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How the WHIMS clinical trial shaped the future of women’s health research WHIMS临床试验如何塑造女性健康研究的未来
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-03-05 DOI: 10.1038/s41574-025-01101-3
Phaedra R. Keller-Norrell
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引用次数: 0
Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment 免疫检查点抑制剂治疗后的抗 PIT1 下丘脑炎
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-27 DOI: 10.1038/s41574-025-01099-8
Shin Urai  (, ), Genzo Iguchi  (, ), Yutaka Takahashi  (, )
{"title":"Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment","authors":"Shin Urai \u0000 (, ), Genzo Iguchi \u0000 (, ), Yutaka Takahashi \u0000 (, )","doi":"10.1038/s41574-025-01099-8","DOIUrl":"10.1038/s41574-025-01099-8","url":null,"abstract":"Anti-PIT1 hypophysitis is a form of paraneoplastic autoimmune hypophysitis. The condition is attributable to the ectopic expression of pituitary-specific positive transcription factor 1 (PIT1) in tumour tissues, which leads to autoimmunity against PIT1-positive anterior pituitary cells. In the past few years, it has been reported that anti-PIT1 hypophysitis can occur as an immune checkpoint inhibitor-related hypophysitis.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 5","pages":"265-266"},"PeriodicalIF":31.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition 肥胖通过内皮特异性胰岛素受体抑制诱导全身胰岛素抵抗
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-26 DOI: 10.1038/s41574-025-01097-w
Olivia Tysoe
{"title":"Obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition","authors":"Olivia Tysoe","doi":"10.1038/s41574-025-01097-w","DOIUrl":"10.1038/s41574-025-01097-w","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 4","pages":"199-199"},"PeriodicalIF":31.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone and muscle crosstalk in ageing and disease 骨骼和肌肉在衰老和疾病中的相互作用
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-26 DOI: 10.1038/s41574-025-01088-x
Ben Kirk, Giovanni Lombardi, Gustavo Duque
{"title":"Bone and muscle crosstalk in ageing and disease","authors":"Ben Kirk, Giovanni Lombardi, Gustavo Duque","doi":"10.1038/s41574-025-01088-x","DOIUrl":"10.1038/s41574-025-01088-x","url":null,"abstract":"Interorgan communication between bone and skeletal muscle is central to human health. A dysregulation of bone–muscle crosstalk is implicated in several age-related diseases. Ageing-associated changes in endocrine, inflammatory, nutritional and biomechanical stimuli can influence the differentiation capacity, function and survival of mesenchymal stem cells and bone-forming and muscle-forming cells. Consequently, the secretome phenotype of bone and muscle cells is altered, leading to impaired crosstalk and, ultimately, catabolism of both tissues. Adipose tissue acts as a third player in the bone–muscle interaction by secreting factors that affect bone and muscle cells. Physical exercise remains the key biological stimulus for bone–muscle crosstalk, either directly via the release of cytokines from bone, muscle or adipocytes, or indirectly through extracellular vesicles. Overall, bone–muscle crosstalk is considered an inherent process necessary to maintain the structure and function of both tissues across the life cycle. This Review summarizes the latest biomedical advances in bone–muscle crosstalk as it pertains to human ageing and disease. We also outline future research priorities to accommodate the understanding of this rapidly emerging field. Bone and muscle are highly interconnected tissues that rely on hormonal signals, secreted factors and other biochemical stimuli to maintain homeostasis, growth and function. This Review discusses key factors in bone–muscle crosstalk and how this crosstalk is affected by ageing and metabolic disease.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 6","pages":"375-390"},"PeriodicalIF":31.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dimorphism in pituitary neuroendocrine tumours 垂体神经内分泌肿瘤的两性二态性
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-25 DOI: 10.1038/s41574-025-01096-x
Shaojian Lin  (, ), Jun Li  (, ), Zhe Bao Wu  (, )
{"title":"Sexual dimorphism in pituitary neuroendocrine tumours","authors":"Shaojian Lin \u0000 (, ), Jun Li \u0000 (, ), Zhe Bao Wu \u0000 (, )","doi":"10.1038/s41574-025-01096-x","DOIUrl":"10.1038/s41574-025-01096-x","url":null,"abstract":"Pituitary neuroendocrine tumours (PitNETs) exhibit notable sex-related differences, particularly in prolactinomas and corticotroph tumours. Findings from the past 5 years in other cancers suggest that interactions between sex hormones and the immune system, as well as epigenetic modifications specific to sex chromosomes, could influence sex differences in tumour development.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 5","pages":"263-264"},"PeriodicalIF":31.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils might link intestinal damage to retinopathy in type 2 diabetes mellitus 中性粒细胞可能与2型糖尿病患者的肠道损伤和视网膜病变有关
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-24 DOI: 10.1038/s41574-025-01094-z
Senegal Carty
{"title":"Neutrophils might link intestinal damage to retinopathy in type 2 diabetes mellitus","authors":"Senegal Carty","doi":"10.1038/s41574-025-01094-z","DOIUrl":"10.1038/s41574-025-01094-z","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 4","pages":"200-200"},"PeriodicalIF":31.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering adipocytes for cancer treatment 工程脂肪细胞用于癌症治疗
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-20 DOI: 10.1038/s41574-025-01095-y
Claire Greenhill
{"title":"Engineering adipocytes for cancer treatment","authors":"Claire Greenhill","doi":"10.1038/s41574-025-01095-y","DOIUrl":"10.1038/s41574-025-01095-y","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 4","pages":"200-200"},"PeriodicalIF":31.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The enduring relevance of the Randle cycle 兰德尔循环的持久相关性
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-19 DOI: 10.1038/s41574-025-01092-1
Azariyas A. Challa
{"title":"The enduring relevance of the Randle cycle","authors":"Azariyas A. Challa","doi":"10.1038/s41574-025-01092-1","DOIUrl":"10.1038/s41574-025-01092-1","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 5","pages":"269-269"},"PeriodicalIF":31.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study that pioneered islet isolation techniques 这项研究开创了胰岛分离技术
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-18 DOI: 10.1038/s41574-025-01093-0
Rula Bany Bakar
{"title":"The study that pioneered islet isolation techniques","authors":"Rula Bany Bakar","doi":"10.1038/s41574-025-01093-0","DOIUrl":"10.1038/s41574-025-01093-0","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 5","pages":"270-270"},"PeriodicalIF":31.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tryptophan metabolism, exercise and depression 色氨酸代谢，运动和抑郁
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-02-11 DOI: 10.1038/s41574-025-01090-3
Brandon A. Yates
{"title":"Tryptophan metabolism, exercise and depression","authors":"Brandon A. Yates","doi":"10.1038/s41574-025-01090-3","DOIUrl":"10.1038/s41574-025-01090-3","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 4","pages":"201-201"},"PeriodicalIF":31.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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