simple, liposomal, and TPGS-modified liposomal forms of 100 and 300 mg/kg of alcoholic ginger extract intraperitoneally for five days.</div></div><div><h3>Results</h3><div>The results of this study showed that administration of liposomal forms of ginger extract reduced TNFα (<em>P</em> &lt; 0.001) and IL6 (<em>P</em> &lt; 0.001) levels in the colon tissue of rats. These compounds also increased SOD and catalase activity in the colon tissue and reduced NO levels. At the histological level, liposomal forms of ginger were also able to reduce tissue inflammation. Also, our results showed that the encapsulation efficiency of ginger extract was 73 ± 0.38%.</div></div><div><h3>Conclusion</h3><div>Overall, this research showed that following UC, the colon inflammation and oxidative stress were higher than the healthy animals. Also, the results of this study showed that administration of the liposomal and TPGS-modified liposome was able to exert strong anti-inflammatory and antioxidant effects compared to simple forms.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102903"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimizing systemic toxicity of doxorubicin via targeted delivery of hypoxia-sensitive polymersomes","authors":"Joanna Ciepła ,&nbsp;Katarzyna Jelonek ,&nbsp;Monika Musiał-Kulik ,&nbsp;Joanna Jaworska ,&nbsp;Justyna Czapla ,&nbsp;Alina Drzyzga ,&nbsp;Tomasz Cichoń ,&nbsp;Sybilla Matuszczak ,&nbsp;Ewelina Pilny ,&nbsp;Magdalena Jarosz-Biej ,&nbsp;Ryszard Smolarczyk","doi":"10.1016/j.nano.2026.102902","DOIUrl":"10.1016/j.nano.2026.102902","url":null,"abstract":"<div><div>Hypoxia is a hallmark of solid tumors that reduces chemotherapy efficacy and enhances systemic toxicity. This study evaluated hypoxia-sensitive polymersomes as a delivery system for doxorubicin (DOX) to improve antitumor efficacy and reduce side effects. Methods: Polymersomes were synthesized, loaded with DOX, and tested on cancer and healthy cells under normoxic and hypoxic conditions. Cytotoxicity, cellular uptake, apoptosis induction, and potential mechanism of degradation were assessed. <em>In vivo</em> efficacy was investigated in 4T1 tumor-bearing mice treated intravenously with free DOX or DOX-loaded hypoxia-sensitive polymersomes (three times 5 mg/kg). Tumor volume, body weight, histology, and immunochemistry were analyzed. <em>In vitro</em>, both free DOX and DOX-loaded polymersomes induced significant cytotoxicity and apoptosis. The effect was enhanced under hypoxia, consistent with elevated NQO1 expression. <em>In vivo</em>, both formulations suppressed tumor growth to a comparable degree; however, polymersome-treated mice exhibited markedly reduced weight loss, indicating lowered systemic toxicity. Histological examination showed extensive necrosis and architectural disruption in tumors from both treatment groups. Hypoxia-sensitive polymersomes effectively deliver doxorubicin to hypoxic regions, achieving tumor growth inhibition comparable to that of the free drug while reducing treatment-associated toxicity. These findings support encapsulated DOX as a promising strategy for safer chemotherapy in hypoxic cancers.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102902"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLGA-Based nanocarriers in drug delivery: Advances in block copolymer engineering, hybrid platforms, and clinical translation","authors":"Pranal Chhetri","doi":"10.1016/j.nano.2025.102896","DOIUrl":"10.1016/j.nano.2025.102896","url":null,"abstract":"<div><div>Poly (lactic-co-glycolic acid) (PLGA) nanoparticles have become one of the most extensively investigated carriers in nanomedicine, significantly valued for their biodegradable, biocompatible, and flexible nature in tailoring drug release. Modern Pharmaceutical research has moved well beyond conventional PLGA formulations, exploring advanced designs like surface modified systems, hybrid systems, and new generation block copolymers. This review gives comprehensive insights on recent advancement and developments in PLGA based nanoparticles, including less explored combinations such as POEGMA and PDXO based blocks, and natural polymer hybrids that offer unique targeting and stability advantages. It also gives in depth clarity in persistent challenges like poor loading of hydrophilic drugs, burst release, opsonization and manufacturing scalability, and highlight some important strategies that have been being developed to address them, like microfluidic fabrication. In conclusion, it is outlined how PLGA based nanosystems can evolve into robust, precision drug delivery systems with a clear path towards clinical adoption.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102896"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostic application of 131I-labeled anti-glypican-3 antibody for targeted radioimmunotherapy in hepatocellular carcinoma","authors":"Ming-Hui Yang ,&nbsp;Kuo-Pin Chuang ,&nbsp;Hsin-Rou Liang ,&nbsp;Po-Chiao Huang ,&nbsp;Shih-Chang Chuang ,&nbsp;Tzu-Chuan Ho ,&nbsp;Ying-Fong Huang ,&nbsp;Cheng-Hui Yuan ,&nbsp;Yu-Chang Tyan","doi":"10.1016/j.nano.2026.102907","DOIUrl":"10.1016/j.nano.2026.102907","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is a highly lethal malignancy and a leading cause of cancer-related mortality worldwide, largely due to its asymptomatic progression and the limited therapeutic efficacy available for advanced stages. Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is overexpressed in approximately 70–80% of HCC cases while remaining absent in healthy liver tissue, making it an ideal theranostic target. In this study, we developed a novel ¹³¹I-labeled anti-GPC3 antibody. This radiopharmaceutical was synthesized with a high labeling yield (~93%) and demonstrated robust in vitro stability (with &gt;81% radiochemical purity retained at 120 h). In vitro MTT assays revealed dose-dependent cytotoxicity, with cell viability significantly reduced to 27.7% at a dose of 6 μCi. In vivo evaluation in a spontaneous HCC mouse model confirmed strong GPC3 expression restricted specifically to tumor tissues. Biodistribution analysis further revealed preferential tumor accumulation (~1.3% injected dose per gram) with minimal radioactivity in non-target organs. Collectively, these findings demonstrate the feasibility and therapeutic potential of ¹³¹I-GPC3 as a targeted theranostic radiopharmaceutical for HCC and other GPC3-expressing malignancies.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102907"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisplatin(IV)-fatty acid prodrug-bound albumin nanoparticles: In vitro, in silico, and in vivo evaluation in breast cancer therapy","authors":"Oly Katari ,&nbsp;Vivek Yadav ,&nbsp;Rajkumar R ,&nbsp;Prabha Garg ,&nbsp;Sanyog Jain","doi":"10.1016/j.nano.2026.102910","DOIUrl":"10.1016/j.nano.2026.102910","url":null,"abstract":"<div><div>The therapeutic outcome of cisplatin (CP) in triple-negative breast cancer (TNBC) is hindered by irreversible protein binding, systemic toxicities, and resistance development. Therefore, we synthesized three CP(IV) prodrugs of fatty acids (FAs) possessing reversible albumin binding to overcome these shortcomings. Among these, CP-OA depicted the most cytotoxicity in MDA-MB-231 and 4T1 cells, showing synergistic effect and potential dose reduction. Albumin nanoparticles of CP-OA (CP-OA NPs) were optimized using a Design of Experiments (DoE) approach, yielding a particle size of 189.6 nm, PDI 0.23, and 77.47% entrapment efficiency. CP-OA NPs showed improved drug loading, sustained release, enhanced apoptosis (∼5 folds), ROS generation (∼2 folds), and mitochondrial depolarization (∼6 folds). The <em>in vivo</em> studies portrayed reduction in tumor volume (5.64-folds), organ toxicities and hemolysis (6.18-folds) compared to marketed formulation. Overall, this study highlights the therapeutic potential of CP(IV) prodrug bound albumin nanoparticles in improving therapeutic efficacy and safety of CP in TNBC.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"72 ","pages":"Article 102910"},"PeriodicalIF":4.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}