Nanomedicine : nanotechnology, biology, and medicine最新文献

Corrigendum to "Redox-responsive micelles from disulfide bond-bridged hyaluronic acid-tocopherol succinate for the treatment of melanoma" [Nanomed.: Nanotechnol. Biol. Med. 14/3 (2018) 713-723]. "二硫键桥接透明质酸-生育酚琥珀酸酯的氧化还原反应胶束用于治疗黑色素瘤"[Nanomed.: Nanotechnol. Biol. Med. 14/3 (2018) 713-723]的更正。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-25 DOI: 10.1016/j.nano.2025.102807

Junping Xia, Yunai Du, Liping Huang, Birendra Chaurasiya, Jiasheng Tu, Thomas J Webster, Chunmeng Sun

引用次数: 0

Machine learning-driven Raman spectroscopy: A novel approach to lipid profiling in diabetic kidney disease.

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-22 DOI: 10.1016/j.nano.2025.102804

Adrianna Kryska, Magdalena Sawic, Joanna Depciuch, Piotr Sosnowski, Klaudia Szałaj, Wiesław Paja, Maryna Khalavka, Anna Sroka-Bartnicka

{"title":"Machine learning-driven Raman spectroscopy: A novel approach to lipid profiling in diabetic kidney disease.","authors":"Adrianna Kryska, Magdalena Sawic, Joanna Depciuch, Piotr Sosnowski, Klaudia Szałaj, Wiesław Paja, Maryna Khalavka, Anna Sroka-Bartnicka","doi":"10.1016/j.nano.2025.102804","DOIUrl":"https://doi.org/10.1016/j.nano.2025.102804","url":null,"abstract":"Diabetes mellitus is a chronic metabolic disease that increasingly affects people every year. It is known that with its progression and poor management, metabolic changes can lead to organ dysfunctions, including kidneys. The study aimed to combine Raman spectroscopy and biochemical lipid profiling, complemented by machine learning (ML) techniques to evaluate chemical composition changes in kidneys induced by Type 2 Diabetes mellitus (T2DM). Raman spectroscopy identified significant differences in lipid content and specific molecular vibrations, with the 1777 cm-1 band emerging as a potential spectroscopic marker for diabetic kidney damage. The integration of ML algorithms improved the analysis, providing high accuracy, selectivity, and specificity in detecting these changes. Moreover, lipids metabolic profiling revealed distinct variations in the concentration of 11 phosphatydylocholines and 9 acyl-alkylphosphatidylcholines glycerophospholipids. Importantly, the correlation between Raman data and lipids metabolic profiling differed for control and T2DM groups. This study underscores the combined power of Raman spectroscopy and ML in offering a low-cost, fast precise, and comprehensive approach to diagnosing and monitoring diabetic nephropathy, paving the way for improved clinical interventions. However, taking into account small number of data related to ethical committee approvals, the study should be verified on a larger number of cases.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102804"},"PeriodicalIF":4.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble microneedle acupuncture patches containing melittin liposomes for the percutaneous treatment of rheumatoid arthritis.

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-22 DOI: 10.1016/j.nano.2025.102806

Tong Xiong, Du Li, Juanjuan Ren, Chuncheng Chen, Shijie Li, Zhuoyue Song, Nenggui Xu, Tao Liu, Shihui Liu

{"title":"Soluble microneedle acupuncture patches containing melittin liposomes for the percutaneous treatment of rheumatoid arthritis.","authors":"Tong Xiong, Du Li, Juanjuan Ren, Chuncheng Chen, Shijie Li, Zhuoyue Song, Nenggui Xu, Tao Liu, Shihui Liu","doi":"10.1016/j.nano.2025.102806","DOIUrl":"https://doi.org/10.1016/j.nano.2025.102806","url":null,"abstract":"Bee venom acupuncture (BVA) offers therapeutic potential for rheumatoid arthritis (RA) but faces challenges from pain and allergies linked to live bee stings. A key hurdle is melittin (Mel), bee venom's main anti-inflammatory component, which degrades rapidly when orally ingested, leading to decreased efficacy and increased toxicity. This study proposes a solution by encapsulating melittin in liposomes to enhance stability and lessen side effects, expanding its clinical applicability. Additionally, the advancement of microneedle technology, which bypasses gastrointestinal issues by targeting the stratum corneum, opens a novel pathway for RA treatment. Employing soluble microneedles loaded with melittin-encapsulated liposomes (Mel-Lip) enables effective transdermal delivery. Results from an adjuvant-induced RA animal model show that Mel-Lip microneedles improve foot health, repair cartilage, and lower inflammatory markers, highlighting microneedling with transdermal nanocarriers as a promising, patient-friendly approach for RA management.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102806"},"PeriodicalIF":4.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploiting novel placental homing peptides for targeted drug delivery in breast Cancer.

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-22 DOI: 10.1016/j.nano.2025.102805

Abdulaziz A Alobaid, Harmesh Aojula, Richard A Campbell, Lynda K Harris

引用次数: 0

Determination diabetes mellitus disease markers in tear fluid by photothermal AFM-IR analysis. 光热AFM-IR法测定泪液中糖尿病疾病标志物。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-07 DOI: 10.1016/j.nano.2025.102803

Daria Kondrakhova, Miriam Unger, Hartmut Stadler, Katarína Zakuťanská, Natália Tomašovičová, Vladimíra Tomečková, Jakub Horák, Tatiana Kimákova, Vladimír Komanický

{"title":"Determination diabetes mellitus disease markers in tear fluid by photothermal AFM-IR analysis.","authors":"Daria Kondrakhova, Miriam Unger, Hartmut Stadler, Katarína Zakuťanská, Natália Tomašovičová, Vladimíra Tomečková, Jakub Horák, Tatiana Kimákova, Vladimír Komanický","doi":"10.1016/j.nano.2025.102803","DOIUrl":"10.1016/j.nano.2025.102803","url":null,"abstract":"The tear fluids from three healthy individuals and three patients with diabetes mellitus were examined using atomic force microscopy-infrared spectroscopy (AFM-IR) and Fourier transform infrared spectroscopy (FTIR). The dried tear samples showed different surface morphologies: the control sample had a dense network of heart-shaped dendrites, while the diabetic sample had fern-shaped dendrites. By using the AFM-IR technique we identified spatial distribution of constituents, indicating how diabetes affects the structural characteristics of dried tears. FTIR showed that the dendritic structures gradually disappeared over time due to glucose-induced lysozyme damage. The tear fluid from diabetes mellitus patients has a higher concentration of glucose, which accelerates the breakdown of lysozyme and, as a result, the quick loss of the dendritic structure. Our study shows that analysis of dry tear fluid can be promising technique for the detection of glycated proteins that reveal long lasting hyperglycemia and diabetes mellitus.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102803"},"PeriodicalIF":4.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy. 谷胱甘肽反应性多肽纳米凝胶包封紫草素用于乳腺癌治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-07 DOI: 10.1016/j.nano.2025.102802

Siqi Li, Qingshuang Wang, Zhilin Li, Jiahe Zhang, Xue Jiang, Shuai Liu, Changshun Lu, Tianhui Liu, Xiangru Feng

{"title":"Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy.","authors":"Siqi Li, Qingshuang Wang, Zhilin Li, Jiahe Zhang, Xue Jiang, Shuai Liu, Changshun Lu, Tianhui Liu, Xiangru Feng","doi":"10.1016/j.nano.2025.102802","DOIUrl":"10.1016/j.nano.2025.102802","url":null,"abstract":"Exploiting the unique physiological and biochemical characteristics of the tumor microenvironment, the development of a polypeptide nanogel capable of responding to these specific properties holds great promise as an effective antitumor strategy. In this study, we synthesized a glutathione-responsive (GSH-responsive) methylated poly (ethylene glycol)-poly (phenylalanine)-poly (cystine) block copolymer (mPPC) through one-step ring-opening polymerization. Shikonin (SHK) was encapsulated within nanogel, designated as mPPC/SHK. The biocompatible and safe nature of mPPC facilitated its accumulation at the tumor site through enhanced permeability and retention effect, leading to efficient release of SHK upon stimulation by high concentrations of GSH. As anticipated, the group of mPPC/SHK displayed enhanced efficacy against tumors, resulting in a tumor inhibition rate of 69.97 % in the 4T1 breast cancer model. Overall, this GSH-responsive polypeptide nanogel encapsulating SHK has tremendous potential as a promising biomedical agent for effective tumor nanotherapy.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102802"},"PeriodicalIF":4.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Exploring the interactions between engineered nanomaterials and immune cells at 3D nano-bio interfaces to discover potent nano-adjuvants" [Nanomed.: Nanotechnol. Biol. Med. 21C (2019) 102037]. “在3D纳米生物界面上探索工程纳米材料和免疫细胞之间的相互作用，以发现有效的纳米佐剂”的勘误表[Nanomed]。: Nanotechnol。医学杂志。医学通报，2016,(5):357 - 357。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1016/j.nano.2024.102800

Ronglin Ma, Huizhen Zheng, Qi Liu, Di Wu, Wei Li, Shujuan Xu, Xiaoming Cai, Ruibin Li

引用次数: 0

Facile fabrication of nano-bioactive glass functionalized blended hydrogel with nucleus pulposus-derived MSCs to improve regeneration potential in treatment of disc degeneration by in vivo rat model. 利用髓核间充质干细胞轻松制备纳米生物活性玻璃功能化混合水凝胶，通过体内大鼠模型提高治疗椎间盘退行性变的再生潜力。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1016/j.nano.2024.102790

Chong Bian, Guangnan Chen, Xiangyang Cheng, Huijie Gu, Zhongyue Huang, Kaifeng Zhou

{"title":"Facile fabrication of nano-bioactive glass functionalized blended hydrogel with nucleus pulposus-derived MSCs to improve regeneration potential in treatment of disc degeneration by in vivo rat model.","authors":"Chong Bian, Guangnan Chen, Xiangyang Cheng, Huijie Gu, Zhongyue Huang, Kaifeng Zhou","doi":"10.1016/j.nano.2024.102790","DOIUrl":"10.1016/j.nano.2024.102790","url":null,"abstract":"Orthopaedic medicine often treats intervertebral disc degeneration (IVDD), which is caused by nucleus pulposus (NP) tissue damage and mechanical stress. Bioactive glasses (BGs), widely used for bone regeneration, can incorporate therapeutic ions into their network. Manganese (Mn) activates human osteoblast integrins, proliferation, and spreading. The CMnBGNPs-NPMSCs are carboxymethyl cellulose hydrogels functionalized with MnBGsNPs and NP-derived mesenchymal stem cells to treat IVDD. To ensure stability and biocompatibility of CMnBGNPs-NPMSCs were characterized for rheological properties like gelation time and swelling ratio. Gene expression analysis of PAX1, FOXF1, CA12, HBB, and OVOS2 via qRT-PCR further assessed the hydrogel's characteristics. Rat models with induced IVDD had hydrogel-MSC composite injected into their intervertebral discs for in vivo studies. Histological examination, immunohistochemical staining for inflammation and disc regeneration markers, and disc height assessments assessed therapeutic efficacy. CMnBGNPs-NPMSCs show promising results for IVDD treatment, offering a novel therapeutic strategy with clinical implications for degenerative disc diseases.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102790"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One stone, three birds: Construction of Cu/ZIF-8@DSF@GOx/HA nanoplatform for synergistic starvation therapy enhanced chemo-/chemodynamic therapy. 一石三鸟：Cu/ZIF-8@DSF@GOx/HA纳米平台的构建，用于协同饥饿治疗增强化疗/化疗动力学治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1016/j.nano.2024.102799

Jing Xia, Guoxin Liu, Chaofan Wang, Zhuo Liu, Fengyu Liu, Hongjuan Li, Yongqian Xu, Shiguo Sun

{"title":"One stone, three birds: Construction of Cu/ZIF-8@DSF@GOx/HA nanoplatform for synergistic starvation therapy enhanced chemo-/chemodynamic therapy.","authors":"Jing Xia, Guoxin Liu, Chaofan Wang, Zhuo Liu, Fengyu Liu, Hongjuan Li, Yongqian Xu, Shiguo Sun","doi":"10.1016/j.nano.2024.102799","DOIUrl":"10.1016/j.nano.2024.102799","url":null,"abstract":"Disulfiram (DSF), as a sixpenny drug for the treatment of alcohol dependence, has demonstrated copper-dependent chemotherapy (CT) effects in recent years. However, as the most common modality in clinical treatment, prolonged use of CT will lead to multidrug resistance (MDR). In this work, a versatile and ingenious nanoparticle Cu/ZIF-8@DSF@GOx/HA (CZDGH) was constructed to deliver DSF, Cu2+ and GOx to tumor cells. Once internalized by tumor cells, GOx depletes glucose blocking the energy supply leading to ST. Then DSF chelates with Cu2+ in situ to generate CuETs, achieving toxicity-intensified CT, the reduced ATP in this process also inhibits the efflux function of P-gp. In the meantime, Cu2+ consumes glutathione (GSH) to enhance oxidative stress, and the converted Cu+ catalyzes internal and external sources of H2O2 into •OH, heightening chemodynamic therapy (CDT). The experimental results demonstrate remarkable multimodal synergistic anticancer effects that overcome MDR.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102799"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and heat shock protein-inhibiting nanoplatform for synergetic cancer chemo/photothermal therapy. 抗炎和热休克蛋白抑制纳米平台协同癌症化疗/光热治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/j.nano.2024.102801

Yuanying Zhang, Nan Yang, Lingling Wang, Yi Zheng, Ziyi Dong, Jiahui Wu, Gege Zhang, Yanling Zhang, Jianda Qiu, Wenbin Wang, Xianwen Wang, Pingping Liang

{"title":"Anti-inflammatory and heat shock protein-inhibiting nanoplatform for synergetic cancer chemo/photothermal therapy.","authors":"Yuanying Zhang, Nan Yang, Lingling Wang, Yi Zheng, Ziyi Dong, Jiahui Wu, Gege Zhang, Yanling Zhang, Jianda Qiu, Wenbin Wang, Xianwen Wang, Pingping Liang","doi":"10.1016/j.nano.2024.102801","DOIUrl":"10.1016/j.nano.2024.102801","url":null,"abstract":"Photothermal therapy is a novel and promising method for cancer treatment due to its controllable property, noninvasive nature, and high selectivity. Nevertheless, tumor recurrence of inflammatory response and tumor tolerance of heat shock protein over-expression remain serious challenges in current photothermal therapy. Additionally, the high dosage requirement of nanomaterial for optimal imaging and therapeutic effect would result in various side effects, organ excretion burdens, and long-term accumulation in the body. In this work, RD/Qu nanoplatform is designed and prepared with near-infrared (NIR) absorbance, high photothermal conversion efficiency, and great chemotherapy effect for synergetic cancer chemo/photothermal therapy at an ultralow-dose. More importantly, both in vitro and in vivo studies demonstrate that it could decrease the expression of HSP70 to fight hyperthermia tumor tolerance and inhibit inflammatory factor COX-2 to suppress tumor recurrence. Therefore, the RD/Qu nanoparticles show excellent outcome in tumor ablation at a quite low dosage, providing a promising avenue for cancer treatment.","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":" ","pages":"102801"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0