Nanotechnology最新文献

{"title":"NCCD: A unique combination of MOF-scaffolded stable luminescent copper nanoclusters (Cu NCs) and carbon dots (Cdots) as a potent antimicrobial agent against Pseudomonas aeruginosa.","authors":"Ayush Amod, Shraddha Singh, Rubina Lawrence, Ananya Anurag Anurag Anand, Sneha Ranjan, Sangeeta Singh, Amaresh Kumar Sahoo, Sintu Kumar Samanta","doi":"10.1088/1361-6528/addacd","DOIUrl":"https://doi.org/10.1088/1361-6528/addacd","url":null,"abstract":"<p><p>Bacterial biofilm infections cause huge cases of morbidity and mortality globally. Cells in bacterial biofilms can easily overcome host immune response and become resistant to conventional antibiotics. Hence, the concurrent issues of biofilm infections demand the urgent development of new therapeutic strategies other than the conventional antibiotic treatment. Herein, we have developed an exclusive combination of fluorescent copper nanoclusters (Cu NCs) with biocompatible and bactericidal fluorescent carbon dots (Cdots) coined as nanocluster-carbon dots (NCCD) as a wide-range antibacterial and antibiofilm agent against Gram-negative Escherichia coli and Gram-positive Bacillus subtilis. Interestingly, NCCD was found effective even against the pathogenic strain of Pseudomonas aeruginosa. CuNCs showed a MIC90 value of 20 ± 2, 7.5 ± 2, and 10 ± 3 µg mL-1 against E. coli, P. aeruginosa and B. subtilis respectively while Cdots showed a MIC90 value of 200 ± 5 and 160 ± 2, against E. coli and B. subtilis respectively. NCCD inhibited the biofilm production in B. subtilis and P. aeruginosa to 40.27% and 68.10%, respectively and that of reduced the mass of established biofilm to 53.09% and 68.43%, respectively. The antibiofilm activity of NCCD was found to increase considerably in combination with biofilm-degrading enzymes like α-amylase and/or DNase. The acidic microenvironment and presence of chelating enzymes in biofilm considerably lower the antibiofilm activity of antibiotics. However, a significant increase in the susceptibility of the biofilm to antibiotics was observed in presence of NCCD. The loss of cell membrane permeability was found to be one of the probable causes of cell death by NCCD. Further, it was demonstrated that NCCD-mediated biofilm degradation may be due to the regulation of bacterial chemotaxis leading to transition of cells from biofilm to planktonic state. Thus, it is conceivable that NCCD could be a potent agent against various antibiotic-resistant bacterial biofilm infections.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor microenvironment-responsive diagnosis and treatment of integrated drug-loaded CdTe quantum dots for treatment tumors.","authors":"Jiahao Su, Tingyuan Yan, Xiankang Zhang, Tingxuan Yan, Zhixiang Wang","doi":"10.1088/1361-6528/add6ad","DOIUrl":"10.1088/1361-6528/add6ad","url":null,"abstract":"<p><p>The acidic tumor microenvironment is a common feature of tumors, and boric acid-functionalized quantum dots (BA-QDs) exhibit pH-sensitive boron affinity effects and fluorescence emission characteristics. In this study, CdTe QDs were prepared using the water phase synthesis method. Additionally, BA-QDs were prepared by modifying QDs with 4-mercaptophenylboric acid. Hesperetin, baicalein, quercetin, and other model drugs were used, with QDs and BA-QDs serving as carriers, to create a drug-loaded system of QDs with tumor microenvironment-responsive drug release performance. The physical and chemical properties were characterized using dynamic light scattering (DLS), Fourier transform infrared spectroscopy, transmission electron microscopy, x-ray diffraction, etc. Our findings showed that the synthesis of drug-loaded QDs with a uniform particle size was successful. The experiments involved studying the adsorption kinetics of the QDs and the degree of dissolution of the drug-loaded QDs<i>in vitro</i>. BA-QDs exhibited pH-responsive drug release and fluorescence emission properties.<i>In vitro</i>cell experiments were conducted to examine the uptake and imaging effects of QDs and BA-QDs at the cell level. The results showed that both QDs and BA-QDs exhibited effective imaging at the cell level. Moreover, the three drug-loaded BA-QDs inhibited HepG2 cancer cells by about 80%, indicating a significant inhibitory effect on cancer cells. Here, we developed a universal new technology for tumor diagnosis and treatment, provided innovative approaches for targeted cancer diagnosis and treatment, and broadened the application scope of nanofluorescence technology.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dots derived from citric acid/glucose for optimizing the retention of propamocarb in reversed-phase chromatography column.","authors":"Caixia Wang, Chengkui Qiao, Fajun Tian, Ruxia Chen, Linlin Guo, Tao Pang, Jun Li, Rongli Pang, Hanzhong Xie","doi":"10.1088/1361-6528/addaca","DOIUrl":"https://doi.org/10.1088/1361-6528/addaca","url":null,"abstract":"<p><p>Carbon dots (CDs) have been widely used in the detection of pesticide residues in foods owning to their easy surface functionalization, adjustable characteristic, stable photoluminescence properties, and high water solubility. Because CDs have variety of functional groups that could achieve multiple retention mechanisms when it as functional ligands for silica gels-based stationary-phases. However, there have no CDs to optimize the retention of propamocarb (PM) in liquid chromatography based on the adsorption capacity of CDs. In this work, a new CDs (NM-CDs) was obtained by a simple hydrothermal method via using citric acid and glucose as two carbon sources. The analysis results of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for 0.001-0.1 μg/mL PM that showed excellent retention from 0.9-2.4 min to 0.7-1.4 min, and a single chromatographic peak when added NM-CDs. At the same time, NM-CDs improved the signal-to-noise ratio and stabilized the mass spectrum for PM. Thus, the addition of NM-CDs has improved the efficiency of the chromatographic process, and the stability and sensitivity of detection concentration PM in the C18 chromatography column. Meanwhile, the excellent results were also revealed in the detection of PM with pesticide multiresidue and complex matrix, which has provided an effective implementation for CDs to detect pesticide residues in food at separation science.&#xD.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging therapeutic strategies and opportunities in targeting protein pathways for breast cancer treatment: a critical review.","authors":"Panneerselvam Theivendren, Parasuraman Pavadai, Selvaraj Kunjiappan, Kaveena Ravi, Natarajan Kiruthiga, Kumarappan Chidamabaram, Shanmugarathinam Alagarsamy, Nagireddy Bhuvan Reddy","doi":"10.1088/1361-6528/add6ae","DOIUrl":"10.1088/1361-6528/add6ae","url":null,"abstract":"<p><p>Understanding breast cancer at a molecular level is essential for developing effective treatments due to its significant impact on women's mortality rates globally. Targeted medicines focus on specific proteins crucial to breast cancer progression, offering a promising treatment avenue. These proteins, often overexpressed or mutated in cancer cells, are vital for cell proliferation, division, and survival. Targeted drugs aim to inhibit these proteins, halting disease progression and sparing non-cancerous cells, which reduces side effects and improves patient quality of life. Key proteins in breast cancer treatment include HER2 (human epidermal growth factor receptor 2), ER (estrogen receptor), and PR (progesterone receptor). Drugs like Trastuzumab target HER2 to impede tumor growth in HER2-positive cancers, while hormone therapies targeting ER and PR improve outcomes for hormone receptor-positive cancers. Examining proteins such as EGFR, HER2/Neu, and ER reveals their roles in cancer pathways, with pathways like PI3K/Akt/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin) and MAPK (mitogen-activated protein kinase) being crucial targets for therapies, potentially revolutionizing breast cancer treatment.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging advancements in ecofriendly nanosorbent technology accompanied with natural fillers: a systematic review.","authors":"Neha Soni, Ranu Nayak","doi":"10.1088/1361-6528/add5fe","DOIUrl":"10.1088/1361-6528/add5fe","url":null,"abstract":"<p><p>Increasing incidence of oil spills due to maritime transportation and improper disposal of refinery waste has caused severe damage to marine ecosystems. Various traditional technologies have been developed to mitigate oil pollution. However, these methods require high-cost and complex multi-step treatments that limits their large-scale applicability. Sorbent-based remediation, particularly porous polymeric sorbents (synthetic and natural), has emerged as a promising strategy for oil spill cleanup. Synthetic polymeric sorbents exhibit high oil sorption capacities, but their non-biodegradability raises ecological concerns. Consequently, research has shifted toward nature-friendly biodegradable polymeric sorbents. Despite their environmental benefits, these sorbents often suffer from inherent hydrophilicity, limited oil selectivity, and low mechanical strength, that restricts their long-term performance. To enhance the oil selectivity and water repellency of biodegradable sorbents, various surface modification strategies have been explored. Chemical surface modifications with hydrophobic materials such as, CNTs, graphene oxide, and fluoroalkanes have proven to be effective in improving the water repellency, but raises concerns regarding toxicity and environmental safety. Recent advancements focus on integrating natural fillers, biomimetic surface engineering, and functional biocompatible coatings to achieve superior oil-water separation performance, while maintaining environmental safety. This review systematically analyzes time-based evolution and advancements in biodegradable polymeric nanosorbents, emphasizing their fabrication techniques, biocompatible surface modifications, and integration of natural fillers for enhanced oil-water separation. A comprehensive literature search was conducted across multiple electronic databases (Web of Science, ScienceDirect, PubMed, and Google Scholar), covering studies published from 2015 to 2024. Studies were selected based on keyword searches and reference mining to ensure comprehensive coverage of relevant developments in the field. By providing a comparative analysis of key performance metrics and identifying research gaps, this review highlights the potential of natural fillers and biomimetic strategies using bio-sources for developing next-generation superhydrophobic nanosorbents.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mRNA lipid nanoparticles in CAR-T therapy: a novel strategy to improve efficacy.","authors":"Zengkai Zhao, Mingmei Li, Xiang Zheng, Pengli Gao, Chenlu Huang, Qingyu Yu, Limin Jin, Linhua Zhang, Dunwan Zhu, Fangzhou Li","doi":"10.1088/1361-6528/add482","DOIUrl":"10.1088/1361-6528/add482","url":null,"abstract":"<p><p>Chimeric antigen receptor T cells (CAR-T) immunotherapy has achieved remarkable progress in the treatment of hematological malignancies. However, it encounters challenges including complex manufacturing processes, high cost, and safety issues. Lipid nanoparticle (LNP) technology, as an advanced gene delivery platform, offers significant advancements to CAR-T therapy through its high efficiency, low immunogenicity, and safety. LNP enable<i>in vivo</i>production of CAR-T cells, thereby improving delivery efficiency, reducing the risks of immunogenicity and insertional mutations, simplifying the production process and reducing costs. The scalability and rapid optimization ability of LNP position them as promising candidates for CAR-T cell production. LNP technology is expected to further promote the development of CAR-T immunotherapy and provide safer and more economical treatment options. Therefore, this paper aims to provide a comprehensive and systematic review of the application of LNP in CAR-T therapy. In this review, we initially outline the fundamental design, process, and current challenges of CAR-T therapy. Subsequently, we present the characteristics of LNP, their advantages as a gene delivery vectors, and how they improve the efficacy of CAR-T therapy. Finally, we summarize the current research landscape of LNP applications in CAR-T therapy. This includes enhancing<i>in vitro</i>transfection of T cells, programming T cells<i>in situ</i>, facilitating T-cell activation, alleviating the side effects of CAR-T therapy, and combining CAR-T therapy with other immunotherapies. These advancements will aid in the design of mRNA delivery systems based on LNP, thereby promoting the development of CAR-T therapy.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in targeted therapy for inflammatory breast cancer: nanomaterials, conventional treatments, and clinical applications.","authors":"Eshana Bhattacharya, Siuli Shaw, Ranu Nayak, Sudeep Bose","doi":"10.1088/1361-6528/add165","DOIUrl":"https://doi.org/10.1088/1361-6528/add165","url":null,"abstract":"<p><p>Inflammatory breast cancer (IBC) presents a formidable challenge due to its rapid progression and unique clinical characteristics within the various manifestations of breast cancer. Despite being rare, its aggressive nature demands innovative approaches beyond conventional treatments. Nanomedicine offers exciting possibilities for improving all types of breast cancer therapeutics including IBC. In this review, we critically assess the current treatment landscape for IBC, highlighting the limitations of traditional methods and addressing the pressing need for new therapeutic strategies. Although many nanomaterials have been explored for breast cancer therapeutics, either alone or in combination with other therapies, only a limited number of nanotherapeutics have been extensively studied for IBC treatment. This review further explores how advancements in nanotechnology, such as nanoparticle- mediated photothermal therapy, Photodynamic therapy, and nanomedicinal targeted therapies can offer novel avenues for addressing the unique biological, technological, and regulatory challenges posed by IBC. IBC-related various nanomedicines based combinatorial therapies are highlighted in this review. It also provides a forward-looking perspective on key research directions and clinical applications.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile synthesis of cubic Ni_1-<i>x</i>Cr<i>_x</i>nanoalloys and their composition-dependent electrocatalytic activity for the hydrogen evolution reaction.","authors":"Md Kawsar Alam, Manish Kumar Mohanta, Daulton White, Jordon Baker, Lisa S Graves, Puru Jena, Indika U Arachchige","doi":"10.1088/1361-6528/add26f","DOIUrl":"https://doi.org/10.1088/1361-6528/add26f","url":null,"abstract":"<p><p>The viability of the electrolysis of water currently relies on expensive catalysts such as Pt that are far too impractical for industrial scale use. Thus, there is considerable interest in developing low-cost, earth-abundant nanomaterials and their alloys as a potential alternative to existing standard catalysts. To address this issue, a synergistic approach involving theory and experiment was carried out. The former, based on density functional theory, was conducted to guide the experiment in selecting the ideal dopant and optimal concentration by focusing on 3d, 4d, and 5d elements as dopants on Ni (001) surface. Subsequently, a series of Ni_1-<i>x</i>Cr<i>_x</i>(<i>x</i>= 0.01-0.09) alloy nanocrystals (NCs) with size ranging from 8.3 ± 1.6-18.2 ± 3.2 nm were colloidally synthesized to experimentally investigate the hydrogen evolution reaction (HER) activity. A compositional dependent trend for electrocatalytic activity was observed from both approaches with Ni_0.92Cr_0.08NCs showed the lowest Δ<i>G</i>_Hvalue and the lowest overpotential (<i>η</i>_-10) at -10 mA cm^-2current density (<i>j</i>), suggesting the highest HER activity among all compositions studied. Among alloy NCs, the highest performing Ni_0.92Cr_0.08composition displayed a mixed Volmer-Heyrovsky HER mechanism, the lowest Tafel slope, and improved stability in alkaline solutions. This study provides critical insights into enhancing the performance of earth-abundant metals through doping-induced electronic structure variation, paving the way for the design of high-efficiency catalysts for water electrolysis.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electron microscopy study of the shell geometry in bent and twisted GaAs-InP core-shell nanowires.","authors":"Spencer McDermott, Trevor R Smith, Ryan B Lewis","doi":"10.1088/1361-6528/add26e","DOIUrl":"https://doi.org/10.1088/1361-6528/add26e","url":null,"abstract":"<p><p>The spontaneous bending of core-shell nanowires through asymmetric shell deposition has implications for sensors, enabling both parallel fabrication and creating advantageous out-of-plane nanowire sensor geometries. This study investigates the impact of shell deposition geometry on the shell distribution and bending of GaAs-InP core-shell nanowires. Scanning and transmission electron microscopy methods are employed to quantify nanowire twisting and bending. A practical analytical electron tomography reconstruction technique is developed for characterizing the nanowire shell distribution, which utilizes the hexagonal nanowire shape to reconstruct two-dimensional cross-sections along the nanowire length. The study reveals that the orientation of the phosphorus beam with respect to the nanowire side facets induces significant variations in nanowire bending and twisting. The findings demonstrate the important role of crystallographic orientation during core-shell nanowire synthesis for engineering the shape of bent nanowire sensors.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved energy storage performance of BOPP sandwich structured films by modulating the topological structure.","authors":"Yi Gong, Xin Wei, Liangbao Liu, Haozhe Jia, Ruijiao Liu","doi":"10.1088/1361-6528/add01d","DOIUrl":"https://doi.org/10.1088/1361-6528/add01d","url":null,"abstract":"<p><p>As the basis of the modern electronics industry, electronic functional materials provide powerful support for the development of science and technology. Biaxially oriented polypropylene (BOPP) dielectric films are widely used in capacitors for excellent dielectric advantages. In this paper, a topological-structured multilayer sandwich dielectric film was designed. BOPP was used as the outer layer, the blend of chlorinated polypropylene/polyvinylidene fluoride (CPP/PVDF) as the middle layer, and two-dimensional boron nitride nanosheets (BNNS) were added to the CPP/PVDF blend to enhance its breakdown strength. The sandwich-structured films had the highest discharged energy density of 5.17 J cm^-3at 3 vol% addition of BNNS in the middle layer, and the charge-discharge efficiency maintained at a high level of 82.1%. The dielectric and energy storage properties of BOPP sandwich films were effectively improved by the introduction of large aspect ratio fillers.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":"36 22","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}