Nanotechnology最新文献_第10页

Targeted therapy for glioblastoma utilizing hyaluronic acid-engineered liposomes for adriamycin delivery.

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-30 DOI: 10.1088/1361-6528/adacef

Yanping Wang, Peiyan Qi, Shenbao Shi, Cong Pang, Weijie Wang, Dazhao Fang

{"title":"Targeted therapy for glioblastoma utilizing hyaluronic acid-engineered liposomes for adriamycin delivery.","authors":"Yanping Wang, Peiyan Qi, Shenbao Shi, Cong Pang, Weijie Wang, Dazhao Fang","doi":"10.1088/1361-6528/adacef","DOIUrl":"10.1088/1361-6528/adacef","url":null,"abstract":"Glioblastoma (GBM) is a malignant tumor with highly heterogeneous and invasive characteristics leading to a poor prognosis. The CD44 molecule, which is highly expressed in GBM, has emerged as a highly sought-after biological marker. Therapeutic strategies targeting the cell membrane protein CD44 have emerged, demonstrating novel therapeutic potential. In this study, we constructed a nanodrug system (HA-Liposome@Dox) based on hyaluronic acid-engineered liposomes delivering adriamycin to target GBM. The system efficiently encapsulated Dox inside the liposomes through a hydrophilic-hydrophobic interaction mechanism, and the resulting HA-Liposome@Dox exhibited excellent loading efficacy, attributed to its uniform particle size distribution and negatively charged surface. Further evaluation revealed that HA-Liposome@Dox possessed excellent stability and safety and could promote the effective uptake of drug particles by CD44-overexpressing tumor cells, thus exerting a more potent cell-killing effect. Notably, in the treatment of GBM, HA-Liposome@Dox demonstrated significantly greater tumor growth inhibition compared to free Dox and prolonged the survival of tumor-bearing mice. Taken together, the present study not only verified the feasibility of HA-Liposome@Dox as an effective therapeutic tool against GBM and other CD44-positively expressing tumors, but also opened a promising new avenue for the clinical treatment of this type of refractory malignancies.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of hierarchical sapphire nanostructures using ultrafast laser induced morphology change. 利用超快激光诱导形貌变化制备层次化蓝宝石纳米结构

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-30 DOI: 10.1088/1361-6528/adab7c

Joshua Cheung, Kun-Chieh Chien, Peter Sokalski, Li Shi, Chih-Hao Chang

{"title":"Fabrication of hierarchical sapphire nanostructures using ultrafast laser induced morphology change.","authors":"Joshua Cheung, Kun-Chieh Chien, Peter Sokalski, Li Shi, Chih-Hao Chang","doi":"10.1088/1361-6528/adab7c","DOIUrl":"10.1088/1361-6528/adab7c","url":null,"abstract":"Sapphire is an attractive material that stands to benefit from surface functionalization effects stemming from micro/nanostructures. Here we investigate the use of ultrafast lasers for fabricating sapphire nanostructures by exploring the relationship between irradiation parameters, morphology change, and selective etching. In this approach a femtosecond laser pulse is focused on the substrate to change the crystalline morphology to amorphous or polycrystalline, which is characterized by examining different vibrational modes using Raman spectroscopy. The irradiated regions are removed using a subsequent hydrofluoric acid etch. Laser confocal measurements quantify the degree of selective etching. The results indicate a threshold laser pulse intensity required for selective etching. This process was used to fabricate hierarchical sapphire nanostructures over large areas with enhanced hydrophobicity, with an apparent contact angle of 140 degrees, and a high roll-off angle, characteristic of the rose petal effect. Additionally, the structures have high broadband diffuse transmittance of up to 81.8% with low loss, with applications in optical diffusers. Our findings provide new insights into the interplay between the light-matter interactions, where Raman shifts associated with different vibrational modes can predict selective etching. These results advance sapphire nanostructure fabrication, with applications in infrared optics, protective windows, and consumer electronics.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface receptor-targeted protein-based nanocarriers for drug delivery: advances in cancer therapy.

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-30 DOI: 10.1088/1361-6528/adad7a

Panneerselvam Theivendren, Parasuraman Pavadai, Suganthan Veerachamy, Ponnusamy Palanisamy, Selvaraj Kunjiappan

{"title":"Surface receptor-targeted protein-based nanocarriers for drug delivery: advances in cancer therapy.","authors":"Panneerselvam Theivendren, Parasuraman Pavadai, Suganthan Veerachamy, Ponnusamy Palanisamy, Selvaraj Kunjiappan","doi":"10.1088/1361-6528/adad7a","DOIUrl":"10.1088/1361-6528/adad7a","url":null,"abstract":"Significant progress has been made in cancer therapy with protein-based nanocarriers targeted directly to surface receptors for drug delivery. The nanocarriers are a potentially effective solution for the potential drawbacks of traditional chemotherapy, such as lack of specificity, side effects, and development resistance. Peptides as nanocarriers have been designed based on their biocompatible, biodegradable, and versatile functions to deliver therapeutic agents into cancer cells, reduce systemic toxicity, and maximize therapy efficacy through utilizing targeted ligands such as antibodies, amino acids, vitamins, and other small molecules onto protein-based nanocarriers and thus ensuring that drugs selectively accumulate in the cancer cells instead of healthy organs/drug release at a target site without effects on normal cells, which inherently caused less systemic toxicity/off-target effect. Moreover, their intrinsic protein backbone naturally degradesin vivo, providing another level of safety over synthetic materials. Various issues like immunogenicity, mass production, and quality control must be addressed for widespread use. However, further studies are necessary to perfect protein engineering and improve drug loading, protein modification, and targeting. Thus, it can be concluded that protein-based nanocarriers targeted against the surface receptors would help achieve cancer management in a more focused manner, thus minimizing toxicity. The further development of these nanoparticles could bring a significant change in cancer treatment so that more personalized, targeted, and safe therapies would be available to all patients.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ternary stochastic neuron- implemented with a single strained magnetostrictive nanomagnet. 用单应变磁致伸缩纳米磁体实现三元随机神经元。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-29 DOI: 10.1088/1361-6528/adac66

Rahnuma Rahman, Supriyo Bandyopadhyay

引用次数: 0

Investigations of modulation method and stress mechanism for the growth of AlGaN channel heterostructures.

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-29 DOI: 10.1088/1361-6528/ada3dd

Baiqi Wang, Yachao Zhang, Shengrui Xu, Yixin Yao, Wenjun Liu, Chenglin Du, Xiaolong Cai, Sheng Wu, Haijun Liu, Yu Zhang, Xue Tang, Jincheng Zhang, Yue Hao

引用次数: 0

C₆₀fullerene improves the contractile activity of the injured ratmuscle gastrocnemius. C60富勒烯可改善大鼠腓肠肌损伤后的收缩活性。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-27 DOI: 10.1088/1361-6528/ada29a

Yuriy Prylutskyy, Dmytro Nozdrenko, Olexandr Motuziuk, Svitlana Prylutska, Natalia Nurishchenko, Daria Franskevych, Vasil Soroca, Vsevolod Cherepanov, Ihor Kalinin, Olha Korzhyk, Uwe Ritter

{"title":"C60fullerene improves the contractile activity of the injured ratmuscle gastrocnemius.","authors":"Yuriy Prylutskyy, Dmytro Nozdrenko, Olexandr Motuziuk, Svitlana Prylutska, Natalia Nurishchenko, Daria Franskevych, Vasil Soroca, Vsevolod Cherepanov, Ihor Kalinin, Olha Korzhyk, Uwe Ritter","doi":"10.1088/1361-6528/ada29a","DOIUrl":"10.1088/1361-6528/ada29a","url":null,"abstract":"The powerful antioxidant properties of C60fullerenes have been widely used in biomedical nanotechnology. Owing to the negative effects of free radicals in oxidative stress processes, antioxidants are required to protect injured muscles. Here, the effect of water-soluble C60fullerenes (daily oral dose 1 mg kg-1) on the process of restoration of contractile activity of skeletal muscle of rats (muscle gastrocnemius) 15 d after the initiation of open trauma of different severity was studied for the first time. The structural organization of C60fullerene nanoparticles in aqueous solution was analyzed by dynamic light scattering and atomic force microscopy techniques. Such biomechanical parameters ofmuscle gastrocnemiuscontraction as integrated muscle power, levels of generation of its maximum and minimum force, and time interval until reaching 50% of the level of force response of the muscle were analyzed. Such biochemical indices as concentrations of c-reactive protein, creatinine, and lactate in the rat blood, as well as indices of pro- and antioxidant balance (activities of superoxide dismutase and catalase, the concentration of reduced glutathione) in the blood and muscle tissue of experimental animals, were investigated. It was found that application of water-soluble C60fullerenes statistically significantly improves biomechanical parameters of contraction of injuredmuscle gastrocnemiusat the level of 30-45 ± 3%, which is confirmed by normalization of biochemical indices in the blood and muscle tissue of rats at the level of 35-50 ± 3% and 20-37 ± 3%, correspondingly, relative to the open injury group. These findings open the possibility of using C60fullerenes as potential therapeutic nanoagents capable of correcting pathological states of the muscular system during the physiological repair of open injuries.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal chalcogenide quantum dots for photochemical and electrochemical hydrogen generation: recent advancements and technological challenges. 用于光化学和电化学制氢的金属硫系量子点：最新进展和技术挑战。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-27 DOI: 10.1088/1361-6528/adaafa

Syed Asim Ali, Iqra Sadiq, Tokeer Ahmad

{"title":"Metal chalcogenide quantum dots for photochemical and electrochemical hydrogen generation: recent advancements and technological challenges.","authors":"Syed Asim Ali, Iqra Sadiq, Tokeer Ahmad","doi":"10.1088/1361-6528/adaafa","DOIUrl":"10.1088/1361-6528/adaafa","url":null,"abstract":"The performance of heterogeneous catalysis, specifically photochemical and electrochemical hydrogen evolution reaction (HER) fundamentally relies upon the prudent choice of catalytic systems with ideal optoelectronic and surface properties. Progressive research in materials processing has hinted at the large-scale applicability of two-dimensional (2D) materials for achieving higher activity in the HER process. Among 2D materials, transition metal chalcogenides (TMCs) have emerged as the advanced materials to enhance the rate of HER on account of their layered structure and chalcogen-sites that exhibit favorable hydrogen binding energies. Developing quantum dots (QDs) is the state-of-the-art methodological approach to tuning the physicochemical properties of TMCs. Herein, we aim to encompass the latest advancements in the TMCs QDs for green hydrogen upscaling with special attention given to the comprehensive understanding of physicochemical properties and experimental benchmarks. Furthermore, we have accounted the major challenges associated with the exploitation of TMCs QDs in HER operations and future perspectives for subscribing to the overall water splitting for hydrogen synthesis in the light of TMCs QDs.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dexamethasone-loaded fibroin nanoparticles promote retinal reattachment in rats by regulating the Th17/Treg balance. 地塞米松负载的纤维蛋白纳米颗粒通过调节 Th17/Treg 平衡促进大鼠视网膜再粘连

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-24 DOI: 10.1088/1361-6528/ad9df2

Linfeng Han, Xiaomeng Li, Genjie Ke, Kai Dong, Guoping Wang, Yonghong Sheng, Liming Tao

{"title":"Dexamethasone-loaded fibroin nanoparticles promote retinal reattachment in rats by regulating the Th17/Treg balance.","authors":"Linfeng Han, Xiaomeng Li, Genjie Ke, Kai Dong, Guoping Wang, Yonghong Sheng, Liming Tao","doi":"10.1088/1361-6528/ad9df2","DOIUrl":"10.1088/1361-6528/ad9df2","url":null,"abstract":"Retinal detachment (RD) is a common acute blinding eye disease, and dexamethasone (DEX), an adrenocorticosteroid, shows protective effects against RD. However, its poor water solubility and low bioavailability limit its effectiveness. To address this, we developed SF@DEX nanomaterials and investigated their therapeutic potential and mechanisms in RD. The nanomaterials were successfully synthesized and characterized, achieving 90% encapsulation efficiency and releasing 60% of DEX within 12 h.In vitro, phagocytosis was measured by flow cytometry, and enzyme-linked immunosorbent assay determined interleukin-17 (IL-17) and interleukin-10 (IL-10) levels. A rat RD model was established surgically, followed by oral administration of silk fibroin (SF), SF@DEX, and DEX. Polymerase chain reaction (PCR) assessed IL-17A and forkhead box P3 (FOXP3) expression, while Western blot analysed transforming growth factor-β1 (TGF-β1), IL-10, IL-17A, and FOXP3 levels. Apoptosis of retinal ganglion cells was evaluated using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, and confocal microscopy detected colocalization of IL-17A and FOXP3. SF@DEX treatment significantly reduced Th17 cells and IL-17A while increasing Tregs, FOXP3, TGF-β1, and IL-10 levels. The severity of RD in rats was notably alleviated by SF@DEX, demonstrating its anti-inflammatory effects through modulation of the Th17/Treg immune balance. These results highlight SF@DEX as a promising nano-based therapy for RD.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective area molecular beam epitaxy of InSb on InP(111)_B: from thin films to quantum nanostructures. InSb在InP(111)B上的选择性区分子束外延：从薄膜到量子纳米结构。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-24 DOI: 10.1088/1361-6528/adaafb

W Khelifi, P Capiod, C Barbot, C Coinon, Y Deblock, C N Santos, N Chaize, M Berthe, P-H Jouneau, S Amarie, J-F Lampin, X Wallart, Ph Ballet, B Grandidier, L Desplanque

{"title":"Selective area molecular beam epitaxy of InSb on InP(111)B: from thin films to quantum nanostructures.","authors":"W Khelifi, P Capiod, C Barbot, C Coinon, Y Deblock, C N Santos, N Chaize, M Berthe, P-H Jouneau, S Amarie, J-F Lampin, X Wallart, Ph Ballet, B Grandidier, L Desplanque","doi":"10.1088/1361-6528/adaafb","DOIUrl":"10.1088/1361-6528/adaafb","url":null,"abstract":"InSb is a material of choice for infrared as well as spintronic devices but its integration on large lattice mismatched semi-insulating III-V substrates has so far altered its exceptional properties. Here, we investigate the direct growth of InSb on InP(111)Bsubstrates with molecular beam epitaxy. Despite the lack of a thick metamorphic buffer layer for accommodation, we show that quasi-continuous thin films can be grown using a very high Sb/In flux ratio. The quality of the films is further studied with Hall measurements on large-scale devices to assess the impact of the InSb surface and InSb/InP interface on the electronic properties. Taking advantage of the optimized growth conditions for the formation of thin films, the selective area molecular beam epitaxial growth of nanostructures is subsequently investigated. Based on cross-sectional transmission electron microscopy and scanning near-field optical microscopy in the middle-wave infrared, ultra-thin and very long in-plane InSb nanowires as well as more complex nanostructures such as nano-rings and crosses are achieved with a good structural quality.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophobic PU fabric with synergistic conductive networks for boosted high sensitivity, wide linear-range wearable strain sensor. 具有协同导电网络的疏水性PU织物，用于增强高灵敏度，宽线性范围可穿戴应变传感器。

IF 2.9 4区材料科学

Nanotechnology Pub Date : 2025-01-24 DOI: 10.1088/1361-6528/ada9f1

Yanyan Ma, Kening Wan, Yuwen Huang, Qichun Feng, Zhaofang Du

{"title":"Hydrophobic PU fabric with synergistic conductive networks for boosted high sensitivity, wide linear-range wearable strain sensor.","authors":"Yanyan Ma, Kening Wan, Yuwen Huang, Qichun Feng, Zhaofang Du","doi":"10.1088/1361-6528/ada9f1","DOIUrl":"10.1088/1361-6528/ada9f1","url":null,"abstract":"Strain sensing fabrics are able to sense the deformation of the outside world, bringing more accurate and real-time monitoring and feedback to users. However, due to the lack of clear sensing mechanism for high sensitivity and high linearity carbon matrix composites, the preparation of high performance strain sensing fabric weaving is still a major challenge. Here, an elastic polyurethane (PU)-based conductive fabric (GCPU) with high sensitivity, high linearity and good hydrophobicity is prepared by a novel synergistic conductive network strategy. The GCPU fabric consists of graphene sheets (GS)/carbon nanotubes (CNTs) elastic conductive layer and a PU elastic substrate. GS and CNTs can be constructed into a synergistic conductive network, and the fabric is endowed with high conductivity (1.193 S m-1). Simulated equivalent circuits show that GS in the conductive network will break violently under applied strain, making the GCPU fabric extremely sensitive (gauge factor 102). CNTs are spatially distributed in GS lamellae, avoiding the phenomenon that the constructed synergistic conductive network is violently fractured under the applied strain, which leads to the decrease of linearity (0.996). Styrene-ethylene-butylene-styrene (SEBS) was used as a dispersant and binder to uniformly disperse and closely bond GS and CNTs into PU fabrics. In addition, the hydrophobicity of SEBS makes the GCPU fabric resistant to water environment (The contact angle is 123°). Due to the good mechanical stability of GCPU fabric, GCPU fabric has a wide strain range (0%-50%) and high cycle stability (over 1000 cycles). In practice, GCPU fabric can accurately simulate and detect the size and deformation motion of human body. Therefore, the successful construction of elastic fabrics with synergistic conductive networks provides a feasible path for the design and manufacture of wearable intelligent fabrics.","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0