Nature Microbiology最新文献_第10页

Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection 金黄色葡萄球菌在慢性感染期间适应利用源自胶原的脯氨酸

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-12 DOI: 10.1038/s41564-024-01769-9

Andreacarola Urso, Ian R. Monk, Ying-Tsun Cheng, Camilla Predella, Tania Wong Fok Lung, Erin M. Theiller, Jack Boylan, Sofya Perelman, Swikrity U. Baskota, Ahmed M. Moustafa, Gaurav Lohia, Ian A. Lewis, Benjamin P. Howden, Timothy P. Stinear, Nicolino V. Dorrello, Victor Torres, Alice S. Prince

{"title":"Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection","authors":"Andreacarola Urso, Ian R. Monk, Ying-Tsun Cheng, Camilla Predella, Tania Wong Fok Lung, Erin M. Theiller, Jack Boylan, Sofya Perelman, Swikrity U. Baskota, Ahmed M. Moustafa, Gaurav Lohia, Ian A. Lewis, Benjamin P. Howden, Timothy P. Stinear, Nicolino V. Dorrello, Victor Torres, Alice S. Prince","doi":"10.1038/s41564-024-01769-9","DOIUrl":"10.1038/s41564-024-01769-9","url":null,"abstract":"Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates. Metabolomics of bronchiolar lavage fluid and fibroblast infection, growth assays and analysis of bacterial mutant strains showed that airway fibroblasts produce collagen during S. aureus infection. Host-adapted bacteria upregulate collagenase, which degrades collagen and releases proline. S. aureus then imports proline, which fuels oxidative metabolism via the tricarboxylic acid cycle. Proline metabolism provides host-adapted S. aureus with a metabolic benefit enabling out-competition of non-adapted strains. These data suggest that clinical settings characterized by airway repair processes and fibrosis provide a milieu that promotes S. aureus adaptation and supports infection. Staphylococcus aureus upregulates collagenase and proline transporters to release collagen-derived proline and exploit fibroblasts as a nutrient source during chronic infection.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 10","pages":"2506-2521"},"PeriodicalIF":20.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41564-024-01769-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. 作者更正：共生菌产生的广谱短效抗菌肽多烯可消灭鼻腔金黄色葡萄球菌

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-08 DOI: 10.1038/s41564-024-01798-4

Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel

引用次数: 0

Bringing microbial ecology into focus 聚焦微生物生态学。

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-06 DOI: 10.1038/s41564-024-01785-9

引用次数: 0

Quantitative principles of microbial metabolism shared across scales 跨尺度共享微生物新陈代谢的定量原则

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-06 DOI: 10.1038/s41564-024-01764-0

Daniel Sher, Daniel Segrè, Michael J. Follows

{"title":"Quantitative principles of microbial metabolism shared across scales","authors":"Daniel Sher, Daniel Segrè, Michael J. Follows","doi":"10.1038/s41564-024-01764-0","DOIUrl":"10.1038/s41564-024-01764-0","url":null,"abstract":"Metabolism is the complex network of chemical reactions occurring within every cell and organism, maintaining life, mediating ecosystem processes and affecting Earth’s climate. Experiments and models of microbial metabolism often focus on one specific scale, overlooking the connectivity between molecules, cells and ecosystems. Here we highlight quantitative metabolic principles that exhibit commonalities across scales, which we argue could help to achieve an integrated perspective on microbial life. Mass, electron and energy balance provide quantitative constraints on their flow within metabolic networks, organisms and ecosystems, shaping how each responds to its environment. The mechanisms underlying these flows, such as enzyme–substrate interactions, often involve encounter and handling stages that are represented by equations similar to those for cells and resources, or predators and prey. We propose that these formal similarities reflect shared principles and discuss how their investigation through experiments and models may contribute to a common language for studying microbial metabolism across scales. Mass, electron and energy balances define metabolic networks in a cell, but this framework could also be applied to interactions, ecosystems and global processes, creating a common language for microbial metabolism across scales.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 8","pages":"1940-1953"},"PeriodicalIF":20.5,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Darwin’s expedition revisited to reveal the evolution of plant–microbe interactions on Galápagos 重访达尔文的探险，揭示加拉帕戈斯植物与微生物相互作用的进化过程

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-06 DOI: 10.1038/s41564-024-01749-z

Viviane Cordovez, Víctor J. Carrión, Gonzalo Rivas Torres, Diego A. Ortiz, Wilson Cabrera, Haig Balian, Adriana Karina Vivanco, Juan E. Pérez-Jaramillo, Jaime Chaves, Diana A. Pazmiño, Pieter van ’t Hof, Jos M. Raaijmakers

引用次数: 0

Aspergillus cvjetkovicii protects against phytopathogens through interspecies chemical signalling in the phyllosphere cvjetkovicii 曲霉通过叶球中的种间化学信号来抵御植物病原体

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-05 DOI: 10.1038/s41564-024-01781-z

Xiaoyan Fan, Haruna Matsumoto, Haorong Xu, Hongda Fang, Qianqian Pan, Tianxing Lv, Chengfang Zhan, Xiaoxiao Feng, Xiaoyu Liu, Danrui Su, Mengyuan Fan, Zhonghua Ma, Gabriele Berg, Shaojia Li, Tomislav Cernava, Mengcen Wang

{"title":"Aspergillus cvjetkovicii protects against phytopathogens through interspecies chemical signalling in the phyllosphere","authors":"Xiaoyan Fan, Haruna Matsumoto, Haorong Xu, Hongda Fang, Qianqian Pan, Tianxing Lv, Chengfang Zhan, Xiaoxiao Feng, Xiaoyu Liu, Danrui Su, Mengyuan Fan, Zhonghua Ma, Gabriele Berg, Shaojia Li, Tomislav Cernava, Mengcen Wang","doi":"10.1038/s41564-024-01781-z","DOIUrl":"10.1038/s41564-024-01781-z","url":null,"abstract":"Resident microbiota produces small molecules that influence the chemical microenvironments on leaves, but its signalling roles in pathogen defence are not yet well understood. Here we show that Aspergillus cvjetkovicii, enriched in rice leaf microbiota, subverts Rhizoctonia solani infections via small-molecule-mediated interspecies signalling. 2,4-Di-tert-butylphenol (2,4-DTBP), identified as a key signalling molecule within the Aspergillus-enriched microbiota, effectively neutralizes reactive oxygen species-dependent pathogenicity by switching off bZIP-activated AMT1 transcription in R. solani. Exogenous application of A. cvjetkovicii and 2,4-DTBP demonstrated varying degrees of protective effects against R. solani infection in diverse crops, including cucumber, maize, soybean and tomato. In rice field experiments, they reduced the R. solani-caused disease index to 19.7–32.2%, compared with 67.2–82.6% in the control group. Moreover, 2,4-DTBP showed activity against other rice phytopathogens, such as Fusarium fujikuroi. These findings reveal a defensive strategy against phytopathogens in the phyllosphere, highlighting the potential of symbiotic microbiota-driven neutralization of pathogenicity. Beneficial Aspergillus cvjetkovicii protects host plants against fungal diseases by inactivating pathogenicity-related gene transcription of phytopathogens via 2,4-DTBP signalling.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 11","pages":"2862-2876"},"PeriodicalIF":20.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopy methods map mobile genetic elements and their bacterial hosts 显微镜方法绘制移动遗传元素及其细菌宿主图谱

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-05 DOI: 10.1038/s41564-024-01774-y

引用次数: 0

Angiopoietin-like 4 protects against endothelial dysfunction during bacterial sepsis 血管生成素样 4 可防止细菌性败血症期间的内皮功能障碍

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-05 DOI: 10.1038/s41564-024-01760-4

Jason Ziveri, Loïc Le Guennec, Isabel dos Santos Souza, Jean-Philipe Barnier, Samuel M. Walter, Youssouf Diallo, Yasmine Smail, Elodie Le Seac’h, Haniaa Bouzinba-Segard, Camille Faure, Philippe C. Morand, Irié Carel, Nicolas Perriere, Taliah Schmitt, Brigitte Izac, Franck Letourneur, Mathieu Coureuil, Thomas Rattei, Xavier Nassif, Sandrine Bourdoulous

{"title":"Angiopoietin-like 4 protects against endothelial dysfunction during bacterial sepsis","authors":"Jason Ziveri, Loïc Le Guennec, Isabel dos Santos Souza, Jean-Philipe Barnier, Samuel M. Walter, Youssouf Diallo, Yasmine Smail, Elodie Le Seac’h, Haniaa Bouzinba-Segard, Camille Faure, Philippe C. Morand, Irié Carel, Nicolas Perriere, Taliah Schmitt, Brigitte Izac, Franck Letourneur, Mathieu Coureuil, Thomas Rattei, Xavier Nassif, Sandrine Bourdoulous","doi":"10.1038/s41564-024-01760-4","DOIUrl":"10.1038/s41564-024-01760-4","url":null,"abstract":"Loss of endothelial integrity and vascular leakage are central features of sepsis pathogenesis; however, no effective therapeutic mechanisms for preserving endothelial integrity are available. Here we show that, compared to dermal microvessels, brain microvessels resist infection by Neisseria meningitidis, a bacterial pathogen that causes sepsis and meningitis. By comparing the transcriptional responses to infection in dermal and brain endothelial cells, we identified angiopoietin-like 4 as a key factor produced by the brain endothelium that preserves blood–brain barrier integrity during bacterial sepsis. Conversely, angiopoietin-like 4 is produced at lower levels in the peripheral endothelium. Treatment with recombinant angiopoietin-like 4 reduced vascular leakage, organ failure and death in mouse models of lethal sepsis and N. meningitidis infection. Protection was conferred by a previously uncharacterized domain of angiopoietin-like 4, through binding to the heparan proteoglycan, syndecan-4. These findings reveal a potential strategy to prevent endothelial dysfunction and improve outcomes in patients with sepsis. Therapeutic administration of angiopoietin-like 4 prevents shock during Neisseria meningitidis infection or lipopolysaccharide-induced sepsis in mice.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"9 9","pages":"2434-2447"},"PeriodicalIF":20.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shining light on the coral photosymbiont family Symbiodiniaceae 揭示珊瑚光合共生科共生藻属的奥秘。

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-02 DOI: 10.1038/s41564-024-01745-3

Madeleine J. H. van Oppen

引用次数: 0

The evolving landscape of live attenuated COVID-19 vaccines 不断发展的 COVID-19 减毒活疫苗。

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2024-08-02 DOI: 10.1038/s41564-024-01770-2

Simone Pecetta, Rino Rappuoli

引用次数: 0