Buğçe Aydın, Serdar Bozoğlu, Nilgün Karatepe, Fatma Seniha Güner
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Folic acid-conjugated magnetic carbon nanotube nanocarriers for targeted delivery of mitoxantrone.
Dual or multi-targeted delivery systems are a crucial aspect of optimal cancer treatment. These systems minimize side effects while maximizing therapeutic efficiency. With this motivation, in this study, we developed a dual-targeted nanocarrier system by modifying bovine serum albumin-coated magnetic carbon nanotubes (mCNT-BSA) with folic acid (FA) to enhance both magnetic and receptor-mediated targeting. The novel carrier was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy-energy dispersive x-ray spectroscopy, x-ray photoelectron spectroscopy, vibrating sample magnetometer, and thermogravimetric analysis. Results confirmed successful FA conjugation and sufficient magnetic properties (14.7 emu g-1) for external guidance. The system demonstrated a high mitoxantrone (MTO) loading capacity (120µg mg-1) and pH-sensitive release behavior, supporting drug release in acidic tumor microenvironments.In vitrocytotoxicity assays showed reduced toxicity of mCNT-BSA-FA/MTO on the MDA-MB-231 cancer cell line to free MTO. These findings suggest that mCNT-BSA-FA is a promising nanocarrier system for dual-targeted and controlled MTO delivery.
期刊介绍：
The journal aims to publish papers at the forefront of nanoscale science and technology and especially those of an interdisciplinary nature. Here, nanotechnology is taken to include the ability to individually address, control, and modify structures, materials and devices with nanometre precision, and the synthesis of such structures into systems of micro- and macroscopic dimensions such as MEMS based devices. It encompasses the understanding of the fundamental physics, chemistry, biology and technology of nanometre-scale objects and how such objects can be used in the areas of computation, sensors, nanostructured materials and nano-biotechnology.
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