Nanomedicine : nanotechnology, biology, and medicine最新文献_第2页

Facile fabrication of nano-bioactive glass functionalized blended hydrogel with nucleus pulposus-derived MSCs to improve regeneration potential in treatment of disc degeneration by in vivo rat model 利用髓核间充质干细胞轻松制备纳米生物活性玻璃功能化混合水凝胶，通过体内大鼠模型提高治疗椎间盘退行性变的再生潜力。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 DOI: 10.1016/j.nano.2024.102790

Chong Bian Phd , Guangnan Chen MD , Xiangyang Cheng MD, Huijie Gu Phd, Zhongyue Huang MD, Kaifeng Zhou MD

{"title":"Facile fabrication of nano-bioactive glass functionalized blended hydrogel with nucleus pulposus-derived MSCs to improve regeneration potential in treatment of disc degeneration by in vivo rat model","authors":"Chong Bian Phd , Guangnan Chen MD , Xiangyang Cheng MD, Huijie Gu Phd, Zhongyue Huang MD, Kaifeng Zhou MD","doi":"10.1016/j.nano.2024.102790","DOIUrl":"10.1016/j.nano.2024.102790","url":null,"abstract":"<div><div>Orthopaedic medicine often treats intervertebral disc degeneration (IVDD), which is caused by nucleus pulposus (NP) tissue damage and mechanical stress. Bioactive glasses (BGs), widely used for bone regeneration, can incorporate therapeutic ions into their network. Manganese (Mn) activates human osteoblast integrins, proliferation, and spreading. The CMnBGNPs-NPMSCs are carboxymethyl cellulose hydrogels functionalized with MnBGsNPs and NP-derived mesenchymal stem cells to treat IVDD. To ensure stability and biocompatibility of CMnBGNPs-NPMSCs were characterized for rheological properties like gelation time and swelling ratio. Gene expression analysis of PAX1, FOXF1, CA12, HBB, and OVOS2 <em>via</em> qRT-PCR further assessed the hydrogel's characteristics. Rat models with induced IVDD had hydrogel-MSC composite injected into their intervertebral discs for <em>in vivo</em> studies. Histological examination, immunohistochemical staining for inflammation and disc regeneration markers, and disc height assessments assessed therapeutic efficacy. CMnBGNPs-NPMSCs show promising results for IVDD treatment, offering a novel therapeutic strategy with clinical implications for degenerative disc diseases.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102790"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One stone, three birds: Construction of Cu/ZIF-8@DSF@GOx/HA nanoplatform for synergistic starvation therapy enhanced chemo−/chemodynamic therapy 一石三鸟：Cu/ZIF-8@DSF@GOx/HA纳米平台的构建，用于协同饥饿治疗增强化疗/化疗动力学治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 DOI: 10.1016/j.nano.2024.102799

Jing Xia MSc , Guoxin Liu PhD , Chaofan Wang MSc , Zhuo Liu MSc , Fengyu Liu PhD , Hongjuan Li PhD , Yongqian Xu PhD , Shiguo Sun PhD

{"title":"One stone, three birds: Construction of Cu/ZIF-8@DSF@GOx/HA nanoplatform for synergistic starvation therapy enhanced chemo−/chemodynamic therapy","authors":"Jing Xia MSc , Guoxin Liu PhD , Chaofan Wang MSc , Zhuo Liu MSc , Fengyu Liu PhD , Hongjuan Li PhD , Yongqian Xu PhD , Shiguo Sun PhD","doi":"10.1016/j.nano.2024.102799","DOIUrl":"10.1016/j.nano.2024.102799","url":null,"abstract":"<div><div>Disulfiram (DSF), as a sixpenny drug for the treatment of alcohol dependence, has demonstrated copper-dependent chemotherapy (CT) effects in recent years. However, as the most common modality in clinical treatment, prolonged use of CT will lead to multidrug resistance (MDR). In this work, a versatile and ingenious nanoparticle Cu/ZIF-8@DSF@GOx/HA (CZDGH) was constructed to deliver DSF, Cu<sup>2+</sup> and GOx to tumor cells. Once internalized by tumor cells, GOx depletes glucose blocking the energy supply leading to ST. Then DSF chelates with Cu<sup>2+</sup> in situ to generate CuETs, achieving toxicity-intensified CT, the reduced ATP in this process also inhibits the efflux function of P-gp. In the meantime, Cu<sup>2+</sup> consumes glutathione (GSH) to enhance oxidative stress, and the converted Cu<sup>+</sup> catalyzes internal and external sources of H<sub>2</sub>O<sub>2</sub> into •OH, heightening chemodynamic therapy (CDT). The experimental results demonstrate remarkable multimodal synergistic anticancer effects that overcome MDR.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102799"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and heat shock protein-inhibiting nanoplatform for synergetic cancer chemo/photothermal therapy 抗炎和热休克蛋白抑制纳米平台协同癌症化疗/光热治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-01-01 DOI: 10.1016/j.nano.2024.102801

Yuanying Zhang MSc , Nan Yang MSc , Lingling Wang MSc , Yi Zheng MSc , Ziyi Dong MSc , Jiahui Wu MSc , Gege Zhang MSc , Yanling Zhang MSc , Jianda Qiu MSc , Wenbin Wang PhD , Xianwen Wang PhD , Pingping Liang PhD

{"title":"Anti-inflammatory and heat shock protein-inhibiting nanoplatform for synergetic cancer chemo/photothermal therapy","authors":"Yuanying Zhang MSc , Nan Yang MSc , Lingling Wang MSc , Yi Zheng MSc , Ziyi Dong MSc , Jiahui Wu MSc , Gege Zhang MSc , Yanling Zhang MSc , Jianda Qiu MSc , Wenbin Wang PhD , Xianwen Wang PhD , Pingping Liang PhD","doi":"10.1016/j.nano.2024.102801","DOIUrl":"10.1016/j.nano.2024.102801","url":null,"abstract":"<div><div>Photothermal therapy is a novel and promising method for cancer treatment due to its controllable property, noninvasive nature, and high selectivity. Nevertheless, tumor recurrence of inflammatory response and tumor tolerance of heat shock protein over-expression remain serious challenges in current photothermal therapy. Additionally, the high dosage requirement of nanomaterial for optimal imaging and therapeutic effect would result in various side effects, organ excretion burdens, and long-term accumulation in the body. In this work, RD/Qu nanoplatform is designed and prepared with near-infrared (NIR) absorbance, high photothermal conversion efficiency, and great chemotherapy effect for synergetic cancer chemo/photothermal therapy at an ultralow-dose. More importantly, both <em>in vitro</em> and <em>in vivo</em> studies demonstrate that it could decrease the expression of HSP70 to fight hyperthermia tumor tolerance and inhibit inflammatory factor COX-2 to suppress tumor recurrence. Therefore, the RD/Qu nanoparticles show excellent outcome in tumor ablation at a quite low dosage, providing a promising avenue for cancer treatment.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102801"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation of aggregated neutrophil extracellular traps in tissues is determining the efficacy of particulate nanoadjuvants 组织中聚集的中性粒细胞胞外陷阱的形成决定了颗粒纳米佐剂的功效

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-11-28 DOI: 10.1016/j.nano.2024.102798

Galyna Bila PhD , Valentyn Utka , Roman Grytsko Dr , Volodymyr Vovk Dr , Rostyslav Bilyy Dr, Prof.

{"title":"Formation of aggregated neutrophil extracellular traps in tissues is determining the efficacy of particulate nanoadjuvants","authors":"Galyna Bila PhD , Valentyn Utka , Roman Grytsko Dr , Volodymyr Vovk Dr , Rostyslav Bilyy Dr, Prof.","doi":"10.1016/j.nano.2024.102798","DOIUrl":"10.1016/j.nano.2024.102798","url":null,"abstract":"<div><div>Neutrophils are essential for innate immunity, using mechanisms like Neutrophil Extracellular Trap (NET) formation to fight pathogens. Aggregated NETs (aggNETs) help resolve inflammation by cleaving pro-inflammatory cytokines, while scattered NETs can exacerbate inflammation, leading to tissue damage. Co-injection of 10 nm nanodiamonds (ND10) with peptide antigens boosts immune responses, including anti-SARS-CoV-2 immunity, due to transient immune responses induced by aggNETs around ND10 particles. Diamond nanoparticles in adjuvant mixtures enhance vaccines, though the optimal dose is uncertain. Our study aimed to find the minimal ND10 amount needed for effective aggNETs formation and a robust immune response with minimal long-term tissue damage. In vivo experiments revealed 1 mg of ND10 per injection significantly enhances immune responses, forming granulomas rich in neutrophil elastase. Lower doses left scattered nanoparticles, insufficient for aggNETs formation. The effective ND10 dose for mice, 1 mg per injection, can be extrapolated to other organisms.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102798"},"PeriodicalIF":4.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nanocrystal-loaded liposome of tanshinone IIA with high drug loading and stability towards efficient liver fibrosis reversion 纳米晶载丹参酮IIA脂质体具有高载药量和稳定性，可有效逆转肝纤维化

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-11-27 DOI: 10.1016/j.nano.2024.102797

Chunyan Cai BS , Kai Liu MMed , Dejun Yang BS , Jijiao Wu BS , Zhaolei Peng BS , Yulin Wang BS , Jingjing Xi BS , Fan Xie MMed , Xiaofang Li Ph.D

{"title":"The nanocrystal-loaded liposome of tanshinone IIA with high drug loading and stability towards efficient liver fibrosis reversion","authors":"Chunyan Cai BS , Kai Liu MMed , Dejun Yang BS , Jijiao Wu BS , Zhaolei Peng BS , Yulin Wang BS , Jingjing Xi BS , Fan Xie MMed , Xiaofang Li Ph.D","doi":"10.1016/j.nano.2024.102797","DOIUrl":"10.1016/j.nano.2024.102797","url":null,"abstract":"<div><div>Tanshinone IIA (TSIIA) is a lipid-soluble pharmacological constituent extracted from the <em>Salvia miltiorrhiza</em> with anti-hepatic fibrosis properties. However, its clinical use has been limited due to its poor water solubility and oral bioavailability. In this paper, we constructed a drug delivery system consisting of a drug nanocrystal core and a liposome shell: TSIIA nanocrystals@liposome (TNC@Lipo). This combination can greatly improve the solubility and bioavailability of poorly water-soluble drugs. TNC@Lipo was prepared by ultrasonic method combined with antisolvent method. In order to obtain the optimal TNC, we optimized the formulation ratio and preparation process of TNC by single-factor experiments. The results showed that TNC@Lipo had higher drug loading (27.86 ± 1.55 %) and superior stability. And TNC@Lipo can significantly reversed CCl<sub>4</sub>-induced liver fibrosis in mice compared with free-TSIIA. In conclusion, this study provides a new approach for the clinical application of TSIIA.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102797"},"PeriodicalIF":4.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid based nanoparticles that mediate sustained thanatin release protect against NDM-1–resistant bacterial infections in a murine model 在小鼠模型中，基于透明质酸的纳米颗粒介导持续的thanatin释放，可防止ndm -1耐药细菌感染。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-11-27 DOI: 10.1016/j.nano.2024.102796

Xiaojun Deng PhD , HaiBo Wang PhD , Chao Fang PhD , Min Xu BS , Zhufei Chu BS , Miaomiao Li BS , Zheng Hou PhD , Hongyan Qin PhD

{"title":"Hyaluronic acid based nanoparticles that mediate sustained thanatin release protect against NDM-1–resistant bacterial infections in a murine model","authors":"Xiaojun Deng PhD , HaiBo Wang PhD , Chao Fang PhD , Min Xu BS , Zhufei Chu BS , Miaomiao Li BS , Zheng Hou PhD , Hongyan Qin PhD","doi":"10.1016/j.nano.2024.102796","DOIUrl":"10.1016/j.nano.2024.102796","url":null,"abstract":"<div><div>Thanatin, a potent cationic antimicrobial peptide, has demonstrated remarkable efficacy against new NDM-1 producing bacteria. However, its clinical application is hampered by suboptimal stability in circulation and limited bioavailability in the human body. To overcome these challenges, a novel thanatin nanomedicine has been developed, which encapsulated thanatin in nanoparticles formed by electrostatic interactions between negatively charged HA and PLGA. The obtained ThaNPs demonstrated good stability, low cytotoxicity, and good metabolic ratio. ThaNPs significantly improve the stability of thanatin in the circulation, increasing its half-life in 50 % serum from 0.6 h to 3.2 h. Notably, the protective effect of ThaNPs against sepsis induced by NDM-1–producing <em>Escherichia coli.</em> was 10-fold higher than that of unencapsulated thanatin. These findings suggest that hyaluronic acid-based nanoparticles have the potentiality to overcome the clinical limitations associated with cationic antimicrobial peptides, thereby providing a novel and effective strategy for treating severe infections caused by antibiotic-resistant bacteria.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"63 ","pages":"Article 102796"},"PeriodicalIF":4.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cholesterol transport capacity of peptide- and polymer-based lipid Nanodiscs 多肽和聚合物脂质纳米盘胆固醇转运能力的比较

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-11-16 DOI: 10.1016/j.nano.2024.102795

Minzhi Yu PhD, Saatvik Vaishnav BS, Kristen Hong Dorsey PhD, May Thazin Phoo BSE, Antonela Rodriguez BS, Anna Schwendeman PhD

引用次数: 0

Retraction notice to “In vitro angiogenic performance and in vivo brain targeting of magnetized endothelial progenitor cells for neurorepair therapies” [Nanomedicine: Nanotechnology, Biology and Medicine 10/1 (2014) 225–234] 用于神经修复疗法的磁化内皮祖细胞的体外血管生成性能和体内脑靶向》[Nanomedicine: Nanotechnology, Biology and Medicine 10/1 (2014) 225-234]的撤稿通知。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-10-19 DOI: 10.1016/j.nano.2024.102793

Elisa Carenza MSc , Verónica Barceló , Anna Morancho MSc , Lisa Levander MSc , Cristina Boada , Anna Laromaine PhD , Anna Roig PhD , Joan Montaner MD, PhD , Anna Rosell PhD

引用次数: 0

Micellar curcumol for maintenance therapy of ovarian cancer by activating the FOXO3a 通过激活 FOXO3a 使微胶囊姜黄醇用于卵巢癌的维持治疗。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-10-01 DOI: 10.1016/j.nano.2024.102789

Jing Wang PhD, MD , Bing Chen MSc , Jiezhen Yang MSc , Qin Tang MSc , Yan Zhong MSc , Jiyu Du MSc , Sheng Wang MSc , Qiang Wu PhD, MD , Yang Lu PhD , Yonghong Song PhD

{"title":"Micellar curcumol for maintenance therapy of ovarian cancer by activating the FOXO3a","authors":"Jing Wang PhD, MD , Bing Chen MSc , Jiezhen Yang MSc , Qin Tang MSc , Yan Zhong MSc , Jiyu Du MSc , Sheng Wang MSc , Qiang Wu PhD, MD , Yang Lu PhD , Yonghong Song PhD","doi":"10.1016/j.nano.2024.102789","DOIUrl":"10.1016/j.nano.2024.102789","url":null,"abstract":"<div><div>Maintenance therapy (MT) for ovarian cancer (OC) is crucial for preventing disease relapse. Curcumol shows effective anti-OC ability and low-toxicity to the normal ovarian epithelial cells, however, its bioavailability is low. Herein, micellar loaded curcumol (MC) was prepared and the anti-tumor ability of MC were performed on OC cells. The results indicated that the IC<sub>50</sub> values of MC in two kinds of OC cells were 37.69 ± 2.43 and 28.54 ± 1.58 μg/mL, respectively. Mechanistically, curcumol could interact with the AKT<sup>Thr308</sup> site, inhibiting the phosphorylation of FOXO3a, which promoted FOXO3a nuclear locating and recruited it to the PERK promoter, activating the ERS induced apoptosis pathway. Moreover, MC inhibited the growth of SKOV3 cells on tumor-bearing nude mice and the DiR-labeled MC could quickly accumulate in the tumor region. MC provides great feasibility to achieve efficient MT for OC based on the nanoplatforms of active ingredients from natural products.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"62 ","pages":"Article 102789"},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals 利用化学修饰纳米复合材料对实验动物大网膜模型的动脉粥样硬化产生积极影响的概念原理。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-09-27 DOI: 10.1016/j.nano.2024.102787

Shamil Akhmedov PhD, MD , Ivan Stepanov MD , Sergey Afanasyev PhD, MD , Sergei Tverdokhlebov PhD , Victor Filimonov PhD , Nikolay Kamenshchikov MD , Anatoly Yermakov PhD , Suowen Xu PhD , Natalia Afanasyeva MD , Boris Kozlov PhD, MD

{"title":"Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals","authors":"Shamil Akhmedov PhD, MD , Ivan Stepanov MD , Sergey Afanasyev PhD, MD , Sergei Tverdokhlebov PhD , Victor Filimonov PhD , Nikolay Kamenshchikov MD , Anatoly Yermakov PhD , Suowen Xu PhD , Natalia Afanasyeva MD , Boris Kozlov PhD, MD","doi":"10.1016/j.nano.2024.102787","DOIUrl":"10.1016/j.nano.2024.102787","url":null,"abstract":"<div><div>The use of chemically modified nanocomposites for atherosclerotic plaques can open up new opportunities for studying their effect on changing the structure of the plaque itself. It was shown on the model of the greater omentum of two groups of experimental animals (rats n = 30), which were implanted with Fe@C NPs nanocomposites of 10–30 Nm size into the omentum area. Group 1 (n = 15) consisted of animals that were implanted with chemically modified Fe@C NPs nanocomposites and control group 2 (n = 15) was with non-modified Fe@C NPs nanocomposites. After 1, 2 and 3 weeks we conducted the morphological study of changes in the structure of the omentum using two dyes (Nile Blue and Sudan III), which are specific for adipose tissue. Chemically modified nanocomposites have demonstrated, in contrast to non-modified nanoparticles, to cause morphological changes in the structure of the greater omentum accompanied by the probable release of a similar antiatherogenic factor.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"62 ","pages":"Article 102787"},"PeriodicalIF":4.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0