Nature Reviews Endocrinology最新文献

{"title":"A call for a multidisciplinary intervention to address severe insulin resistance during pregnancy","authors":"Clipper F. Young, Diana Isaacs","doi":"10.1038/s41574-025-01164-2","DOIUrl":"10.1038/s41574-025-01164-2","url":null,"abstract":"Immediate attention is paramount for addressing the escalating prevalence of severe insulin resistance during pregnancy. A collaborative and multidisciplinary approach involving clinical care, public health initiatives and advanced technologies is essential for enhancing care, improving maternal and fetal outcomes, and mitigating long-term metabolic risks.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"586-587"},"PeriodicalIF":40.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144898113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical nutrition therapy for the management of type 2 diabetes mellitus","authors":"Luigi Barrea, Ludovica Verde, Annamaria Colao, Lawrence J. Mandarino, Giovanna Muscogiuri","doi":"10.1038/s41574-025-01161-5","DOIUrl":"10.1038/s41574-025-01161-5","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a major global health concern. Medical nutrition therapy has a key role in T2DM management, with dietary interventions being central to improving glycaemic control and overall metabolic health. Growing evidence suggests that certain dietary strategies can exert direct metabolic benefits independent of weight reduction. The Mediterranean diet has consistently demonstrated metabolic and cardiovascular benefits, along with improved glycaemic control, even in the absence of substantial weight reduction. Low-energy and very-low-energy diets, characterized by moderate to severe caloric restriction, respectively, have also been associated with improvements in cardiometabolic markers and glycaemic regulation. Ketogenic diets promote nutritional ketosis and have shown benefits on glycaemic control, insulin sensitivity and other metabolic outcomes, often preceding substantial weight loss. Intermittent fasting strategies, such as alternate-day fasting or the 5:2 model, and time-restricted eating, have likewise been linked to enhanced glycaemic control and favourable metabolic and cardiovascular effects, although their long-term efficacy and safety require further investigation. This Review aims to provide an evidence-based synthesis of the main nutritional strategies used in the treatment of T2DM, with a focus on their underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation. Medical nutrition therapy (MNT) is a key component of the management of type 2 diabetes mellitus (T2DM), and there is increasing evidence that specific dietary interventions can improve metabolic health in T2DM independently of weight loss. This Review assesses several key MNT strategies for their efficacy in T2DM management.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 12","pages":"769-782"},"PeriodicalIF":40.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents","authors":"Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W. M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki","doi":"10.1038/s41574-025-01167-z","DOIUrl":"10.1038/s41574-025-01167-z","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"656-656"},"PeriodicalIF":40.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01167-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus on acromegaly therapeutic outcomes: an update","authors":"Shlomo Melmed, Luigi di Filippo, Maria Fleseriu, Moisés Mercado, Niki Karavitaki, Mark Gurnell, Roberto Salvatori, Stylianos Tsagarakis, Marco Losa, Pietro Maffei, Alberto M. Pereira, Eliza B. Geer, Laurence Katznelson, Aart Jan van der Lely, Jens Bollerslev, Daniela Esposito, Susan M. Webb, Maria Chiara Zatelli, Elena Valassi, Sebastian Neggers, Philippe Chanson, Ken K. Y. Ho, Adriana G. Ioachimescu, Beverly M. K. Biller, Susan L. Samson, Ursula B. Kaiser, Katharina Schilbach, Raúl M. Luque, Felipe F. Casanueva, Ilan Shimon, Cesar L. Boguszewski, Nienke Biermasz, Annamaria Colao, Rosa Pirchio, Steven W. J. Lamberts, Pinar Kadioglu, Michael Buchfelder, Stefano Frara, Sabrina Chiloiro, Stephan Petersenn, Monica R. Gadelha, Manel Puig-Domingo, Anton Luger, Thierry Brue, Albert Beckers, Diego Ferone, David R. Clemmons, Yona Greenman, Mónica Marazuela, Pietro Mortini, Christian J. Strasburger, Andrea Giustina","doi":"10.1038/s41574-025-01148-2","DOIUrl":"10.1038/s41574-025-01148-2","url":null,"abstract":"The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of medical management guidelines in 2018, new pharmacological agents and new treatment approaches have been developed. Fifty-two experts in the management of acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and management. Current outcome goals were considered, with a focus on the effect of current and emerging somatostatin receptor ligands, the growth hormone receptor antagonist pegvisomant and the dopamine agonist cabergoline on biochemical control, clinical control, adenoma mass and surgical outcomes. Participants assessed factors that determine pharmacological choices, as well as the proposed use of each agent. Here, we present consensus recommendations highlighting how an evidence-based acromegaly management algorithm could be optimized in clinical practice. In this Consensus Statement, an international group of experts provide updated recommendations on the treatment of acromegaly, including discussion of treatment outcomes.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 11","pages":"718-737"},"PeriodicalIF":40.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01148-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein misfolding in β-cell failure","authors":"Claire Greenhill","doi":"10.1038/s41574-025-01169-x","DOIUrl":"10.1038/s41574-025-01169-x","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"591-591"},"PeriodicalIF":40.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset colorectal cancer as an emerging disease of metabolic dysregulation","authors":"Mengxi Du, David A. Drew, Marcus D. Goncalves, Yin Cao, Andrew T. Chan","doi":"10.1038/s41574-025-01159-z","DOIUrl":"10.1038/s41574-025-01159-z","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common malignancies and the second leading cause of cancer-related death worldwide. Early-onset CRC (EOCRC), diagnosed in adults under the age of 50 years, has emerged as a pressing public health concern owing to its alarming rise in incidence since the 1990s. This trend, observed in the USA and at least eight other high-income countries, starkly contrasts with the declining incidence rates of late-onset CRC (age 50 years and above), largely attributed to early disease detection and lifestyle changes. Concurrent with the rising number of cases of EOCRC, the burden of metabolic diseases, particularly obesity and type 2 diabetes mellitus (T2DM), has surged among young populations. Despite well-documented links between metabolic dysfunction and late-onset CRC, understanding the precise role of obesity and T2DM in the pathogenesis of EOCRC remains in its infancy. This narrative Review synthesizes evidence on the relationship of obesity and T2DM with EOCRC, focusing on pathophysiological mechanisms and the mediating roles of diet and lifestyle factors. It also discusses potential clinical and public health strategies to address obesity and T2DM for EOCRC prevention, highlighting knowledge gaps and future research directions. Cases of early-onset colorectal cancer (EOCRC) have risen alarmingly since the 1990s, alongside a surge in metabolic diseases, particularly obesity and type 2 diabetes mellitus (T2DM), among young populations. This Review synthesizes evidence regarding the association of obesity and T2DM with EOCRC.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 11","pages":"686-702"},"PeriodicalIF":40.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in patients with obesity: challenges, applications and future directions","authors":"Mickael Tordjman, Zahi A. Fayad, Tammie L. S. Benzinger, Maria G. Trivieri, Meena Bansal, Reshmi Srinath, Bachir Taouli","doi":"10.1038/s41574-025-01166-0","DOIUrl":"10.1038/s41574-025-01166-0","url":null,"abstract":"Imaging has a growing role in the evaluation of obesity-related disorders and the effects of weight loss, especially given the increasing use of glucagon-like peptide 1 agonists. New imaging biomarkers are emerging. Artificial intelligence applications for automated quantification of body composition underline future capabilities of whole-body MRI to comprehensively assess patients with obesity.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"588-590"},"PeriodicalIF":40.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose tissue thermogenesis is not proportional to temperature","authors":"Olivia Tysoe","doi":"10.1038/s41574-025-01163-3","DOIUrl":"10.1038/s41574-025-01163-3","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"591-591"},"PeriodicalIF":40.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Drug Insight: selective agonists and antagonists of the glucocorticoid receptor","authors":"Andrew McMaster, David W. Ray","doi":"10.1038/s41574-025-01165-1","DOIUrl":"10.1038/s41574-025-01165-1","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"656-656"},"PeriodicalIF":40.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01165-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of hyperglycaemia and diabetes mellitus during hospitalization","authors":"Thaer Idrees, Iris Castro-Revoredo, Ketan K. Dhatariya, Lucas Hernandez, Guillermo E. Umpierrez","doi":"10.1038/s41574-025-01157-1","DOIUrl":"10.1038/s41574-025-01157-1","url":null,"abstract":"Diabetes mellitus, which affects over 537 million people worldwide, considerably increases the risk of emergency room visits and admissions to hospital. Inpatient hyperglycaemia in patients with or without diabetes mellitus is associated with higher rates of complications, extended hospital stays and increased mortality when compared with patients with normoglycaemia. The American Diabetes Association recommends a target range of 5.6–10.0 mmol/l (100–180 mg/dl) for levels of glucose in the blood of patients in intensive care units (ICUs), as well as in general medicine and surgery. Insulin therapy remains the cornerstone of managing inpatient hyperglycaemia, with intravenous insulin preferred in ICU and basal–bolus regimens favoured in non-ICU settings. While bedside capillary blood glucose monitoring is standard for adjusting insulin doses, continuous glucose monitoring provides a more comprehensive glycaemic assessment and enhances the prevention of hypoglycaemia in high-risk hospitalized patients. This Review outlines the latest evidence in managing diabetes mellitus and hyperglycaemia within hospitals. Inpatient hyperglycaemia is found in the settings of known diabetes mellitus, previously undiagnosed diabetes mellitus and stress hyperglycaemia, and is associated with poor outcomes. Current approaches to managing inpatient hyperglycaemia and diabetes mellitus are outlined in this Review.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 12","pages":"757-768"},"PeriodicalIF":40.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01157-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}