环境中抗真菌耐药性的进化

IF 19.4 1区 生物学 Q1 MICROBIOLOGY
Norman van Rhijn, Johanna Rhodes
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引用次数: 0

摘要

农业和卫生保健环境中出现的耐药真菌感染对粮食安全、公共卫生和自然环境造成了严重影响。它们对处于危险中的患者群体构成重大危害,这些患者往往会获得严重的、有时危及生命的感染。随着杀菌剂在环境中的使用越来越多,对杀菌剂和抗真菌药物的耐药性对健康构成了威胁。本文综述了全球范围内杀菌剂和抗真菌药物耐药性的演变、出现和扩展。我们讨论了不同的抗真菌剂和杀菌剂,它们的作用方式和耐药机制。此外,我们概述了耐药真菌在环境热点和冷点的出现和扩展的现状。最后,我们总结了降低抗真菌药物耐药性的替代方案和未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evolution of antifungal resistance in the environment

Evolution of antifungal resistance in the environment

The emergence of drug-resistant fungal infections in agriculture and healthcare settings has caused severe implications for food security, public health and natural environments. They pose a substantial hazard for at-risk patient populations who often acquire serious and sometimes life-threatening infections. With the increasing use of fungicides in the environment, acquisition of resistance to fungicides and antifungal drugs pose a risk to health. In this Review we summarize the evolution, emergence and expansion of fungicide and antifungal drug resistance globally. We discuss different antifungals and fungicides, their modes of action and resistance mechanisms. Furthermore, we outline the current state of knowledge about the emergence and expansion of resistant fungi in hotspots and coldspots in the environment. Finally, we summarize alternative options and future directions in reducing antifungal resistance.

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来源期刊
Nature Microbiology
Nature Microbiology Immunology and Microbiology-Microbiology
CiteScore
44.40
自引率
1.10%
发文量
226
期刊介绍: Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.
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