Synthesis and characterization of piroxicam and M (M = Pd(II), Ag(I)) complex nanoconjugates with orange quantum dots for enhanced antimicrobial and anticancer activity.

IF 2.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nanotechnology Pub Date : 2025-04-30 DOI:10.1088/1361-6528/adc4eb

Ahmed M Kamal El-Sagheir, Aya M Soliman, Alaa Elsaghir, Momen M Thabet, Ahmed Faried Abdel Hakiem, Ahmed S Aboraia

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引用次数: 0

Abstract

Conjugation and loading of piroxicam and its metal complexes; Palladium(II) (PdL₂) and Silver(I) (AgL) synthesized and characterized by different techniques including infrared, UV-Vis spectroscopy, spectrofluorimetry, transmission electron microscope, x-ray powder diffraction and Zeta potential analyses were achieved. Orange quantum dots (OQDs) nanoparticle showed good stability, encapsulation and loading efficiency and controlled release of loaded piroxicam and its metal complexes. Generally, new OQQs conjugates showed enhanced antimicrobial and anticancer activity.In vitroantimicrobial activity screening demonstrated thatAg(I)-OQDs conjugate displayed potent antibacterial effect that was 1.8-fold againstE. colihigher than piroxicam (MIC = 31.85µM), wherePd(II)-OQDs conjugate depicted the highest activity with MIC of 33.05µM againstP. aeruginosa. In case of G + ve bacteria,Agconjugate had potent activity which was 2.3-fold onS. aureushigher than piroxicam (MIC = 43.12µM), whilePdconjugate exerted promising activity that was 3.5-fold againstE. faecalishigher than piroxicam (MIC = 74.57µM).Agconjugate showed the most promising antifungal activity with 2.5-folds more than piroxicam. Thein vitroantiproliferative activity depicted that all synthesized conjugates showed better Cytotoxic effect than piroxicam, specificallyPdconjugate which had IC50 values with by 2-fold lower than piroxicam on human liver cancer cell lineHepg2.WhilePdandAgconjugates showed 2.3 and 1.9-fold higher effect on human colon cancer cell lineHT-29compared to piroxicam.

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吡罗昔康与M (M= Pd （II), Ag (I)）纳米配合物的合成及表征

吡罗西康及其金属配合物的缀合与负载合成了钯（II）（PdL2）和银(I) (AgL)，并采用红外光谱、紫外可见光谱、荧光光谱、透射电镜、XRPD和Zeta电位等不同技术对其进行了表征。OQDs纳米颗粒对吡罗西康及其金属配合物具有良好的稳定性、包封效率和控释效果。总的来说，新的OQQs偶联物显示出增强的抗菌和抗癌活性。体外抗菌活性筛选表明，Ag(I)-OQDs偶联物对大肠杆菌的抗菌效果比吡罗西康（MIC= 31.85µM）高1.8倍，其中Pd(II)-OQDs偶联物对铜绿假单胞菌的抗菌效果最高，MIC为33.05µM。在G+ve细菌中，Ag偶联物对金黄色葡萄球菌（S. aureus）的活性是吡罗西康（MIC= 43.12µM）的2.3倍，Pd偶联物对粪肠球菌（E. faecalis）的活性是吡罗西康（MIC= 74.57µM）的3.5倍。银偶联物的抗真菌活性是吡罗西康的2.5倍。体外抗增殖活性表明，合成的Pd偶联物对人肝癌细胞株HepG2的IC50值比吡罗西康低2倍，均优于吡罗西康。Pd和Ag偶联物对人结肠癌细胞株HT-29的作用分别比吡罗西康高2.3倍和1.9倍。

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来源期刊

Nanotechnology 工程技术-材料科学：综合

CiteScore

7.10

自引率

5.70%

发文量

820

审稿时长

2.5 months

期刊介绍： The journal aims to publish papers at the forefront of nanoscale science and technology and especially those of an interdisciplinary nature. Here, nanotechnology is taken to include the ability to individually address, control, and modify structures, materials and devices with nanometre precision, and the synthesis of such structures into systems of micro- and macroscopic dimensions such as MEMS based devices. It encompasses the understanding of the fundamental physics, chemistry, biology and technology of nanometre-scale objects and how such objects can be used in the areas of computation, sensors, nanostructured materials and nano-biotechnology.