Younhun Kim, Colin J. Worby, Sawal Acharya, Lucas R. van Dijk, Daniel Alfonsetti, Zackary Gromko, Philippe N. Azimzadeh, Karen W. Dodson, Georg K. Gerber, Scott J. Hultgren, Ashlee M. Earl, Bonnie Berger, Travis E. Gibson
{"title":"Author Correction: Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain","authors":"Younhun Kim, Colin J. Worby, Sawal Acharya, Lucas R. van Dijk, Daniel Alfonsetti, Zackary Gromko, Philippe N. Azimzadeh, Karen W. Dodson, Georg K. Gerber, Scott J. Hultgren, Ashlee M. Earl, Bonnie Berger, Travis E. Gibson","doi":"10.1038/s41564-025-02042-3","DOIUrl":"https://doi.org/10.1038/s41564-025-02042-3","url":null,"abstract":"<p>Correction to: <i>Nature Microbiology</i> https://doi.org/10.1038/s41564-025-01983-z, published online 6 May 2025.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"127 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gali Tzlil, María del Carmen Marín, Yuma Matsuzaki, Probal Nag, Shota Itakura, Yosuke Mizuno, Shunya Murakoshi, Tatsuki Tanaka, Shirley Larom, Masae Konno, Rei Abe-Yoshizumi, Ana Molina-Márquez, Daniela Bárcenas-Pérez, José Cheel, Michal Koblížek, Rosa León, Kota Katayama, Hideki Kandori, Igor Schapiro, Wataru Shihoya, Osamu Nureki, Keiichi Inoue, Andrey Rozenberg, Ariel Chazan, Oded Béjà
{"title":"Structural insights into light harvesting by antenna-containing rhodopsins in marine Asgard archaea","authors":"Gali Tzlil, María del Carmen Marín, Yuma Matsuzaki, Probal Nag, Shota Itakura, Yosuke Mizuno, Shunya Murakoshi, Tatsuki Tanaka, Shirley Larom, Masae Konno, Rei Abe-Yoshizumi, Ana Molina-Márquez, Daniela Bárcenas-Pérez, José Cheel, Michal Koblížek, Rosa León, Kota Katayama, Hideki Kandori, Igor Schapiro, Wataru Shihoya, Osamu Nureki, Keiichi Inoue, Andrey Rozenberg, Ariel Chazan, Oded Béjà","doi":"10.1038/s41564-025-02016-5","DOIUrl":"https://doi.org/10.1038/s41564-025-02016-5","url":null,"abstract":"<p>Aquatic bacterial rhodopsin proton pumps harvest light energy for photoheterotrophic growth and are known to contain hydroxylated carotenoids that expand the wavelengths of light utilized, but these have not been characterized in marine archaea. Here, by combining a marine chromophore extract with purified archaeal rhodopsins identified in marine metagenomes, we show light energy transfer from diverse hydroxylated carotenoids to heimdallarchaeial rhodopsins (HeimdallRs) from uncultured marine planktonic members of ‘<i>Candidatus</i> Kariarchaeaceae’ (‘<i>Candidatus</i> Asgardarchaeota’). These light-harvesting antennas absorb in the blue-light range and transfer energy to the green-light-absorbing retinal chromophore within HeimdallRs, enabling the use of light that is otherwise unavailable to the rhodopsin. Furthermore, we show elevated proton pumping by the antennas in HeimdallRs under white-light illumination, which better simulates the light conditions encountered by these archaea in their natural habitats. Our results indicate that light-harvesting antennas in microbial rhodopsins exist in families beyond xanthorhodopsins and proteorhodopsins and are present in both marine bacteria and archaea.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"82 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pragya D. Yadav, Kaushal Baid, Deepak Y. Patil, Tahmina Shirin, Mohammed Ziaur Rahman, Alison J. Peel, Jonathan H. Epstein, Joel M. Montgomery, Raina K. Plowright, Henrik Salje, Emily S. Gurley, Syed M. Satter, Arinjay Banerjee
{"title":"A One Health approach to understanding and managing Nipah virus outbreaks","authors":"Pragya D. Yadav, Kaushal Baid, Deepak Y. Patil, Tahmina Shirin, Mohammed Ziaur Rahman, Alison J. Peel, Jonathan H. Epstein, Joel M. Montgomery, Raina K. Plowright, Henrik Salje, Emily S. Gurley, Syed M. Satter, Arinjay Banerjee","doi":"10.1038/s41564-025-02020-9","DOIUrl":"https://doi.org/10.1038/s41564-025-02020-9","url":null,"abstract":"<p>Nipah virus (NiV) is a zoonotic paramyxovirus belonging to the genus <i>Henipavirus</i>, which infects <i>Pteropus</i> bat species in Southeast and South Asia. Since its discovery in the late 1990s in Malaysia, NiV has caused outbreaks in humans in Singapore, Bangladesh, India and the Philippines. The spillover pathway for the most recent NiV outbreak in 2023 in Kerala, India, remains speculative. NiV causes serious disease in infected humans, with a mean case-fatality rate of 70%, and no approved treatment or vaccines exist. Humans have been infected directly from bats through shared food or through infected bridging hosts, including pigs and horses, although other spillover pathways may exist. Here, we review the pathways of NiV spillover and transmission, highlighting areas needing further research. We emphasize the importance of collaborative and multidisciplinary efforts both in the laboratory and in the field, and the implementation of a One Health strategy to prevent future epidemics.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"58 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chorong Park, Aaron J. Ferrell, Nathan Meade, Peter S. Shen, Derek Walsh
{"title":"Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff","authors":"Chorong Park, Aaron J. Ferrell, Nathan Meade, Peter S. Shen, Derek Walsh","doi":"10.1038/s41564-025-02009-4","DOIUrl":"https://doi.org/10.1038/s41564-025-02009-4","url":null,"abstract":"<p>Many viruses potently inhibit host protein synthesis, termed host shutoff, while employing strategies to sustain their own translation. How and why certain host mRNAs continue to be translated at later infection stages remains unclear. Here, using RNAseq and polysome profiling, we show that during shutoff by vaccinia virus (VacV), several host mRNAs increase in polysome occupancy but only a few, primarily <i>JUN</i> that encodes the Jun transcription factor, result in increased protein abundance across multiple cell lines. While dispensable for Jun production, translation of viral mRNAs depended on the small ribosomal protein, Receptor for Activated C Kinase 1 (RACK1) and the eukaryotic Initiation Factor, eIF3. These differential eIF3 dependencies are associated with structurally distinct 5′ untranslated regions in viral versus <i>JUN</i> mRNAs. Cryo-electron microscopy structures of 40S ribosomes from mock-infected or VacV-infected cells showed that when bound to eIF3, the rotational range of the RACK1-containing 40S head domain broadens during infection. Our data reveal how eIF3-bound 40S ribosomes are remodelled late in infection and the distinct strategies of translation initiation that arise during shutoff to produce host and viral proteins required for poxvirus spread.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"35 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhixin Lyu, Xinxing Yang, Atsushi Yahashiri, Stephen Ha, Joshua W. McCausland, Xinlei Chen, Brooke M. Britton, David S. Weiss, Jie Xiao
{"title":"Third track model for coordination of septal peptidoglycan synthesis and degradation by FtsN in Escherichia coli","authors":"Zhixin Lyu, Xinxing Yang, Atsushi Yahashiri, Stephen Ha, Joshua W. McCausland, Xinlei Chen, Brooke M. Britton, David S. Weiss, Jie Xiao","doi":"10.1038/s41564-025-02011-w","DOIUrl":"https://doi.org/10.1038/s41564-025-02011-w","url":null,"abstract":"<p>In <i>Escherichia coli</i>, FtsN is thought to coordinate septal peptidoglycan (sPG) synthesis and degradation. Its E domain interacts with the sPG synthesis complex, FtsWIQLB, and its SPOR domain interacts with denuded glycan (dnG), intermediates of sPG degradation. Here we used single-molecule tracking of FtsN and FtsW to investigate how FtsN coordinates the two opposing processes. We found that the SPOR domain binds to dnG cooperatively. This binding sequesters FtsWIQLB on dnG, which we call the dnG-track, and prevents dnG degradation. SPOR domain’s release from dnGs exposes dnGs to degradation, moves FtsN to the sPG synthesis track and activates FtsWIQLB. In addition, FtsN self-interacts through the SPOR domain, promoting the multimerization of FtsWIQLB on both tracks. This self-interaction may create a sensitive switch, regulating FtsN’s partitioning between dnG- and sPG-tracks to coordinate sPG degradation and synthesis while also controlling the balance between sequestered and active populations of the sPG synthesis complex. Our data reveal a third track that plays an important role in sPG synthesis and degradation across space and time, complementing the previously discovered sPG-track and FtsZ-track in <i>E. coli</i> for robust septal cell wall constriction.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"26 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wendy K. Jo, Andres Moreira-Soto, Angélica Cristine Almeida Campos, Luiz Gustavo Bentim Góes, Maria Angélica Mares-Guia, Andrea Rasche, Ana Maria Bispo de Filippis, Gabriela Hernández-Mora, Sham Nambulli, Daniel G. Streicker, W. Paul Duprex, Jan Felix Drexler
{"title":"Ecology and evolutionary trajectories of morbilliviruses in Neotropical bats","authors":"Wendy K. Jo, Andres Moreira-Soto, Angélica Cristine Almeida Campos, Luiz Gustavo Bentim Góes, Maria Angélica Mares-Guia, Andrea Rasche, Ana Maria Bispo de Filippis, Gabriela Hernández-Mora, Sham Nambulli, Daniel G. Streicker, W. Paul Duprex, Jan Felix Drexler","doi":"10.1038/s41564-025-02005-8","DOIUrl":"https://doi.org/10.1038/s41564-025-02005-8","url":null,"abstract":"<p>Bats are important reservoirs of paramyxoviruses, yet their role in the evolutionary origins of viruses pertaining to the paramyxoviral genus <i>Morbillivirus</i>, such as measles virus, remains unclear. Here, combining field surveys and data mining, we identified six divergent morbilliviruses by investigating wild bats (38/1,629 RT–PCR-positive) and non-human primates (NHP, 13/1,370 RT–PCR-positive) in Brazil and Costa Rica over 14 years. High morbillivirus concentrations of up to 10<sup>9</sup> RNA copies per g and RNA staining in different organs suggested systemic infection. Of 117 vampire bats, 35.9% had neutralizing antibodies against a primary vampire bat morbillivirus isolate, suggesting frequent non-fatal infections. In vitro assays using bat CD150 for cell entry and partial cross-neutralization of bat-associated morbillivirus by heterologous sera suggested conserved entry and antigenicity. NHP-associated, but not bat-associated morbilliviruses, used human CD150 and nectin-4 cellular receptors, suggesting differential zoonotic potential. Macroevolutionary reconstructions revealed predominance of Neotropical bat hosts during morbilliviral diversification, including bat-associated host shifts into Mexican pigs and Brazilian NHPs. These data argue for increased surveillance, experimental risk assessments and intervention strategies to mitigate risks of reservoir-bound morbilliviruses shifting hosts.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"97 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes M. Keegstra, Zachary C. Landry, Sophie T. Zweifel, Benjamin R. K. Roller, Dieter A. Baumgartner, Francesco Carrara, Clara Martínez-Pérez, Estelle E. Clerc, Martin Ackermann, Roman Stocker
{"title":"Risk–reward trade-off during carbon starvation generates dichotomy in motility endurance among marine bacteria","authors":"Johannes M. Keegstra, Zachary C. Landry, Sophie T. Zweifel, Benjamin R. K. Roller, Dieter A. Baumgartner, Francesco Carrara, Clara Martínez-Pérez, Estelle E. Clerc, Martin Ackermann, Roman Stocker","doi":"10.1038/s41564-025-01997-7","DOIUrl":"https://doi.org/10.1038/s41564-025-01997-7","url":null,"abstract":"<p>Copiotrophic marine bacteria contribute to the control of carbon storage in the ocean by remineralizing organic matter. Motility presents copiotrophs with a risk–reward trade-off: it is highly beneficial in seeking out sparse nutrient hotspots, but energetically costly. Here we studied the motility endurance of 26 marine isolates, representing 18 species, using video microscopy and cell tracking over 2 days of carbon starvation. We found that the trade-off results in a dichotomy among marine bacteria, in which risk-averse copiotrophs ceased motility within hours (‘limostatic’), whereas risk-prone copiotrophs converted ~9% of their biomass per day into energy to retain motility for the 2 days of observation (‘limokinetic’). Using machine learning classifiers, we identified a genomic component associated with both strategies, sufficiently robust to predict the response of additional species with 86% accuracy. This dichotomy can help predict the prevalence of foraging strategies in marine microbes and inform models of ocean carbon cycles.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"18 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Ding, Alvaro Fernández-Montero, Amir Mani, Elisa Casadei, Ryuichiro Miyazawa, Congjin Zhou, Lise Chaumont, Marijan Posavi, Stephen D. Cole, Yasuhiro Shibasaki, Fumio Takizawa, Irene Salinas, J. Oriol Sunyer
{"title":"Secretory IgM regulates gut microbiota homeostasis and metabolism","authors":"Yang Ding, Alvaro Fernández-Montero, Amir Mani, Elisa Casadei, Ryuichiro Miyazawa, Congjin Zhou, Lise Chaumont, Marijan Posavi, Stephen D. Cole, Yasuhiro Shibasaki, Fumio Takizawa, Irene Salinas, J. Oriol Sunyer","doi":"10.1038/s41564-025-02013-8","DOIUrl":"https://doi.org/10.1038/s41564-025-02013-8","url":null,"abstract":"<p>The coating of microbiota by secretory immunoglobulins (sIgs) determines which bacteria colonize the gut and influences bacterial metabolism. Previous work has identified sIgA and sIgT as mediators of gut homeostasis. However, sIgM coats a large proportion of the gut microbiota in humans and teleost fish, thus suggesting a conserved role of sIgM in microbiota homeostasis. Here, to investigate this hypothesis, we used the teleost rainbow trout as a model system. Depletion of IgM from trout resulted in severe microbiota-dependent gut tissue damage, body weight loss, bacterial translocation and gut dysbiosis. IgM depletion led also to alterations in microbiota-derived metabolites, including short-chain fatty acids and essential amino acids. Supporting a protective role for sIgM in the gut, high mortality of IgM-depleted fish occurred in an experimental colitis model as a result of severe systemic bacteraemia and septic shock. Our findings uncover sIgM as a previously unrecognized regulator of microbiota homeostasis and metabolism.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"44 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing Zhu, Robert McElroy, Janvhi Suresh Machhar, Joel Cassel, Zihan Zheng, Behzad Mansoori, Hongrui Guo, Sen Guo, Christian Pangilinan, Jinghui Liang, Dongliang Shen, Lu Zhang, Qin Liu, Andrew V. Kossenkov, Dario C. Altieri, Paul M. Lieberman, Shou-Jiang Gao, Pinghui Feng, Maureen E. Murphy, Jikui Song, Joseph M. Salvino, Qiming Liang, Jae U. Jung, Chengyu Liang
{"title":"Kaposi’s sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production","authors":"Qing Zhu, Robert McElroy, Janvhi Suresh Machhar, Joel Cassel, Zihan Zheng, Behzad Mansoori, Hongrui Guo, Sen Guo, Christian Pangilinan, Jinghui Liang, Dongliang Shen, Lu Zhang, Qin Liu, Andrew V. Kossenkov, Dario C. Altieri, Paul M. Lieberman, Shou-Jiang Gao, Pinghui Feng, Maureen E. Murphy, Jikui Song, Joseph M. Salvino, Qiming Liang, Jae U. Jung, Chengyu Liang","doi":"10.1038/s41564-025-02018-3","DOIUrl":"https://doi.org/10.1038/s41564-025-02018-3","url":null,"abstract":"<p>Mitochondrial dynamics are pivotal for host immune responses upon infection, yet how viruses manipulate these processes to impair host defence and enhance viral fitness remains unclear. Here we show that Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus also known as human herpesvirus 8, encodes Bcl-2 (vBcl-2), which reprogrammes mitochondrial architecture. It binds with NM23-H2, a host nucleoside diphosphate (NDP) kinase, to stimulate GTP loading of the dynamin-related protein (DRP1) GTPase, which triggers mitochondrial fission, inhibits mitochondrial antiviral signalling protein (MAVS) aggregation and impairs interferon responses in cell lines. An NM23-H2-binding-defective vBcl-2 mutant fails to evoke fission, leading to defective virion assembly due to activated MAVS–IFN signalling. Notably, we identify two key interferon-stimulated genes restricting vBcl-2-dependent virion morphogenesis. Using a high-throughput drug screening, we discover an inhibitor targeting vBcl-2–NM23-H2 interaction that blocks virion production in vitro. Our study identifies a mechanism in which KSHV manipulates mitochondrial dynamics to allow for virus assembly and shows that targeting the virus–mitochondria interface represents a potential therapeutic strategy.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"4 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David W. Adams, Milena Jaskólska, Alexandre Lemopoulos, Sandrine Stutzmann, Laurie Righi, Loriane Bader, Melanie Blokesch
{"title":"West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems","authors":"David W. Adams, Milena Jaskólska, Alexandre Lemopoulos, Sandrine Stutzmann, Laurie Righi, Loriane Bader, Melanie Blokesch","doi":"10.1038/s41564-025-02004-9","DOIUrl":"https://doi.org/10.1038/s41564-025-02004-9","url":null,"abstract":"<p>Our understanding of the factors underlying the evolutionary success of different lineages of pandemic <i>Vibrio cholerae</i> remains incomplete. The West African–South American (WASA) lineage of <i>V. cholerae</i>, responsible for the 1991–2001 Latin American cholera epidemic, is defined by two unique genetic signatures. Here we show that these signatures encode multiple distinct anti-phage defence systems. Firstly, the WASA-1 prophage encodes an abortive-infection system, WonAB, that renders the lineage resistant to the major predatory vibriophage ICP1, which, alongside other phages, is thought to restrict cholera epidemics. Secondly, a unique set of genes on the <i>Vibrio</i> seventh pandemic island II encodes an unusual modification-dependent restriction system targeting phages with modified genomes, and a previously undescribed member of the Shedu defence family that defends against vibriophage X29. We propose that these anti-phage defence systems likely contributed to the success of a major epidemic lineage of the ongoing seventh cholera pandemic.</p>","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"236 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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