Nanotechnology最新文献_第4页

Composition-dependent properties of ultra-thin MoSi_xbased extreme ultraviolet pellicle. 超薄钼基极紫外光膜的成分依赖性质。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-05-09 DOI: 10.1088/1361-6528/add305

Munsu Choi, Juhee Hong

{"title":"Composition-dependent properties of ultra-thin MoSixbased extreme ultraviolet pellicle.","authors":"Munsu Choi, Juhee Hong","doi":"10.1088/1361-6528/add305","DOIUrl":"https://doi.org/10.1088/1361-6528/add305","url":null,"abstract":"Extreme ultraviolet (EUV) pellicle is essential for protecting photomask from external contamination in EUV lithography (EUVL), a critical technology for nanometer-scale photolithography. However, achieving high optical transmittance, thermal stability, and mechanical robustness in pellicle for high-power EUVL processes remains challenging. This study fabricated EUV pellicles using multilayer MoSixthin films with varying Mo-to-Si ratios and protective capping layers. As Mo content increased, mechanical and thermal properties improved, while optical transmittance decreased. MoSi2(x= 2) exhibited the highest tensile strength and >90% fabrication yield. In contrast, MoSi3.4(x= 3.4) showed enhanced optical properties, and MoSi2.3(x= 2.3) offered superior thermal performance. These results highlight the composition-dependent trade-offs in optimizing pellicle performance for EUVL applications. In contrast to previous studies, which investigated a single MoSi2composition, this study systematically explores a broad compositional range of MoSix(x= 1.6-3.4). A distinct contribution of this work is the quantitative linkage established between mechanical performance, particularly ultimate tensile strength, and fabrication yield. The results reveal that no single composition optimizes all critical properties simultaneously, highlighting the necessity of trade-off-based material selection for application-specific requirements in EUVL. This study offers a guideline for optimizing EUV pellicle design, contributing to higher wafer throughput, improved equipment utilization, and reduced operational costs in high-volume lithography.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic mechanism behind the influence of intercalated heteroatom Sn on the slip energy barrier in layered WS₂. 杂原子Sn对层状WS2中滑移能垒影响的电子机制。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-05-08 DOI: 10.1088/1361-6528/add166

Dulin Huang, Gonglei Shao, Xu Zhang, Zhen Zhou

{"title":"Electronic mechanism behind the influence of intercalated heteroatom Sn on the slip energy barrier in layered WS2.","authors":"Dulin Huang, Gonglei Shao, Xu Zhang, Zhen Zhou","doi":"10.1088/1361-6528/add166","DOIUrl":"https://doi.org/10.1088/1361-6528/add166","url":null,"abstract":"Frictional losses often result in substantial economic costs, and the application of lubricants can markedly mitigate these losses. Recently, layered materials have garnered extensive research interest due to their exceptional lubricating properties. However, the exploration of sliding mechanisms associated with intercalated heteroatoms in layered materials remains a subject of considerable uncertainty. In this work, we employ density functional theory to unravel the friction modulation mechanism of Sn atoms intercalated in layered WS2. Our findings demonstrate that Sn intercalation significantly reduces the sliding energy barrier (down to 0.96 meV atom-1), while the friction force and shear strength are minimized to 0.0011 nN atom-1and 0.0008 GPa, respectively, outperforming conventional two-dimensional materials such as MoS2and graphene. Furthermore, Sn intercalation enhances interlayer electrostatic repulsion and suppresses dynamic charge density fluctuations. To quantitatively elucidate the energy barrier variation, we propose a novel metric-total charge density difference evolution (Δρ2). This discovery provides theoretical guidance for designing ultra-low-friction lubricants and is expected to advance energy efficiency in industrial machinery.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CVD-grown SnS₂active layers on AlGaN/GaN HEMT for arsenic (III) ions detection. cvd生长的sns2活性层在AlGaN/GaN HEMT上检测砷（III）离子。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-05-06 DOI: 10.1088/1361-6528/adcc37

Nipun Sharma, Adarsh Nigam, Jai Mishra, Ashok Kumar, Srinjoy Mitra, Ankur Gupta, Sudhiranjan Tripathy, Mahesh Kumar

{"title":"CVD-grown SnS2active layers on AlGaN/GaN HEMT for arsenic (III) ions detection.","authors":"Nipun Sharma, Adarsh Nigam, Jai Mishra, Ashok Kumar, Srinjoy Mitra, Ankur Gupta, Sudhiranjan Tripathy, Mahesh Kumar","doi":"10.1088/1361-6528/adcc37","DOIUrl":"https://doi.org/10.1088/1361-6528/adcc37","url":null,"abstract":"The pervasive contamination of water sources by the toxic heavy metal arsenic presents a serious threat to human health and ecological systems. This raises the critical need for innovative detection platforms that can detect such contamination at low cost and as part of an onsite, distributed sensor network. In this context, we report an Arsenic (As3+) ion detection system that was fabricated using 2D SnS2functionalized AlGaN/GaN high electron mobility transistor (HEMT). SnS2layers were grown on the HEMT surface by chemical vapor deposition (CVD) which depicts hexagonal oriented nanosheets with crystal edges. The source and drain tri-metal contacts of Au/Cr/Al were fabricated by thermal evaporation using shadow mask. The sensor response was analyzed by measuring the variation in drain to source current of the device after introducing varied concentrations of As3+ions, ranging from 1 ppb to 10 ppm. The observed sensitivity of the device is 0.42μA ppb-1, with a detection limit of 0.90 ppb, and a response time of 3.2 s. Further, real-time data analysis was performed by the integration of the developed sensor with a customized printed circuit board connected with an Arduino Nano 33 Bluetooth Low Energy (BLE) module for data transmission. The concept of growing the SnS2layer as a functionalizing layer by CVD results in quick response, good repeatability, and selectivity thereby eliminating the need for any additional reference electrode. Integration of the developed AlGaN/GaN HEMT sensor with Arduino Nano 33 BLE makes it an ideal candidate for portable heavy metal ion sensing device for onsite detection.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 20","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical synthesis and supercapacitor performance of manganese and cerium oxide-doped polyaniline composites. 锰铈掺杂聚苯胺复合材料的电化学合成及其超级电容器性能。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-05-06 DOI: 10.1088/1361-6528/add01e

Hilal Yildirim Kalyon, Yakup Fatih Karasan, Metin Gencten

引用次数: 0

Bulk synthesis of mixed transition metal dichalcogenide and performance as working electrode in Li, Na, and K-ion half cells. 混合过渡金属二硫化物的体合成及其在Li， Na和k离子半电池中作为工作电极的性能。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/adcf30

Arijit Roy, Gurpreet Singh

{"title":"Bulk synthesis of mixed transition metal dichalcogenide and performance as working electrode in Li, Na, and K-ion half cells.","authors":"Arijit Roy, Gurpreet Singh","doi":"10.1088/1361-6528/adcf30","DOIUrl":"https://doi.org/10.1088/1361-6528/adcf30","url":null,"abstract":"Nanosheets of mixed or cation-substituted Transition metal dichalcogenide (TMD) are promising materials for a range of applications, including electrodes for electrochemical energy storage devices. Yet such materials are expensive to produce in large quantities (gram levels or higher). Here, we report on a two-step process, which involves precursor pyrolysis and sulfur annealing for the preparation of bulk powders of MoxW1-xS2. The structural and morphological properties of the synthesized cation-substituted TMD alloy are compared with high-purity commercially sourced MoWS2and MoS2/WS2hybrid specimens. Notably, the electrochemical characteristics of synthesized MoxW1-xS2exhibit exceptional first-cycle specific charge capacities for lithium-ion (638 mAh g-1), sodium-ion (423 mAh g-1), and potassium-ion (328 mAh g-1) half-cells. All the cells showed capacity decay in longer-term cycling tests, arising from volume changes in TMD conversion-type electrodes. To mitigate the capacity decay, a voltage cut-off method is implemented, which minimizes irreversibility and structural distortion of TMD during cycling, even at higher cycling currents with nearly 100% average cycling efficiency. The findings of this study demonstrate a proficient and scalable synthesis methodology poised to be utilized across an array of layered TMD materials, with benefits to both industry and fundamental research into alkali-metal-ion energy storage.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 21","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisynergistic antibacterial and anti-inflammatory effects of silver-anchored polydopamine nanocomposites hydrogel on periodontitis. 银锚定聚多巴胺纳米复合水凝胶对牙周炎的多协同抗菌和抗炎作用。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/adcf2f

Rui Ruan, Qiaoxin Li, Xinglong Zhang, Zihan Dai, Wei Qiang, Mengdie Ji, Mengjie Liu, Jian Chen, Hongda Zhu

{"title":"Multisynergistic antibacterial and anti-inflammatory effects of silver-anchored polydopamine nanocomposites hydrogel on periodontitis.","authors":"Rui Ruan, Qiaoxin Li, Xinglong Zhang, Zihan Dai, Wei Qiang, Mengdie Ji, Mengjie Liu, Jian Chen, Hongda Zhu","doi":"10.1088/1361-6528/adcf2f","DOIUrl":"https://doi.org/10.1088/1361-6528/adcf2f","url":null,"abstract":"Conventional treatment modalities for periodontitis are less effective in removing bacterial plaques and biofilms, which tend to induce an inflammatory microenvironment in periodontal tissue and lead to disease progression. To overcome this limitation, we designed a silver-anchored polydopamine (PDA) nanocomposites hydrogel system (P-Ag@PDA gels, ∼200 nm) for multisynergistic treatment of periodontitis. PDA nanoparticles could synergize with silver to exert powerful bactericidal activity and reduce tissue damage caused by reactive oxygen species (ROS) or inflammatory factors. Meanwhile, the low-temperature photothermal process facilitated the penetration of nanoparticles into the bacterial biofilm, solving the challenge of biofilm removal in periodontitis. Poloxamer 407 thermosensitive hydrogel helped the nanocomposites adhere to the bacterial surface, overcoming the problem of reduced efficacy due to the rapid loss of the drug in the oral cavity. The antibacterial, biofilm scavenging, ROS scavenging and anti-inflammatory properties of P-Ag@PDA gels were investigatedin vitro and in vivo. The results revealed that P-Ag@PDA gels with NIR light stimulation were more effective than tinidazole (TNZ) in attenuating ROS-induced periodontal tissue damage and removing biofilms, while exhibiting similar antimicrobial effects. This study provided a highly promising biomaterial for the treatment of periodontal infections.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 21","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing light-trapping and defect minimization in ultrathin amorphous silicon solar cells using dualp-layer architecture. 利用双层结构平衡超薄非晶硅太阳能电池的光捕获和缺陷最小化。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/adcf2d

Niveditha Nair, Anjitha M Pillai, Rita Rizzoli, Harish Lakhotiya, Arne Nylandsted Larsen, Peter Balling, Sanjay K Ram

{"title":"Balancing light-trapping and defect minimization in ultrathin amorphous silicon solar cells using dualp-layer architecture.","authors":"Niveditha Nair, Anjitha M Pillai, Rita Rizzoli, Harish Lakhotiya, Arne Nylandsted Larsen, Peter Balling, Sanjay K Ram","doi":"10.1088/1361-6528/adcf2d","DOIUrl":"https://doi.org/10.1088/1361-6528/adcf2d","url":null,"abstract":"Ultrathin solar cell devices based on amorphous silicon offer significant advantages in terms of cost and stability, provided they are effectively integrated with light-trapping strategies. However, integrating these devices with photonic nanotextures is challenging due to the high defect concentrations that may result from the deposition of ultrathin material layers on textured substrates. This study utilizes a cost-effective, scalable approach using quasiperiodic nanowrinkles as textured substrates for ultrathin amorphous silicon solar cells fabricated in ap-i-nconfiguration, with a 100 nm absorber layer. To enhance the performance on the nanowrinkles, a dualp-layer architecture, comprising a thin hydrogenated amorphous silicon protective layer combined with a nanocrystallinep-type layer is employed. These nanowrinkle solar cell devices show significant improvements, up to ∼33%, in power conversion efficiency compared to their flat substrate counterparts. The dualp-layer approach is effective in mitigating the adverse effect of defects, demonstrating a maximum of ∼33% increase in short-circuit photocurrent densities compared to single-p-layer configuration in the highest efficiency device. Simulation studies are conducted to analyze the electrical characteristics and charge transport phenomenon of the device layers, and the improved performance of the final device.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 21","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etching processes of Si(111) surfaces with bunched steps via atomic hydrogen irradiation intermittently observed by atomic force microscopy. 用原子力显微镜观察了原子氢辐照对Si（111）表面的簇阶蚀刻过程。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/adcf2e

Tomoaki Miyagi, Akira Sasahara, Masahiko Tomitori

{"title":"Etching processes of Si(111) surfaces with bunched steps via atomic hydrogen irradiation intermittently observed by atomic force microscopy.","authors":"Tomoaki Miyagi, Akira Sasahara, Masahiko Tomitori","doi":"10.1088/1361-6528/adcf2e","DOIUrl":"https://doi.org/10.1088/1361-6528/adcf2e","url":null,"abstract":"Silicon (Si) (111)-(7 × 7) surfaces with wide terraces and bunched steps were passivated with atomic hydrogen (H) and subsequently etched by irradiation of atomic H. The atomic H can suppress the reactivity of Si surfaces by terminating the dangling bonds of Si surfaces. Meanwhile, atomic H can break the periodic atomic structures such as (7 × 7) on the Si surfaces. In the present study, we intermittently repeated the atomic H irradiation to the H-terminated Si(111) surface and frequency-modulation atomic force microscopy observation in a conventional vacuum chamber. When H2gas was introduced to the cracker with a gas flow rate of 1 sccm (≈1.7 × 10-8m3·s-1), corresponding to an atomic H flux of 2.5 × 1016cm-2·s-1, one hour of the atomic H irradiation increased the roughness of the terrace from 1.4 nm up to 1.9 nm. With increasing the gas flow rate to 10 sccm, pits were formed on the surface and enlarged to 20-40 nm diameters across the bunched step with shallow flat bottoms and non-uniform winding edges. The surface etching probably starts from the adsorption of H on the lower-coordinated Si atoms exposed at the bunched steps. The side walls of pits seemed to consist of {110} and {100} facets that are readily etched due to the smaller number of the back bonds of Si atoms.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 21","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of piroxicam and M (M = Pd(II), Ag(I)) complex nanoconjugates with orange quantum dots for enhanced antimicrobial and anticancer activity. 吡罗昔康与M (M= Pd （II), Ag (I)）纳米配合物的合成及表征

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/adc4eb

Ahmed M Kamal El-Sagheir, Aya M Soliman, Alaa Elsaghir, Momen M Thabet, Ahmed Faried Abdel Hakiem, Ahmed S Aboraia

{"title":"Synthesis and characterization of piroxicam and M (M = Pd(II), Ag(I)) complex nanoconjugates with orange quantum dots for enhanced antimicrobial and anticancer activity.","authors":"Ahmed M Kamal El-Sagheir, Aya M Soliman, Alaa Elsaghir, Momen M Thabet, Ahmed Faried Abdel Hakiem, Ahmed S Aboraia","doi":"10.1088/1361-6528/adc4eb","DOIUrl":"10.1088/1361-6528/adc4eb","url":null,"abstract":"Conjugation and loading of piroxicam and its metal complexes; Palladium(II) (PdL2) and Silver(I) (AgL) synthesized and characterized by different techniques including infrared, UV-Vis spectroscopy, spectrofluorimetry, transmission electron microscope, x-ray powder diffraction and Zeta potential analyses were achieved. Orange quantum dots (OQDs) nanoparticle showed good stability, encapsulation and loading efficiency and controlled release of loaded piroxicam and its metal complexes. Generally, new OQQs conjugates showed enhanced antimicrobial and anticancer activity.In vitroantimicrobial activity screening demonstrated thatAg(I)-OQDs conjugate displayed potent antibacterial effect that was 1.8-fold againstE. colihigher than piroxicam (MIC = 31.85µM), wherePd(II)-OQDs conjugate depicted the highest activity with MIC of 33.05µM againstP. aeruginosa. In case of G + ve bacteria,Agconjugate had potent activity which was 2.3-fold onS. aureushigher than piroxicam (MIC = 43.12µM), whilePdconjugate exerted promising activity that was 3.5-fold againstE. faecalishigher than piroxicam (MIC = 74.57µM).Agconjugate showed the most promising antifungal activity with 2.5-folds more than piroxicam. Thein vitroantiproliferative activity depicted that all synthesized conjugates showed better Cytotoxic effect than piroxicam, specificallyPdconjugate which had IC50 values with by 2-fold lower than piroxicam on human liver cancer cell lineHepg2.WhilePdandAgconjugates showed 2.3 and 1.9-fold higher effect on human colon cancer cell lineHT-29compared to piroxicam.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A doxorubicin-loaded polymeric nanocarrier with 2,2'-binaphthyl-1,1'-diol-based backbone and tannic acid coating for enhanced stability and antitumor applications. 一种负载阿霉素的聚合物纳米载体，具有2,2'-联萘-1,1'-二醇基骨架和单宁酸涂层，用于增强稳定性和抗肿瘤应用。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-04-30 DOI: 10.1088/1361-6528/add26d

Xiaoxia Guo, Chaofan Wang, Lihong Fan, Jie Wang, Qianqiu Wang, Chenfan Duan, Ban Chen, Heshuang Dai

{"title":"A doxorubicin-loaded polymeric nanocarrier with 2,2'-binaphthyl-1,1'-diol-based backbone and tannic acid coating for enhanced stability and antitumor applications.","authors":"Xiaoxia Guo, Chaofan Wang, Lihong Fan, Jie Wang, Qianqiu Wang, Chenfan Duan, Ban Chen, Heshuang Dai","doi":"10.1088/1361-6528/add26d","DOIUrl":"https://doi.org/10.1088/1361-6528/add26d","url":null,"abstract":"This study presents PBVT, a polyurethane-based nano-drug delivery system incorporating BINOL (2,2'-binaphthyl-1,1'-diol), tannic acid (TA), and phenylboronic acid (PBA), to overcome critical challenges in cancer therapy such as low drug-loading capacity, nanoparticle instability, and systemic toxicity. Polyurethane was chosen as the base material due to its exceptional versatility, offering tunable mechanical properties, biocompatibility, and chemical stability, making it ideal for constructing robust nanocarriers for drug delivery. BINOL is incorporated for the first time into a nano polyurethane framework, featuring dual naphthalene rings that enable strong π-π stacking interactions with doxorubicin (DOX), achieving a high drug-loading capacity (48.6%) and encapsulation efficiency (89.8%). TA enhances system stability and biocompatibility through hydrogen bonding, while its phenolic hydroxyl groups provide antioxidant and antibacterial properties, reducing infection risks during chemotherapy. PBA is integrated into the polyurethane backbone adding pH-responsive drug release capabilities, allowing selective and controlled release of DOX in acidic tumor microenvironments. In vitro, cellular experiments confirmed the low cytotoxicity of PBVT against normal cells and the potent anticancer activity of PBVT-DOX in tumor cells in a dose-dependent manner. The system demonstrated sustained drug release and stability for over two weeks under physiological conditions. PBVT-DOX represents a novel, efficient platform for targeted cancer therapy and the development of advanced polyurethane-based nanomaterials for biomedical applications.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0