葡萄糖和氨基酸代谢交汇处的胰岛激素

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Phillip J. White, Nicolai J. Wewer Albrechtsen, Jonathan E. Campbell
{"title":"葡萄糖和氨基酸代谢交汇处的胰岛激素","authors":"Phillip J. White, Nicolai J. Wewer Albrechtsen, Jonathan E. Campbell","doi":"10.1038/s41574-025-01100-4","DOIUrl":null,"url":null,"abstract":"The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted by islets, exert powerful control in various metabolic tissues to drive nutrient uptake, storage and metabolism. Their canonical actions on glycaemia have positioned these hormones in opposition, however, their metabolic actions extend beyond controlling blood levels of glucose. Indeed, these islet hormones are just as influential in regulating lipid and amino acid metabolism and it is becoming clear that many of these actions involve an interplay between insulin and glucagon, which is contrary to the dogmatic view that these hormones are antagonistic in nature. Finally, we postulate that examining the effects of islet hormones on the metabolism of individual metabolites is overly simplistic. Here, we discuss the actions of each islet hormone alone and in combination with the others in regulating glucose and amino acid metabolism and explore how these signalling networks are closely linked and strongly influence one another. This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells, β-cells and δ-cells regulates islet hormone secretion and how islet hormones control the metabolism of different nutrients.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 7","pages":"397-412"},"PeriodicalIF":40.0000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Islet hormones at the intersection of glucose and amino acid metabolism\",\"authors\":\"Phillip J. White, Nicolai J. Wewer Albrechtsen, Jonathan E. Campbell\",\"doi\":\"10.1038/s41574-025-01100-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted by islets, exert powerful control in various metabolic tissues to drive nutrient uptake, storage and metabolism. Their canonical actions on glycaemia have positioned these hormones in opposition, however, their metabolic actions extend beyond controlling blood levels of glucose. Indeed, these islet hormones are just as influential in regulating lipid and amino acid metabolism and it is becoming clear that many of these actions involve an interplay between insulin and glucagon, which is contrary to the dogmatic view that these hormones are antagonistic in nature. Finally, we postulate that examining the effects of islet hormones on the metabolism of individual metabolites is overly simplistic. Here, we discuss the actions of each islet hormone alone and in combination with the others in regulating glucose and amino acid metabolism and explore how these signalling networks are closely linked and strongly influence one another. This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells, β-cells and δ-cells regulates islet hormone secretion and how islet hormones control the metabolism of different nutrients.\",\"PeriodicalId\":18916,\"journal\":{\"name\":\"Nature Reviews Endocrinology\",\"volume\":\"21 7\",\"pages\":\"397-412\"},\"PeriodicalIF\":40.0000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41574-025-01100-4\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41574-025-01100-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

朗格汉斯胰岛是微调代谢的核心,以确保在禁食和摄食之间的过渡期间代谢稳态。胰岛素和胰高血糖素是胰岛产生和分泌的主要激素,对各种代谢组织起着强有力的控制作用,驱动营养物质的摄取、储存和代谢。它们对血糖的典型作用使这些激素处于对立状态,然而,它们的代谢作用超出了控制血糖水平。事实上,这些胰岛激素在调节脂质和氨基酸代谢方面同样有影响力,而且越来越清楚的是,许多这些作用涉及胰岛素和胰高血糖素之间的相互作用,这与这些激素在本质上是拮抗的教条观点相反。最后,我们假设检查胰岛激素对个体代谢物代谢的影响过于简单。在这里,我们讨论了每种胰岛激素单独和与其他激素联合调节葡萄糖和氨基酸代谢的作用,并探讨了这些信号网络是如何紧密联系和强烈影响彼此的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Islet hormones at the intersection of glucose and amino acid metabolism

Islet hormones at the intersection of glucose and amino acid metabolism

Islet hormones at the intersection of glucose and amino acid metabolism
The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted by islets, exert powerful control in various metabolic tissues to drive nutrient uptake, storage and metabolism. Their canonical actions on glycaemia have positioned these hormones in opposition, however, their metabolic actions extend beyond controlling blood levels of glucose. Indeed, these islet hormones are just as influential in regulating lipid and amino acid metabolism and it is becoming clear that many of these actions involve an interplay between insulin and glucagon, which is contrary to the dogmatic view that these hormones are antagonistic in nature. Finally, we postulate that examining the effects of islet hormones on the metabolism of individual metabolites is overly simplistic. Here, we discuss the actions of each islet hormone alone and in combination with the others in regulating glucose and amino acid metabolism and explore how these signalling networks are closely linked and strongly influence one another. This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells, β-cells and δ-cells regulates islet hormone secretion and how islet hormones control the metabolism of different nutrients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信