Nature Microbiology最新文献

SIV reservoir depletion and clearance from neonatal macaques following transient CCR5 depletion. 短暂CCR5耗竭后新生猕猴SIV库耗竭和清除。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-19 DOI: 10.1038/s41564-026-02511-3

Jesse D Deere, David Merriam, Kawthar Machmach, W L William Chang, Michael Nekorchuk, Gema Méndez-Lagares, Hung Kieu, Joseph Dutra, Justin Fontaine, Denise R Andal, Kateland Sipe, Elizabeth Heninger, Margaret Martin, Wenze Lu, Ning Chin, Connie Chen, Bryant Chi-Thien Tran, Jessica Salinas, Corey N Miller, Steven G Deeks, Jeffrey D Lifson, Kathleen Engelman, Diogo Magnani, Keith Reimann, Mario Stevenson, Jacob D Estes, Dennis J Hartigan-O'Connor

{"title":"SIV reservoir depletion and clearance from neonatal macaques following transient CCR5 depletion.","authors":"Jesse D Deere, David Merriam, Kawthar Machmach, W L William Chang, Michael Nekorchuk, Gema Méndez-Lagares, Hung Kieu, Joseph Dutra, Justin Fontaine, Denise R Andal, Kateland Sipe, Elizabeth Heninger, Margaret Martin, Wenze Lu, Ning Chin, Connie Chen, Bryant Chi-Thien Tran, Jessica Salinas, Corey N Miller, Steven G Deeks, Jeffrey D Lifson, Kathleen Engelman, Diogo Magnani, Keith Reimann, Mario Stevenson, Jacob D Estes, Dennis J Hartigan-O'Connor","doi":"10.1038/s41564-026-02511-3","DOIUrl":"https://doi.org/10.1038/s41564-026-02511-3","url":null,"abstract":"Antiretroviral therapy (ART) suppresses viraemia in people with human immunodeficiency virus (HIV), but HIV provirus persists indefinitely in CD4-expressing cells. Cells containing active provirus express viral proteins and have been successfully targeted using broadly neutralizing antibodies (bnAbs). In contrast, cells containing latent provirus cannot be specifically targeted without latency reactivation. Meaningful depletion of the latent HIV or simian immunodeficiency virus (SIV) reservoirs has not been demonstrated except with cytotoxic conditioning for bone-marrow transplantation. Here we show that both the active and latent SIV reservoirs can be eliminated from infant macaques via profound but transient depletion of cells that express CCR5 using a single shot of CCR5/CD3 bispecific antibody. Neonatal rhesus macaques were infected with SIVmac251, then treated with ART beginning at 1 week after infection, followed by treatment with either a CCR5/CD3-bispecific or a CD4-specific antibody, both of which depleted target cells and accelerated the decline in plasma viraemia. Upon ART cessation, while rebound occurred quickly in all animals treated with ART alone, most animals treated with CCR5/CD3 bispecific antibody remained aviraemic for >3 months. Several remained aviraemic to the end of follow-up and efforts to detect replication-competent virus were unsuccessful. Our results show that bispecific antibody treatment achieves meaningful depletion of the replication-competent SIV reservoir and supports the possibility that clinically meaningful depletion of the HIV reservoir might be achievable for recently infected individuals.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":" ","pages":""},"PeriodicalIF":18.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From professional isolation to global connection with Women in Phage. 从专业隔离到与噬菌体妇女的全球联系。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-19 DOI: 10.1038/s41564-026-02519-9

Fatma Abdelrahman

引用次数: 0

Disentangling microbiota-dependent and -independent impacts of antibiotics on host physiology. 抗生素对宿主生理的依赖和独立影响。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-19 DOI: 10.1038/s41564-026-02453-w

Lilach Zelik, Yehonatan Levin, Jasmin Sawaed, Shahar Telpaz, Mor Zigdon, Meital Nuriel-Ohayon, Elad Rubin, Ateret Gordon, Zheniya Mogilevski, Amit Yehuda, Aya Awad, Hanaa Shaalan, Shira Ben-Simon, Sonia Modilevsky, Maria Naama, Jay Dalvi, Lelyan Moadi, Marina Kurtz, Shira Perez, Sondra Turjeman, Michal Werbner, Soliman Khatib, Omry Koren, Amir Erez, Shai Bel

{"title":"Disentangling microbiota-dependent and -independent impacts of antibiotics on host physiology.","authors":"Lilach Zelik, Yehonatan Levin, Jasmin Sawaed, Shahar Telpaz, Mor Zigdon, Meital Nuriel-Ohayon, Elad Rubin, Ateret Gordon, Zheniya Mogilevski, Amit Yehuda, Aya Awad, Hanaa Shaalan, Shira Ben-Simon, Sonia Modilevsky, Maria Naama, Jay Dalvi, Lelyan Moadi, Marina Kurtz, Shira Perez, Sondra Turjeman, Michal Werbner, Soliman Khatib, Omry Koren, Amir Erez, Shai Bel","doi":"10.1038/s41564-026-02453-w","DOIUrl":"https://doi.org/10.1038/s41564-026-02453-w","url":null,"abstract":"Antibiotics are believed to affect host physiology by altering the gut microbiota. However, it remains unclear which effects of antibiotics are microbiota dependent and which are microbiota independent. Here we present a resource encompassing host and microbiota responses to antibiotic treatment and a computational tool with which to analyse them. Metagenomic and transcriptomic analyses of conventional and germ-free mice revealed that antibiotic administration routes and their combinations affect host and microbiota responses. We developed CompoRes-a computational tool that distinguishes the microbiota-independent impact of antibiotic-induced perturbations, revealing that antibiotics directly impact host physiology. We found that diurnal expression of major histocompatibility complex class II in the mouse colon is controlled by glucose via feeding. This pattern was lost during antibiotic treatment as vancomycin altered feeding behaviour in a microbiota-independent and evolutionarily conserved manner. Together, our study establishes a direct, non-microbial pathway by which antibiotics reshape host immunity and circadian physiology.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":" ","pages":""},"PeriodicalIF":18.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic surveillance of an imported recombinant Clade Ib and IIb monkeypox virus case in India. 印度一例输入性重组进化支Ib和IIb猴痘病毒病例的基因组监测。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-19 DOI: 10.1038/s41564-026-02508-y

Rima R Sahay, Juhi Khurana, Anitha P Moorkoth, Biju Pp, Anita M Shete, Savita Yadav, Triparna Majumdar, Shruti Rani, Neetu Vijay, Deepak Mali, Shreeyash Kamble, Shubhangi Gavari, Pranita Gawande, Hari Marathe, Ajay K Acharya, Nivedita Gupta, Pragya D Yadav

引用次数: 0

G-protein-coupled receptor sensing of farnesol controls fungal dormancy and is susceptible to bacterial interference. g蛋白偶联受体感应法尼醇控制真菌休眠，易受细菌干扰。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-19 DOI: 10.1038/s41564-026-02509-x

Aliang Xia, Daiying Xu, Chenyue Zhao, Yingao Huang, Mengyao Yang, Yuxiao Zhao, Huiquan Liu, Xiaojie Wang, Qinhu Wang, Guanghui Wang, Jun Guo, Zhensheng Kang, Jin-Rong Xu, Cong Jiang

{"title":"G-protein-coupled receptor sensing of farnesol controls fungal dormancy and is susceptible to bacterial interference.","authors":"Aliang Xia, Daiying Xu, Chenyue Zhao, Yingao Huang, Mengyao Yang, Yuxiao Zhao, Huiquan Liu, Xiaojie Wang, Qinhu Wang, Guanghui Wang, Jun Guo, Zhensheng Kang, Jin-Rong Xu, Cong Jiang","doi":"10.1038/s41564-026-02509-x","DOIUrl":"https://doi.org/10.1038/s41564-026-02509-x","url":null,"abstract":"Conidial dormancy is a critical survival strategy for fungi under stress, yet the mechanisms governing the switch between dormancy and germination remain unclear. Here we identify the G-protein-coupled receptor, Rsd1, as a farnesol-responsive sensor controlling this dormancy switch in the plant pathogen Fusarium pseudograminearum, which causes Fusarium crown rot. Under high population density and nutrient limitation, endogenous farnesol activates Rsd1 and downstream signalling pathways to suppress conidial germination. Rsd1 also responds to extracellular farnesol, linking environmental signals to an intrinsic transcriptional programme for dormancy. This adaptive response enhances survival but creates a fitness trade-off during plant infection. Specific rhizosphere-associated bacteria also contribute by promoting or inhibiting germination of dormant conidia through farnesol-Rsd1 sensing. Consortia assembled from these bacteria altered the balance between stress-resilient dormancy and infection-associated germination, thereby modulating disease severity. Our findings demonstrate how microbial interactions reshape intrinsic fungal regulatory programmes governing dormancy and infection.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":" ","pages":""},"PeriodicalIF":18.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy. 发布者更正：微生物来源的10-羟基硬脂酸激活PPARα，恢复肠道上皮屏障完整性，增强抗逆转录病毒治疗。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-16 DOI: 10.1038/s41564-026-02530-0

Dylan Kramer, Clarissa Santos Rocha, Christopher A Gaulke, Marie Nearing, Sumathi Sankaran-Walters, Ikaika Loque, Anugraha Kidigannappa, Eric Pham, Shuang Hu, Patrawin Wanakumjorn, Ramona Abbattista, Abhaya Dandekar, Roland Faller, Satya Dandekar

引用次数: 0

Acute infection as a driver of chronic diseases and the unsung benefits of vaccination. 急性感染作为慢性疾病的驱动因素和疫苗接种的潜在好处。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-16 DOI: 10.1038/s41564-026-02506-0

In Su Cheon, Mark T Esser, Jie Sun

引用次数: 0

Family matters in the root microbiota. 家族关系到根部的微生物群。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-12 DOI: 10.1038/s41564-026-02507-z

Davide Bulgarelli

引用次数: 0

Sickle cell haemoglobin status shapes malaria parasite genotype in asymptomatic infections. 镰状细胞血红蛋白状态影响无症状感染中的疟原虫基因型。

IF 18.7 1区生物学

Nature Microbiology Pub Date : 2026-10-08 DOI: 10.1038/s41564-026-02502-4

Helena D Hopson, Alejandra Herbert-Mainero, Aline Gaelle Bouopda-Tuedom, Charlène Tina Nanssong-Vomo, Brigitte Tumamo Fotso, Belinda Claire Kiam, Ibrahima Ibrahima, Clément Onguene, Luc Abate, Radoslaw Igor Omelianczyk, Heather D Evans, Lyra E Horton, Gavin Band, Tracey J Lamb, Lawrence S Ayong, Sandrine E Nsango, Ellen M Leffler

{"title":"Sickle cell haemoglobin status shapes malaria parasite genotype in asymptomatic infections.","authors":"Helena D Hopson, Alejandra Herbert-Mainero, Aline Gaelle Bouopda-Tuedom, Charlène Tina Nanssong-Vomo, Brigitte Tumamo Fotso, Belinda Claire Kiam, Ibrahima Ibrahima, Clément Onguene, Luc Abate, Radoslaw Igor Omelianczyk, Heather D Evans, Lyra E Horton, Gavin Band, Tracey J Lamb, Lawrence S Ayong, Sandrine E Nsango, Ellen M Leffler","doi":"10.1038/s41564-026-02502-4","DOIUrl":"https://doi.org/10.1038/s41564-026-02502-4","url":null,"abstract":"Sickle cell haemoglobin (HbS) confers protection against symptomatic malaria caused by Plasmodium falciparum. HbS carriers with symptomatic malaria harbour parasites enriched for P. falciparum sickle-associated alleles (Pfsa+), which appear to partially overcome HbS-mediated protection, but their role in asymptomatic infections is unclear. Here we conducted a cross-sectional survey of 2,246 healthy schoolchildren in a region of high malaria transmission in Cameroon. Analysing the parasite Pfsa and the human HbS genotypes for 1,701 asymptomatic P. falciparum infections confirmed that heterozygous HbS (HbAS) and homozygous non-HbS (HbAA) genotypes have similar rates of asymptomatic infection. However, the HbS genotype is strongly associated with parasites carrying the Pfsa+ alleles at the Pfsa1 and Pfsa3 loci, indicating a selective advantage for these alleles in HbS carriers. Our findings reveal that the protective effect of HbS is complex: HbS has a protective effect before symptoms appear against Pfsa- parasites and Pfsa+ alleles may contribute to the lower rates of symptomatic disease observed in HbS carriers. In HbS-mediated protection against malaria, both resistance and tolerance and ongoing co-evolution with parasites should be considered.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":" ","pages":""},"PeriodicalIF":18.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteria regulate collective behaviour by mechanosensing cell–cell collisions 细菌通过机械感应细胞-细胞碰撞来调节集体行为

IF 28.3 1区生物学

Nature Microbiology Pub Date : 2026-10-06 DOI: 10.1038/s41564-026-02505-1

Laure Le Blanc, Giona Cattaneo, Nathel Heraud, Einollah Sarikhani, Dhivya Pushpa Meganathan, Chia-Ni Tsai, Anum Tahir, Marco J. Kühn, Zeinab Jahed, Sangwoo Kim, Alexandre Persat

{"title":"Bacteria regulate collective behaviour by mechanosensing cell–cell collisions","authors":"Laure Le Blanc, Giona Cattaneo, Nathel Heraud, Einollah Sarikhani, Dhivya Pushpa Meganathan, Chia-Ni Tsai, Anum Tahir, Marco J. Kühn, Zeinab Jahed, Sangwoo Kim, Alexandre Persat","doi":"10.1038/s41564-026-02505-1","DOIUrl":"https://doi.org/10.1038/s41564-026-02505-1","url":null,"abstract":"Dense bacterial populations often navigate complex and heterogeneous environments using collective behaviours including group motility. Whether local interactions within a population can regulate collective order is unclear. Here we show using live imaging, single-cell tracking and simulations that Pseudomonas aeruginosa regulates collective order by mechanosensing cell–cell collisions, enabling adaptive surface exploration. Collision-induced reversals suppress collective cell alignment in dense bacterial populations. While a non-reversing mutant remains locked in cohesive near-linear motion regardless of density, wild-type cells adapt to local crowding, transitioning from isotropic motion in crowds to unidirectional exploration at the colony front. With increasing density, collisions generate information that feeds back on single-cell motility to regulate collective order, providing a navigational advantage. This advantage extends to spatially structured environments, such as micromazes, where collision-induced reversals prevent cells from becoming trapped at physical boundaries. These findings reveal that bacterial collective organization is not merely an emergent consequence of physical interactions, but a feedback-regulated state.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"24 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0