Nanomedicine : nanotechnology, biology, and medicine最新文献_第2页

Size-dependent renal filtration model explains human pharmacokinetics of a functional nanoparticle: The SPAGOPIX-01 clinical trial 尺寸依赖性肾过滤模型解释了功能纳米粒子的人体药代动力学：SPAGOPIX-01 临床试验。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-07-17 DOI: 10.1016/j.nano.2024.102774

引用次数: 0

Brain-targeting redox-sensitive micelles for codelivery of TMZ and β-lapachone for glioblastoma therapy 用于治疗胶质母细胞瘤的 TMZ 和 β-拉帕醌联合给药的脑靶向氧化还原敏感胶束。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-07-02 DOI: 10.1016/j.nano.2024.102772

Yuxiang Dai MD , Yuanping Min MSc , Lu Zhou MM , Longyang Cheng MM , Hongbin Ni MD , Yang Yang PhD , Wendi Zhou MSc

{"title":"Brain-targeting redox-sensitive micelles for codelivery of TMZ and β-lapachone for glioblastoma therapy","authors":"Yuxiang Dai MD , Yuanping Min MSc , Lu Zhou MM , Longyang Cheng MM , Hongbin Ni MD , Yang Yang PhD , Wendi Zhou MSc","doi":"10.1016/j.nano.2024.102772","DOIUrl":"10.1016/j.nano.2024.102772","url":null,"abstract":"<div><p>Glioblastoma (GBM) is a central nervous system cancer with high incidence and poor survival rates. Enhancing drug penetration of the blood-brain barrier (BBB) and targeting efficacy is crucial for improving treatment outcomes. In this study, we developed a redox-sensitive targeted nano-delivery system (HCA-A2) for temozolomide (TMZ) and β-lapachone (β-Lapa). This system used hyaluronic acid (HA) as the hydrophilic group, arachidonic acid (CA) as the hydrophobic group, and angiopep-2 (A2) as the targeting group. Control systems included non-redox sensitive (HDA-A2) and non-targeting (HCA) versions. In vitro, HCA-TMZ-Lapa micelles released 100 % of their payload in a simulated tumor microenvironment within 24 h, compared to 43.97 % under normal conditions. HCA-A2 micelles, internalized via clathrin-mediated endocytosis, showed stronger cytotoxicity and better BBB penetration and cellular uptake than controls. In vivo studies demonstrated superior tumor growth inhibition with HCA-A2 micelles, indicating their potential for GBM treatment.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective macromolecular methylprednisolone prodrug nanomedicine prevents glucocorticoid-induced muscle atrophy and osteoporosis in a rat model of spinal cord injury 具有神经保护作用的大分子甲基强的松龙原药纳米药物可防止糖皮质激素诱导的脊髓损伤大鼠肌肉萎缩和骨质疏松症。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-07-02 DOI: 10.1016/j.nano.2024.102773

{"title":"Neuroprotective macromolecular methylprednisolone prodrug nanomedicine prevents glucocorticoid-induced muscle atrophy and osteoporosis in a rat model of spinal cord injury","authors":"","doi":"10.1016/j.nano.2024.102773","DOIUrl":"10.1016/j.nano.2024.102773","url":null,"abstract":"<div><p>To address the adverse side effects associated with systemic high-dose methylprednisolone (MP) therapy for acute spinal cord injury (SCI), we have developed a <em>N</em>-2-hydroxypropyl methacrylamide copolymer-based MP prodrug nanomedicine (Nano-MP). Intravenous Nano-MP selectively targeted to the inflamed SCI lesion and significantly improved neuroprotection and functional recovery after acute SCI. In the present study, we comprehensively assessed the potential adverse side effects associated with the treatment in the SCI rat models, including reduced body weight and food intake, impaired glucose metabolism, and reduced musculoskeletal mass and integrity. In contrast to free MP treatment, intravenous Nano-MP after acute SCI not only offered superior neuroprotection and functional recovery but also significantly mitigated or even eliminated the aforementioned adverse side effects. The superior safety features of Nano-MP observed in this study further confirmed the clinical translational potential of Nano-MP as a highly promising drug candidate for better clinical management of patients with acute SCI.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured gadolinium(III) micelles: Synthesis, characterization, cytotoxic activities, and MRI applications in vivo 纳米结构钆（III）胶束：合成、表征、细胞毒性活性和核磁共振成像在体内的应用。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-07-02 DOI: 10.1016/j.nano.2024.102770

{"title":"Nanostructured gadolinium(III) micelles: Synthesis, characterization, cytotoxic activities, and MRI applications in vivo","authors":"","doi":"10.1016/j.nano.2024.102770","DOIUrl":"10.1016/j.nano.2024.102770","url":null,"abstract":"<div><p>Gadolinium-based contrast agents (GBCAs) are used in around 40 % of MRI procedures. Despite initial perceptions of minimal risk, their long-term use has emphasized the need to reduce toxicity and develop more efficient GBCAs with extended blood retention. Advancements in nanomaterials have led to improved GBCAs, enhancing MRI diagnostics. This study synthesizes and characterizes nanostructured gadolinium(III) micelles as superior MRI contrast agents. The complexes, [Gd(L)2], where L is a ligand of the N-alkyl-<em>N</em>-methylglucamine surfactant series (L8, L10 or L12, L10), form nanostructured micelles in aqueous solution. Gd(L8)2 and Gd(L10)2 relaxivities remained stable across concentrations. Compared to Gd-DTPA, Gd(III) micelles showed enhanced T1-weighted MRI contrast. Gd(L12)2 micelles exhibited cytotoxicity against B16F10 melanoma cells (IC<sub>50</sub> 42.5 ± 2.2 μM) and L292L929 fibroblasts (IC<sub>50</sub> 52.0 ± 2.5 μM), with a selectivity index of 1.2. <em>In vivo</em> application in mice brain T2-weighted images suggests nanostructured Gd(III) micelles are promising MRI contrast agents for targeting healthy organs or tumors.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient enrichment of free target sequences in an integrated microfluidic device for point-of-care detection systems 在用于床旁检测系统的集成微流控装置中高效富集游离目标序列。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-07-02 DOI: 10.1016/j.nano.2024.102771

Elisa Erice PhD , Oihane Mitxelena-Iribarren PhD , Sergio Arana PhD , Charles H. Lawrie PhD , Maite Mujika PhD

{"title":"Efficient enrichment of free target sequences in an integrated microfluidic device for point-of-care detection systems","authors":"Elisa Erice PhD , Oihane Mitxelena-Iribarren PhD , Sergio Arana PhD , Charles H. Lawrie PhD , Maite Mujika PhD","doi":"10.1016/j.nano.2024.102771","DOIUrl":"10.1016/j.nano.2024.102771","url":null,"abstract":"<div><p>Nucleic acid biomarker detection has great importance in the diagnosis of disease, the monitoring of disease progression and the classification of patients according to treatment decision making. Nucleic acid biomarkers found in the blood of patients have generated a lot of interest due to the possibility of being detected non-invasively which makes them ideal for monitoring and screening tests and particularly amenable to point-of-care (POC) or self-testing. A major challenge to POC molecular diagnostics is the need to enrich the target to optimise detection. In this work, we describe a microfabricated device for the enrichment of short dsDNA target sequences, which is especially valuable for potential detection methods, as it improves the probability of effectively detecting the target in downstream analyses. The device integrated a heating element and a temperature sensor with a microfluidic chamber to carry out the denaturation of the dsDNA combined with blocking-probes to enrich the target. This procedure was validated by fluorescence resonance energy transfer (FRET) technique, labelling DNA with a fluorophore and a quencher. As proof of concept, a 23-mer long dsDNA sequence corresponding to the L858R mutation of the <em>EGFR</em> gene was used. The qualitative results obtained determined that the most optimal blocking rate was obtained with the incorporation of 11/12-mer blocking-probes at a total concentration of 6 μM. This device is a powerful DNA preparation tool, which is an indispensable initial step for subsequent detection of sequences via nucleic acid hybridisation methods.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor effect of nanophotothermolysis mediated by zinc phthalocyanine particles 酞菁锌颗粒介导的纳米光热作用的抗肿瘤效果。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-28 DOI: 10.1016/j.nano.2024.102768

Olga A. Bezborodova MD , Andrey A. Pankratov PhD , Boris Y. Kogan PhD , Elena R. Nemtsova MD , Julia B. Venediktova MSc , Tatyana A. Karmakova MD , Alexander V. Butenin PhD , Raisa K.-G. Feizulova PhD , Varvara A. Khokhlova MSc , Ekaterina A. Obraztsova PhD , Andrey D. Kaprin MD

引用次数: 0

Radiological properties of nano-hydroxyapatite compared to natural equine hydroxyapatite quantified using dual-energy CT and high-field MR 使用双能 CT 和高场磁共振量化纳米羟基磷灰石与天然马羟基磷灰石的放射学特性。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-26 DOI: 10.1016/j.nano.2024.102765

Katarzyna Skierbiszewska DVM , Urszula Szałaj PhD Eng. , Bernard Turek DVM PhD DSc , Olena Sych PhD Eng. , Tomasz Jasiński DVM PhD , Witold Łojkowski Professor , Małgorzata Domino DVM MSc PhD DSc

{"title":"Radiological properties of nano-hydroxyapatite compared to natural equine hydroxyapatite quantified using dual-energy CT and high-field MR","authors":"Katarzyna Skierbiszewska DVM , Urszula Szałaj PhD Eng. , Bernard Turek DVM PhD DSc , Olena Sych PhD Eng. , Tomasz Jasiński DVM PhD , Witold Łojkowski Professor , Małgorzata Domino DVM MSc PhD DSc","doi":"10.1016/j.nano.2024.102765","DOIUrl":"10.1016/j.nano.2024.102765","url":null,"abstract":"<div><p>In equine medicine, assisted bone regeneration, including use of biomaterial substitutes like hydroxyapatite (HAP), is crucial for addressing bone defects. To follow-up on the outcome of HAP-based bone defect treatment, the advancement in quantified diagnostic imaging protocols is needed. This study aimed to quantify and compare the radiological properties of the HAP graft and natural equine bone using Magnetic Resonance (MR) and Computed Tomography (CT), both Single (SECT) and Dual Energy (DECT). SECT and DECT, allow for the differentiation of three HAP grain sizes, by progressive increase in relative density (RD). SECT, DECT, and MR enable the differentiation between natural cortical bone and synthetic HAP graft by augmentation in Effective Z and material density (MD) in HAP/Water, Calcium/Water, and Water/Calcium reconstructions, alongside the reduction in T2 relaxation time. The proposed quantification provided valuable radiological insights into the composition of HAP grafts, which may be useful in follow-up bone defect treatment.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1549963424000340/pdfft?md5=33a6f4eeddd77a85bbe49e328545d946&pid=1-s2.0-S1549963424000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cell-derived exosomes as cell free nanotherapeutics and nanocarriers 间充质干细胞衍生的外泌体作为无细胞纳米疗法和纳米载体。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-22 DOI: 10.1016/j.nano.2024.102769

Ali Imran Abid PhD , Guillaume Conzatti PhD , Florence Toti PhD , Nicolas Anton PhD , Thierry Vandamme PhD

{"title":"Mesenchymal stem cell-derived exosomes as cell free nanotherapeutics and nanocarriers","authors":"Ali Imran Abid PhD , Guillaume Conzatti PhD , Florence Toti PhD , Nicolas Anton PhD , Thierry Vandamme PhD","doi":"10.1016/j.nano.2024.102769","DOIUrl":"10.1016/j.nano.2024.102769","url":null,"abstract":"<div><p>Many strategies for regenerating the damaged tissues or degenerating cells are employed in regenerative medicine. Stem cell technology is a modern strategy of the recent approaches, particularly the use of mesenchymal stem cells (MCSs). The ability of MSCs to differentiate as well as their characteristic behaviour as paracrine effector has established them as key elements in tissue repair (Shaer et al., 2014<span><sup>1</sup></span>). Recently, extracellular vesicles (EVs) shed by MSCs have emerged as a promising cell free therapy (Citation}Rani, S., Ryan, A. E., Griffin, M. D., and Ritter, T., 2015<span><sup>2</sup></span>). This comprehensive review encompasses MSCs-derived exosomes and their therapeutic potential as nanotherapeutics. We also discuss their potency as drug delivery nano-carriers in comparison with liposomes. A better knowledge of EVs behaviour in vivo and of their mechanism of action are key to determine parameters of an optimal formulation in pilot studies and to establish industrial processes.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1549963424000388/pdfft?md5=c0be17492409b70cb143942a63ed1a16&pid=1-s2.0-S1549963424000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of mesenchymal stromal cells with silibinin-loaded PLGA nanoparticles improves their therapeutic efficacy for cutaneous wound repair 用含有 Silibinin 的 PLGA 纳米颗粒修饰间充质基质细胞，提高其对皮肤伤口修复的疗效。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-20 DOI: 10.1016/j.nano.2024.102767

Ningfei Shen MSc , Anna Polyanskaya MSc , Xiaoli Qi PhD , Aya Al Othman MSc , Anastasia Permyakova PhD , Marina Volkova PhD , Alexandre Mezentsev PhD , Mikhail Durymanov PhD

{"title":"Modification of mesenchymal stromal cells with silibinin-loaded PLGA nanoparticles improves their therapeutic efficacy for cutaneous wound repair","authors":"Ningfei Shen MSc , Anna Polyanskaya MSc , Xiaoli Qi PhD , Aya Al Othman MSc , Anastasia Permyakova PhD , Marina Volkova PhD , Alexandre Mezentsev PhD , Mikhail Durymanov PhD","doi":"10.1016/j.nano.2024.102767","DOIUrl":"10.1016/j.nano.2024.102767","url":null,"abstract":"<div><p>The use of mesenchymal stromal cells (MSCs) for treating chronic inflammatory disorders, wounds, and ischemia-reperfusion injuries has shown improved healing efficacy. However, the poor survival rate of transplanted cells due to oxidative stress in injured or inflamed tissue remains a significant concern for MSC-based therapies. In this study, we developed a new approach to protect MSCs from oxidative stress, thereby improving their survival in a wound microenvironment and enhancing their therapeutic effect. We produced PLGA nanoparticles loaded with the cytoprotective phytochemical silibinin (SBN), and used them to modify MSCs. Upon internalization, these nanoformulations released SBN, activating the Nrf2/ARE signaling pathway, resulting in threefold reduction in intracellular ROS content and improved cell survival under oxidative stress conditions. Modification of MSCs with SBN-loaded PLGA nanoparticles increased their survival upon transplantation to full-thickness cutaneous wounds and improved wound healing. This study suggests that MSC modification with cytoprotective nanoparticles could be a promising approach for improving wound healing.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles 通过金涂层磁性纳米粒子的非致命磁机械致动增强化疗效果。

IF 4.2 2区医学

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-18 DOI: 10.1016/j.nano.2024.102766

Cristina Stavilă PhD student , Dumitru Daniel Herea PhD , Mihaela Camelia Zară PhD , George Stoian PhD , Anca Emanuela Minuti PhD , Luminița Labușcă PhD - MD , Marian Grigoraș PhD , Horia Chiriac PhD , Nicoleta Lupu PhD , Adriana Petrovici PhD student , Adriana Aniță PhD - MD , Dragos Aniță PhD - MD

{"title":"Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles","authors":"Cristina Stavilă PhD student , Dumitru Daniel Herea PhD , Mihaela Camelia Zară PhD , George Stoian PhD , Anca Emanuela Minuti PhD , Luminița Labușcă PhD - MD , Marian Grigoraș PhD , Horia Chiriac PhD , Nicoleta Lupu PhD , Adriana Petrovici PhD student , Adriana Aniță PhD - MD , Dragos Aniță PhD - MD","doi":"10.1016/j.nano.2024.102766","DOIUrl":"10.1016/j.nano.2024.102766","url":null,"abstract":"<div><p>Remote magneto-mechanical actuation (MMA) of magnetic nanoparticles (MNP) is emerging as a promising therapy method in oncology. However, translation to the clinic faces the challenge of whole-body action and the reluctance about indiscriminate mechanical action of the nanoparticles on tumor and healthy cells. Here, we show how the MMA method based on magnetically-rotated gold-coated MNP boosts only the activity of an unbound antitumor drug, without physical damage of cells via MNP. Therefore, in clinical practice, the effect of antitumor drug can be safely increased systemically while maintaining drug concentrations at current doses.</p></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1549963424000352/pdfft?md5=78865600aecf94690c303cb654fad111&pid=1-s2.0-S1549963424000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0